PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
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2022
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IF 7.926
Shinuo Wang,Yinghao Ruan,Haosheng Sun,Ludong Yi,Di Liu,Jun Wang,Zhaohong Zhang,Dawei Fang
Hydrodynamic cavitation (HC) technology with double parallel orifice plates can further enhance the degradation effect and heat generation efficiency and play an important role in practical large-scale organic wastewater treatment and energy saving. In this study, based on the optimal hole numbers in single orifice plate, the influences of the hole number and distribution in double parallel orifice plate on Basic Violet 1 (BV-1) degradation and heat generation are studied in detail. Furthermore, the effects of some experimental parameters (inlet pressure, initial concentration, solution temperature and solution volume) on BV-1 degradation and heat generation in 4 + 4 parallel orifice plate HC system are deeply studied. Then, the effect of added H 2 O 2 on the BV-1 degradation and heat generation is also investigated. In addition, the capturing experiments of free radicals (•OH and •O 2 - ) are carried out. Finally, the BV-1 degradation pathway and possible degradation mechanism are proposed by analyzing the data of UV–vis spectrum, LC-MS and total organic carbon (TOC). The final results show that the solution temperature can be raised from 20.05 °C to 57.71 °C under the experimental conditions of 4 + 4 parallel orifice plates, 3.0 bar inlet pressure , 5.0 L total solution volume and 10 mg/L initial concentration for 90 min continuous circulation and the BV-1 degradation ratio can be achieved by 75.98 %. The system can generate 785.40 kJ heat at 48.50 USD/m 3 cost and achieve 29.09 % thermal efficiency . For 1:30 molar ratio of BV-1 and H 2 O 2 , the solution temperature can be further raised to 63.32 °C in 90 min continuous cycling. 95.38 % BV-1 degradation ratio can be obtained and the 909.72 kJ heat can be generated, reaching the 33.69 % thermal efficiency. It is hoped that this work can provide a new strategy for enhancing the degradation of organic dyes and resource utilization of heat by using double parallel orifice plate HC technology.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
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2022
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IF 5.876
Yongkui Liu,Fumin Wang,Xubin Zhang,Qing Zhang,Yi Zhai,Guojun Lv,Mengyao Li,Mengyue Li
Development of economic routes for synthesis of hollow titanium silicalite-1 (TS-1) zeolite is of great importance in industry. However, there are still challenges to synthesize hollow TS-1 zeolite without anatase TiO 2 . In this work, a one-step strategy without mesoporogen by the solid-phase conversion method was successfully developed to synthesize anatase-free hollow TS-1. The appropriate low amount of TPAOH (TPA/SiO 2 = 0.13) and the suitable crystallization temperature (170 °C) can not merely induce the formation of hollow structures, but also enable more titanium to enter the framework. Moreover, the transformation mechanism based on crystallization rate and dissolution rate was proposed according to the investigation of the transformation process. The hollow TS-1 with large cavities exhibits high catalytic activity and recycle stability in 1-hexene epoxidation. The efficient strategy reported in this paper will provide new opportunities for further promoting the industrial application of hollow TS-1.
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FREE RADICAL BIOLOGY AND MEDICINE
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2021
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IF 7.376
Yue Zhang,Shibo Sun,Weiping Xu,Rui Yang,Yijia Yang,Jianli Guo,Kun Ma,Jianqiang Xu
Shikonin , a naturally occurring naphthoquinone with potent anti-tumor activity, has been reported to induce cancer cell death via targeting selenoenzyme thioredoxin reductase 1 (TrxR1; TXNRD1). However, the interaction between shikonin and TrxR1 remains unclear, and the roles of the cellular antioxidant system in shikonin induced cell death are obscure. Here, we found that shikonin modified the Sec 498 residue of TrxR1 to fully inhibit its antioxidant activity , however, the shikonin-modified TrxR1 still remained intrinsic NADPH oxidase activity, which promotes superoxide anions production. Besides, TrxR1 efficiently reduced shikonin in both selenocysteine dependent and selenocysteine independent manners, and the oxygen-coupled redox cycling of shikonin also generates excessive superoxide anions. The inhibitory effects and the redox cycling of shikonin towards TrxR1 caused cancer cell ROS-dependent necroptosis. Interestingly, as we evaluated, some cancer cell lines were insensitive to shikonin, especially kelch-like ECH associated protein 1 (KEAP1)-mutant non-small cell lung cancer (NSCLC) cells, which harbor constitutive activation of the nuclear factor-erythroid 2-related factor 2 (NRF2). NADPH bankruptcy caused by glucose starvation or glucose limitation (inhibiting glucose transporter 1 by BAY-876) could efficiently overcome the resistance of KEAP1-mutant NSCLC cells to shikonin. Glucose-6-phosphate dehydrogenase (G6PD), was known as a rate-limiting enzyme in the pentose phosphate pathway , however, the pharmacological inhibition of G6PD by 6-aminonicotinamide (6-AN), enhanced the shikonin-induced cytotoxicity but has no selectivity on KEAP1-mutant NSCLC cells. This study will be helpful in applying shikonin for potential chemotherapy, and in combinational treatment of KEAP1-mutant NSCLC.
