CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Pengpeng Lu,Jincheng Cheng,Yifan Li,Li Li,Qiang Wang,Chiyang He
A novel porous β ‐cyclodextrin/pillar[5]arene copolymer was prepared using tetrafluoroterephthalonitrile as cross-linker for rapid removal of variety of organic pollutants. The copolymer was characterized by water contact angle, scanning electron microscope, FT-IR spectrum, solid-state 13 C NMR spectrum, thermo-gravimetric analysis, nitrogen adsorption-desorption isotherms, and elemental analysis. Results showed that the co-polymer had good water immersibility, co-existing micro-/meso-pores, and a large specific surface area (BET) of 479 m 2 /g. The copolymer presented high adsorption capacity with the maximum adsorption capacity of 258 mg/g for bisphenol A and good reusability and reproducibility. It also showed fast binding kinetics with the apparent second-order rate constants of 0.109−0.179 g/mg·min and simultaneously rapid removal ability with removal efficiencies of 74–90% within 30 s for variety of organic pollutants. The new copolymer can be potentially used as adsorbent for rapidly removing a wide range of organic pollutants in wastewater.
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高影响因子
WATER RESEARCH
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2020
·
IF 9.13
Chen Zhong,He Zhao,Qingzhen Han,Hongbin Cao,Feng Duan,Junyi Shen,Yongbing Xie,Wanqian Guo,Shanshan Sun
As an important raw material and intermediate of widely used antibiotics cefazolin and cefazedone, 2-mecapto-5-methyl-1,3,4-thiadizaole (MMTD) in antibiotic wastewater is hardly decyclized during wastewater treatment, posing great risk to the environment. This work proposed a green “coupling-oxidation” process to enhance ring-opening of MMTD during antibiotic wastewater treatment. In particular, the significant role of humic substances (HS) as pre-coupling reagent was emphasized. Real HS and different model HS, especially quinones, not only efficiently pre-coupled MMTD (>95%) but also promoted the MMTD removal by MnO 2 (from 72.4% to 92.4%). Mass spectrometric analysis indicated that MMTD pre-coupled to HS would be oxidized with ring opening to environmental-friendly sulfonated HS, while direct oxidation of MMTD produced MMTD dimers or sulfonated MMTD that would not undergo ring opening. Theoretical calculations indicated that pre-coupling to HS enabled the ring-opening oxidation by increasing the nucleophilicity and decreasing ring-opening barrier of thiadiazole. Based on the density function theory (DFT), the global nucleophilicity index (Nu) followed the trend of HS-MMTD > MMTD dimer > sulfonated MMTD, while the ring-opening barrier followed the trend of HS-MMTD (274 kJ/mol) < first ring of MMTD dimers (286 kJ/mol) < MMTD (338 kJ/mol). Theoretical calculations further confirmed that the cross-coupled HS-MMTD intermediate was more likely to be decyclized than intermediates from direct oxidation. Moreover, nitrogen, acetaldehyde group, sulfate and CO 2 were the products of thiadiazole ring degradation. Pre-coupling of MMTD with HS provides a new idea and strategy in developing a green and sustainable scheme for wastewater treatment.
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International Journal of Applied Ceramic Technology
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2025
·
IF 2.3
Wenying Jiang,Chuanjin Tian,Zhiyang Ju,Yumin Liu,Shaojian Fu,Wenyan Zhao,Zhipeng Xie
The non-radiative recombination loss at the interface is a huge obstacle to improving the photovoltaic performance of perovskite solar cells (PSCs), especially carbon-based PSCs (C-PSCs). Here, we propose a strategy for synergistic regulation of interface defects and carrier transport through functional groups of long-chain ammonium salt molecules to form 2D perovskite passivation layers by surface treatment with 5-aminovalerate hydroiodide (5-AVAI). The results indicate that the carboxyl group (–COOH) in 5-AVAI molecules can form coordination bonds with uncoordinated Pb 2+ ions, thereby anchoring to the surface of the perovskite film. Simultaneously, the electrostatic interaction between the amino group (–NH 3 + ) and I − ions in 5-AVAI inhibits the formation of iodide vacancies, enhances defect passivation, and improves the transport and transfer efficiency of interfacial carriers. The atmospherically generated 5-AVAI-modified C-PSCs exhibited an efficiency of 16.50% and retained 85% of their initial efficiency for 80 days in atmospheric environment.
