CHEMICAL ENGINEERING SCIENCE
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2026
·
IF 5.1
Shu Wang,Lifang Chen,Chuxin Qi,Zhen Song,Xiang Zhang,Zhiwen Qi
Dual-role ILs act as solvent and PTC for efficient aromatic O,S-glycosidations. • Multilevel screening and experimental validation identify the optimal IL. • Screened optimal IL achieves superior performance with various acceptors. • Mechanism analysis reveals the intensification mechanism.Provide a general strategy for screening ILs in aromatic O,S-glycosidations. Aromatic O,S-glycosidations between (thio)phenols and glycosyl halides are valuable for synthesizing aromatic O,S-glycosides but often limited by immiscible reactants. This work presents a reaction intensification strategy for efficient O,S-glycosidations by using dual-role ionic liquids (ILs) that act as solvent and phase transfer catalyst (PTC). Taking the reaction between 4-nitrophenol and 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl bromide to form p-nitrophenyl-2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside as an example, multilevel computational screening, experimental validation, and comprehensive mechanistic analysis are performed to identify the optimal dual-role IL and understand the explicit intensification mechanism. Specifically, 11,890 IL candidates are first screened as solvents via solubility indicators and physical properties. The easiness of formation and hydrophobicity of ion pairs transferring the liquid–liquid interface are considered to screen ILs as PTCs. After these, 36 potential ILs are filtered out. Considering the availability, 1-octyl-3-methyl-imidazolium tetrafluoroborate is eventually tested via experiment and achieves the best performance. Compared with the basecase IL reported previously, the yield is improved from 34.2 % to 53 %. Meanwhile, this IL exhibits far more superior catalytic efficiency with different acceptors. The acceptors involved are common phenols (i.e., 4-nitrophenol, phenol and p-Cresol) and thiophenols (i.e., 4-methylbenzenethiol, 4-nitrobenzenethiol), which corresponds to O- and S-bridge products, respectively. Mechanism analyses reveal that the reaction is mainly intensified through the extraction effect of ion pair led by the IL, which promotes ion pair transfer from aqueous phase to IL phase and thus leads to better contacts of reactants and catalytic efficiency. Clearly, this work offers useful guidance to screen dual-role ILs as solvent and PTC for efficient aromatic O,S-glycosidations.
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Chemical Science
·
2026
·
IF 8.1
Siyuan Ren,Muhammad Abbas,Zhibin Xie,Zilin Lu,Jasim Yousaf,Muhammad Ishaq,Zhuanghao Zheng,Jun Zhao,Shuo Chen,Guangxing Liang
The development of efficient and stable photocathodes from earth-abundant materials is a critical challenge for photoelectrochemical (PEC) hydrogen production. While Cu2ZnSnS4 (CZTS) is a promising absorber due to its ideal bandgap and non-toxic constituents, its performance is plagued by severe interfacial recombination. This work addresses this limitation through the precise engineering of a zinc-titanium oxide (Zn,Ti)O electron transport layer (ETL) in Mo/CZTS/CdS/(Zn,Ti)O/Pt photocathodes. We systematically investigate the influence of atomic-layer-deposited (Zn,Ti)O on the heterojunction's microstructure, band alignment, and charge transfer kinetics. A suite of characterization studies reveals that a suitable ETL thickness forms a dense, conformal coating and establishes an optimal spike-like conduction band offset at the CdS/(Zn,Ti)O interface, which minimizes bulk and interfacial charge-transfer resistance. Consequently, the optimized photocathode achieves a remarkable photocurrent density of 29.2 mA cm−2 at 0 VRHE and a high half-cell solar-to-hydrogen efficiency (HC-STH) of 7.02%. This study demonstrates that fine control of composite ETLs is a powerful strategy to unlock the potential of CZTS and related earth-abundant absorbers for scalable solar fuel production.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2026
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IF 3.9
Chenya Li,Jianzhi Wang,Hongyan Zhang,Yanping Liu,Faquan Yu
Methyl-1,4-benzoquinone (2-MBQ) is a valuable quinone compound with extensive applications in pharmaceuticals, materials science, and fine chemicals. In this study, the aerobic oxidation of o-cresol to 2-MBQ, using oxygen as the oxidant, was optimized by comparing two Co-Schiff base catalysts, Co-salophen and Co-salen, to identify the most efficient catalytic system. A continuous-flow microreactor was then employed to further enhance the reaction process, leveraging its superior gas–liquid mass transfer and precise control over the reaction parameters. Under optimized conditions, the microreactor achieved 99% o-cresol conversion and 87% 2-MBQ yield within 50 min, significantly outperforming the traditional batch reactor, which required 180 min to achieve 98% conversion and only 82% yield. Kinetic studies revealed that the reaction follows a second-order kinetic model, with an activation energy of 24.45 kJ/mol for the synthesis of 2-MBQ from o-cresol. These results highlight the advantages of microreactors in accelerating reaction time and improving product selectivity, providing valuable insights for the synthesis of 2-MBQ and the application of microreactors in chemical processes.
