ENVIRONMENTAL RESEARCH
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2022
·
IF 8.431
Boyu Jia,Tianbao Liu,Juanjuan Wan,Andrei Ivanets,Yujia Xiang,Lijuan Zhang,Xintai Su
Microbial reduction of hexavalent chromium (Cr (VI)) shows better efficiency and cost-effectiveness. However, immobilization of Cr (III) remains a challenge as there is a limited supply of electron donors. A greener and cleaner option for donating external electrons was using bioelectrochemical systems to perform the microbial reduction of Cr(VI). In this system, we constructed a polydopamine (PDA) decorated Shewanella oneidensis MR-1 ( S. oneidensis MR-1) bioelectrode with bidirectional electron transport, abbreviated as PDA@ S. oneidensis MR-1. The conjugated PDA distributed on the intracellular and extracellular of individual S. oneidensis MR-1 has been shown to accelerate electron transfer by outer membrane C-type cytochromes and flavin-bound MtrC/OmcA pathway by various electrochemical analyses. As expected, the PDA@ S. oneidensis MR-1 biofilm achieved 88.1% Cr (VI) removal efficiency (RE) and 58.1% Cr (III) immobilization efficiency (IE) within 24 h under the autotrophic conditions at the optimal voltage (−150 mV) compared with the control potential (0 mV). The PDA@ S. oneidensis MR-1 biofilm showed increased RE activity was attributed to the shortening of the distance between individual bacteria by PDA. This research provides a viable strategy for in situ bioremediation of Cr(VI) polluted aquatic environment.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2023
·Vol. 34
·期 36
·1-9
·
IF 2.8
Xiong Lu,Hu Haisheng,Liu Meitang,Zhang Chongji
Upconversion materials have significant application prospects in many fields due to the advantages of being excited by infrared light. However, the development of upconversion materials is constrained by low upconversion efficiency and low luminescence intensity. The aim of this work is to improve the luminescence efficiency and intensity of fluorine-based upconversion luminescent materials through ternary alkali metal doping. A series of ternary alkali metal-doped Li x Na y K (1−x−y) YF 4 :Yb 3+ , Er 3+ novel upconversion luminescent materials were synthesized by a one-step facile hydrothermal method, and their mechanisms were explored. The results show that the doping of Li, Na, and K ions changes the crystal structure of Li x Na y K (1−x−y) YF 4 :Yb 3+ , Er 3+ , thereby affecting the spatial structural relationship between the rare-earth ions, which changes the energy transfer efficiency to them. The luminescence intensity of the prepared Li x Na y K (1−x−y) YF 4 :Yb 3+ , Er 3+ was 30 times higher than that of the undoped samples when doped with Li, Na, and K ions in a molar ratio of 10:6:9. This study provides a simple and effective method for the preparation of upconversion materials with excellent luminescent properties.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Yong Zheng,Qian Wang,Yongjun Zheng,Zhen Wang,Dayong Tian
Electrolytic recovery of pure aluminum is a conventional method for the recycling of waste aluminum alloys, which is very important to economic development and environmental protection. However, the conventional electrolytic recovery process suffers from several inherent problems, which restricts the further development of this technology. In this study, an air- and moisture-stable 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ionic liquid was applied in the dissolution of aluminum chloride. The upper phase of the resulting mixture was used as a low-temperature electrolyte in the electrolytic recovery of pure aluminum. The results of cyclic voltammetry and linear sweep voltammetry showed that aluminum could be electrodeposited from the electrolyte and that the main impurity elements of the aluminum alloy could also be stripped off by the electrolytic method. Based on these measurements, the electrolytic recovery process was conducted at 0.2−0.6 V and 303.2−373.2 K. Scanning electron microscope micrographs showed that smooth, compact and well-adherent deposits were obtained at 0.4 V from 303.2 to 323.2 K. In this situation, the preferred crystallographic orientation of these deposits was the (200) plane. Meanwhile, the mass content of aluminum in all deposits was higher than 99.6% according to the purity characterization. This study may be useful for the further application of ionic liquids in the low-temperature recycling of waste aluminum alloys.