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2021
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IF 5.909
Yangjinghua Yu,Runjun Sun,Zhong Wang,Mu Yao,Guohe Wang
Graphene oxide (GO) composite materials as adsorbent have been widely researched in the adsorption various heavy metal contaminated water . In order to improve its structural stability and adsorption properties, self-support GO/Sodium Alginate (SA)/1, 2-Propanediamine (PDA) composite membrane was prepared by vacuum filtration. The performance of amino functional groups in composite membranes was observed using X-ray photoelectron spectrum (XPS). The X-ray diffraction (XRD) was used to characterize the interlayer spacing. The Pb 2+ adsorption properties of composite membranes were discussed by intermittent adsorption experiments. Intermittent adsorption experiments include the subject of the pH, contact time, adsorption film weight, concentration of metal ion and temperature change. The Pb 2+ adsorption on the composite membrane strongly depends on pH. After 20 min of adsorption, the membrane reached the adsorption equilibrium, and the adsorption rate was fast. The maximum adsorption capacity of the composite membrane to Pb 2+ was 189.25 mg g −1 . The adsorption process of the membrane was consistent with the chemisorption process and mono-layer adsorption process. The GO/SA/PDA membranes can be used to the adsorption of Pb 2+ , which might give contribution to environmental protection.
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高影响因子
ARCHIVES OF ORAL BIOLOGY
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2021
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IF 2.635
Yujia Cui,Mingru Bai,Daimo Guo,Yueyi Yang,Haoran Chen,Jianxun Sun,Jing Xie,Xuedong Zhou
Objective Insulin-like growth factor 1 (IGF1) is one of the vital factors in regenerative endodontics . Previous studies have focused on the role of IGF1 in the mineralization of dental tissues. However, the role of IGF1 in the neural differentiation of dental stem cells was little discussed. Design IGF1 was overexpressed in human stem cells from the apical papilla (hSCAPs) by lentivirus and knocked down in hSCAPs by small interfering RNA . The neural differentiation level of hSCAPs was investigated histologically by HE staining and Nissl staining after neural induction for 3 days. The expression of proteins was examined by western blot and immunofluorescence. Results IGF1 promoted neural differentiation of hSCAPs, more cell processes and Nissl-positive body stained cells. IGF1 overexpression could both promote glial differentiation in hSCAPs, characterized by the increase of S100β and GFAP proteins, and neuronal differentiation , characterized by the increase of βIII-tubulin and functional GAD67/vGLUT1 proteins. Conversely, IGF1 knockdown suppressed both glial and neuronal differentiation. IGF1 activated AKT to regulate the early neural differentiation of hSCAPs. Conclusions The results indicate IGF1 could promote neural differentiation of hSCAPs by activating AKT signaling and provide a cue for the candidate of induced neural seeding cells in regenerative endodontics.
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PubMed
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
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2021
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IF 4.094
Xianhao Min,Qifei Xie,Zhiguo Wang,Xinzhong Wang,Mingxiang Chen
As traditional capping ligands like oleic acid (OA) and oleylamine (OLA) cannot efficiently maintain the optoelectronic properties and stability of iodide perovskite nanocrystals (NCs), post synthesis surface modification with some other ligand is a convenient and valid method to solve these problems to some extent. Here we promote a long carbon chain ligand with a thiol group, 1-Octadecanethiol (ODT), to realize the passivation of the surface of CsPbI 3 NCs after the synthesis process. After modification, our ODT-CsPbI 3 NCs exhibit excellent optical properties with a high PLQY of 93% and outstanding stability under different conditions compared to the untreated samples.
