Advanced Materials Interfaces
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2025
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IF 4.4
Li Xu,Chen Chen,Zishan Li,Jie Zhang,Shufei Hu,Shuyue Ren,Peng Luo,Zhixian Gao
This study presents the development of a novel material capable of efficiently enriching and recovering pathogenic bacteria from food matrices without requiring surface modification of biological components or complex chemical conjugation. A nanocellulose-based chitosan aerogel (CNF-CS) is synthesized via cross-linking of nanocellulose, extracted from pulp, with chitosan. The CNF-CS aerogel enables selective adsorption of negatively charged bacterial cells through electrostatic interactions. When integrated with a custom-designed micro-injection extrusion enrichment device, the system achieves rapid and efficient enrichment and recovery of foodborne pathogens. The CNF-CS aerogel-based system demonstrated a high enrichment efficiency of (96.30 ± 1.01)% and an elution rate of (89.16 ± 3.08)% for target pathogens. The entire enrichment and elution process is completed within (6.16 ± 0.05) min using 800 mL liquid samples or complex real-food matrices, including milk, watermelon, and oyster. Furthermore, the constituent materials of the CNF-CS aerogel are environmentally benign, biodegradable, and derived from sustainable sources. The aerogel can be tailored in terms of size, shape, and thickness to meet specific application requirements, highlighting its adaptability and strong potential for practical implementation and widespread adoption.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2025
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IF 4.7
Jing Zhang,Yifei Pu,Baichuan Zhuang,Jifei Zhuo,Xiaoli Xie,Shuang Xie,Tengfei Qu,Guangjun Gou
To address the challenge of removing heavy metal ions from industrial effluents, chitosan-based adsorbent materials have been extensively reported, particularly in terms of composite materials and the introduction of groups. In this paper, β- cyclodextrin ( β -CD) and amidoxime (AO) were simultaneously chemically cross-linked with chitosan (CTS) for the first time, resulting in amidoxime functionalized chitosan/ β- cyclodextrin composite (CTS-g-AO- β -CD) which was primarily applied to remove toxic metal ions. The adsorption capacities of CTS-g-AO- β -CD were 35.66, 31.28, 16.46 mg/g for Cu 2+ , Pb 2+ and Zn 2+ . The adsorption of Cu 2+ and Pb 2+ followed the pseudo-second-order kinetic and the Langmuir isotherm model, whereas the adsorption of Zn 2+ adhered to the pseudo-second-order kinetic and Freundlich isotherm model more closely. After five regeneration cycles, CTS-g-AO- β -CD still retained a certain adsorption performance, demonstrating its potential for application as a novel adsorbent.
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高影响因子
Acta Biomaterialia
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2018
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IF 6.383
Huan Yang,Cui Tang,Chunhua Yin
Estrone-modified glycol chitosan nanoparticles (GCNP-ES) based on the mechanisms of ES-mediated endocytosis and intracellular pH-responsive drug release were developed for the treatment of breast cancer. GCNP-ES were prepared by grafting copolymerization of glycol chitosan with 2-(diisopropylamino)ethyl methacrylate to generate GCNP prior to ES conjugation. The particle size, zeta potential , and paclitaxel (PTX) encapsulation efficiency of GCNP-ES were characterized. In particular, GCNP-ES exhibited pH-responsive dissociation properties while maintaining stability under long-term storage and lyophilization. The drug release of PTX-loaded GCNP-ES (PTX/GNCP-ES) was modestly prolonged with considerable pH sensitivity. GCNP-ES promoted internalization in breast cancer MCF-7 cells by approximately 5-fold as compared to GCNP, and the internalized GCNP-ES was mainly localized in the endosomes of MCF-7 cells. PTX/GNCP-ES exhibited higher cytotoxicity and cell apoptosis ratio than GCNP. In mice with MCF-7 breast cancer xenograft, PTX/GCNP-ES showed higher accumulation at the tumor site, which resulted in a higher tumor inhibition ratio (81.4%) than that achieved by PTX/GCNP (69.4%) and PTX solution (48.8%). Furthermore, no histological and hematological toxicity was detected in in vivo studies of PTX/GCNP-ES. Overall, these results suggested the potential applicability of GCNP-ES as a drug delivery system for breast cancer therapy. Statement of Significance Most breast cancers are hormone dependent. Herein, we developed a estrone-modified glycol chitosan nanoparticles (GCNP-ES) as a drug delivery system to overcome the drawbacks of chemotherpeutic drugs, including poor water solubility and lack of specifity. GCNP-ES could provide efficient drug delivery in breast cancer cells. The study demonstrated that GCNP-ES could dissociate under mildly acidic conditions, leading to the timely payload release of the drug in target tumor cells following internalization. The conjugated estrone of the nanoparticles could significantly increase drug accumulation in the tumor site and result in enhanced therapeutic effect. Thus, the potential applicability of GCNP-ES was suggested.
