SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Qian Wu,Xinping He,Chenyi Cui,Chenchen Jiao,Baojin Qi,Jinjia Wei
Mixed matrix membranes (MMMs) incorporating metal–organic frameworks (MOFs) hold significant promise for gas separation applications. However, the inherent disparity between the organic polymer matrix and the inorganic fillers frequently leads to interfacial incompatibility issues. In this study, we adopted an in-situ interfacial crosslinking strategy to fabricate MMMs incorporating NH 2 -Zn 2 (Bim) 4 nanosheets that simultaneously act as nanofillers and reactive crosslinkers. Specifically, during the thermal imidization reaction process, the amino groups of NH 2 -Zn 2 (Bim) 4 not only establish hydrogen bonding interactions with the carbonyl groups of polyamic acid (PAA) (the precursor of polyimide), but undergo dehydration reactions with carboxyl groups, leading to the formation of stable amide linkages. Meanwhile, the aromatic structure of the BI units, a key monomer of polyimide, closely resembles that of the ligands of NH 2 -Zn 2 (Bim) 4 , which can establish π-π stacking interactions, further improving the interfacial compatibility between the polymer matrix and MOF fillers. Among the prepared samples, MMMs incorporating 33.3 wt% NH 2 -Zn 2 (Bim) 4 nanosheets exhibit the maximum H 2 permeability of 680.5 Barrer, and its H 2 /N 2 and H 2 /CO 2 selectivities were 18.7 and 13.3, respectively, which were close to or even exceeded the Robeson upper bound. The proposed in-situ interfacial engineering based on chemical crosslinking provides a novel and effective route for fabricating high-performance MMMs with enhanced interfacial compatibility, demonstrating great potential for hydrogen separation applications.
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高影响因子
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
·
2024
·Vol. 25
·期 4
·477-487
·
IF 2.2
Chen Jianmin,Yu Sijin,He Zemin,Zhu Danhong,Cai Xiaozhen,Ruan Zhipeng,Jin Nan
Background: Cinnamic acid and its derivatives have gained significant attention in recent medicinal research due to their broad spectrum of pharmacological properties. However, the effects of these compounds on xanthine oxidase (XO) have not been systematically investigated, and the
inhibitory mechanism remains unclear. Objectives: The objective of this study was to screen 18 compounds and identify the XO inhibitor with the strongest inhibitory effect. Furthermore, we aimed to study the inhibitory mechanism of the identified compound. Methods: The effects of
the inhibitors on XO were evaluated using kinetic analysis, docking simulations, and in vivo study. Among the compounds tested, 4-NA was discovered as the first XO inhibitor and exhibited the most potent inhibitory effects, with an IC50 value of 23.02 ± 0.12 μmol/L.
The presence of the nitro group in 4-NA was found to be essential for enhancing XO inhibition. The kinetic study revealed that 4-NA inhibited XO in a reversible and noncompetitive manner. Moreover, fluorescence spectra analysis demonstrated that 4-NA could spontaneously form complexes with
XO, referred to as 4-NA–XO complexes, with the negative values of ΔH and ΔS. Results: This suggests that hydrogen bonds and van der Waals forces play crucial roles in the binding process. Molecular docking studies further supported the kinetic analysis and provided insight
into the optimal binding conformation, indicating that 4-NA is located at the bottom outside the catalytic center through the formation of three hydrogen bonds. Furthermore, animal studies confirmed that the inhibitory effects of 4-NA on XO resulted in a significant reduction of serum uric
acid level in hyperuricemia mice. Conclusion: This work elucidates the mechanism of 4-NA inhibiting XO, paving the way for the development of new XO inhibitors.
