INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2017
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IF 3.671
Yukun Jiao,Mengliu Zhang,Shumei Wang,Chunyan Yan
The objectives of this study were to evaluate the anti-diabetic and anti-hyperlipidemic effects and relative mechanisms of guava polysaccharides (GPs) in rats with type 2 diabetic mellitus (T2DM). The chemical characterization and monosaccharide compositions of GPs, named as GP-1, GP-2, GP-3, and GP-4, were determined by PMP-HPLC and FT-IR. The results revealed that all GPs had the typical saccharide absorptions, and all were heteropolysaccharides. In addition, GPs efficiently decreased levels of fasting blood glucose, glucosylated serum protein, serum insulin, homeostasis model assessment of insulin resistance, total cholesterol, triglyceride and serum alanine transaminase, improved oral glucose tolerance, and increased insulin sensitivity in rats with T2DM. Histopathological observations suggested that GP-1, GP-3, and GP-4 could alleviate injury in pancreatic islet cells, and Western blot analysis showed that these GPs upregulated gene expression of the insulin receptor, insulin receptor substrate 2, Akt, and glucose transporter type 4. Taken together, these data suggest that GPs may be beneficial in treating T2DM and reducing the risk of hyperlipidemia, vascular disease, and cirrhosis via the PI3K/Akt signaling pathway.
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高影响因子
Journal of Energetic Materials
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2017
·
IF 1.557
Xi Li,Qiu-han Lin,Xin-Ying Zhao,Zhi-Wei Han,Bo-liang Wang
Thermal techniques (differential scanning calorimetry (DSC) and the vacuum stability test (VST)), according to STANAG 4147, and non-thermal techniques (Fourier transform infrared (FTIR) spectrometry and X-ray diffractometry (XRD)) were used to examine compatibility issues for 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane (CL-20) with a selection of insensitive explosives, including nitroguanidine (NQ), 2,4,6-trinitrotoluene (TNT), 2,6-diamino-3,5-dinitropyridine-1-oxide (ANPyO), 2,4,6-triamino-1,3,5-trinitrobenzene (TATB), 3-nitro-1,2,4-triazol-5-one (NTO) and 2,6-diamino-3,5-dinitropyrazine-1-oxide (LLM-105). DSC measurements showed that ANPyO, TATB, NTO and LLM-105 were compatible with CL-20. The compatibility of CL-20/NQ, CL-20/TNT, CL-20/ANPyO, CL-20/TATB, CL-20/NTO and CL-20/LLM-105 mixtures was further explored using the VST, which revealed that all the selected insensitive explosives were compatible with CL-20. Possible chemical interactions were suspected for CL-20/TATB from the FTIR results and for CL-20/NTO from XRD analysis. In summary, ANPyO and LLM-105 demonstrated the optimal compatibility with CL-20.
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CHEMICAL ENGINEERING SCIENCE
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2024
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IF 4.1
Zhongjian Tan,Yuwei Yan,Jiacong Liao,Huanhuan Shi,Yun Zheng,Weizheng Xu,Chen Yi,Zhiying Dai,Chenyang Xu
Droplet microfluidic technology can use each microdroplet as a microreactor, which has the advantages of low reagent dosage, less cross contamination, and fast reaction time. Combining concentration gradient generation with droplet formation and capture to form a two-dimensional reaction condition screening platform (including reactant concentration and reaction time) is expected to broaden the application range of microfluidic screening. In this work, a microfluidic chip that can dynamically generate and capture microdroplets and form static microdroplet array was designed and fabricated. An optimized Christmas tree structure by adjusting the horizontal channel length ratio was used to generate a chemical concentration gradient while obtaining a uniform outlet flow rate, forming a droplet array with different concentrations. The performance of droplet array with microfluidic concentration gradient (DA-MCG) was verified using sodium fluorescein as a model reagent. The chromogenic reaction of NaOH and phenolphthalein, and luminol chemiluminescence reaction were used to verify the two-dimensional screening ability of DA-MCG. The results indicated that the DA-MCG has the potential to be applied in the field of multi-dimensional drug screening.
