RENEWABLE ENERGY
·
2024
·
IF 9
Moyu Liao,Ruofei Xiang,Xinwen Zhou,Zhongxu Dai,Li Wang,Hang Qin,Hanning Xiao
Hydrogen generation via methanol steam reforming is a promising method for producing renewable energy. In this work, a series of Mn 2+ -substituted CuAl 2 O 4 spinels were prepared by solution combustion method, and the crystal structure, micromorphology, chemical constitution, reduction behavior, acidity, specific surface area and surface chemical state of the spinels were comprehensively characterized by various equipments. The obtained spinels were washcoated on Cu foams to prepare monolithic catalysts, and the catalytic performance of the catalysts was evaluated in a methanol steam reforming microreactor. Compared with the binary Cu–Al spinel, the Mn 2+ substitution led to a decrease in the particle size, a change in the chemical composition and reduction behavior, a decline in the acidity, an increase in the specific surface area, and an improvement in the surface chemical state. As a result, the release rate of active Cu from the Mn-containing CuAl 2 O 4 spinel was significantly slowed down and the formed nanoparticles were fine, which was believed to be in favor of maintaining a stable catalytic performance longer. Among the prepared catalysts, the monolithic catalyst loaded with Cu 0.4 Mn 0.6 Al 2 O 4 exhibited the highest activity and stability. The findings of this work suggested that introducing Mn 2+ might be a promising way to regulate the Cu releasing property for obtaining a better sustained release catalyst system.
✓ 已验证
产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 20
·6909-6918
·
IF 6.1
Hongjun Chen,Liming Deng,Sheng Zhao,Shuyi Liu,Feng Hu,Linlin Li,Jianwei Ren,Shengjie Peng
Developing efficient and durable hydrogen evolution reaction (HER) electrocatalysts is critical for industrial and sustainable hydrogen production. Herein, a simple co-precipitation strategy is proposed to successfully construct catalysts with a Mott–Schottky heterojunction by coupling a transition-metal phosphate to the surface of stripped MXene thin-layer nanosheets (M3(PO4)2@MXene, M = Co, Ni, and Fe). The Co3(PO4)2@MXene with a unique tightly connected 2D/2D heterostructure and built-in electric field induces directional electron transfer at the interface, regulates the polarized structure of the active sites, and accelerates both mass and electron transport. Consequently, the optimized Co3(PO4)2@MXene demonstrates outstanding HER performance, achieving low overpotentials of 46 and 58.6 mV at 10 mA cm−2 in alkaline freshwater and seawater electrolytes, respectively. Moreover, the Co3(PO4)2@MXene heterojunction catalyst maintains stable operation at a high current density of 500 mA cm−2 for over 100 h in alkaline seawater electrolytes. More importantly, Co3(PO4)2@MXene can offer a low potential of 1.71 V at 500 mA cm−2 with stable operation for 50 h in a flow-type alkaline seawater electrolyser. This study provides a unique heterostructure in an electrocatalyst for an efficient HER and presents its potential application in seawater electrolysis.
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2024
·Vol. 13
·期 20
·3316
·
IF 4.7
Xiaonian Cao,Yunfei Hou,Qingqing Liu,Qian Yang,Min Liu,Haixu Lin,Qingxi Ren,Jian Mao
The unique flavour contribution of higher alcohols in alcoholic beverages has received growing attention; however, there is a dearth of information on their in vivo metabolic kinetics. In this study, the composition and content of higher alcohols in different alcoholic beverages from ChineseBaijiuandLujiuwere studied via in vivo analysis using Bama pigs to elucidate the mechanisms for intoxication of alcohol in vitro and in drinkers. Direct injection combined with gas chromatography–mass spectrometry (GC-MS) were used to accurately quantify a total of 14 higher alcohols in five alcoholic beverages. Based on the external standard method, a total content of 289.37–938.33 mg/L was detected, mainly 1-butanol, 3-methyl-1-butanol, 1-hexanol, 2-methyl-1-propanol and 2-butanol. Then, headspace solid-phase microextraction (HS-SPME) and solid-phase extraction (SPE) combined with GC-MS analysis strategy, respectively, were adopted to continuously monitor the changes in the concentrations of ethanol and 11 higher alcohols in the blood within 24 h after gavage of different alcoholic beverages, and the key pharmacokinetic parameters were analysed. The peak concentration (Cmax) and area under curve (AUC) of blood higher alcohols were significantly lower than those of ethanol (p <0.05), accompanied by a later peak time (Tmax) and a larger apparent clearance rate (CL_F), and there were certain differences between the same higher alcohols in different alcoholic beverages and between different higher alcohols in the same alcoholic beverage. This work provides valuable insights into the metabolism of alcoholic beverages.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2017