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Catalysts
·
2025
·Vol. 15
·期 12
·1160
·
IF 4
Liya Zheng,Yongshui Qu,Yibing Li,Yuanxin Cao,Quanyuan Wei,Ming Fang
To address the challenges of difficult recovery, significant environmental hazards associated with homogeneous catalysts, and insufficient catalytic activity of heterogeneous supports in the catalytic dehydration of fructose to produce 5-hydroxymethylfurfural (5-HMF), this study employs a straightforward nitric acid modification method to prepare an acid-activated silica gel catalyst for application in this reaction system. Through systematic investigation of the influence of modification conditions on catalyst performance and economic benefits, optimal reaction conditions were determined: DMSO as the solvent, nitric acid-modified silica gel as the catalyst, a reaction temperature of 120 °C, a solid–liquid ratio of 1:30 (g∙mL−1), and a fructose-to-catalyst mass ratio of 1:1. Under these conditions, the maximum 5-HMF yield reached 91.6%. Characterization via specific surface area, pore size analysis, and acid/base site characterization (NH3-TPD) revealed that nitric acid modification preserved the silica gel’s pore structure. Through oxidative cleaning, etching to expose silanol groups, and inducing surface defects, this process significantly increased the number of acid sites on the silica gel surface, thereby enhancing catalytic activity. This study presents a low-cost, easily recoverable, and environmentally friendly heterogeneous catalytic strategy for the efficient conversion of fructose into 5-HMF. It also provides experimental guidance for the targeted functionalization of silica-based catalytic materials, holding significant implications for advancing the high-value utilization of biomass resources.
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BIOCHEMICAL PHARMACOLOGY
·
2022
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IF 6.1
Mengmeng Wang,Xuqin Guo,Man Yang,Yawen Zhang,Fanyi Meng,Yinshuang Chen,Mengxi Chen,Tian Qiu,Jiawei Li,Zhi Li,Qi Zhang,Fang Xu,Haiyang Zhang,Weipeng Wang
Clinically, 5-fluorouracil (5-Fu) is a first-line drug for the treatment of patients with colorectal cancer (CRC). However, chemoresistance to 5-Fu-based chemotherapy is a leading obstacle in achieving effective treatment for CRC, especially microsatellite stable (MSS) CRC. Since the cytotoxicity of 5-Fu is negatively correlated with oxytocin receptor (OXTR) expression in MSS CRC cell lines, our current study aimed to investigate the synergistic antitumor activity of 5-Fu combined with atosiban , an antagonist of OXTR. Our results suggested that atosiban remarkably potentiated the inhibitory effect of 5-Fu on the growth of MSS-type CRC cells in vitro and in vivo . Moreover, 5-Fu induced GATA3 in MSS CRC cells and tumors, which were eradicated by atosiban. Further investigation showed that atosiban strengthened the antitumor activity of 5-Fu through eradiation of 5-Fu-induced GATA3 in MSS-type CRC cells. Taken together, our findings suggest that atosiban potentiates the antitumor effect of 5-Fu by abolishing 5-Fu-induced GATA3, which provides a novel therapeutic strategy for MSS-type CRC via the combination of atosiban and 5-Fu.
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BRITISH JOURNAL OF NUTRITION
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2015
·Vol. 114
·期 6
·866-872
·
IF 3.453
Xihong Zhou,Jingqing Chen,Weiche Wu,Xinxia Wang,Yizhen Wang
n-3 Long-chain PUFA up-regulate intestinal lipid metabolism. However, whether these metabolic effects of PUFA on intestine are mediated by AMP-activated protein kinase (AMPK) remains to be elucidated. To determine the effects of α-linolenic acid (ALA) on intestinal fatty acid (FA) metabolism and whether these effects were affected by AMPK deletion, mice deficient in the catalytic subunit of AMPKα1 or AMPKα2 and wild-type (WT) mice were fed either a high-fat diet (HF) or HF supplemented with ALA (HF-A). The results showed that ALA supplementation decreased serum TAG content in WT mice. ALA also increased mRNA expression of genes (carnitine palmitoyltransferase 1a, acyl-CoA oxidase 1, medium-chain acyl-CoA dehydrogenase, cytochrome P450 4A10 and pyruvate dehydrogenase kinase isoenzyme 4a) involved in intestinal lipid oxidation and mRNA expression of TAG synthesis-related genes (monoacylglycerol O-acyltransferase 2, diacylglycerol O-acyltransferases 1 and 2) in WT mice. Consistent with these, expression levels of phosphorylated AMPKα1 and AMPKα2 were also increased in WT mice after ALA addition. However, in the absence of either AMPKα1 or AMPKα2, ALA supplementation failed to increase intestinal lipid oxidation. In addition, no significant effects of either diet (HF and HF-A) or genotype (WT, AMPKα1–/– and AMPKα2–/–) on FA uptake in the intestine and faecal TAG output were observed. Our results suggest that AMPK is indispensable for the effects of ALA on intestinal lipid oxidation.
