SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2020
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IF 3.232
Xiangying Jin,Pengran Guo,Peng Guan,Song Wang,Yongqian Lei,Guanhua Wang
In this article, a modified paper separation channel SERS substrate was fabricated by a pen writing method for the simultaneous separation and detection of thiuram and dimethoate . The hydrophilic channel was fabricated with both sides of hydrophobic barrier by the Alkylketene dimer (AKD) modified paper substrate, of which the flow dynamic was well conformed to the Lucas-Washburn model and could be used to separate pesticides effectively. As modified by Ag nanoparticles (AgNPs) and ZnO nanoparticles (ZnONPs), the hydrophilic channel exhibited high recyclable SERS detection activity and stability. The separation and detection performance with different target proportion, channel width and sample volume were studied in detail, which have significant influence on the diffusion process. Additionally, the Raman detects intensity on the substrate also showed linear relationship from 100 to 1000 μg/L. The calculated limit of detects (LODs) under optimal experimental conditions were 54.57 and 19.16 μg/L for dimethoate and thiuram, respectively. Due to the loading of ZnONPs, the substrate could be used repeatably with good stability. The convenient preparation, effective separation and repeatability make this paper based separation channel SERS substrate have great potential application on the fast separation and simultaneous detection of various pesticides in complex field.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2020
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IF 4.65
Zhu Lu,Jun Dong,Qingyan Han,Wei Gao,Yongkai Wang,Jihong Liu,Zhongyu Wang,Zeyu Sun,Boyang Wang,Jianxia Qi
Here, we successfully synthesized silver-coated gold nanorods (Au@Ag NRs) via a facile wet chemical method . The catalytic property of Au@Ag NRs in water solution was much better than that of Au NRs in water solution. To obtain high catalytic properties, we self-assembled a single-layer Au@Ag NR array by evaporation on a silicon wafer . The catalytic activity of the Au@Ag NR array was probed using the reduction of 4-nitrothiophenol. The reaction processes were monitored and identified through in situ surface-enhanced Raman spectroscopy based on the confocal Raman microscope system. This study provides a simple and fast method to improve the catalytic property of the noble nanoparticles .
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BIOCONJUGATE CHEMISTRY
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2020
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IF 4.031
Qi Wang,Yongjun Hu,Ningjing Jiang,Junjie Wang,Meng Yu,Xiumei Zhuang
Hepatocellular carcinoma (HCC), which is one of the three major cancers, has attracted growing attention due to its high mortality, health care cost, and circumscribed therapeutic methods. Hence, the development of a fast, accurate, and flexible method to detect α-fetoprotein (AFP), the specific marker of HCC, is significant for diagnosis and treatment of cancer. Here, we constructed a novel SERS biosensing platform combining the target-responsive DNA hydrogel for the sensitive detection of AFP. The linker strand in DNA hydrogel is an aptamer that can specifically recognize AFP and accurately control the release of immunoglobulin G (IgG) encapsulated in hydrogel. In the presence of AFP, the hydrogels were disentangled and the IgG was released. Thereafter, the released IgG was captured by SERS probes and biofunctional magnetic beads through formation of sandwich-like structures, resulting in the signal of Raman tags decreasing in the supernatant after magnetic separation. Due to the ultrahigh sensitivity of the SERS biosensor, the proposed method has a wide detection linear range (50 pg/mL to 0.5 μg/mL) and a detection limit down to 50 pg/mL. Moreover, the sequence of the linker strand in the DNA hydrogel can be specifically encoded into a new aptamer that responds to other cancer markers. This convenient and inexpensive detection method provides a new strategy for the detection of tumor markers.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2020
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IF 3.232
Jie Xie,Liangyu Li,Imran Mahmood Khan,Zhouping Wang,Xiaoyuan Ma
Herein, we reported a simple, flexible and sensitive surface-enhanced Raman scattering (SERS) substrate to detect methyl parathion residues in real life. The substrate was fabricated by filter paper and gold nanoparticles (Au NPs) with excellent reproducibility and stability. First, Au NPs were synthesized by the seed mediated growth method and assembled to the filter paper through immersion. The Raman probe molecule 4-MBA was used to evaluate performance of the substrate for an optimized signal using a portable Raman spectrometer coupled with 785 nm laser. Then, the paper-based substrate was applied to detect methyl parathion standard solution whose detection limit was down to 0.011 μg/cm 2 , and the linear range was between 0.018 μg/cm 2 and 0.354 μg/cm 2 . Afterwards, actual sample (apple) spiked with methyl parathion was taken to verify the practicality of the substrate by a simple way of “press–peel off”. The recovery rate was ranged from 94.09% to 98.72%, indicating that this method is reliable in actual sample detection without complicated pretreatment steps. This work demonstrates that the flexible paper-based substrate combined with portable Raman instruments can be potentially applied to on-site detection of hazardous substances in the field of food safety.