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EUROPEAN JOURNAL OF HISTOCHEMISTRY
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2023
·
IF 2
Zhongzhu Tang,Lei Wang,Yunwang Chen,Xiaomin Zheng,Runyu Wang,Bingxue Liu,Shiqi Zhang,Huimin Wang
Quercetin (Que) has been proven to enhance the chemosensitivity of multiple cancers, including colon cancer (CC). However, whether the combination of Que and 5-fluorouracil (5-FU) has a synergistic effect on drugresistant CC cells has not previously been reported. The effect of Que (5 and 10 μg/mL) on cell vitality and apoptosis of CC and CC drug-resistant cells was examined using a cell counting kit-8 (CCK-8) and flow cytometry. After cells were treated with 5-FU (10, 40 μg/mL), Que (10 μM, 40 μM), or 5-FU in combination with Que, cell proliferation, apoptosis, oxidative stress-related factors, reactive oxygen species (ROS), and nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase-1 (HO-1) pathway-related factors were examined by colony formation assay, flow cytometry, ELISA, ROS kit, immunofluorescence assay, and Western blot. The results showed that 5-FU reduced cell viability and induced apoptosis of CC as well as 5-FU-resistant CC cells. Que further restrained the proliferation, oxidative stress-related factors (SOD, CAT, GPx, and GR), ROS production, and induced apoptosis in CC cells and 5-FU-resistant CC cells induced by 5-FU. Moreover, the combination of Que and 5-FU attenuated the Nrf2/HO-1 pathway-related marker levels in CC cells and 5- FU-resistant CC cells. Therefore, our results suggest that Que reverses 5-FU resistance in CC cells via modulating the Nrf2/HO-1 pathway.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Yanhua Lei,Mengchao Ding,Sha Cheng,Da Huo,Fei Zhang,Tao Liu,Yuliang Zhang
The transition metal sulfide MoS 2 has attracted great interest from the scientific community as an excellent co-catalyst for promoting Fe 2+ /Fe 3+ cycling in advanced oxidation processes to enhance the efficiency of H 2 O 2 decomposition. A photothermal-enhanced photo-Fenton pollutant degradation strategy was proposed. Hybrids of magnetically recyclable Fe 3 O 4 fabricated 1 T-2 H MoS 2 (1 T-2 H MoS 2 @Fe 3 O 4 ) with excellent photothermal conversion efficiency were fabricated to overcome the limitations of relatively low catalytic activity and cycling stability in Fenton reaction. XRD , Raman, TEM and hysteresis loop were employed to evaluate the heterogeneous phase 1 T-2 H MoS 2 nanoflowers as well as the magnetic property . The 1 T-2 H MoS 2 @Fe 3 O 4 hybrids with excellent photothermal conversion efficiency not only enhance the reaction temperature of the Fenton reaction occurring on the material surface, but also demonstrate an effective interfacial photothermal water evaporation efficiency. Due to the synergistic effect of photocatalysis and photo-Fenton catalytic reaction , a quick degradation of simulated pollution were achieved in 5 mins with 98.3% degradation, which could be further improved to 99% due to the photothermal promoting reaction. The 1 T-2 H MoS 2 @Fe 3 O 4 hybrids exhibit good magnetic recyclability, cyclic stability and photothermal performance, which endow it a wide potential application in the field of environmental remediation and the field of water evaporation at the photothermal interface, etc.
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JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Yanyun Hao,Hui Li,Xiaoyan Ge,Yang Liu,Jialin Yin,Xia Li,Yutong Liu,Hongfei Chen,Lingling Huang,Jing Zou,Shiying Zhang,Hao Wu,Zhiyue Zhang
Immunotherapy has fundamentally altered cancer treatment; however, its effectiveness is clinically hampered by insufficient intratumoral T lymphocyte infiltration and failed T lymphocyte priming. Additionally, inducing cancer-specific immune responses while sparing normal cells remains challenging. Herein, we developed a redox-activatable polymeric nanoswitch (c-N@IM/JQ) that remained ‘off’ status in circulation but rapidly switched ‘on' after entering the tumor. Toll-like receptor (TLR) 7/8 agonist (imidazoquinoline, IMQ) and bromodomain and extraterminal inhibitor (JQ1) are locked in c-N@IM/JQ with a redox-cleavable linker (switch off). Upon systemic administration , c-N@IM/JQ with c-RGD peptide modification preferentially accumulated at tumor sites and responded to the high glutathione levels to release native IMQ for fully mobilizing T lymphocyte army, and JQ1 for removing the programmed death ligand (PD-L)-1 protection on tumor cells (switch on). These strengthened T lymphocyte armies are easily accessible to these de-protected tumor cells, revitalizing the immune response against tumors.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