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高影响因子
Catalysts
·
2025
·Vol. 15
·期 11
·
IF 4
Juan Du,Wanting Qiu,Sunbal Ayaz,Jian Long,Wenze Guo,Ling Zhao,Zhenhao Xi
2,5-furandicarboxylic acid (FDCA), a high-value biomass-derived monomer, serves as a crucial building block for sustainable polymers including polyesters, polyamides, and polyurethanes. This study systematically investigated the catalytic oxidation of 5-hydroxymethylfurfural (HMF) to FDCA over Pt/Al2O3and Pt–Bi/Al2O3catalysts. The 5Pt/Al2O3catalyst yielded 60.6% FDCA after 12 h under optimized conditions (80 °C, 0.1 MPa O2, 1 equiv. Na2CO3). Remarkably, Bi-modified 5Pt–1Bi/Al2O3catalyst dramatically enhanced catalytic performance, achieving 94.1% FDCA yield within 6 h under optimized conditions (80 °C, 1.5 MPa O2, 2 equiv. Na2CO3). Comprehensive characterization revealed that the exceptional activity originates from Bi–O–Pt interactions that modulate the electronic structure and oxidation state of Pt active sites, which facilitates the oxidation of intermediate 5-formyl-2-furancarboxylic acid (FFCA) to FDCA, the rate-limiting step of HMF oxidation. This work demonstrates an efficient Bi-promoted Pt catalytic system for FDCA production with significant potential for industrial application.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2019
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IF 6.361
Fei Li,Huanshun Yin,Yan Chen,Siyu Wang,Jingyan Li,Yuemei Zhang,Chunxiao Li,Shiyun Ai
DNA formylation (5-formylcytosine, 5fC) is a major epigenetic modification involved in alterations in the DNA double helix structure and protein identification. Due to the low amount in all mammalian tissues and cells, it is necessary to develop a rapid, sensitive and efficient method for detecting 5fC for further understanding the biological functions of 5fC. Thus, a novel PEC biosensor was constructed using P-g-C 3 N 4 -WS 2 nanocomposite as photoactive material. Firstly, AuNPs/P-g-C 3 N 4 -WS 2 /ITO electrode was prepared as substrate electrode. Secondly, the probe DNA and complementary DNA (containing 5fC base) was modified to the electrode surface based on the formation of Au-S bonds between AuNPs and thiol group on the probe DNA and hybridization, respectively. Finally, the amino functionalized MnO 2 nanoflowers were further modified to the electrode surface by covalent interaction between the aldehyde group on the 5fC and the amino group on MnO 2 nanoflowers. The sensitive and specific detection of 5fC can be achieved by oxidizing ascorbic acid with MnO 2 nanoflowers and quenching the photoactivity of P-g-C 3 N 4 -WS 2 nanocomposite. The sensor has a detection range of 0.01–200 nM and a detection limit of 3.8 pM. Moreover, this sensor has excellent detection specificity, stability and reproducibility.
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·Vol. 51
·期 25
·46911-46917
·
IF 5.6
Pengxin Xu,Zili Zhou,Yaqi Wang,Ergeng Zhang,Zhanyong Wang,Ding Zhou
Highly transparent ceramics of Zr 4+ and Sc 3+ ions co-doped 5 at.%Yb: Lu 2 O 3 were prepared by using wet-chemical precipitant method combined with pressureless sintering in flowing H 2 atmosphere, where Zr 4+ was induced as the sintering aid and Sc 3+ as the band regulators to realizing spectral broadening of Yb:Lu 2 O 3 . The microstructure, broad emission band, PL spectrum and optical properties of the Zr 4+ and Sc 3+ co-doped 5 at.%Yb:Lu 2 O 3 ceramic samples were investigated by SEM, XRD, PL spectrum and other characterization methods. The results indicate that the maxim FWHM of the excitation emission spectrum of Yb:(Lu X Sc 1-X ) 2 O 3 ceramic is 15 nm when x = 0.5. Furthermore, the incorporation of Zr 4+ at a doping concentration of 2 at.% alleviated the microstructural inhomogeneity of the Yb:(Lu 0.5 Sc 0.5 ) 2 O 3 ceramics and significantly reduced the grain size, resulting in high transparency of up to 81.2 % at 1200 nm wavelength. These findings demonstrate a great potential of this ceramic for applications in ultrafast short pulse laser media.
