Nano-Micro Letters
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2026
·Vol. 18
·期 1
·391
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IF 38.5
Lu Hui,Yu Yang,Wu Wenqiang,He Zeping,Hu Kaiyu,Yang Wenqiang,Han Xun,Pan Caofeng
Perovskite single-crystal heterojunction arrays exhibit significant application potential in advanced optoelectronics, however, achieving comprehensive control over crystallographic and spatial properties of the array remains challenging. Here, we report a selective epitaxial growth strategy for fabricating single-crystal MAPbCl3/MAPbBr3 and MAPbBr3/MAPbI3 heterojunction arrays. This method employs patterned polymer templates to define the pixel dimension and arrangement, while the underlying single-crystal substrate guides the crystal orientation of the heterojunction array, enabling precise control over the pixel size, pixel arrangement angle and crystal plane. The self-powered photodetector arrays were fabricated based on these heterojunctions, showing a specific detectivity of 6.0 × 1011 Jones, a weak-light detection limit of 9 nW cm−2 and long-term operation stability under zero bias. Furthermore, the light pattern with different illumination intensities could be clearly imaged by the device array in the self-powered mode. This work establishes a robust method of fabricating the single-crystal heterojunction arrays for advanced optoelectronic applications.
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JOURNAL OF FLUORESCENCE
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2026
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IF 3.4
Wu Hanqing,Xu Shichang,Wu Wenxiu,Zeng Hongyu,Yang Kai,Xu Jingshui
Copper ions (Cu²⁺) are essential trace elements that play a vital role in maintaining physiological activities, while their homeostasis imbalance is associated with the pathogenesis of various diseases. Therefore, developing a highly selective and sensitive detection method for copper ions (Cu²⁺) is of significant importance. This study successfully synthesized a novel fluorescent probe, tetraphenylimidazole derivative (TPHB), for the specific recognition of copper ions (Cu²⁺). It exhibits excellent optical properties, including fluorescence quenching upon Cu²⁺ binding. The detection limit reaches as low as 0.047 µM, with a binding constant (K) of 3.56 × 10⁴ M − ¹, demonstrating its high sensitivity. Fluorescence calibration curves, mass spectrometry, and ¹H NMR spectroscopy confirmed a 2:1 Cu²⁺ binding ratio for TPHB. It exhibits strong resistance to interference from common ions such as Al³⁺. Furthermore, it was successfully applied in rapid detection test strips, demonstrating excellent detection performance in simulated water samples.
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NATURE
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2026
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IF 56.1
Guan Ningzi,Kong Deqiang,Gao Xianyun,Niu Lingxue,Zhou Yang,Yu Guiling,Gao Tian,Liu Mengyao,Ma Wenbo,Jin Yiyu,Yin Jianli,Zhao Shangang,Ye Haifeng
Sustained and controlled delivery of glucose-lowering agents using engineered designer cells is recognized as an effective strategy for diabetes therapy 1 . However, current technologies rely on external signal control or have been programmed into mammalian cells using synthetic gene networks, which pose safety concerns arising from transplantation 2 , 3 . Here we developed an engineered oral-deliverable g lucose-sensing and functional response probiotic living drug for ‘sense-and-respond’-based control of diabetic blood glucose. We created a glucose sensor based on a synthetic gene circuit that incorporates the glucose-responsive transcriptional regulator HexR, coupled with a synthetic promoter. Upon oral administration of the engineered probiotics carrying the sensor, the cells reside temporarily in the intestine and regulate the expression of therapeutic transgenes in response to glucose levels that exceed the normal threshold. We show efficacy from the engineered probiotics for glycaemic control in multiple diabetic mouse and non-human primate models, demonstrating that long-term oral administration drives clear improvements in lipid profiles, while also attenuating development of multiple diabetic complications. Our probiotics-based living drug enables therapeutic dosing in response to real-time blood glucose levels, providing a programmable, orally deliverable sense-and-respond platform for metabolic therapy without transplantation.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Bo Peng,Jing Yang,Rui Lin,Yuling Han,Hongning Wang,Runqi Zhou,Tong Yan,Shilin Liu,Hanwei Jiang,Yunshan Li,Tianshu Zhang,Yuhao Peng,Xinyu Xue,Huawei Shen,Jinlin Song,Ximu Zhang
Periodontitis is a prevalent chronic inflammatory disease that causes progressive periodontal tissue loss and systemic complications. However, conventional therapies often remove biofilms without fully resolving inflammation or regenerating tissue. Here, we report a flexible wireless ultrasonic patch loaded with ZIF-8 nanoparticles containing the anti-inflammatory antioxidant senkyunolide A (SenA@ZIF-8) for on-demand drug release. A piezoelectric transducer converts 1 MHz ultrasound into ≈ 10 V, 9 mA electrical output, heating a tridecanoic acid phase-change matrix to ≈ 43 °C to trigger SenA@ZIF-8 release. In vitro, SenA@ZIF-8 was biocompatible and outperformed free SenA in protecting periodontal ligament stem cells from H₂O₂-induced oxidative damage: it reduced intracellular ROS levels and restored the activity of antioxidant enzymes. In macrophages, ZIF-8 loading enhanced intracellular SenA uptake and markedly suppressed LPS-induced proinflammatory mediator expression while promoting M2 marker expression. In a rabbit model of ligature-induced periodontitis, repeated ultrasonic-triggered SenA@ZIF-8 delivery markedly reduced periodontal inflammation. Micro‑computed tomography (Micro-CT) and histology showed that the device-treated sites exhibited the greatest alveolar bone regeneration and collagen deposition, accompanied by minimal inflammation. This innovative MOF-based ultrasonic patch can relieve oxidative stress and inflammation through minimally invasive, precise, and on-demand drug delivery, thereby promoting periodontal regeneration. This approach has significant translational potential as an adjunct therapy to improve periodontal treatment outcomes and patient compliance.