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ELECTROCHIMICA ACTA
·
2024
·
IF 5.5
Yuhui Wang,Tong Zhang,Yong Huang,Shaonan Gu,Shu Zhang,Zhi Wang,Junhao Liu,Xuzhong Gong
Precise regulation of oxygen reduction reaction (ORR) for 2e-ORR or 4e-ORR is of great importance in designing efficient catalysts for electrochemical reactions. Currently, the exact roles of the functional groups and their possible synergistic functions still remain controversial. In this work, catalysts with different combinations of N and O functional groups were prepared using graphite to regulate ORR selectivity. Meanwhile, the quantum chemical parameters of various functional group combinations in the literature were summarized by using DFT calculation, and a method was provided to explain the relationship between functional group combinations, electronic structure and ORR selectivity by HOMO orbital delocalization index (ODI H ) and Mulliken population (MP). Finally, combining the molecular level calculations, a close correlation between the molecular structures with the tendency of 2e-ORR or 4e-ORR was established. Among them, the combination of C=O, N-Graphitic and Pyridinic-Pyrrolic-Graphitic nitrogen structure promoted 4e-ORR. C-O, O=C-O, N-Pyridinic and N-Pyrrolic promoted 2e-ORR. This study has revealed the essential difference between 2e-ORR and 4e-ORR, and provided a direction for determining the structure of 2e-ORR or 4e-ORR catalysts.
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SENSORS AND ACTUATORS B-CHEMICAL
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2024
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IF 8
Xuemeng Li,Jinxiu Wei,Kai Zhu,Yuanyuan Liu,Lei Wu,Kuo Yang,Shenfei Zong,Zhuyuan Wang,Yiping Cui
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused the global pandemic known as coronavirus disease 2019 (COVID-19). Accurate screening of SARS-CoV-2 is crucial in controlling the spread of the virus. Moreover, the false positive diagnosis will cause significant waste of the medical resources. Hence, we introduce a s uper- r esolution d ual f luorescence c o-localization (SR-DFC) strategy for the detection of SARS-CoV-2, which can greatly reduce false positive rates. In the SR-DFC assay, fluorescent capture probes are first modified onto periodically structured gold array substrates to capture the spike protein of SARS-CoV-2. Then, fluorescent recognition probes are added to identify SARS-CoV-2, forming sandwich-like immune complex structures. SR-DFC is realized by utilizing single-molecule localization microscopy (SMLM). Specific recognition of SARS-CoV-2 will induce high fluorescence colocalization between the capture probes and recognition probes. Owing to the high spatial resolution of SMLM, nonspecific adsorption can be well excluded, which greatly improves the specificity and significantly reduces false positive rates. Using a pixel counting method proposed by our group, quantitative detection of SARS-CoV-2 could be realized. The detection range covered in this study is between 0.1 ng/mL to 1000 ng/mL. By simply changing capture probes and recognition probes, the SR-DFC strategy is feasible for the detection of other targets, indicating a good universality. Such a highly accurate sensing strategy holds promising potential in the screening of infectious diseases.
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PHYTOCHEMISTRY
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2024
·
IF 3.2
Hao-Dong Yang,Yuan-Gui Yang,Zhi-Shu Tang,Kang Ma,Hong-Bo Xu
Acanthopanacis cortex (the dried root bark of Acanthopanax gracilistylus W. W. Smith) has been used for the treatment of rheumatic diseases in China for over 2000 years. Four previously undescribed lignans ( 1 – 4 ) and 12 known lignans ( 5 – 16 ) were isolated from Acanthopanacis cortex. In this study, the inhibitory activities of compounds 1 – 16 against neutrophil elastase (NE), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) are reported. The results show that compounds 1 – 16 exhibit weak inhibitory activities against NE and COX-1. However, compounds 2 , 6 – 8 and 13 – 16 demonstrate better COX-2 inhibitory effects with IC 50 values from 0.75 to 8.17 μ Μ. These findings provide useful information for the search for natural selective COX-2 inhibitors.