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Journal of Environmental Chemical Engineering
·
2025
·Vol. 14
·期 1
·120635
·
IF 7.2
Nan Xiang,Huajun Sun,Guifeng Tang,Na Zhang,Chuanhui Gao,Yuetao Liu,Chuanxing Wang,Junwei Ding,Li Ding
Photocatalytic conversion of CO 2 into solar fuels presents a promising strategy for mitigating greenhouse gas emissions. The reduction of CO 2 to methanol not only enables carbon resource recycling but also facilitates the production of sustainable fuels. In this study, a litchi-shell-like TiO 2 /WO 3 -5 hollow heterojunction catalyst was constructed, featuring surface alkalization and abundant oxygen vacancies. This unique architecture provides a high specific surface area and plentiful active sites, thereby significantly enhancing CO 2 adsorption capacity. Under neutral conditions (pH = 7), the TiO 2 /WO 3 -5 catalyst achieves a remarkable methanol production rate of 780 μmol·g⁻¹ ·h⁻¹ with a high selectivity of 88.6 %, substantially outperforming its individual counterparts, pure TiO 2 and WO 3 . Furthermore, the catalyst demonstrates excellent stability over multiple reaction cycles. A series of characterizations, including EPR, PL, TRPL, and in situ DRIFTS, collectively verify the formation of a Z-type heterojunction, which effectively promotes the spatial separation of photoinduced charge carriers and suppresses the formation of CO and CH 4 . This work underscores the crucial synergy between Z-type heterojunction engineering and surface defect manipulation in enhancing reaction selectivity and efficiency. The TiO 2 /WO 3 -5 catalyst offers a prospective platform for CO 2 -to-fuel conversion and provides valuable guidance for the design of advanced photocatalysts.
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IEEE SENSORS JOURNAL
·
2025
·
IF 4.5
Zelong Li,Xuemei Lin,Zengshan Yu,Guochao Shi,Wenying Zhou,Jiahao Cui,Shan Guo,Mingli Wang
Accurate and sensitive detection of bilirubin, cholic acid, and Alanine aminotransferase (ALT) is essential for the early detection of hepatobiliary diseases in healthcare and the medical field. Integrating surface-enhanced Raman scattering (SERS) with deep learning algorithm has shown great application prospect in the early identification of markers of hepatobiliary diseases. Here, an regular Ag decorated Cu-Ag nanoisland-liked SERS biosensor (Ag@5/Ag-Cu@20/PSS) was constructed by using pattered sappire substrate as a template. An additional 5 mins of Ag nanofilm significantly improved the SERS signal intensity and homogeneity, and the sensitivity was enhanced by two orders of magnitude up to 10-10 M for 4-aminothiophenol (4-ATP). Importantly, deep learning algorithms included temporal convolutional networks (TCN), convolutional neural networks (CNN), recurrent neural network (RNN) and Transformer were used to deeply mine SERS spectral data of bilirubin, cholic acid and ALT, extract effective features, and establish an accurate classification and prediction model. Results indicating that the developed SERS biosensor combined with Transformer model demonstrated excellent accuracy (ACC) of 0.9816±0.0090 in qualitatively and quantitatively analyzing of bilirubin, cholic acid, and ALT. The successful application of the SERS biosensor will help improve the accuracy of early identification of bilirubin, cholic acid, and ALT disease markers and promote the early intervention and treatment of hepatobiliary diseases.
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Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Xu Duan,Jian Yang,Guang Hu,Chen Yang,Yangfan Chen,Qingcai Liu,Shan Ren,Jiangling Li
In this work, based on a type of energy band engineering strategy as calcination , TiO 2 /ZSM-5 hybrids for photodegradation of methyl orange (MO) in water under UV light have been developed via a facile solid state diffusion method. Effects of varied calcination temperatures on TiO 2 /ZSM-5 hybrids have been systematically characterized including XRD , FT-IR, SEM, TEM , EDX mapping, BET, PL , EIS , UV–vis DRS, active species trapping experiments and Mott-Schottky curves. It was found that the calcination temperature influenced photocatalytic activity , typically on physicochemical properties of materials and adjustment for the energy gap and band position of TiO 2 . The XRD analysis revealed that hybridization of ZSM-5 kept the crystal phase of TiO 2 as anatase unchanged with the high-rising calcined temperature. The optimum sample calcined at 450 °C named as Z-T (450) presented nearly 99% degradation rate for MO, owing to optimal uniform distribution, highest specific surface area and best charge separation/transfer efficiency. The FT-IR comparison result that the functional groups and peak strength of the used catalyst were alike as before, showed the stability of photocatalyst . Adoption of calcination strategy does provide not only a clean, low-cost and highly efficient path to approach the complete degradation of azo dyes , but also a chance for photocatalytic technology to fulfill the implementation in industrial applications.
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