Science Signaling
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2026
·Vol. 19
·期 948
·
IF 7
Qian Zhang,Yuedan Zhu,Yi Chen,Wenhao Hou,Aolong Sun,La Yan,Xingzhu Liu,Yu Yuan,Chaoxin Gao,Junfeng Xie,Rui Zhang,Haiyang Chen
Aging impairs intestinal stem cell (ISC) function, disrupting epithelial homeostasis and regenerative repair. Loss of ISC quiescence promotes intestinal dysfunction and contributes to organismal aging. Here, we report an epitranscriptomic mechanism through which a decrease in adenosine-to-inosine (A-to-I) RNA editing by the adenosine deaminase ADAR in ISCs during aging disrupts a conserved signaling axis that maintains ISC quiescence. In Drosophila melanogaster , ISC-specific loss of dADAR triggered hyperproliferation and tissue aging, whereas dADAR overexpression reduced age-related gut dysfunction and extended life span. Intestinal injury induced a decrease in dADAR, which was necessary for tissue regeneration, and in the zinc finger protein dZn72D, which stabilized dADAR to support intestinal homeostasis during aging. dADAR edited transcripts encoding the RNA binding protein Pumilio (dPUM) to generate an isoform that inhibited translation of two components of the mitogen-activated protein kinase (MAPK), dEGFR and dERK, thereby maintaining ISC quiescence. The abundance of ADAR2 and of the dZn72D ortholog ZFR decreased in human colonic crypts with aging and in mouse colon after injury, suggesting that attenuation of ADAR activity may play a conserved role in ISC aging and in facilitating colonic regeneration. Our work identifies a conserved mechanism of epitranscriptomic regulation that safeguards tissues and the decay of ADAR-mediated RNA editing as a form of age-related epigenetic information loss that disrupts ISC homeostasis.
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CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Junyi Feng,Jiwei Zhang,Mengyi Tang,Xiaodan Zhang,Xiaoshuang Chen,Xuesong Feng,Kaifa Du,Wei Li,Huayi Yin,Bowen Deng,Dihua Wang
Efficient capture and separation of Cs + from nuclear wastewater remains a central challenge in nuclear chemical engineering. Here, a solvent-free solid-state conversion strategy is developed to directionally transform natural kaolinite into sodalite under thermally driven solid-state conditions, yielding a Cs + -selective capture material with intrinsic ion-sieving properties. The resulting sodalite exhibits a high Cs + adsorption capacity of up to 242.96 mg/g in weakly acidic solutions and reaches adsorption equilibrium within approximately 50 min, demonstrating fast uptake kinetics. Isotherm and kinetic analyses demonstrate that Cs + adsorption proceeds via a monolayer, chemisorption-dominated process governed by ion exchange. Multiscale characterization combined with theoretical calculations reveals that Cs + capture arises from the synergistic effects of size-matched pore confinement and spatially confined ion-exchange sites within the sodalite framework. These findings establish kaolinite-derived sodalite as a viable inorganic platform for the efficient separation and long-term management of radionuclides in nuclear wastewater.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Jing Wen,Jingyang Wang,Huining Lai,Zhengang Zhao
Pomelo peel, a major byproduct of pomelo processing, was utilized to isolate rhamnogalacturonan-I (RG-I) pectin via a novel approach combining low-concentration alkaline extraction with dielectric barrier discharge (DBD) plasma treatment, followed by characterization. The extracted pectin (DAP) was characterized by its esterification degree, monosaccharide composition, molecular weight, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), triple-helix structure, and scanning electron microscopy (SEM). Results revealed that DBD increased its RG-I content while preserving its overall structure. Additionally, the effects of DAP, oil phase, CaCO₃ concentration, and glucono-δ-lactone (GDL) concentration on the properties of the resulting emulsion gel were investigated. In vitro release studies indicated that the emulsion gel followed the Korsmeyer-Peppas model, demonstrating controlled-release behavior. After simulated in vitro digestion, 70% of the encapsulated naringenin available for release in intestine. This study provides a theoretical foundation for the green extraction of RG-I pectin from pomelo peel and application in delivery systems.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Mingzhu Liu,Xueyan He,Bo Peng,Jin Wu,Zunquan Zhao,Jialei Bai,Jingran Sun,Yanjun Fang
Highly mimetic enzymatic Mn₃O₄/gold nanoparticle (AuNP) composites were prepared, which catalyze the oxidation of tert-butylhydroquinone (TBHQ) to red 2-tert-butyl-1,4-benzoquinone (TBBQ) for TBHQ detection. Absorbance at 487 nm (A₄₈₇) correlates linearly with TBHQ concentrations in the range of 0.52–50 μg/mL, with a limit of detection (LOD) of 0.063 μg/mL, and a limit of quantification (LOQ) of 0.21 μg/mL. TBBQ quenches the fluorescence of copper/iodine-doped carbon dots (Cu,I-CDs) at 500 nm via the inner filter effect (IFE), forming an “on-off” fluorescence probe for TBHQ. TBHQ concentration correlates linearly with the fluorescence intensity difference (F₀ − F) in the range of 0.31–54 μg/mL, with an LOD of 0.054 μg/mL and an LOQ of 0.18 μg/mL. This study uses a dual-mode detection approach to determine TBHQ in various food samples, with recovery rates ranging from 82.5% to 103.0%. The method is sensitive, accurate, cost-effective, and suitable for the rapidly analyzing of TBHQ in food.