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INTERNATIONAL IMMUNOPHARMACOLOGY
·
2026
·
IF 5.6
Yangyang Song,Jie Song,Shuxian Liu,Jiyang Zhang,Ziyuan Liu,Haoyun Chen,Shiwen Wang,Tao Zhuang,Guisen Zhang
Depression and anxiety disorders are highly comorbid, yet their complex pathogenesis often limits the efficacy of monotherapy. Growing evidence implicates neuroinflammation in their pathogenesis. Co-drugs that linked two active molecules into a single compound and released the drugs after administration, which offering improved efficacy and tolerability than individual drug mixtures or monotherapy. In this work, five new co-drugs ODV-NSAIDs were synthesized from O -desmethylvenlafaxine (ODV) with non-steroidal anti-inflammatory drugs (NSAIDs) to achieve synergistic antidepression and anxiolytic effects. In vitro stability studies exhibited that these co-drugs can be metabolized into two single drugs within 60 min in simulated intestinal fluid. In both acute and chronic LPS-induced models, co-drug ODV-NAP significantly ameliorated depressive-like behaviors, evidenced by increased sucrose preference, reduced immobility in the tail suspension test (TST) and forced swim test (FST), and enhanced locomotion in the open field test (OFT). Furthermore, ODV-NAP decreased brain levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and malondialdehyde (MDA), while elevating serotonin (5-HT), norepinephrine (NE), and superoxide dismutase (SOD) activity. Nissl staining confirmed ODV-NAP significantly attenuated hippocampal neuronal damage. Moreover, western blotting revealed ODV-NAP inhibited the TLR4/NF-κB signaling pathway and upregulated BDNF and p-TrkB protein expression. ODV-NAP also inhibited LPS-induced p65 nuclear translocation in BV-2 microglia in vitro , and caused no toxicity in histology. Thus, co-drug ODV-NAP represented a promising novel candidate for treating depression and anxiety.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 4
·123461
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IF 7.5
Rongfang Yuan,Junyi Yuan,Caiyun Zhang,Huilun Chen,Beihai Zhou,Waseem Hassan,Ao Li
Residual sulfamethoxazole (SMX) in aquatic environments poses risks to ecosystems and human health. Due to their exceptional mechanical strength and chemical durability, ceramic membranes (CMs) provide a suitable platform for heterogeneous catalytic oxidation. The synthesis of Fe 2 O 3 -CeO 2 @CM for catalyzing ozone oxidation to remove SMX was done in this study using a hydrothermal in-situ growth technique. The findings showed that when the Fe/Ce molar ratio was 1:3, the calcination temperature was 500°C, and the catalyst loading was 8.4 mg/g, the SMX was totally removed in 10 min in the presence of Fe 2 O 3 -CeO 2 @CM. The characterisation results showed that the material comprised FeCe solid solution and Fe 2 O 3 particles, exhibiting multiple valence states (Fe 2+ /Fe 3+ , Ce 3+ /Ce 4+ ). Based on the quenching experiments, ·OH, ·O 2 - , and 1 O 2 radicals were shown to be involved, with ·O 2 - and 1 O 2 playing primary roles. Mechanistically, the Fe 2+ /Fe 3+ and Ce 3+ /Ce 4+ species in the catalyst exhibited favourable redox cycling, promoting oxygen vacancy regeneration and serving as key active sites for catalysing O 3 decomposition. Furthermore, the system demonstrated excellent cycling stability, maintaining SMX removal rates above 95% after five cycles and achieving 94% removal in actual wastewater, effectively mitigating membrane fouling. An effective and reliable technique for eliminating antibiotics from wastewater is presented in this work.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Yaopeng Pu,Yuyu Wang,Fei Pan,Yulong Ma,Feng Lin,Wenxin Ji,Yuanyuan Li,Yonggang Sun