·
IF 4.3
Xia-Rong Wang,Si-Qian Gao,Xiao-Qian Niu,Long-Jian Li,Xiao-Ying Ying,Zhong-Jie Hu,Jian-Qing Gao
Capsaicin has been used in clinical applications for the treatment of pain disorders and inflammatory diseases. Given the strong pungency and high oil/water partition coefficient of capsaicin, capsaicin-loaded nanolipoidal carriers (NLCs) were designed to increase permeation and achieve the analgesic, anti-inflammatory effect with lower skin irritation. Capsaicin-loaded NLCs were prepared and later optimized by the Box–Behnken design. The physicochemical characterizations, morphology, and encapsulation of the capsaicin-loaded NLCs were subsequently confirmed. Capsaicin-loaded NLCs and capsaicin-loaded NLCs gel exhibited sustained release and no cytotoxicity properties. Also, they could significantly enhance the penetration amount, permeation flux, and skin retention amounts of capsaicin due to the application of NLCs. To study the topical permeation mechanism of capsaicin, 3,3′-dioctadecyloxacarbocyanine perchlorate (Dio) was used as a fluorescent dye. Dio-loaded NLCs and Dio-loaded NLCs gel could effectively deliver Dio up to a skin depth of 260 and 210 μm, respectively, primarily through the appendage route on the basis of version skin sections compared with Dio solution, which only delivered Dio up to 150 μm. In vivo therapeutic experiments demonstrated that capsaicin-loaded NLCs and capsaicin-loaded NLCs gel could improve the pain threshold in a dose-dependent manner and inhibit inflammation, primarily by reducing the prostaglandin E2 levels in the tissue compared with capsaicin cream and capsaicin solution. Meanwhile, skin irritation was reduced, indicating that application of NLCs could decrease the irritation caused by capsaicin. Overall, NLCs may be a potential carrier for topical delivery of capsaicin for useful pain and inflammation therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2024
·
IF 11.4
Jiayue Dong,Peizeng Yang,Deyang Kong,Yiqiang Song,Junhe Lu
Polycyclic aromatic hydrocarbons (PAHs) have become a global environmental concern due to their potential hazardous implication for human health. In this study, we found that sulfate radical (SO 4 •− ) could effectively degrade naphthalene (NAP), a representative PAH in groundwaters, generating 1-naphthol. This intermediate underwent further degradation, yielding ring-opening products including phthalic acid and salicylic acid. However, the presence of nitrite (NO 2 − ), a prevalent ion in subsurface environments, was observed to compete with NAP for SO 4 •− , thus slowing down the NAP degradation. The reaction between NO 2 − and SO 4 •− generated a nitrogen dioxide radical (NO 2 • ). Concurrently, in-situ formed 1-naphthol underwent further oxidization to the 1-naphthoxyl radical by SO 4 •− . The coupling of 1-naphthoxyl radicals with NO 2 • gave rise to a series of nitrated NAP, namely 2-nitro-1-naphthol, 4-nitro-1-naphthol, and 2,4-dinitro-1-naphthol. In addition, the in-situ formed phthalic acid and salicylic acid also underwent nitration , generating nitrophenolic products, although this pathway appeared less prominent than the nitration of 1-naphthol. When 10 μΜ NAP was subjected to heat activated peroxydisulfate oxidation in the presence of 10 μΜ NO 2 − , the total yield of nitrated products reached 0.730 μΜ in 120 min. Overall, the presence of NO 2 − dramatically altered the behavior of NAP degradation by SO 4 •− oxidation and contributed to the formation of toxic nitrated products. These findings raise awareness of the potential environmental risks associated with the application of SO 4 •− -based oxidation processes for the remediation of PAHs-polluted sites in presence of NO 2 − .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 17
·7639-7645
·
IF 2.7
Qianxi Wang,Yuyu Dai,Xueli Hong,Yunyang Hong,Rui Zhang,Xinhuan Yan
Non-precious metal catalysts play a significant role in the field of hydrogenation. This study synthesized Co-BTC from cobalt nitrate hexahydrate and 1,3,5-tricarboxylic acid benzene. By changing the calcination temperature of Co-BTC in an inert atmosphere, a series of novel non-precious metal Co/C microsphere catalysts were successfully prepared. The composition and structure of the Co/C-n catalysts were characterised by FESEM, TEM, XRD, IR, XPS and BET. These results confirm that 1,3,5-benzenetricarboxylic acid provides a rich carbon matrix and metallic Co nanoparticles are generated by self-reduction on the carbon matrix. The graphite matrix formed during the calcination process has a rich pore structure and good dispersion of active components on the catalyst surface, which is very favourable for the catalytic