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Pharmaceutics
·
2026
·Vol. 18
·期 6
·634
·
IF 6.9
Yan Lin,Xian Zhang,Fulin Bi,Guangji Wang,Jin Yang
Background/Objectives:Despite the presumption of bioequivalence for BCS Class I drugs due to their high solubility and permeability, recent evidence indicates that those with rapid systemic elimination exhibit heightened vulnerability toCmaxnon-equivalence, primarily attributable to intrasubject variability in gastrointestinal transit and absorption kinetics. It is well known that gastric emptying is a significant physiological-dependent factor. But, does the formulation affect gastric emptying?Methods:Using zidovudine as a model drug, formulations containing sodium carboxymethyl starch (CMS-Na), pregelatinized starch, hydroxypropyl methylcellulose (HPMC), and lactose were investigated for their effects on gastric emptying kinetics, and the impact of excipient-mediated gastric emptying prolongation on pharmacokinetic parameters was also evaluated.Results:Relative to AZT alone (Cmax= 13,350 ng/mL; gastric %ID = 11.3%), co-administration with CMS-Na, pregelatinized starch, or HPMC significantly prolonged gastric retention (%ID: 23.4%, 30.5%, and 40.8% at 22.5 min) and reducedCmaxin rats by 47.8%, 34.4%, and 35.1%, respectively, with no effect on intestinal permeability. Viscosity positively correlated with gastric emptying delay.Conclusions:Our rat findings provide new possible mechanistic evidence that certain viscosity-modifying excipients can delay gastric emptying and reduceCmaxof zidovudine, a rapidly eliminated BCS Class I drug, with potential implications for biowaiver risk assessment. Gastric emptying is not only a physiological-dependent variation but also, in cases where common excipients may significantly delay gastric emptying, a formulation-dependent rate-limiting step. For such drugs, excipient-induced gastric emptying delay poses an underappreciated risk to the biowaiver approach, necessitating more prudent regulatory assessment that encompasses the dynamic interplay among sequential rate processes governing drug disposition.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xin Qi,Zhuo Chen,Xiaotong He,Jiu-Qiang Xiong
The global challenge of antibiotic contamination calls for a comprehensive approach that integrates various technological, economic, and social factors to design effective, and sustainable solutions. Microalgae-based biotechnologies offer a sustainable and efficient approach to mitigating residual antibiotics while curbing the spread of antibiotic resistance genes. In this study, we found that the widely distributed microalgal species Chlamydomonas reinhardtii can efficiently degrade tetracycline, oxytetracycline (OTC), and doxycycline. Despite this promising result, the enzymatic mechanisms underlying this degradation process remain largely unknown. Taking OTC as a model chemical, we demonstrated that neither cytochrome P450 enzymes nor primary amine oxidase in C. reinhardtii were essential for OTC degradation using enzyme inhibition assays. Further identification and characterization of a novel tropinone reductase I (TRI) demonstrated that this enzyme catalyzes the demethylation of OTC, achieving a remarkable removal efficiency of 93.10% within 24 h. Additionally, informative analysis of metagenomic and metatranscriptomic databases revealed a widespread distribution and transcriptional activity of genes encoding TRI homologs across diverse environmental settings. The widespread distribution and transcriptional activity of TRI homologs suggest potential for TRI-mediated OTC degradation in diverse marine settings. These fundamental understandings of enzymatic catalysis processes not only provide critical insights into improving environmental management strategies, but also offer new lights on the unknown global impacts of novel phytoplankton enzymes.