The escalating severity of global water scarcity and pollution necessitates the development of efficient and sustainable treatment technologies. Solar-driven interfacial evaporation presents an environmentally friendly, low-energy solution for both seawater desalination and wastewater treatment. In this study, we introduce a multifunctional integrated spherical evaporator composed of lignin-wrapped ZnFe 2 O 4 /chitosan‑carbon aerogel spheres (ZFO/CLCA), employing renewable chitosan as a three-dimensional flexible framework. By integrating ZnFe 2 O 4 , a visible-light-active semiconductor, with sodium lignosulfonate, known for its excellent photothermal conversion capabilities, we constructed a three-component organic hybrid featuring an in-situ formed hierarchical porous structure through a one-step carbonization process. The resulting ZFO/CLCA material demonstrates a high density of interconnected multiscale pores, a substantial specific surface area, and broad-spectrum absorption (93.48% across 250–2500 nm). Under simulated solar irradiation (1 kW m −2 ), this material exhibits an evaporation rate of 2.33 kg m −2 h −1 and a solar-to-steam conversion efficiency of 94.54%. The distinctive through-hole structure effectively prevents surface salt accumulation in high-salinity environments (3.5–20 wt% NaCl) via concentration-gradient-driven ion reverse diffusion, maintaining excellent long-term stability over 12 h of continuous operation. Importantly, during photothermal evaporation, the material concurrently catalyzes the degradation of organic pollutants, achieving an 87.10% degradation rate of tetracycline (100 mg L −1 ). In the context of real industrial wastewater treatment containing high salt concentrations and antibiotics, the evaporator produces clean effluent that complies with discharge standards. This study highlights a multifunctional spherical carbon aerogel evaporator that integrates efficient photothermal evaporation, salt resistance, and catalytic degradation, thereby, establishing a promising material platform for integrated solar-driven water treatment systems with both scientific significance and practical application potential.
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Small
·
2026
·
IF 11.8
Hang Zhang,Yinuo Wu,Zhen Zhang,Ying Hou,Peizhi Liu,Ting Liao,Bingshe Xu,Yanhui Song,Haixia Zhang,Junjie Guo,Ziqi Sun
M-N-C single-atom catalysts have been demonstrated to be a promising class of non-noble-metal based catalysts, but their activity is largely constrained by the symmetrical electronic density distribution of the M-N 4 moieties. Herein, a ZIF-8 derived Fe/Fe dual-center catalyst (FeN 4 /FeO 5 @NC) is constructed by introducing a O-FeO 4 configuration adjacent to the Fe-N 4 sites to form asymmetric dumbbell-shaped FeN 4 -O-FeO 4 active sites, resulting in improved intrinsic activity of Fe─N─C catalyst. The dumbbell FeN 4 -O-FeO 4 dual-center catalyst features an electron transfer pathway of “FeN 4 → bridged O → FeO 4 ”, which breaks the symmetry of the electronic density distribution of the Fe moiety and regulates the position of the d-band center, increasing the electron transfer efficiency, reducing the desorption energy barrier of the rate-determining step, and enhancing the activation ability of O 2 molecules. The obtained FeN 4 -O-FeO 4 dual-center catalyst exhibits excellent ORR performance in a pH-universal range. The liquid-state Zn-air battery (ZAB) with this FeN 4 -O-FeO 4 dual-center catalyst delivers an outstanding open circuit voltage of 1.502 V and a peak power density of 246 mW cm −2 , superior to the Pt/C-cathode ZAB. This work represents an exploration of ways to improve the ORR performance of Fe─N─C catalysts and provides a paradigm for rationally designing low-cost, highly catalytic, and stable non-noble metal catalysts.