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PubMed
高影响因子
Cell Reports
·
2023
·Vol. 42
·期 11
·113349-113349
·
IF 8.8
Shao Q,Wijaya CS,Wang S,Meng X,Yuan C,Ma C,Xu S
Maintaining cellular viability relies on the integrity of the plasma membrane, which must be repaired upon damage. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion is a crucial mechanism involved in membrane repair. In C. elegans epidermal cell hyp 7, syntaxin-2 (SYX-2) facilitates large membrane wound repair; however, the underlying molecular mechanism remains unclear. Here, we found that SNAP-25 protein RIC-4 and synaptobrevin protein SEC-22 are required for SYX-2 recruitment at the wound site. They interact to form a SNARE complex to promote membrane repair in vivo and fusion in vitro. Moreover, we found that SEC-22 localized in multiple intracellular compartments, including endosomes and the trans-Golgi network, which recruited to the wounds. Furthermore, inhibition of RAB-5 disrupted SEC-22 localization and prevented its interaction with SYX-2. Our findings suggest that RAB-5 facilitates the formation of the RIC-4/SEC-22/SYX-2 SNARE complex and provides valuable insights into the molecular mechanism of how cells repair large membrane wounds.
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RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2021
·Vol. 90
·期 12
·2376-2380
·
IF 0.868
Abbas N.,Shabir G.,Saeed A.,Tirmizi S. A.,Echeverría G. A.,Piro O. E.,Erben M. F.
Abstract The present study is devoted to the synthesis of 4-chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and its transition metal complexes. Synthesis of the ligand has been achieved by the condensation reaction of N,N -diethylsalicylaldehyde with 4-chloro-2-aminophenol in acidic medium. Metals complexes of the ligand with different transition metal ions [M 2+ = Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), and Pd(II)] have been accumulated in alcoholic media and characterized by spectroscopic methods. UV-Vis analysis of the complexes indicates the ligand coordination to the metal ions via both OH groups and the azomethine nitrogen atom, acting as a tridentate ligand. Anticancer tests of selected complexes demonstrate moderate in vitro activity of Cu(II) complex against HeLa cell line.
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JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Wen Li,Hexiang Wang,Yuan Zhang,Limin Zhao,Pengfeng Guo,Hua Cao,Xiang Liu
Pyridinium 1,4-zwitterionic thiolates were regarded as powerful and versatile building blocks to prepare nitrogen- and sulfur-containing heterocycles. Herein, we reported a copper-catalyzed formal [4 + 1] annulation of pyridinium 1,4-zwitterionic thiolates and diazo compounds without any additives to access a library of trifunctionalized indolizines in good yields. Besides, isoquinolinium 1,4-zwitterionic thiolates and imidazolium 1,4-zwitterionic thiolates were also applied to this formal [4 + 1] annulation reaction. Of particular note is that various functional groups such as −CO2R, −CO2NR2, −CF3, −CN, and −(O)P(OR)2 could be easily introduced into cycloaddition products indolizines by this strategy.
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高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2013
·Vol. 23
·期 6
·1451-1458
·
IF 1.174
Yu Xiaoke,Weng Wandan,Guo Xiaxia,Zheng Yueqing
Two polymeric carboxylato-bridged manganese(II) complexes, \( {}_{\infty }^{1} \) [Mn(bpe)(NBA) 2 ] ( 1 ) and \( {}_{\infty }^{1} \) [Mn(bpe)(MBA) 2 ] ( 2 ) (bpe = 1,2-di(4-pyridyl)ethylene; HNBA = m-nitrobenzoic acid; HMBA = m-methyl-benzoic acid), were synthesized and characterized. Compounds 1 and 2 are isostructural. X-ray diffraction studies show that the title compounds possess a double chain structure. The chains in 1 and 2 are assembled into 2-D layers via C–H···O hydrogen bonds interactions. Furthermore, owing to the offset face-to-face π–π stacking interactions, the adjacent 2-D layers embed into each other to form a 3-D supramolecular framework. Variable-temperature (2–300 K) magnetic susceptibility measurements show the presence of weak antiferromagnetic interactions between the high-spin Mn(II) (S = 5/2) ions through a carboxylato bridge with the best fit parameters for 1 being J = −0.13 cm −1 , zJ′ = −0.098 cm −1 and for 2 , J = −0.33 cm −1 , zJ′ = −0.001 cm −1 .