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Journal of CO2 Utilization
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2018
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IF 5.503
Xue-Dong Li,Yu Cao,Ran Ma,Liang-Nian He
Efficient CuI/1,10-phen-catalyzed three-component cascade reaction of propargylic alcohols, CO 2 , and 2-aminoethanols has been firstly developed for the thermodynamically favourable preparation of 2-oxazolidinones. In the presence of commercially available CuI, 1,10-phen (1,10-phenanthroline) and t -BuOK, the cascade reaction afforded the desired products in good to excellent yields with a broad substrate scope (14 examples). The predicted copper complex Cu 2 I 2 (phen) 2 in situ formed from CuI and 1,10-phen could activate the triple bond through coordination. The isolation of α-alkylidene cyclic carbonate as the reaction intermediate suggests that the carboxylative cyclization of propargylic alcohol with CO 2 , followed by ring-opening reaction, is involved in the one-pot three-component cascade reaction.
研究领域:
有机化学
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催化
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二氧化碳利用
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合成方法学
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ACS Applied Materials & Interfaces
·
2026
·
IF 8.2
Qianjun Su,Hui Duan,Qiyan Li,Mengdan Zhang,Pan Liu,Huixue Chen,Weili Li,Ping Liu,Chunlin Chen,Ruiyuan Liu,Pengfei Li
Persistent infection with high-risk HPV in women can progress to cervical intraepithelial neoplasia and even cervical cancer. This study investigated the cytotoxic and immunomodulatory effects of the TBTCN-TDG photodynamic therapy (PDT) probe in treating HPV-associated cervical lesions. The TBTCN-TDG probe was designed by integrating a donor-acceptor-π-acceptor 1 (D-A-π-A1) structure (TBTCN) with TDG, a moiety targeting Galectin-1, and its targeting ability in HPV-positive SiHa cells was confirmed. The in vitro results demonstrated that TBTCN-TDG combined with light treatment significantly inhibited SiHa cell proliferation, increased apoptosis, and activated immune responses by stimulating dendritic cells, macrophages, and NK cells, through enhanced NF-κB pathway signaling. In vivo, this targeted photosensitizer exhibited substantial therapeutic effects under laser excitation, as evidenced by TUNEL staining, which showed increased apoptosis in lesions. Immune analysis indicated that TBTCN-TDG enhanced NK cell viability and elevated the levels of pro-inflammatory cytokines under laser excitation, such as TNF-α, IFN-γ, and IL-6, confirming immune response activation. In conclusion, the combination of TBTCN-TDG and PDT effectively targets cells infected with HPV, enhances immune responses, and suppresses HPV infection. This suggests a novel therapeutic strategy for photodynamic immunotherapy in patients with cervical high-risk HPV infections.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2025
·Vol. 27
·期 45
·24273-24283
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IF 2.9
Jin Zou,Daoyun Zhu,Zhongfei Mu,Song Xu,Nurahmat Wali,Fugen Wu,Huafeng Dong,Xin Zhang,Xiao Wu,Yifei Luo,Yuchun Zhan
Near-infrared (NIR) spectroscopic technology has shown extensive application prospects. However, developing NIR phosphors with tunability and high thermal stability is a huge challenge. In this work, a highly promising phosphate compound, K3Ga2(PO4)3, has been successfully synthesized. When doped with Cr3+ ions, it is particularly noteworthy that Cr3+ exhibits highly efficient and thermally stable broadband NIR luminescence in the tetrahedral coordination environment. This unique property makes K3Ga2(PO4)3:Cr3+ a compelling candidate for advanced photonic applications. Therefore, studying the luminescent properties of Cr3+ rare earth ions doped into tetrahedral sites is of great significance. In the tetrahedral coordination environment of K3Ga2(PO4)3:Cr3+ ions exhibit broadband near-infrared emission spanning from 700 to 1100 nm (λem = 822 nm, FWHM = 124 nm) under 452 nm blue light excitation. Remarkably, the quantum efficiency reaches as high as 70.9%, demonstrating its exceptional potential for advanced photonic applications. In addition, the phosphors demonstrated exceptional thermal stability with near-zero thermal quenching. The NIR luminescence intensity at 373 K and 423 K retained 109.0% and 90.4% of its initial room-temperature value, respectively. This remarkable performance can be attributed to the material's ultra-wide band gap, and minimal electron–phonon coupling. The NIR pc-LED devices, fabricated by integrating the optimized K3Ga1.93(PO4)3:0.07Cr3+ phosphors with a blue LED chip (λex = 455 nm), achieved a near-infrared output power of 274 mW with a conversion efficiency of 5.42% under a driving current of 100 mA. Experimental results demonstrate that the fabricated NIR pc-LED exhibits significant potential for applications in night vision and vein imaging technologies. This study provides a strategic framework for designing high-performance NIR pc-LED devices, utilizing K3Ga2(PO4)3:Cr3+ as an efficient phosphor-converted light source, and offers valuable insights for practical implementation in advanced optical systems.