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Food Chemistry-X
·
2026
·
IF 9.2
Weiyi Xu,Yutong Meng,Fan Yu,Huanfeng Ye,Xuejiao Xu,Jie Chen,Xianrui Liang,Sheng Fang
This study evaluated Osmanthus fragrans fruit (OFF) peel as a potential source of anthocyanin-based natural colorants. Anthocyanins were extracted using acidified ethanol and purified by macroporous resin adsorption, yielding a pigment-rich extract with a recovery of 10.4 ± 0.2% from dried peel. HPLC–MS/MS analysis indicated that cyanidin-3-O-rutinoside (C3R) was the predominant anthocyanin in the extract. The molar absorptivity of C3R was experimentally determined to enable more accurate quantification of C3R-rich systems. The purified extract exhibited typical pH-dependent color behavior, maintaining a stable red coloration under acidic conditions (pH 2.0–4.0). Thermal stability experiments showed that C3R degradation was strongly influenced by temperature and pH, and the degradation behavior followed first-order kinetics. In addition, the extract displayed measurable antioxidant capacity in DPPH and FRAP assays. These results demonstrate that O. fragrans fruit peel is a promising source of C3R-rich anthocyanins with potential applications as natural colorants in acidic food systems.
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APPLIED CATALYSIS A-GENERAL
·
2026
·
IF 4.8
Linlin Wang,Bingjie Liu,Meng Liu,Jikun Li,Jinglei De,Yangchuan Ke
A BiOCl/ZIS heterojunction was constructed by ultrasound-assisted assembly. • Interfacial coupling induced directional redistribution of photocarriers. • 3-BZ efficiently degraded concentrated RhB, CR, and TC under visible light. • 3-BZ achieved efficient photocatalytic H₂O₂ production under visible light. • In situ XPS and DFT supported type-II electron transfer from ZIS to BiOCl. An ultrasound-assisted assembly route was used to construct a BiOCl/Zn₃In₂S₆ (ZIS) heterojunction for visible-light-driven pollutant degradation and H₂O₂ production. After 120 min of irradiation, the optimized composite degraded 99.59% of Rhodamine B (RhB, 600 mg/L), 99.82% of Congo red (CR, 200 mg/L), and 83.50% of Tetracycline (TC, 80 mg/L). In a separate O₂-saturated medium containing 10 vol% isopropanol, the H₂O₂ yield reached 5644 μmol g⁻¹ over the same period. In situ irradiated X-ray photoelectron spectroscopy showed that Bi 4 f, Cl 2p, and O 1 s shifted toward lower binding energies, whereas the ZIS-associated core levels shifted toward higher binding energies. These opposite changes indicate photoelectron enrichment in BiOCl and electron depletion in ZIS. Density functional theory calculations revealed a larger work function for BiOCl (6.72 eV) than for ZIS (5.33 eV), while the differential charge density confirmed interfacial electron redistribution. Together with the density-of-states and experimental band-edge results, these findings support a type-II pathway in which electrons migrate from the ZIS conduction band (CB) to the BiOCl CB, while holes transfer from the BiOCl valence band (VB) to the ZIS VB. The resulting carrier separation favors O₂ reduction toward H₂O₂ formation and promotes oxidative pollutant degradation. Download: Download high-res image (225KB) Download: Download full-size image
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124745
·
IF 7.5
Siyu Zhang,Yangxiang Xiong,Yixuan Zhao,Xu Cao,Tianqi Wang,Ping Zhang
Bisphenol A (BPA) pollution severely threatens aquatic ecology and human health, and peroxymonosulfate (PMS)-based advanced oxidation processes are efficient for refractory organic pollutant remediation. Our previous study realized the in-situ synthesis of nitrogen-doped swine manure biochar (NBC) for enhanced PMS catalysis, yet abundant endogenous silicon in swine manure remains inert as SiO 2 and fails to contribute to catalysis, restricting the full resource utilization of livestock waste. Targeting this bottleneck, we herein develop a facile ball-milling coupled with HF etching strategy to activate intrinsic silicon on NBC without exogenous dopants. This approach converts inert SiO 2 into reactive Si–O–C interfacial sites while preserving the original nitrogen-doped carbon framework, yielding a Si modified biochar (Si-NBC). Benefiting from the synergistic effect