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Advanced Fiber Materials
·
2022
·Vol. 4
·期 5
·1069-1080
·
IF 12.958
Wang Caihong,Liu Ke,Wang Dong,Wang Guomin,Chu Paul K.,Meng Zheyi,Wang Xuefen
Hierarchical CuO–ZnO/SiO 2 (CZS) nanofibrous membranes are designed and fabricated to remove Congo red and 4-nitrophenol two common small molecular pollutants in water. The electrospun SiO 2 fibrous membrane is serves as the substrate for hydrothermal depositing CuO–ZnO nanosheets. The CZS nanofibrous membrane shows good adsorption characteristics for Congo red due to the hierarchical morphology and the adsorption kinetics where isotherm follows the pseudo-second-order model and Langmuir model, respectively. The maximum adsorption capacity for Congo red is 141.8 mg/g. Moreover, the membrane exhibits excellent catalytic reduction activity for 4-nitrophenol under mild conditions and over 96% of the pollutants are degraded within 90 s. The CZS nanofibrous membrane has promising prospects in applications in water treatment and environmental protection because of the good flexibility, easy fabrication, excellent adsorption, and catalytic activity. Graphical abstract
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POLYMER JOURNAL
·
2019
·Vol. 52
·期 1
·145-152
·
IF 2.639
Bai Hongyuan,Han Li,Ma Hongwei,Yang Lincan,Li Chao,Liu Pibo,Shen Heyu,Lei Lan,Zhang Songbo
A sulfur-containing styrene derivative, 4-methylenethiochromane (META), was subjected to anionic copolymerization with isoprene (Ip) modified with different additives. The reactivity of META can be effectively regulated with additives; thus, gradient and alternating copolymers were prepared in a facile manner. When THF and TMEDA were utilized in the copolymerization, the reactivity was better than that observed without additives, and thus, gradient copolymers with different gradient extents can be synthesized. In addition, metal alkoxides (such as sodium 2,3-dimethylpentan-3-olate (NaODP) and potassium tert -butoxide ( t -BuOK)) were better able to regulate the reactivity, and the copolymers exhibited alternating and nearly alternating sequences. Therefore, the regulation of the alternating or gradient copolymerization of META and Ip was facilely realized through the use of additives.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Yi Zhang,Yuhang Liu,Pran Gopal Karmaker,Lilei Zhang,Kaijing Yang,Lianfang Chen,Xiupei Yang
2,6-Dichloro-4-nitroaniline, alias dicloran (DCN), is a broad-spectrum pesticide that can cause irreversible damage to the human body. Therefore, it is of great significance to develop a technology for the rapid and convenient detection of DCN. Luminescent metal organic frameworks have attracted extensive attention in the field of sensing and detection due to their excellent optical properties. In this study, two kinds of 2D Cd-MOFs (CdMOF-1 and CdMOF-2) were developed for the detection of residual DCN in the environment. Both CdMOFs exhibit excellent solvent and acid–base stability and can respond to DCN quickly and sensitively in a short time (30 s). CdMOFs not only have good selectivity and anti-interference toward DCN but also have good reusability. Under the conditions of DCN concentrations of 1–15 and 0.3–30 μM, the change in fluorescence intensity of CdMOF-1 and CdMOF-2 showed a good linear relationship with DCN concentration (R2 = 0.999/0.991), and the detection limits were 0.36 and 0.12 μM, respectively. Through ultraviolet–visible absorption spectroscopy (UV–Vis), X-ray photoelectron spectroscopy, fluorescence lifetime, and density functional theory calculations, it is revealed that the fluorescence quenching mechanisms of DCN for two kinds of Cd-MOFs are competitive absorption and photoinduced electron transfer, and there may be a weak π–π interaction. Finally, it is demonstrated that by using two types of fluorescent CdMOFs to make the fluorescent test paper and detect actual soil, these can be applied to the actual scene and achieve onsite real-time detection.
