LANGMUIR
·
2014
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IF 4.384
Hong Wang,Hao Wang,Xiaoqiong Yang,Qin Wang,Yajiang Yang
Ion-unquenchable and thermally on–off reversible room temperature phosphorescence (RTP) can be induced by entrapping 3-bromoquinoline (3-BrQ) into supramolecular gels formed by the self-assembly of a sorbitol derivative (DBS). In comparison with conventional substrates inducing RTP, the gel state 3-BrQ/DBS can produce strong RTP due to the efficient restriction of the vibration of 3-BrQ. Notably, the rather inconvenient deoxygenation is no longer necessary in the preparation of 3-BrQ/DBS gels. The produced RTP was found to be very fast to reach stable, not depending on the standing time. As a reference, in the liquid state of 3-BrQ/sodium deoxycholate (NaDC), stable RTP can be observed after standing for 5 h. The investigation of RTP quenching indicates that the mechanism of RTP induced by DBS gels mainly involves the microenvironment in which 3-BrQ is located. 3-BrQ was entrapped in the hydrophobic 3D network structure of DBS gels, thereby restricting the motion and collision of 3-BrQ and avoiding RTP quenching and additionally quenching by ions. Furthermore, the RTP of 3-BrQ/DBS gels show an excellent “on–off” effect at 10 or 80 °C. This indicates that the solid DBS gel is beneficial for the preparation of RTP sensor devices.
研究领域:
材料科学
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超分子化学
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光物理
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光学传感
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
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2022
·Vol. 147
·期 20
·11467-11475
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IF 4.755
Ma Xiao‑Hua,Hu Jie,Li Quan‑Guo,Li Peng,Liu Xuan,Yan Xiao-Min,Cheng Chun-Sheng,Li San-Xi
This study describes the apparent thermodynamics and reaction kinetics of the synthesis of [(5,6-dimethyl dicarboxylate-3-pyridine) methyl]-trimethyl ammonium bromide (DPTAB) and established a reaction kinetics model firstly. Simultaneous thermal analysis coupled with Fourier transform infrared and mass spectrometry (STA-FTIR-MS) was utilized to study the mechanism of the decomposition reaction of DPTAB firstly also. The finding is that the apparent activation energy of the synthesis reaction of DPTAB is 69.27 kJ mol −1 , and the apparent reaction heat is –74.46 kJ mol −1 (based on the moles of dimethyl 5-bromomethylpyridine-2,3-dicarboxylate). Under thermal runaway conditions, the adiabatic temperature rise is 8.87 K. The synthesis reaction kinetic equation is \(r=5.876\times {10}^{13}\cdot \mathrm{exp}\left(-69.27/RT\right)\cdot {C}_{\mathrm{CMPE}}^{ 0.893}\cdot {C}_{\mathrm{TMA}}^{ 1.136}\) . Under a nitrogen atmosphere, the decomposition of DPTAB undergoes an endothermic melt accompanied by an exothermic decomposition process. The decomposed products, trimethylamine reacts with bromomethane further to form tetramethylammonium bromide salt that undergoes an endothermic sublimation at 583 K, and the enthalpy of sublimation is 72.92 kJ mol −1 .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Yongchun Zhou,Da Bao,Shengnan Sun,Chen Cheng,Sen Zhang,Minlin Qing,Miao Zhao,Jing Guo
Chitosan grafting coumarin-3-carboxylic acid (CS-g-CCA) fiber with fluorescent function and enhanced tensile strength was successfully prepared by in-situ wet-spinning. FTIR and NMR results demonstrate that CCA is successfully grafted onto the CS molecule chains. As the grafting rate increases from 4.2 to 15.8 %, the spinning solution viscosity increases from 22 to 54 Pa·s. SEM observations show that the CS and CS-g-CCA fiber surfaces and cross-sections exhibit homogeneity and smoothness. Likewise, as the drawing ratio increases from 1.0 to 1.4, 2D WAXS patterns illustrate the molecular chain oriented significantly along the drawing direction. The CS-g-CCA fiber (the grafting rate of 15.8 %) exhibits a maximum breaking strength of 1.06 cn/dtex, increasing by 20 % more than the CS fiber. Meanwhile, it has a peak fluorescence intensity of around 480 nm. In addition, the continuous preparation process simplifies the technological route and improves the preparation efficiency of CS-g-CCA fiber. As-prepared CS-g-CCA fiber with enhanced tensile strength and elevated fluorescence efficiency lays the foundation for potential application in fluorescent probes , anti-counterfeiting, and biomedicine fields.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2022