HaoJun Tian,Jiangzhou Luo,Xiangyun Liu,Xueping Zong,Song Xue
PIM-1 thin film composite (TFC) membrane has attracted great attention for organic solvent nanofiltration (OSN) because of its high porosity and excellent solution process-ability. However, the PIM-1 thin selective layer may swell excessively in polar solvents such as methanol and acetone, and thus it makes the connection between the PIM-1 selective layer and the porous support unstable, which can significantly impair its separation performance. In this work, a series of novel PIM-1 TFC membranes was obtained by spin-coating of PIM-1/tetrahydrofuran solution onto α-Al 2 O 3 ceramic supports followed by a thermal treatment process. Since the nitrile group within PIM-1 tends to experience a thermal crosslinking reaction forming stable triazine rings after heat treatment, thus the organic solvent resistance ability of PIM-1 TFC membrane was greatly enhanced. Results showed that the thermally treated PIM-1 TFC membranes possess better chemical stability in polar solvents and acceptable permeances for various solvents (e.g., 2 ∼ 4.2 L·m −2 ·h −1 ·bar −1 for methanol, and 4.3 ∼ 6.8 L·m −2 ·h −1 ·bar −1 for toluene). For instance, the PIM-1 TFC membrane termed as PIM-1-3 wt%-1h TFC showed a methanol permeance of 3.8 L·m −2 ·h −1 ·bar −1 with a rejection of 96.5% towards Congo red (M w = 697 Da). Moreover, compared to the pristine PIM-1 TFC membrane, the thermally treated PIM-1 TFC membrane possesses better separation stability after the long-term static immersion test in acetone and DMF for 7 days, and it also exhibit good stability in the continuous filtration test using 20 mg·L −1 Congo Red methanol solution, demonstrating a promising outlook in OSN fields.
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PHYSICA SCRIPTA
·
2023
·Vol. 98
·期 9
·095923
·
IF 2.9
Sen Peng,Chen Li,Tianyi Yan,Shengxiang Huang,Leilei Qiu,Lianwen Deng
For the MCu2Nb2O8 (M=Ca, Mg, Zn or Ni) composite ceramics, it is still a difficult problem to achieve both high Q×f valule and near-zero temperature coefficient of resonant frequency (τf). In this paper, the (1-x)MgCu2Nb2O8 − xTiO2 (0 ≤ x ≤ 0.28) ceramics were fabricated by the two-step sintering (TSS) technique. Results of x-ray diffraction (XRD) and Raman spectroscopy proved that the ceramic samples were composite phases of MgNb2O6, CuO and TiO2. The chemical compositions and valences of Mg, Cu, Nb, O and Ti were investigated by x-ray photoelectron spectroscopy (XPS). Scanning electron microscopy (SEM) showed that proper TiO2 addition could promote growth of grains and increase the average grain size. Appropriate TiO2 content and enhanced densification contributed to the 0.84MgCu2Nb2O8 − 0.16TiO2 ceramics sintered at 935 °C with εr = 18.75, Q×f = 34,398 GHz (f0 = 7.8 GHz), and τf = −0.56 ppm/°C, exhibiting potential applications in Low Temperature Co-fired Ceramic (LTCC) devices.
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Crystals
·
2023
·Vol. 13
·期 9
·1296
·
IF 2.7
Yan Wang,Jiajing Li,Haipeng Zhu,Qilei Wang,Tulai Sun,Tao Ni,Yanghong Lin,Yu Liu,Minmin Mao,Ji Hu,Bing Liu,Hadi Barzegar Bafrooei,Zhongyan Ma,Yingjie Ren,Feng Shi,Ehsan Taheri-Nassaj,Dawei Wang,Kaixin Song
Mg2SiO4and MgSiO3ceramics with superior microwave dielectric properties are considered to be promising candidates for 5G applications. However, a slight deviation from the stoichiometric Mg/Si ratio will significantly influence their microwave dielectric properties, which will hinder their practical applications. In this work, thexMgO-SiO2(x= 1~2) ceramics were synthesized by a solid-state reaction method. The influence of the Mg/Si ratioxon the crystalline phase, microstructure, and microwave dielectric properties was investigated through X-ray diffraction (XRD), a scanning electron microscope (SEM), and the resonant cavity method. The XRD patterns revealed the coexistence of Mg2SiO4and MgSiO3within thexrange of 1~2, which was further demonstrated by the energy-dispersive X-ray spectra. The SEM images show a typical polycrystalline morphology of ceramics with an inhomogeneous grain size distribution. It is found that the microwave dielectric properties fluctuate at both sides of thexrange while those remain relatively stable with minor changes at the intermediate components, indicating an obvious low composition dependence helpful for practical applications. Further, a demonstrator of a microstrip patch antenna for 5G applications using the 1.5MgO-SiO2ceramic was designed and fabricated, and a return loss of −16.2 dB was demonstrated, which demonstrated the potential applications.Keywords:MgO-SiO2systems;5G application;microwave dielectric ceramics;phase composition