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高影响因子
JOURNAL OF THE TEXTILE INSTITUTE
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2025
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IF 1.5
Na-won Baek
Enzyme-based dyeing processes have demonstrated the efficacy of synthetic templates; however, research on natural templates remains limited. This study explores the feasibility of enzyme dyeing processes for cellulose and protein fibers and verifies the potential of chitosan (CS) as a template to replace chemical templates. The dyeing mechanism of textiles was thoroughly analyzed using liquid chromatography-tandem mass spectrometry. The dyeability and functionality of dyed textiles were examined through Fourier-transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The color and colorfastness of textiles were evaluated using color depth analysis and various fastness tests. The results demonstrated that applying CS templates in the dyeing process increased K/S values and improved colorfastness for both silk and cotton fabrics. The K/S value of the dyed silk fabric increased from 5.6 to 7.8 following the application of the chitosan template, with color fastness improving by approximately one grade. For the dyed cotton fabric, the K/S value rose from 2.2 to 3.1, and color fastness improved by one or two grades on average.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Junyan Guo,Mohammad Rizwan Khan,Naushad Ahmad,Wanli Zhang,Lanhuan Meng
Chitosan (CS) films functionalized with cinnamaldehyde (CIN)-derived Schiff base and Fe 3+ coordination were developed for pH-responsive antimicrobial food packaging. The Schiff base-Fe 3+ crosslinking system enhanced tensile strength by 39.59% and reduced water vapor permeability by 11.25%, while imparting pH-triggered CIN release via acid-hydrolyzable imine bonds. Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis confirmed uniform dispersion of CIN/Fe and improved crystallinity. The films demonstrated bactericidal activity against foodborne pathogens (89.52% for Escherichia coli ATCC 25922, 82.98% for Staphylococcus aureus ATCC 25923) combined with moderate 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging (37.41% at 30 min), suggesting primary application in antimicrobial packaging. In fruit preservation trials, strawberries and passion fruit coated with CS/CIN/Fe films showed 33.17% and 29.36% lower weight loss, respectively, extending shelf life by suppressing respiration-driven spoilage. Cytotoxicity (<0.21% hemolysis) and biocompatibility (>80% cell viability) validated safety. This work presents a sustainable strategy for intelligent packaging by integrating dynamic Schiff base-metal coordination, addressing both food waste and plastic pollution.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2017
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IF 3.671
Zhaotong Cong,Yanbin Shi,Yang Wang,Yanhong Wang,Jing’e Niu,Nana Chen,Haoyue Xue
In this study, we present a novel cross-linked unimolecular micelle based on chitosan. For controlling drug delivery via oral administration, emodin (EMO) encapsulated micelles were loaded into sodium alginate hydrogel matrix to construct the pH-sensitive hydrogel/micelle composites. The optimized formulation of micelle that consists of 8.06% CaCl 2 , 1.71% chitosan and 26.52% β-GP was obtained by the combination of Box-Behnken experimental design and response surface methodology. The morphological analysis showed that the micelles exhibited a smaller diameter of about 80 nm in aqueous solution, but dilated to 100–200 nm in hydrogel owing to the formation of polyelectrolyte complexes. The physical characteristics in simulated digestive fluids were investigated, demonstrating that the ratio of hydrogel to micelle distinctly affected swelling, degradation and in vitro drug release behaviors. The hydrogel/micelle (1:1) exhibited a sustained-release profile, while hydrogel/micelle (3:1) exhibited a colon-specific profile. Their corresponding release mechanisms revealed that the release of drug from these two formulations followed a complex process, in which several mechanisms were involved or occurred simultaneously. These results demonstrated that the pH-sensitive hydrogel/micelle composites constructed with biocompatible materials can be a promising sustained-release or site-specific drug delivery system for instable or hydrophobic drugs.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
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IF 4.539
Zhe Li,Xiaoxia Jiang,Ziheng Yao,Fucai Chen,Lin Zhu,Hongning Liu,Liangshan Ming
In this study, cellulose nanocrystals (CNC)/chitosan (CS)/glutaraldehyde (Glu) ternary composites were synthesized using cross-linking method with different CNC/CS ratios (1:1, 2:1, 3:1, 4:1, w/w). The composites were firstly characterized using various techniques, such as SEM , FT-IR, isothermal nitrogen adsorption/desorption and TGA . They were further used as solid stabilizers for the preparation of O/W Pickering emulsions. The appearance of emulsions, size and zeta potential and rheological properties of the droplets were investigated. The results showed that the cross-linked biopolymer composites had high surface area, variable morphology and special three-dimensional networks, and showed good emulsifying capacity. Furthermore, the droplet size and zeta potential of emulsions as functions of pH (2–12), temperature (4–60 °C) and ion strength (0–1000 mM) were studied, and the results confirmed that the emulsions prepared with CNC/CS composites had good physical stability at different varying conditions. This study suggested that CNC/CS composites could significantly improve the emulsifying capacity and therefore had great potential for application in the pharmaceutical and food sciences.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