reaction. In the hydrogenation of o-chloronitrobenzene (o-CNB) to o-chloroaniline (o-CAN), the Co/C-500 catalyst showed the best catalytic performance. At 80 °C and 2 MPa H2 for 60 minutes, the conversion rate of o-CNB reached 99% and the selectivity reached 99%. When the reaction takes 5 minutes, the conversion rate reaches 10.5%, and the TOF value reaches 36.3 h−1. The Co/C-500 catalyst can be easily recycled and reused after reaction with the help of a magnetic field. Moreover, this catalyst is also effective in the selective hydrogenation of other nitroaromatic hydrocarbons containing halogen or unsaturated groups to corresponding aniline. This simple and direct synthesis method may lead to the economic production of large-scale Co/C catalysts, which is an attractive prospect for the industrial trial production of corresponding aniline.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Kunhan Chen,Dong Wang,Jiawei Du,Qikuan Cheng,Lu Zhang,Weibang Xia,Yunming Wang,Huamin Zhou
Challenges remain in the design and manufacture of acoustic devices with excellent broadband sound absorption performance. Herein, an efficient acoustic absorber with hierarchical pore structure and additional acoustic-electrical energy conversion mechanism is reported in which combined zirconia porous ceramics and P(VDF-TrFE) piezoelectric aerogels. Reticular cross-scale pore structure enables sound waves to propagate and dissipate effectively. The vibrations generated by piezoelectric aerogels under acoustic excitation further consume sound waves through converting acoustic energy into electrical energy based on the local piezoelectric and triboelectric effect, which improves the medium and low-frequency sound absorption capability. The average sound absorption coefficient of the prepared acoustic composites reaches 0.87 while the noise reduction coefficient is 0.54. Furthermore, the composites also possess low density, high compressive strength, good hydrophobicity and thermal insulation properties for applications. Therefore, this innovative strategy offers new design ideas for the next generation of high-performance acoustic materials with promising applications in transportation and industrial construction.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Chemistry-X
·
2025
·
IF 8.2
Yuhang Zhu,Zhangtie Wang,Xiang Li,Siyu Chen,Daoxin Dai,Weihu Li,Binhai Shi,Baolong Wang,Guoliang Jie,Baiyi Lu
Sakura, a traditional edible flower, has been investigated for its anti-glycation potential; however, the bioactive components remain unclear. Polyphenols are recognized for their exceptional anti-glycation properties. In this study, main polyphenols were identified from seven varieties through metabolomics. 5-O-caffeoylquinic acid (5-OCA), 3-O-caffeoylquinic acid (3-OCA), and caffeic acid were confirmed as key agents through multivariate analysis, which was further validated by anti-glycation assessments. The concentrations of these polyphenols in Cerasus serrulata ‘Kanzan’ (CK) were 2.52 ± 0.08, 3.31 ± 0.18 and 2.38 ± 0.15 mg/g, respectively, contributing to its superior AGEs inhibition ratio (100 μg/mL) of 76.11 ± 0.40 %. Simulated digestion revealed that isomerization between 5-OCA and 3-OCA occurred during the gastric phase. Both compounds were metabolized to caffeic acid in the intestinal phase, contributing to a sustained anti-glycation activity of 64.74 ± 1.11 %. Overall, our study provides a theoretical basis for the development of Sakura-based functional foods targeting anti-glycation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 2.6
Hai-Xia Xu,Qiao-Ting Xu,Zhong-Ping Yin,Ji-Guang Chen,Qing-Feng Zhang
Summary Obesity is becoming a top global health problem. Inhibition of digestive enzymes is an effective approach in weight management due to the reduction of energy absorption. In this study, the inhibitory effects of luteolin on α-glucosidase and pancreatic lipase were investigated in vitro and in vivo via enzyme kinetics, fluorescence quenching, molecular docking and rat experiments. The results showed that luteolin inhibited α-glucosidase and pancreatic lipase in a mixed-type and uncompetitive manner with IC 50 values of 29.31 and 42.74 μg mL −1 respectively. The binding of luteolin with the two enzymes caused the quenching of intrinsic fluorescence of protein. Molecular docking simulation revealed that luteolin could be located in the active pocket of α-glucosidase and interact with the key amino acid residues. Moreover, a hydrophobic interaction and a van der Waals force were formed between luteolin and the key amino acid residues of pancreatic lipase (His264 and Ser153). In vivo studies further confirmed that luteolin could significantly decrease the absorption of glucose and triacylglyceride in rats by inhibiting α-glucosidase and pancreatic lipase.