·
IF 6.371
Hongxia Chen,Yutian Yang,Rihuang Nie,Cheng Li,Shuangwu Xu,Mengcheng Zhou,Xinyu Zhang,Hongming Zhou
Na 3 V 2 (PO 4 ) 3 has been widely studied due to its stable three-dimensional transmission channel structure as a cathode electrode of sodium ion batteries , but its micro particle size and low intrinsic electronic conductivity limit its further development. Therefore, hierarchical porous micro-nano NVP/C materials were successfully prepared using a metal-organic frameworks (MOFs) precursor. Because of the unique hierarchical porous micro-nano structure, 3D highly conductive network between surface and particles, and high specific surface area, M-NVP/C exhibits outstanding rate capability (95.0 mAh g −1 at a current density of 10 C) and extraordinary stable cycle life (the capacity decays from 111.2 mAh g −1 to 108.8 mAh g −1 after 500 cycles at 1 C, with a capacity retention rate of 97.8 %). This method provides a promising pathway for the application of MOFs in battery materials and promotes the development of SIBs in large-scale energy storage systems.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2022
·Vol. 49
·期 1
·241-252
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IF 3.134
Xing Qianqian,Zhao Jiancheng,Zhu Yulei,Hou Xianglin,Wang Yingxiong
5-Chloro-2-pentanone (5C2P) and its derivatives are widely utilized in the pharmaceutical and agrochemical industry. A new catalytic approach was proposed to convert 3-acetyl-1-propanol to 5C2P using bis(trichloromethyl)carbonate (triphosgene, BTC) as the efficient chlorine source. Various qualitative and quantitative nuclear magnetic resonance techniques ( 1 H, 13 C NMR), especially 1D selective gradient total correlation spectroscopy (Sel-TOCSY) and 2D heteronuclear single quantum correlation ( 1 H- 13 C HSQC) were used in the process. The reaction conditions, such as temperature, time, mole ratio, solvent as well as initiator were optimized. Experiment results showed that the yield of 5C2P reached a maximum of 97.93% in 1,2-dichloroethane at 80 °C after 2 h under the initiation of N,N-dimethylacetamide, and the optimal molar ratio of 3-acetyl-1-propanol to BTC was 1:0.4. The reaction mechanism was proposed and confirmed accordingly. Interestingly, an intermediate product of 1-(dimethylamino)ethyl carbonochloridate was observed, and its chemical structure was characterized by both Sel-TOCSY and 1 H- 13 C HSQC. This study enriched the catalytic reaction ways for the preparation of 5C2P.
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Pharmaceutics
·
2022
·Vol. 14
·期 11
·2307
·
IF 6.525
Xueyan Gou,Fenglin Ran,Jinru Yang,Yanrong Ma,Xin’an Wu
Background: Organic anion transporter 1 (OAT1) and OAT3 have an overlapping spectrum of substrates such that one can exert a compensatory effect when the other is dysfunctional. As a result, the knockout of either OAT1 or OAT3 is not reflected in a change in the excretion of organic anionic substrates. To date, only the mOAT1 and mOAT3 individual knockout mouse models have been available. Methods: In this study, we successfully generated aSlc22a6/Slc22a8double-knockout (KO) rat model using CRISPR/Cas9 technology and evaluated its biological properties. Results: The double-knockout rat model did not expressionmRNAfor rOAT1 or rOAT3 in the kidneys. Consistently, the renal excretion ofp-aminohippuric acid (PAH), the classical substrate of OAT1/OAT3, was substantially decreased in theSlc22a6/Slc22a8double-knockout rats. The relativemRNAlevel ofSlco4c1was up-regulated in KO rats. No renal pathological phenotype was evident. The renal elimination of the organic anionic drug furosemide was nearly abolished in theSlc22a6/Slc22a8knockout rats, but elimination of the organic cationic drug metformin was hardly affected. Conclusions: These results demonstrate that this rat model is a useful tool for investigating the functions of OAT1/OAT3 in metabolic diseases, drug metabolism and pharmacokinetics, and OATs-mediated drug interactions.Keywords:OAT1/OAT3;CRISPR/Cas9;gene knockout;pharmacokinetic
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HIGH PERFORMANCE POLYMERS
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2022
·
IF 1.73
Rui Chen,Bao Dongmei,Jiaye Jiang,Chuanbo Sun,Han Chen,Min Zhang