of Si–O–C bridges and inherent nitrogen active sites, the optimized Si-NBC achieves 98% BPA removal within 20 min and 42% total organic carbon mineralization, with a rate constant 18-fold higher than pristine NBC. It performs robustly across pH 3–9, tolerates common coexisting anions, and maintains removal above 90% for 72 h in a continuous-flow reactor. Mechanistic investigations reveal a synergistic non-radical regime: singlet oxygen, generated at C–C and graphitic N sites, dominates the oxidative process, while an electron-transfer pathway, mediated by graphitic N and Si–O–C bridges, accelerates interfacial charge shuttling. Degradation intermediates exhibit markedly reduced ecotoxicity compared to parent BPA. By leveraging in-situ interfacial engineering of biomass-derived carbons, this work both valorizes the underutilized silicon in livestock waste and establishes a mechanistic rationale for the design of high-performance, eco-friendly PMS catalysts.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Ruoyan Yang,Zishuo Zhang,Rui Chen,Lingxiao Gong,Jing Wang
[Bmim]Cl-assisted xylanase hydrolysis enriches FAX 3 to 258.39 mg/g FOs. • FOs increased sialidase activity but suppressed that of α-N-acetylglucosaminidase and β-galactosidase vs control ( p < 0.05). • FOs with higher FAX 3 /FAX 2 ratio showed significantly stronger inhibition of exo -α-L-fucosidase ( p < 0.05). Feruloylated oligosaccharides (FOs) are bioactive conjugates that exhibit promising synergistic effects on gut microbiota modulation and intestinal barrier protection, yet their efficacy is highly structure-dependent. This study developed a synergistic strategy combining ionic liquid (IL, 1-butyl-3-methylimidazolium chloride) pretreatment with xylanase hydrolysis to selectively produce feruloylated arabinoxylobiose (FAX 2 ) and feruloylated arabinoxylotriose (FAX 3 ) from corn bran. The IL-pretreated FOs (FOsA) achieved a FAX 3 /FAX 2 ratio of 4.86, which was 2.16-fold higher than that of the non-pretreated group (FOsB). Although in vitro assays confirmed that FOs were not directly utilized as a carbon source by Akkermansia muciniphila ( A. muciniphila ), both FOsA and FOsB significantly modulated its mucin-degrading enzyme activities ( p < 0.05). Specifically, both fractions increased sialidase activity while reducing α- N -acetylglucosaminidase and β-galactosidase activities. Notably, FOsA, with a higher FAX 3 /FAX 2 ratio, exhibited significantly stronger inhibition of exo -α-L-fucosidase activity than FOsB ( p < 0.05 ). These findings demonstrate that FOs act as effective modulators of A. muciniphila enzymatic functions rather than metabolic substrates, and that their fine structural composition critically influences their regulatory potency on mucin-degrading enzymes, with potential implications for maintaining intestinal mucus barrier integrity. Download: Download high-res image (320KB) Download: Download full-size image
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2026
·Vol. 132
·期 9
·833
·
IF 3
Pang Qingyong,Meng Xiangqing,Han Junfeng,Jing Min,Ma Fukun
Sodium acetate trihydrate (SAT) possesses a high latent heat of phase transition; however, its high degree of supercooling, low thermal conductivity, and susceptibility to phase separation limit its practical applications. This study proposes an XG-stabilized BNNS/Al 2 O 3 composite nucleation modification strategy that suppresses SAT supercooling through the combined regulation of Al 2 O 3 particles and two-dimensional BNNS, while utilizing BNNS to improve heat transfer performance. Experimental results show that 2 wt% XG effectively suppresses phase separation, 0.5 wt% Al 2 O 3 reduces the supercooling to 5.53 ℃, and BNNS further lowers the supercooling to 0.65 ℃ while increasing the thermal conductivity to 1.543 W·m − 1 ·K − 1 .Furthermore, after 100 thermal cycles, the composite exhibited good thermal energy retention capacity. This composite achieves a good overall balance between supercooling suppression, thermal energy storage density, and thermal conductivity, demonstrating application potential in the fields of low-to-medium-temperature thermal energy storage and thermal management.
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危险品化学品经营许可证（带存储）