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IF 5.162
Mou Zhou,Fang Lin,Wendan Li,Linying Shi,Yanhui Li,Guiqiu Shan
Nowadays, treatment to the infected wounds caused by bacterial even multi-resistant bacterial strains and subsequently complete skin regeneration remain a critical clinical challenge. Herein, a novel multi-functional platform (Alg/ [email protected] /PRP) was prepared as wound dressings by mixing platelet rich plasma (PRP) with the sodium alginate (Alg) based dressing containing nano silver (Ag)-doped carboxymethyl chitosan grafted polyamideamine ( [email protected] ) cationic polymers. The present dressings exhibited high swelling, suitable water vapor transmission rate (WVTR), and good mechanical properties and degradability, as well as sustained release of PRP. Besides, the component of [email protected] nanoparticles endow them with excellent antibacterial performance, while the incorporation of PRP promotes the effect of anti-inflammatory and angiogenesis by up-regulating relative activity factor expression of TGF-β1, CD31 and α-SMA and down-regulating the inflammatory-relative genes including TNF-α, IL-6 and IL-1β, all of which promote the closure of wound and produce a superior healing effect to the commercial Aquacel Ag group. This work indicates that the prepared Alg/ [email protected] /PRP wound dressing is a promising biomaterial with synergistic effect of antibacterial property and wound healing.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2024
·Vol. 35
·期 1
·1-15
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IF 4.2
Zhang Chenxi,Tan Chenjie,Shen Hangchong,Xu Qianqian,Pan Jiadong,Wang Xin
Hydrogels are currently widely used in regenerative medicine and wound repair due to their superior biocompatibility, reliable mechanical strength, and good morphological memory. We aimed to prepare a self-expanding hydrogel that can be used as a skin expander for the repair of large soft skin tissue defects. Self-expanding hydrogels were prepared by chemical cross-linking, which consisted of water-soluble chitosan (CS), acrylamide (AM), methylene bisacrylamide (NMBA), etc. Five groups of in vitro experiments, including (CS-AM) of 0% (pure AM group), 13.9%, 27.8%, 41.7%, and 55.6%, were conducted to determine mechanical properties, swelling properties, cytotoxicity, etc. In the rat model, both a tight skin area (neck) and a loose skin area (back) were selected for expansion with hydrogels. A total of 27.8% of the CS-AM samples expanded stably under the skin of the rats, achieving 370% expansion in the tight zone and 490% expansion in the flaccid zone. Subcutaneous histopathological examination suggested that the inflammation index of the pericolloid tissue was lower in the CS-AM group than in the pure AM group. Our results demonstrate that self-expanding CS-AM hydrogels have great potential for application as skin expanders. Graphical
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2022
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IF 6.371
Yuhang Yang,Xian Zhang,Zhuang Cheng,Zihui Wen,Jiage Yu,Feng Wang,Yu Ding
Silicon possesses high theoretical specific capacity but suffers from huge volume expansion and poor electrical conductivity during cycling, resulting in significantly reduced capacity and poor cycling stability. These issues could greatly be alleviated by the encapsulation of silicon nanoparticles in carbon materials. Therefore, a three-dimensional (3D) network Si@CTS precursor was prepared in this work through in-situ encapsulation of silicon nanoparticles in stable hydrogel formed by crosslinking chitosan with glutaraldehyde as a cross-linking agent. After freeze-drying followed by oxidation stabilization at 280 ºC for 2 h under air and subsequent heat treatment at 800 ºC for 2 h under Ar atmosphere, uniformly distributed 3D Si@C composites were obtained. The effects of added amounts of carbon nanotubes (CNTs) on the structures and electrochemical properties of the as-obtained composites were investigated. The results showed uniformly distributed silicon nanoparticles in the amorphous carbon layer owing to the freeze-drying and oxidation treatments conducive to maintaining the skeleton structure of the material. The amorphous carbon and appropriate CNTs effectively buffered the volume changes, as well as improved the ionic and electronic conductivity. Si@C/CNTs-10% showed better comprehensive electrochemical performances at CNTs added amount of about 10 wt%. The discharge specific capacities at 0.1 A·g −1 after 150 cycles, as well as at 1.0 and 2.0 A·g −1 after 1000 cycles were estimated to 943.1, 461.3, and 123.1 mAh·g −1 , respectively.