Two effective flame retardant additives hsalaminopyridine phosphaphenanthrene (HAD) and methoaminopyridine phosphaphenanthrene (MAD) were respectively prepared with DOPO, aminopyridine, salicylaldehyde and 3-Methoxysalicylaldehyde. Subsequently, HAD and MAD was added into epoxy resin (EP) respectively, and flame retardancy of EP/HAD and EP/MAD thermosets were dramatically enhanced. The result of cone calorimeter (CC) test revealed that both HAD and MAD showed perfect smoke suppression performance. In respect of transmittance and mechanical properties, there was a huge difference between HAD and MAD. The introduction of HAD dramatically harmed transmittance and mechanical properties of EP, while, EP/10%MAD was transparent and nearly possessed the same mechanical properties with pure EP.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 3
·1-10
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IF 5.7
Fan Xiaoyu,Zhang Shuai,Li Rui,Chen Yafei,Jiang Shuhan,Liu Tao,Shao Xiaodong,Wang Shuhao,Yue Qiaoli
Novel and portable cotton swab–based fluorometry was constructed for the first time for 3-aminosalicylic acid (3-ASA) and 5-aminosalicylic acid (5-ASA) detection. It was carried out by fluorescence enhancement on silver (Ag)–doped black phosphorus quantum dots (Ag@BPQD). Ag@BPQD were prepared from AgNO 3 and bulk black phosphorus in N, N-dimethylformamide (DMF) solution by solvothermal decomposition after mechanical exfoliation. Ag@BPQD show blue fluorescence with a quantum yield (QY) of 2.43%. In the presence of Ag@BPQD, 3-ASA exhibited bright blue fluorescence (λ ex = 328 nm, λ em = 448 nm). The fluorescence of 5-ASA was also enhanced significantly and exhibited bright green emission (λ ex = 328 nm, λ em = 484 nm). The linear range of 3-ASA is 0–90 μM with a detection limit (LOD) of 0.10 μM, relative standard deviation (RSD) ≤ 2.04%, and a recovery range of 98.0–104.3%. The linear range of 5-ASA is 0–120 μM with a LOD of 0.12 μM, RSD ≤ 1.34%, and a recovery range of 98.0–101.3%. When 3-ASA and 5-ASA were mixed in different ratios, the fluorescence showed different colors. The possible mechanism of the interaction between 3-ASA (or 5-ASA) and Ag@BPQD may be ascribed to the generation of excited-state intramolecular proton transfer. To realize convenient detection of 3-ASA and 5-ASA, a Ag@BPQD portable sensing method using cotton swabs were built. The proposed approach provides the detection of 3-ASA and 5-ASA in environmental and biological samples with high efficiency, accuracy and portability. Graphical Abstract
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CATALYSIS TODAY
·
2022
·
IF 6.562
Yiming Ma,Yushuai Sang,Kai Wu,Qingfeng Liu,Hong Chen,Yongdan Li
Low selectivity and complex product distribution are the main challenges for the utilization of lignin. Herein, the selective production of 2-(tert-butyl)-3-methylphenol (TBC), an antioxidant in the polymer industry, from depolymerization of enzymatic hydrolysis lignin (EHL) on a hydrothermally synthesized MoS 2 catalyst is studied. The total aromatic monomer yield is 124.1 mg/g EHL and the selectivity of TBC is up to 40.3 wt% in methanol at 280 °C under 2 MPa H 2 for 6 h. The FT-IR analysis of products reveals that MoS 2 has a high activity for demethylation, dehydroxylation and alkylation, and the dimer conversions reveal that C-O and C-C bonds in EHL are broken with MoS 2 . The guaiacol and its derivants are identified as the intermediate for formation of TBC in EHL depolymerization according to the effect of time on product distribution and monomer conversion.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Shuaishuai Yuan,Xiuxia Sun,Shunjie Yan,Shifang Luan,Lingjie Song,Jinghua Yin
Vaseline gauze is a common type of wound dressing that consist of absorbent gauze impregnated with white petrolatum. It has excellent anti-adhesive property which can reduce trauma during dressing changes. However, this kind of wound dressing doesn’t have bacterial killing property. Thus, a new kind of wound dressing that has anti-adhesive and bactericidal properties is needed urgently. Creating slippery liquid-impregnated porous surfaces (SLIPS) that insensitive to the structure of porous solid are generally viewed as a new anti-adhesion strategy. To expand the potential utility of SLIPS as substitute for vaseline gauze, dual-functional slippery membranes with anti-adhesion and bactericidal properties by using triclosan , vegetable oils and polylactic acid (PLA) were prepared. It’s demonstrated that the triclosan-loaded/vegetable oils-infused PLA membranes (T/V-PM) has good cytocompatibility in vitro . Notably, the T/V-PM can gradually release biocide molecule into surrounding aqueous media. Moreover, the T/V-PM can kill planktonic bacterial cells without loss of their antifouling property. The in vivo study revealed that the T/V-PM can prevent the secondary injuries during wound dressing changes. This simple and low-cost strategy can be applied to inhibit blood and bacterial adhesion , and prevent tissue adhesion at the wound site. It’s confirmed that the T/V-PM have great potential as substitute for vaseline gauze.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Yan Yi,Xiangyu Wang,Yaxian Zhang,Jun Ma,Ping Ning