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Laser & Photonics Reviews
·
2023
·
IF 11
Chunli Zhao,Yuan Gao,Jing Wang,Jianbei Qiu
Lead-free rare-earth-based perovskites have received widespread attention for their unique optical properties, although achieving efficient broadband near-infrared (NIR) emission with these materials remains a challenge. Here the synthesis of a rare earth-based double perovskite (Cs 2 NaScCl 6 ) by an improved solid phase method is reported. The doping of Cr 3+ led to the formation of [CrCl 6 ] 3− octahedron, which exhibited a broadband NIR emission peaked at 950 nm and a half-peak width of 162 nm. It is worth noting that with the same actual Cr 3+ content, the luminous intensity of Cs 2 NaScCl 6 synthesized by the improved solid-phase synthesis is four times higher than the product synthesized by the hydrothermal method. an efficient Cl − -Cr 3+ charge transfer sensitization facilitated by localized electrons in [CrCl 6 ] 3− octahedron is the mechanism for the strong NIR emission of Cr 3+ is proposed. Calculations based on density functional theory and Bader charge analysis support the notion that electrons in [CrCl 6 ] 3− octahedrons are strongly localized in Cs 2 NaScCl 6 :Cr 3+ , which is conducive to the Cl − –Cr 3+ charge transfer process, resulting the internal quantum efficiency of 100% and external quantum yield as 42.3%. The highly efficient ultra-broadband NIR emission with excellent stability offers many opportunities for applications in the field of NIR night vision and bio-imaging.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xing Wu,Junyang Zhang,Huanting Wang,Yuning Huo,Zongli Xie
Graphene oxide (GO) membranes are emerging for water treatment. Meanwhile, challenges remain due to membrane fouling and their instability in aqueous solutions. Herein, a novel GO-based mixed-dimensional membrane with superior antifouling and nonswelling properties was prepared by assembling two-dimensional (2D) GO nanosheets and zero-dimensional (0D) copper(I) oxide-incorporated titanium dioxide photocatalyst (CT). The decoration of CT in GO nanosheets tuned the microstructure and surface hydrophilicity while creating more transport channels in CT/GO membranes. This resulted in a high water permeance of 171.5 L m–2 h–1 bar–1 and improved selectivity to various dye molecules (96.2–98.6%). Due to the significantly enhanced antibacterial properties of the CT nanoparticles, the growth of bacteria on the surface of the CT/GO membrane was suppressed (threefold less than that on the GO membrane). Moreover, the embedding of photocatalysts also allowed CT/GO membranes to exhibit ∼9-fold improvement in antibacterial activity and organic dye degradation performance under visible-light irradiation. This study offers a powerful solution to enhance the nanofiltration performance and antibacterial properties of GO membranes toward practical applications.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Hong Zeng,Hongli Yang,Yue Tang,Xiaojuan Niu,Yuangen Wu
A facile and simple colorimetric biosensor was first established for paraquat (PQ) detection based on the aptamer-enhanced oxidation process of 3,3′,5,5′-tetramethylbenzidine (TMB) by Ag + . The study confirmed that the interaction of PQ-15 aptamer with Ag + accelerates the electron transfer from the aptamer-Ag + complex to dissolved oxygen, which enhances the release of superoxide anion radicals (O 2 ̇ − ) and facilitates the catalytic oxidation of the chromogenic substrate. PQ-15 aptamer will preferentially bind to PQ molecules, resulting in no further enhancement of the catalytic activity of Ag + . Molecular docking results revealed that the PQ molecules are attached to the stem-loop region of the PQ-15 aptamer through σ-π conjugation interactions. The proposed method is simple that only contains Ag + and corresponding aptamer. The limit of detection (LOD) of the constructed colorimetric biosensor for PQ detection was determined to be 16.5 μg·L -1 , belowing the maximum residue limit in fruits and vegetables set by the EU. Moreover, the colorimetric biosensor showed excellent selectivity and anti-interference properties, which was validated for detecting PQ residues in several typical agricultural and water samples.
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