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高影响因子
Bioactive Carbohydrates and Dietary Fibre
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2016
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IF 0
Zhihua Wang,Yongbin Yan,Wei Li,Lihua Wang,Guoyuan Li,Caiqin Qin
Two kinds of water-soluble hydroxypropyl chitosan (HPCS) samples with different weight-average molecular weights ( M w ) (HHPCS for higher M w , 1.43×10 5 Da; LHPCS for lower M w , 5.71×10 3 Da) were used to investigate their absorption and distribution in mice by oral administration after being labeled by fluorescein isothiocyanate . The result of in vitro degradation showed that HPCS degraded more easily in the presence of lysozyme than in pepsin . After oral administration of HPCS, HPCS would undergo a series of degradation and absorption under the action of tissue cells and enzymes in the body. The absorption and distribution of HPCS in organ tissues was significantly influenced by its M w . With the decrease of M w , the absorption rate and amount of HPCS increased. In fact, only a small amount of HPCS and its catabolite with low M w was absorbed by the tissues, and most HPCS was metabolized and excreted out of body rapidly. Additionally, there was some accumulation of HPCS in liver, and so HPCS content in liver and kidney was higher. The whole HPCS plasma concentration was lower instead, due to rapid plasma clearance . The absorbed HPCS molecules still maintained a relatively higher concentration even after 16 h in the tested tissues. The research results gave some valuable data for the application of water-soluble chitosan in food and biomedicine , especially as a potential candidate for drug delivery systems.
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TEXTILE RESEARCH JOURNAL
·
2025
·
IF 1.9
Qirong Cai,Zhengkai Chen,Meng Li,Yifei Wang,Ying Wu,Yingjun Li,Dongxiao Ji,Xiaohong Qin
Aromatic textiles are a significant application of aromatherapy, and the durability and washability of such textiles are critical performance metrics. In this study, in situ embedded aromatic yarns were developed to enhance the longevity and wash resistance of the embedded fragrance. Electrospun nanofibers were employed as efficient carriers for aromatic agents, with ylang ylang oil (YYO) selected as the core material and chitosan (CS) as the wall material. The nanocapsules were prepared using ionic gelation to encapsulate the aromatic compound. The morphology, cross-linking, and thermal stability of the nanocapsules were characterized using scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. The results indicate that cross-linking occurred between CS and sodium tripolyphosphate, YYO was effectively encapsulated within the nanocapsules, and the thermal stability was enhanced. These nanocapsules were then incorporated into nanofibers through electrospinning, which were subsequently deposited onto cotton webs, forming a novel aromatic yarn through further processing. The morphology, mechanical properties, and aromatic properties of the aromatic yarns were characterized. As a result, the nanofibers were coated inside the yarn, and the retention rate of YYO remained at 67.25% after 28 days. After 20 washing cycles, the YYO content in the aromatic yarn was 0.5 mg/g, indicating strong controlled-release performance and wash resistance. This study provides insights into the preparation of textiles with long-lasting aromatic properties and durability.
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危险品化学品经营许可证（带存储）