The aquatic plant Egeria najas based biochar was innovatively constructed by modifying it with Fe 2 (SO 4 ) 3 (Fe 2 (SO 4 ) 3 @EN-BC) for Cr(VI) removal. The characterizations of Fe 2 (SO 4 ) 3 @EN-BC confirmed that Fe 2 (SO 4 ) 3 was attached to biochar in form of Fe 2 O 3 after hydrolysis and calcination under high temperature. The results showed that Fe 2 (SO 4 ) 3 @EN-BC had a high removal efficiency of Cr(VI) with approaching 99.88%, which was about 7 times higher compared to unmodified biochar (EN-BC). Batch experiments of Cr(VI) removal included initial concentration, reaction temperature, solution pH and kinetics were conducted. The adsorption kinetics could be more accurately explained using pseudo-second order kinetics model , indicating the chemical adsorption controlled the reaction process. According to the Langmuir model, the maximum adsorption capacities for Cr(VI) were 138.79, 159.36 and 190.91 mg/g at 298, 313 and 333 K, respectively. Moreover, based on FTIR and XPS results, the Fe 2 (SO 4 ) 3 @EN-BC surface was loaded with many functional groups conducive to Cr(VI) adsorption. The main removal mechanisms of Cr(VI) by Fe 2 (SO 4 ) 3 @EN-BC included adsorption and reduction, and the percentage of Cr(VI) removed by adsorption and reduction were 19.1% and 80.9%, respectively.
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Frontiers in Aging Neuroscience
·
2022
·
IF 5.702
Wang Wang,Guoxue Zhu,Yuwen Wang,Wei Li,Shilin Yi,Kai Wang,Lu Fan,Juanjuan Tang,Ruini Chen
Background Parkinson’s disease (PD) is a multifactorial degenerative disease of the central nervous system, which affects mostly older adults. To date, research has focused on the progression of PD. Simultaneously, it was confirmed that the imbalances in gut microbiota are associated with the onset and progression of PD. Accurate diagnosis and precise treatment of PD are currently deficient due to the absence of effective biomarkers. Methods In this study, the pharmacodynamic study of cyanidin-3- O -glucoside in PD mice was used. It intends to use the “imbalance” and “balance” of intestinal microecology as the starting point to investigate the “gut-to-brain” hypothesis using metabolomic-combined 16S rRNA gene sequencing methods. Simultaneously, metabolomic analysis was implemented to acquire differential metabolites, and microbiome analysis was performed to analyze the composition and filter the remarkably altered gut microbiota at the phylum/genera level. Afterward, metabolic pathway and functional prediction analysis of the screened differential metabolites and gut microbiota were applied using the MetaboAnalyst database. In addition, Pearson’s correlation analysis was used for the differential metabolites and gut microbiota. We found that cyanidin-3- O -glucoside could protect 1-methyl-4-phenyl-1,2,3,6− tetrahydropy ridine (MPTP)-induced PD mice. Results Metabolomic analysis showed that MPTP-induced dysbiosis of the gut microbiota significantly altered sixty-seven metabolites. The present studies have also shown that MPTP-induced PD is related to lipid metabolism, amino acid metabolism, and so on. The 16S rRNA sequencing analysis indicated that 5 phyla and 22 genera were significantly altered. Furthermore, the differential gut microbiota was interrelated with amino acid metabolism, and so on. The metabolites and gut microbiota network diagram revealed significant correlations between 11 genera and 8 differential metabolites. Conclusion In combination, this study offers potential molecular biomarkers that should be validated for future translation into clinical applications for more accurately diagnosing PD. Simultaneously, the results of this study lay a basis for further study of the association between host metabolisms, gut microbiota, and PD.
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