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ANALYTICAL LETTERS
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2021
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IF 2.329
Mengke Jin,Jiajia Shan,Xue Wang,Tao Ren,Xinjing Li
Florfenicol has been widely used in livestock and aquaculture to treat bacterial infections. Due to the abuse of antibiotics, florfenicol has been released into the environment. Thus, there is a need for the rapid determination of trace levels of florfenicol in the environment. To improve the sensitivity for florfenicol, solid phase extraction (SPE) was employed to enrich florfenicol from multi-residue antibiotic mixtures followed by in situ determination by surface-enhanced Raman spectroscopy (SERS). Activated carbon, C18, graphene oxide (GO), and sand were applied to concentrate florfenicol in water. Silver nanoparticles (AgNP)-coated silicon (AgNPs@Si) substrate was employed to determine florfenicol enriched on the adsorbent. The results showed that the detection limit of florfenicol in water was 2.8 × 10−9 mol/L following the adsorption and enrichment of activated carbon. Besides, activated carbon was performed to extract florfenicol from the multi-residue antibiotic mixtures, including enrofloxacin, norfloxacin, and florfenicol. The results showed that activated carbon combined with SERS specifically determined florfenicol in complex antibiotic mixtures with a detection limit of 2.8 × 10−9 mol/L. Moreover, to better understand the adsorption mechanisms, the mechanism of the interaction of florfenicol with activated carbon was investigated.
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SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Qiao-Yan Jiang,Ding Li,Yuhui Liu,Zheng-Sheng Mao,Youjia Yu,Ping Zhu,Qilan Xu,Yang Sun,Li Hu,Jie Wang,Jin Chen,Feng Chen,Yue Cao
A novel, recyclable, portable, and low-cost SERS sensor-AuBPs@MoS 2 @tinfoil box is fabricated layer-by-layer by self-assembly method for the first time, which achieved the purpose of high throughput SERS tracking. Diquat (DQ) is one of the most widely used herbicides in the world since paraquat was banned. Benefiting from the “hot spots” generated by AuBPs@MoS 2 , the sensor successfully realizes straightforward SERS recognition of DQ in complex compounds, which detection limit is as low as 1.0 × 10 −15 M. The preprocessing is not required for the detection of real samples, which promotes the practical application of forensic medicine and environmental engineering.
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FOOD CHEMISTRY
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2021
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IF 7.514
Shuyun Bi,Di Shao,Yue Yuan,Rui Zhao,Xu Li
A novel surface-enhanced Raman spectroscopy (SERS) method for the determination of nitrofurazone was developed using AuNPs/ γ -Al 2 O 3 nanoparticles protected by β -cyclodextrin ( β -CD) as substrate prepared in our lab. The optimum experimental conditions were obtained from single factor procedure and response surface modeling. A linear relationship ( I SERS = 508.96 c + 31987.87, c : nmol L −1 , R 2 = 0.996) between SERS intensity and the concentration of nitrofurazone in the range of 3.3 – 667.0 nmol L −1 was established, the limit of detection (LOD) was found at nmol L −1 level (0.37 nmol L −1 by 3 S 0 / S ). The selectivity for the method was studied by the influences of foreign substances on the determination. The recoveries and RSD (n = 5) for the six meat samples were 95.1 % – 104.5% and 2.4 % – 4.8% respectively, which suggesting that the new SERS method was successfully to detecting nitrofurazone.
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SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Huasheng Lai,Gongke Li,Zhuomin Zhang
In this work, a native beta-cyclodextrin capped silver nanoparticles decorated Ti 3 C 2 T x nanosheets (Ti 3 C 2 T x -AgNPs@β-CD) surface-enhanced Raman scattering (SERS) substrate was developed by a facile one-pot method. The two-dimensional Ti 3 C 2 T x nanosheets not only acted as the supporter to load AgNPs, but also served as chemical enhancement material. Meanwhile, β-CD played a critical role in the control of morphology and size of AgNPs, and its supramolecular structure also endowed the Ti 3 C 2 T x -AgNPs@β-CD substrate with selectivity. The Ti 3 C 2 T x -AgNPs@β-CD substrate exhibited excellent sensitivity, good intra-batch and inter-batch reproducibility, and long-term stability by detecting methylene blue model molecule. Then, the substrate was applied for selective determination of erythrosin B among pigment additives via the host-guest size-matching effect. The proposed SERS method with linear range of 1−100 mg/L and detection limit of 30 μg/L could realize rapid SERS analysis of erythrosin B in dyed food samples within 15 min with recoveries of 78.1 %–113.2 %. Erythrosin B was actually found in dyed cherry with 49 mg/kg and marshmallow with 16 mg/kg, and the result matched well with that of UV–vis method. Such a robust substrate possessed great values for efficient and rapid on-site SERS analysis in food safety issues.