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高影响因子
Journal of Physical Chemistry C
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2021
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IF 4.126
Fuyong Zhang,Wei Zhou,Xuewei Xiong,Yuhao Wang,Kang Cheng,Jincan Kang,Qinghong Zhang,Ye Wang
Catalytic transformation of CO2 into chemicals in large demand such as ethanol has attracted much research attention under the background of establishing carbon-neutral societies. Supported Rh catalysts are promising candidates for the hydrogenation of CO2 to ethanol but suffer from low ethanol productivity and poor catalyst stability. Here, we report that zeolite silicalite-1 embedded Na-promoted Rh nanoparticles (Na-Rh@S-1) demonstrate high productivity and stability for CO2 hydrogenation to ethanol. The ethanol selectivity of 24% was attained at a CO2 conversion of 10%, and the space-time yield of ethanol reached 72 mmol gRh–1 h–1, which outperformed most of the Rh-based catalysts reported to date. While a reference catalyst prepared by impregnation underwent deactivation, the Na-Rh@S-1 catalyst was stable for at least for 100 h owing to the confinement effect. The Na+ modifier played crucial roles in enhancing the CO2 conversion and ethanol selectivity by suppressing methane formation. The characterizations suggest that the presence of Na+ enables the coexistence of Rh0 and Rh+ and enhances CO2 adsorption, thus boosting ethanol formation. A comparative study between CO and CO2 hydrogenation reveals that the Na-Rh@S-1 catalyst is significantly more active and selective toward CO2 hydrogenation to ethanol.
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高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2021
·Vol. 22
·期 21
·11466
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IF 5.924
Miaomiao Qi,Xiang Liu,Ying Zhou,Haoyu Wang,Ying Zhao,Jing Ren,Jin Xiang
G protein-coupled estrogen receptor 1 (GPER1) is a potential therapeutic target for treating triple-negative breast cancers (TNBC). However, modulators for GPER1 that can be used to treat TNBC have not appeared. Berberine (BBR) is a bioactive isoquinoline alkaloid with high oral safety. In recent years, BBR has shown an inhibitory effect on TNBC tumors such as MDA-MB-231, but the molecular target remains unclear, which hinders related clinical research. Our work proved that BBR is a modulator of GPER1 that can inhibit cell viability, migration, and autophagy of MDA-MB-231 cells. The inhibitory effect of BBR on MDA-MB-231 cells has a dependence on estrogen levels. Although BBR promoted the proteasome, which is a major factor in the degradation of GPER1, it could still induce the protein level of GPER1. Correspondingly, the transcription of cellular communication network factor 2 (CCN2) was promoted. BBR could bind to GPER1 directly and change the secondary structure of GPER1, as in the case of 17β-estradiol (E2). In addition, BBR induced not only a high degree of co-localization of GPER1 and microtubule-associated protein 1 light chain 3 (MAP1LC3), but also the accumulation of sequestosome 1 (SQSTM1/p62) by the inhibition of the nuclear translocation of the nuclear factor-kappa B (NF-κB) subunit (RELA/p65), which indicates NF-κB inhibition and anti-cancer effects. This result proved that the promotional effect of BBR on the GPER1/NF-κB pathway was closely related to its inhibitory effect on autophagy, which may serve as a new mechanism by which to explain the inhibitory effect of BBR on MDA-MB-231 cells and expand our understanding of the function of both BBR and GPER1.Keywords:berberine;binding;co-localization;GPER1;MAP1LC3;NF-κB
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JOURNAL OF MEMBRANE SCIENCE
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2021
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IF 8.742
Yanjiao Wang,Ge Yang,Hailing Guo,Xianglong Meng,Guodong Kong,Zixi Kang,Rémy Guillet-Nicolas,Svetlana Mintova
HKUST-1 nanocrystals (50–80 nm) were homogeneously dispersed in a polyetherimide (PEI) polymer matrix . The use of a capping agent (sodium formate) prevented the agglomeration of HKUST-1 nanocrystals in the casting solution. The highly dispersed HKUST-1 nanocrystals were found to strengthen the interactions with the PEI and minimize the interfacial holes by providing more accessible Cu unsaturated metal sites for the C O bonds on the five-membered rings of the PEI matrix. The PEI membrane loaded with 30 wt % HKUST-1 nanocrystals (30-N-HKUST-1/PEI) showed a high H 2 permeability (193.3 Barrer at 25 °C under 1.5 bar) and good ideal H 2 /CH 4 and H 2 /CO 2 selectivity factor of 101.7 and 20.6 in a single gas test, respectively. In the gas mixture test, it also showed a good separation performance, i.e., a H 2 /CH 4 and H 2 /CO 2 selectivity factor of 82.4 and 16.5 was measured, respectively. The 30-N-HKUST/PEI membrane was tested in a gas mixture at different temperatures (25–100 °C), different pressures (0–3 bar) and various time (5–72 h) to study the performance in more realistic conditions thus to be further considered in the separation of syngas.