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PubMed
高影响因子
FUEL
·
2022
·
IF 8.035
Hang Xu,Shaokang Wang,Fengmin Wu,Qinlin Yuan,Yafei Guo,Yinke Zhang,Xuefeng Wei,Jun Zhang
One of the disadvantages of using inorganic solid catalysts is the formation of solid waste. The use of fully-organic solid catalysts can reduce secondary pollution by simple combustion or bio-degradation. Here, an organic polymerization carrier, calix[4]resorcinarene, with polyhydroxyl characteristics, was synthesized. A cobalt containing ionic liquid was successfully chemically bonded to the hydroxyl groups on the carrier surface using 3-chloropropyltrimethoxysilane as linking agent. The resulting fully-organic supported ionic liquid catalyst was coupled with oxone for desulfurization. The micro-structure of the catalyst was composed of a porous spatial network structure. The reaction system exhibited excellent dibenzothiophene (DBT) removal (93.3%) after 90 min under the optimum experimental conditions (20 °C, 6 g of model oil with an initial sulfur content of 1000 ppm, 0.2 g of 20 wt% oxone solution with a dosage frequency of three, 15% of CoCl 2 , 0.15 g of catalyst, and 2 g of [Bmim]BF 4 ). After six regeneration cycles, the sulfur removal remained above 90%. The desulfurization kinetics and mechanism were also discussed, and it was found that the hyperbolic model provided a better fit to the experimental data compared to the pseudo first-order model. The likely mechanism involves DBT being extracted using the ionic liquid [Bmim]BF 4 before being oxidized by the catalyst/oxone system to form DBTO 2 , which is easily removed from the system using polar solvents.
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POLYHEDRON
·
2022
·
IF 2.975
Xian-Hao Feng,Zhi-Chao Yu,Wei Zhang,Carl Redshaw,Timothy J. Prior,Tie-Hong Meng,Chun-Rong Li,Zhu Tao,Xin Xiao
In the work, we have studied the interaction of cucurbit[7]uril (Q[7]) with 1-[4-(dimethylamino)phenyl]-ethanone (DAPE) using a variety of techiniques including 1 H NMR spectroscopy, UV–vis adsorption and fluorescence spectroscopies, Isothermal titration calorimetry and single crystal X-ray diffraction. Results revealed the formation of a 1:1 complex, whilst the molecular structure of the species [(Q[7]@DAPE)Ca(H 2 O) 3 ] 2 (CdCl 4 ) 2 ·31(H 2 O) is reported.
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Journal of Physical Chemistry C
·
2022
·
IF 4.177
Tongxin Xiao,Ying Chen,Yuning Liang
The photocatalytic conversion of CO2 into hydrocarbon fuels by utilizing abundant solar energy is a promising and eco-friendly approach to address the energy crisis and global warming. In this work, the sensitizer Ni(II) tetra(4-carboxylphenyl)porphyrin (NiTCPP) was successfully combined with TiO2 nanotube arrays (TiO2NTs) by three methods, and their performances in the photocatalytic reduction of CO2 under simulated solar irradiation were studied. The results showed that NiTCPP/TiO2NTs exhibit a greatly ameliorated photocatalytic activity, and the photocatalytic reduction activities of NiTCPP/TiO2NTs prepared by different methods were different. The catalyst prepared by the impregnation method displayed the highest photoreduction efficiency. The reduction rate of CO2 into CH4 was up to 33.89 μmol/cm2/h with a quantum efficiency of 0.65% (at 420 nm), about 5 times that of the bare TiO2NTs. The introduction of NiTCPP not only efficiently expands the light absorption range but also enhances the charge separation efficiency. Furthermore, a possible mechanism of its CO2 photoreduction performances was systematically presented.
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