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Surfaces and Interfaces
·
2025
·
IF 6.3
Jinyue Yang,Jianxin Wang,Yongwen Lin,Xin Huang,Guangming Yin,Haixia Yu,Wendi Wang,Xinyou Zhang,Hong Pan
Transition metal sulfides are considered potential electrode materials for supercapacitors because of their low electronegativity, high electrochemical activity, and rich oxidation–reduction properties , but they also have the disadvantages of poor cycle stability and low magnification performance. In-situ growth sulfides on the current collector can strengthen the structural stability of the electrode to a certain extent, but this method only obtains a weak binding of the sulfide and current collector. With the progress of cycling, repeated structural evolution will inevitably lead to metal dissolution and sulfide shedding. In this study, nickel-poor reactants were cleverly adopted to synthesize one in-situ sulfide on nickel foam (NF) by activating the nickel element in NF to participate in the formation of sulfide, so as to obtain the in-situ electrode material with flower shape and gradient Ni content, named as Ni (2-x) CoS 4 /Ni 2 CoS 4 /Ni electrode. By further compounding polyaniline (PANI) on the surface of Ni (2-x) CoS 4 /Ni 2 CoS 4 /Ni electrode, the in-situ gradient Ni (2-x) CoS 4 /Ni 2 CoS 4 /Ni-PANI composite electrode (ISG-NCS-PANI) was obtained. This in-situ bimetallic sulfide has not only high stability, but also high reactivity. The flower shape with a large specific surface area is also beneficial to enhance the rate performance. As a result, the specific capacitance of the composite electrode is up to 2909.4 F g −1 at 1 A g −1 . After 5000 cycles, the capacity remains 83.8 %. The asymmetric supercapacitor (ASC) composed of activated carbon (AC) negative electrode has a specific capacitance of 211.11 F g −1 at 1 A g −1 . The power density of 749.99 W kg −1 shows the maximum energy density of 65.97 Wh kg −1 . The above results prove that ISG-NCS-PANI electrode holds significant potential for application prospect in the domain of energy storage and conversion.
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MOLECULAR CELL
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2024
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IF 14.5
Zhenxi Zhang,Yanting Yang,Yang Chen,Jingyu Su,Wenjing Du
The functional integrity of CD8 + T cells is closely linked to metabolic reprogramming; therefore, understanding the metabolic basis of CD8 + T cell activation and antitumor immunity could provide insights into tumor immunotherapy. Here, we report that ME2 is critical for mouse CD8 + T cell activation and immune response against malignancy. ME2 deficiency suppresses CD8 + T cell activation and anti-tumor immune response in vitro and in vivo . Mechanistically, ME2 depletion blocks the TCA cycle flux, leading to the accumulation of fumarate. Fumarate directly binds to DAPK1 and inhibits its activity by competing with ATP for binding. Notably, pharmacological inhibition of DAPK1 abolishes the anti-tumor function conferred by ME2 to CD8 + T cells. Collectively, these findings demonstrate a role for ME2 in the regulation of CD8 + T cell metabolism and effector functions as well as an unexpected function for fumarate as a metabolic signal in the inhibition of DAPK1.
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Polymers
·
2024
·Vol. 16
·期 13
·1863
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IF 4.7
Yan Qiu,Xinyang Zhao,Hong Li,Sijun Liu,Wei Yu
The viscosity and viscoelasticity of polyelectrolyte solutions with a single electrostatic interaction have been carefully studied experimentally and theoretically. Despite some theoretical models describe experimental results well, the influence of multiple interactions (electrostatic and hydrophobic) on rheological scaling is not yet fully resolved. Herein, we systematically study the microstructures and rheological properties of short-side-chain perfluorosulfonic acid (S-PFSA), the most promising candidate of a proton exchange membrane composed of a hydrophobic backbone with hydrophilic side-chains, in water/2-propanol. Small-angle X-ray scattering confirms that semiflexible S-PFSA colloidal particles with a length of ~38 nm and a diameter of 1–1.3 nm are formed, and the concentration dependence of the correlation length (ξ) obeys the power law ξ~c−0.5consistent with the prediction of Dobrynin et al. By combining macrorheology with diffusing wave spectroscopy microrheology, the semidilute unentangled, semidilute entangled, and concentrated regimes corresponding to the scaling relationships ηsp~c0.5, ηsp~c1.5, and ηsp~c4.1are determined. The linear viscoelasticity indicates that the entanglement concentration (ce) obtained from the dependence of ηspon the polymer concentration is underestimated owing to hydrophobic interaction. The true entanglement concentration (cte) is obtained by extrapolating the plateau modulus (Ge) to the terminal modulus (Gt). Furthermore, Geand the plateau width, τr/τe(τrand τedenote reptation time and Rouse time), scale as Ge~c2.4and τr/τe~c4.2, suggesting that S-PFSA dispersions behave like neutral polymer solutions in the concentrated regime. This work provides mechanistic insight into the rheological behavior of an S-PFSA dispersion, enabling quantitative control over the flow properties in the process of solution coating.