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Journal of Materials Chemistry A
·
2021
·Vol. 9
·期 26
·14710-14721
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IF 12.732
He Huang,Wanyue Ye,Caicheng Song,Yingcen Liu,Xiaotong Zhang,Yu Shan,Yuzhen Ge,Shufen Zhang,Rongwen Lu
The selective oxidation of primary carbon–hydrogen bonds in the methyl group of toluene to corresponding oxygenates is of immense significance. This transformation, however, remains challenging and often requires either extensive optimization of the present chemical operating processes or, more importantly, the design and development of novel catalysts. In this paper, we achieve the confinement of uniform Au nanoparticles by using Silicalite-1 (Au@Silicalite-1) via an improved impregnation method for solvent-free oxidation of toluene by oxygen to benzaldehyde. In situ Ar+ etching XPS experiments revealed that in the evolution of Au0 and Au3+ species in a single Au@Silicalite-1 crystal the proportion of the Au3+ species becomes enriched from 0 on the surface to >80% in the center. In the synergetic catalysis between Au0 and Au3+ species, it was observed that the electron-rich Au0 species activated oxygen to form superoxide anion radicals, while the electron-deficient Au3+ species promoted activation of the primary carbon–hydrogen bond in toluene and enabled efficient desorption of the desired product benzaldehyde with selectivity >90%. For comparison, Silicalite-1 or SiO2 supported Au0-rich catalysts exhibited strong adsorption of benzaldehyde, generating overoxidized benzoic acid as the main product.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Bin Zhou,Lei Lin,Bingzhi Li
Flap endonuclease 1 (FEN1) is a nuclease overexpressed in cells with a high replicate rate, which has been recognized as a potential biomarker in the molecular diagnosis of cancers. In this work, we developed a fluorescent biosensor based on exponential amplification reaction (EXPAR) to realize the rapid and sensitive detection of FEN1. A DNA probe specific for FEN1 is used for the generation of reporter DNA (rDNA), and then the rDNA hybridizes with a template, triggering EXPAR to produce substantial rDNA exponentially. However, when no FEN1 is in the system, the EXPAR will not be initiated because of the lack of rDNA. Derived from the high amplification efficiency of EXPAR, the rapid quantification of FEN1 with a limit of detection (LOD) of 0.5 fM was realized. It is also revealed that this biosensor exhibits good selectivity towards FEN1 under the challenge from real samples including extracts of cells and solid tumors. Furthermore, this sensor was reengineered for the analysis of FEN1 inhibitors, which shows promise in the screening and evaluation of potential drugs targeting FEN1. This work integrates EXPAR into the biosensing of FEN1 for the first time, which provides a promising tool for FEN1-related biomedical investigations.
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高影响因子
OPTICAL MATERIALS
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2021
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IF 3.08
Yue Li,Linna Guo,Tiesheng Li,Bowen Yang
The ultra-small Lu6O5F8: 1%Er3+/10%Yb3+ up-conversion nanoparticles (UCNPs) were prepared via a co-precipitation method and used for detection of metal ions . Compared with other metal ions (Na+, Mg2+, Al3+, Fe2+, Co2+, Cd2+, etc), the up-conversion luminescence (UCL) intensity was reduced by 90% in the presence of Cu2+. Moreover, Strong quenching (65%) of the emission was observed upon the addition of Cu2+ in the concentration range of 0–10 μM. Meanwhile, the Cu2+ luminescence quenching mechanism was studied in detail. Under the 980 nm (1550 nm) excitation, the red UCL intensity of (Lu0.79Y0.1)6O5F8: 1%Er3+/10%Yb3+ and (Lu0.85Gd0.04)6O5F8: 1%Er3+/10%Yb3+ UCNPs enhanced about 4.67 (19.3) times and 3.95 (8.89) times than that of Y3+, Gd3+-absent samples, respectively. The temperature-sensing effect of Lu6O5F8: 1%Er3+/10%Yb3+ was also studied in detail, including not only this thermally coupled level (Er3+ 2H11/2, 4S3/2), but also the non-thermally coupled levels (Er3+ 2H11/2, 4F7/2). The absolute (S a ) and relative sensitivity (S r ) of Lu6O5F8: 1%Er3+/10%Yb3+ based on non-thermally coupled levels is much higher than that based on thermally coupled levels in the 293–473 K range. The maximum S a and S r is 0.087 and 0.0185 K −1 at 293 K. These meaningful results indicate that Lu6O5F8: 1%Er3+/10%Yb3+ materials have broad prospects in UCL multifunctional applications.
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