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JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 7.3
Yuting Sun,Hui Yang,Jiaqi Yuan,Limin Wang,Shanshan Song,Rongrong Chen,Xubin Bao,Li Jia,Tiantian Yang,Xiaofei Zhang,Qian He,Yong Gan,Zehong Miao,Jinxue He,Chunhao Yang
Poly(ADP-ribose) polymerase inhibitors (PARPi) have significant efficacy in treating BRCA-deficient cancers, although resistance development remains an unsolved challenge. Herein, a series of phthalazin-1(2H)-one derivatives with excellent enzymatic inhibitory activity were designed and synthesized, and the structure–activity relationship was explored. Compared with olaparib and talazoparib, compound YCH1899 exhibited distinct antiproliferation activity against olaparib- and talazoparib-resistant cells, with IC50 values of 0.89 and 1.13 nM, respectively. Studies of the cellular mechanism revealed that YCH1899 retained sensitivity in drug-resistant cells with BRCA1/2 restoration or 53BP1 loss. Furthermore, YCH1899 had acceptable pharmacokinetic properties in rats and showed prominent dose-dependent antitumor activity in olaparib- and talazoparib-resistant cell-derived xenograft models. Overall, this study suggests that YCH1899 is a new-generation antiresistant PARPi that could provide a valuable direction for addressing drug resistance to existing PARPi drugs.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 14
·11554
·
IF 5.6
Chehao Lee,Guang Xin,Fan Li,Chengyu Wan,Xiuxian Yu,Lijuan Feng,Ao Wen,Yu Cao,Wen Huang
Ninjurin 1 (NINJ1) is a double-transmembrane cell-surface protein that might mediate plasma membrane rupture (PMR) and the diffusion of inflammatory factors. PMR is a characteristic of acinar cell injury in severe acute pancreatitis (SAP). However, the involvement of NINJ1 in mediating the PMR of acinar cells in SAP is currently unclear. Our study has shown that NINJ1 is expressed in acinar cells, and the expression is significantly upregulated in sodium-taurocholate-induced SAP. The knockout of NINJ1 delays PMR in acinar cells and alleviates SAP. Moreover, we observed that NINJ1 expression is mediated by Ca2+concentration in acinar cells. Importantly, we found that Ca2+overload drives mitochondrial stress to upregulate the P53/NINJ1 pathway, inducing PMR in acinar cells, and amlodipine, a Ca2+channel inhibitor, can reduce the occurrence of PMR by decreasing the concentration of Ca2+. Our results demonstrate the mechanism by which NINJ1 induces PMR in SAP acinar cells and provide a potential new target for treatment of SAP.Keywords:nerve-injury-induced protein 1;plasma membrane rupture;severe acute pancreatitis
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APPLIED PHYSICS LETTERS
·
2023
·Vol. 122
·期 24
·
IF 4
Gong Xin,Li Guannan,Lin Hua,Zhou Zengjie,Tang Jianfeng,Lu Yuming
BiFeO 3 -BaTiO 3 (BFO-BTO)-based lead-free electroceramics have long been synthesized using the microwave sintering approach, but the resulting multiferroic performance has not been excellent. In this work, we report an attempt to achieve competitive ferroelectric properties in microwave-sintered x BFO-(1– x )BTO ( x = 0.6–0.8) ceramics. Adopting a sintering process with a short dwell time of 30 min at 970 °C, we obtain high-quality ceramics with a high density, pure perovskite structure, uniform element distribution, and coarse grains. Furthermore, the fabricated ceramics can reproduce the typical characteristics of pure BFO-BTO, including a morphotropic phase boundary (MPB), relaxor ferroelectric behavior, weak ferromagnetism, and enhanced ferroelectricity near the MPB. More remarkably, a large intrinsic remnant polarization P r as high as ∼28 μ C/cm 2 is achieved by combing the MPB-enhanced ferroelectricity and the advantages of microwave synthesis. The maximal P r accomplished here is competitive with that of the same bulk solid solution obtained via other fabrication approaches. Our study illustrates that microwave synthesis is a powerful approach with which to prepare high-performance BFO-BTO-based ceramics.
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