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TALANTA
·
2024
·
IF 5.6
Xiaohu Liu,Ruifeng Xie,Kang Li,Zhelei Zhu,Xi Huang,Qian He,Zhe Sun,Haiyang He,Yuancai Ge,Qingwen Zhang,Hu Chen,Yi Wang
We have developed a convenient surface-enhanced Raman scattering (SERS) platform based on vertical standing gold nanowires (v-AuNWs) which enabled the on-mask detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) related substances such as the Spike-1 protein and the corresponding pseudo-virus. The Spike-1 protein was clearly distinguished from BSA protein with an accuracy above 99 %, and the detection limit could be achieved down to 0.01 μg/mL. Notably, a similar accuracy was achieved for the pseudo-SARS-CoV-2 (pSARS-2) virus as compared to the pseudo-influenza H7N9 (pH7N9) virus. The sensing strategy and setups could be easily adapted to the real SARS-CoV-2 virus and other highly contagious viruses. It provided a promising way to screen the virus carriers by a fast evaluation of their wearing v-AuNWs integrated face-mask which was mandatory during the pandemic.
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高影响因子
CRYSTENGCOMM
·
2024
·Vol. 27
·期 1
·38-45
·
IF 2.6
Jiali Han,Shujun Zhu,Xinxin Chen,Haichao Zhou,Jianguo Pan,Shangke Pan
In recent years, lead-free organic–inorganic hybrid zero-dimensional metal halides have attracted considerable attention due to their outstanding optical properties, largely attributed to the confinement of localized metal groups. We report the discovery of a newly structured [MMim]2[CuI3] crystal with a distinct [CuI3]2− trigonal planar structure encapsulated by inert organic [MMim]+ clusters. The structure, composition, and thermal stability of the crystal were analyzed using XRD and TG–DTA. The optical properties of [MMim]2[CuI3] crystals were both experimentally measured and theoretically calculated. These crystals exhibit intense broadband orange luminescence with pronounced Stokes shifts and a microsecond-scale fluorescence lifetime decay, primarily due to self-trapped exciton emission. Temperature-dependent fluorescence spectra were also recorded to explore the luminescence mechanism. In summary, these findings highlight the remarkable potential of lead-free [MMim]2[CuI3] crystals in advancing optoelectronic applications.
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高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Shuhong Nie,Zheng Wang,Xiaohui Jiang,Liangmin Yu,Mengxuan Sun
Reasonable heteroatom doping and structural construction can improve the performance of electromagnetic wave (EMW) absorbing materials. Eugenol-acrylate monomer (EAM) with rich double bonds is synthesized from eugenol and acrylic anhydride by esterification without solvation. EAM and acrylonitrile (AN) are used as raw materials, the EAM as a source of carbon, the AN as nitrogen source. According to different molar ratios, a series of eugenol-group polymer microspheres with particle size ranging from 0.8 to 1.5μm are prepared by precipitation polymerization through one-pot method. Furthermore, N-doped carbonization microspheres with excellent EMW absorption properties are prepared by a controlled carbonization process with particle size ranging from 0.4 to 1.0μm. In this study, the molar ratios of EAM and AN are adjusted to optimize the EMW absorption properties of the prepared EMW absorbing materials of carbonization microspheres. It is confirmed that carbonization microspheres have good EMW absorption performance at an EAM to AN ratio of 7:3 and a thickness of 3 mm, the minimum reflection loss (RL min ) is −40.89 dB (12.56 GHz), and the effective absorption bandwidth (EAB) is 5.01 GHz (10.01–15.02 GHz). In this work, derivatives of eugenol with rich double-bond from a wide range of sources are involved in the process of copolymerizing microspheres maintained morphological stability before and after carbonization, which provided an efficient and easy method for the preparation of nitrogen and oxygen doped carbon microspheres, enriched the types of wave absorbing materials, and laid a foundation for future work.
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