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Zan Cui,Chenyu Shi,Ran An,Yan Tang,Yinping Li,Xueting Cao,Xukai Jiang,Chang-Cheng Liu,Min Xiao,Li Xu
Cancer vaccines utilizing nanoparticle (NP) structures that integrate antigens and adjuvants to enhance delivery and stimulate immune responses are emerging as a promising avenue in cancer immunotherapy. However, the development of cancer vaccines has been significantly hindered by the low immunogenicity of tumor antigens. To address this challenge, substantial efforts have been made in developing innovative adjuvants to elicit effective immune responses. In this study, we develop a NP cancer vaccine assisted by a polysaccharide derivative adjuvant, designed through a computational strategy, to evoke effective antigen-specific antitumor immunity. Using TLR4 as the putative receptor, we conducted a comprehensive evaluation of a prescreening library consisting of 34 inulin derivatives through docking and molecular dynamics simulation. Consequently, a new derivative, benzoylated inulin (InBz), is selected as the most promising TLR4 agonist. The adjuvant effect of InBz is evaluated by fabricating InBz NPs encapsulating the model antigen ovalbumin (OVA). In vitro, InBz-OVA NPs effectively activate the TLR4 signaling pathways and facilitate dendritic cell maturation, thereby enhancing the antigen delivery and presentation. In vivo, InBz-OVA NPs outperform a commercial aluminum-based adjuvant, elicit robust antibody titers, induce antigen-specific cytotoxic T lymphocytes, and achieve significant tumor suppression in murine models. Besides, the adjuvant effects of other representative derivatives, namely, acetylated and chloroacetylated inulin, with moderate and low potential from the library, are also chemically synthesized and experimentally evaluated and found to be in agreement with computational predictions, confirming the credibility of the strategy. This study provides an effective platform for the pursuit of efficient polysaccharide-based vaccine adjuvants.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 1
·177
·
IF 4.6
Zhi Lu,Yifan Guo,Shilin Li,Jiaqi Ding,Yingzi Ren,Kun Tang,Jiefeng Wang,Chengxin Li,Zishuo Shi,Ziqi Sun,Hongbo Meng,Guangxin Wang
Water electrolysis is a promising path to the industrialization development of hydrogen energy. The exploitation of high-efficiency and inexpensive catalysts become important to the mass use of water decomposition. Ni-based nanomaterials have exhibited great potential for the catalysis of water splitting, which have attracted the attention of researchers around the world. Here, we prepared a novel Mo-doped NiFe-based layered double hydroxide (LDH) with a nanoarray microstructure on Ni foam. The doping amount of Mo can significantly change the microstructure of the electrocatalysis, which will further affect the oxygen evolution reaction (OER) performance of water splitting. This novel nanomaterial required only an overpotential of 227 mV for 10 mA cm−2and a Tafel slope of 54.8 mV/dec in 1 M KOH. Meanwhile, there was no Mo, and the NiFe-LDH needed 233 mV to attain to 10 mA cm−2. Compared to the NiFe-LDH without Mo, the NiFeMo-LDH nanosheet arrays exhibited enhanced activities with 17.1 mV/dec less Tafel in OER. The good performance of the electrocatalyst is ascribed to the special nanosheet arrays and the heterostructure of the Ni-Fe-Mo system. These features help to increase the active surface, enhancing the efficient charge transfer and the reactive activity in OER.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2024
·
IF 4.9
Zhang Qing,Dai Ziliang,Zhang Lili,Wang Zhiguo
Complex interactions between cellulose molecules and small molecules of deep eutectic solvents (DESs) can lead to dramatic changes in the structure of the hydrogen bond network in cellulose. However, the molecular and ionic evolution mechanism of DESs on cellulose nanofibrillation is still unclear. In this study, the mechanism and the critical role of ions in DESs on cellulose nanofibrillation were investigated. The results showed that cellulose nanofibers (CNFs) with a diameter of less than 200 nm could be prepared directly using DES consisting of lactic acid (LA) and chloride, e.g., LA/ammonium chloride (NH 4 Cl) or LA/dodecyltrimethylammonium chloride (DTAC). Using LA/Zinc chloride (ZnCl 2 ), CNFs with a diameter of less than 100 nm can be prepared. The Kamlet-Abboud-Taft parameters (KAT value) showed that DESs containing LA had higher hydrogen bond acidity ( α ) than other systems (such as ethylene glycol and urea) without LA, which provided more active protons to improve the proton mobility in the cellulose nanofibrillation. Also, DESs composed of LA and Cl − had high hydrogen bond alkalinity ( β ), which led to great changes in the original hydrogen bond network of cellulose and the formation of a new hydrogen bond structure, thereby easing the dissolution of the cellulose. Thus, the cellulose hydroxy groups could be esterified by the LA under high-temperature moistening conditions, and the CNFs prepared by the DES system containing LA and Cl − had the highest degree of substitution (DS) (up to 0.73 in LA/ZnCl 2 system) after high-temperature moistening.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）