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APPLIED SURFACE SCIENCE
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2021
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IF 6.707
Sijia Liu,Xiaoran Tian,Jiaqi Guo,Xianming Kong,Lingzi Xu,Qian Yu,Alan X. Wang
Multi-functional plasmonic fabric comprised of silver nanoparticles (Ag NPs) and cotton gauze was fabricated through an in-situ growth method. Ag NPs with high density were immobilized on the surface of cotton fibers. The plasmonic cotton gauze exhibits excellent flexible features, temporal stability and SERS enhancement factors close to 10 5 × . The plasmonic cotton gauze was labelled with multiplexed Raman probes and used for anti-counterfeiting applications. The encoding information could be readily changed by adjusting the ratio between components in the mixture of Raman probe molecules. This novel strategy could create rich Raman information based on the combination of a few Raman probes, which significantly increases the security levels in anti-counterfeiting. The plasmonic cotton gauze was also employed as a flexible SERS substrate for sensing pesticide from irregular surfaces of orange by a simple swiping process.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
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IF 4.098
Kaiqiang Wang,Jinjie Li
The fabrication of sensitive and reliable interfacial plasmonic platform for measuring chemical contaminants in various phases is an exciting topic in the food industry and for environment monitoring. In this study, a high-performance surface-enhanced Raman spectroscopy (SERS) analytic platform was developed through self-assembly of the gold@4-mercaptobenzoic acid@silver nanoparticles (Au@4-MBA@Ag NPs) at the cyclohexane/water interface. By addition of the inducer ethanol, the Au@4-MBA@Ag NPs in aqueous phase was effectively migrated to the biphasic interface, forming a large-scale close-packed nanoparticle array. The average gap between adjacent nanoparticles was smaller than 3 nm, where intensive SERS “hot spots” were created for high-sensitive detection. Furthermore, using the sandwiched 4-MBA molecule as the internal standard to correct the Raman signal fluctuations, the point-to-point and batch-to-batch reproducibility of Au@4-MBA@Ag array were improved with lower relative standard deviation (RSD) values of 8.84% and 14.97%, respectively, and pesticides (thiram and thiabendazole) analysis in both aqueous and organic phases were achieved with higher accuracy (R 2 of 0.986 and 0.990) as compared with those without 4-MBA correction (R 2 of 0.867 and 0.974). The high-throughput fabrication of the self-assembled nanoparticle array is a promising approach for development of a sensitive and reliable SERS platform for chemical contaminants monitoring in multiphase.
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TALANTA
·
2021
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IF 6.057
Bing Liu,Shiya Zheng,Haitao Li,Junjie Xu,Hanyu Tang,Yi Wang,Yingchao Wang,Fei Sun,Xiangwei Zhao
Ultrasensitive, multiplex, rapid, and accurate quantitative determination of trace antibiotics remains a challenging issue, which is of importance to public health and safety. Herein, we presented a multiplex strategy based on magnetic nanoparticles and surface-enhanced Raman scattering (SERS) nanotags for simultaneous detection of chloramphenicol (CAP) and tetracycline (TTC). In practice, SERS nanotags based on Raman reporter probes (RRPs) encoded gold-silver core-shell nanostars were used as detection labels for identifying different types of antibiotics, and the magnetic nanoparticles could be separated simply by magnetic force, which significantly improves the detection efficiency, reduces the analysis cost, and simplifies the operation. Our results demonstrate that the as-proposed assay possesses the capacities of high sensitivity and multiplexing with the limits of detection (LODs) for CAP and TTC of 159.49 and 294.12 fg mL −1 , respectively, as well as good stability and reproducibility, and high selectivity and reliability. We believe that this strategy holds a great promising perspective for the detection of trace amounts of antibiotics in microsystems, which is crucial to our life. Additionally, the assay can also be used to detect other illegal additives by altering the appropriate antibodies or aptamers.
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SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Xiuting Li,Hongmei Liu,Chenjie Gu,Jinjie Zhang,Tao Jiang
The acquisition of a robust plasmonic substrate with both appreciable molecule anchoring and quantitative detection features is a prerequisite for the reliable adhibition of surface-enhanced Raman scattering (SERS) technology. Herein, an innovative sophisticated SERS substrate was proposed by spin-coating titanium dioxide (TiO 2 ) onto a flexible polydimethylsiloxane (PDMS) film followed by the modification of triangular silver (Ag) nanoplates through in-situ reduction. The absence of organic surfactants during this process rendered the substrate great opportunity in effectively enriching molecules and the assembly of TiO 2 and Ag made it a reusable and sensitive SERS platform. After a recyclable monitoring of 4-aminothiophenol (4-ATP) with different concentrations was carried out by reusing the hybrid substrate for 8 cycles, a limit of detection as low as 1.58 × 10 −9 M was achieved. The distinctive intrinsic Raman signal from PDMS matrix was further verified to successfully correct the poor detection linearity by serving as internal standard and the coefficient of linear correlation (R 2 ) was improved from 0.967 to 0.997. In this regard, the as-prepared multifunctional PDMS/TiO 2 /Ag hybrid substrate with simulation-estimated electromagnetic “hot spots” exhibited remarkable quantitative recyclable detection performance.
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