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CHEMICAL PAPERS
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2026
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IF 2.7
Zhu Li,Gao Xizi,Zhang Lijuan,Zhang Jun,Guo Sheng
Advanced oxidation processes (AOPs) based on persulfate (PS) have been widely applied in environmental remediation owing to their ability to generate strong oxidizing reactive species. However, the traditional homogeneous and heterogeneous PS activation systems are prone to cause secondary pollution problems such as the leaching of toxic metals or the formation of sludge. To overcome these technical bottlenecks, this study constructed a ternary catalyst-free system coupling mechanical stirring (MA), ultrasonic irradiation (US), and PS, aiming to efficiently degrade organic contaminants in water bodies. In the proposed MA/US/PS system, peroxymonosulfate (PMS) demonstrates a significantly higher removal rate of Rhodamine B (RhB) than those of sodium persulfate (PDS), ammonium persulfate (PNS), and hydrogen peroxide (H 2 O 2 ) under the same conditions, which could be associated with the asymmetry structure of PMS, potentially facilitating its activation. Moreover, the MA/US/PMS system maintains stable catalytic activity over a broad pH range (3.09–10.52) and demonstrates excellent degradation efficiency in the presence of various coexisting anions and in actual water matrices. The effects of key operational parameters such as PMS dosage, agitation speed, ultrasonic power, and temperature on the degradation efficiency is comprehensively investigated. By combining radical quenching tests and electron paramagnetic resonance (EPR) techniques, the dominant reactive species responsible for RhB removal are identified. This work proposes an efficient, green, and catalyst-free activation strategy for PMS, which holds great potential for the advanced treatment of actual wastewater.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Tang Xiaoting,Xu Zhengyi,Liu Yafeng,Du Xiaoxia,Lu Xinqiong,Li Hua
This paper proposes a plasma modification-trichlorosilane impregnation composite process for fabricating paper microfluidic channels, which is applied to paper spray mass spectrometry detection of prohibited drugs in serum samples from health supplement addition. Plasma modification plays a dual core role: precisely constructing hydrophilic microchannels on silane-impregnated filter paper and stripping surface residual impurities and ash to optimize physicochemical properties. The plasma-modified microchannel paper spray ionization system (PM-PSI) significantly reduces sample loss during migration versus conventional paper spray ionization (PSI), thus enhancing the detection signal of target analytes in blood samples. Combined with filter paper’s matrix effect mitigation and plasma-induced surface optimization, PM-PSI exhibits better detection efficiency than traditional electrospray ionization (ESI) for direct blood sample analysis. Performance validation with venlafaxine showed that PM-PSI increased the signal intensity by 3–5 times and reduced the relative standard deviation (RSD) by 5–6 times compared with PSI at 50–500 ng/mL, and the signal intensity was 10–30 times higher than that of ESI. Quantitative analysis of four typical prohibited drugs (venlafaxine, reserpine, risperidone, sildenafil) revealed their linear range of 1–1000 ng/mL with a significantly improved coefficient of determination (R 2 ) versus PSI. Moreover, PM-PSI coupled with a domestic miniaturized mass spectrometer successfully detected the parent ions of the four drugs at 300 ng/mL, confirming its suitability for complex sample analysis of miniaturized mass spectrometers and providing a technical solution for rapid on-site testing. Graphical abstract A plasma modification-trichlorosilane impregnation process fabricates paper microfluidic channels for paper spray mass spectrometry detection of prohibited drugs in blood. Plasma modification constructs hydrophilic microchannels on silane-impregnated filter paper while removing surface impurities. The plasma-treated paper spray ionization system (PT-PSI) reduces sample loss versus conventional PSI, enhancing detection signals. PT-PSI outperforms electrospray ionization (ESI) for direct blood analysis, increasing signal intensity 3–5-fold versus PSI and 10–30-fold versus ESI, while reducing relative standard deviation 5–6-fold. Quantitative analysis of four drugs (venlafaxine, reserpine, risperidone, sildenafil) showed a linear range of 1–1000 ng/mL with improved R 2 .
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Microsystems & Nanoengineering
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2026
·Vol. 12
·期 1
·261
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IF 11.1
Jiang Yimeng,Liang Misheng,Xie Ying,Su Ruige,Wang Bo,Wu Fan,Bian Xiaomeng,Tian He,You Rui
Recently, advances in human-machine interfaces have raised performance demands on flexible sensors. Achieving fast response, wide detection range, and high sensitivity remains a key challenge in flexible pressure sensor design. Here, we present a novel fully-porous flexible capacitive pressure sensor (FPFCPS) with a sandwich structure, comprising laser-induced Cu-composited graphene (LICuG) electrodes and a polyurethane foam dielectric layer modified with ionic liquid and coated with PVA hydrogel. The hierarchical porosity and conductivity of LICuG enable coupled mechanical interlocking and electronic polarization at the electrode-dielectric interface, improving interfacial contact, compressibility, and capacitive response. The sensor achieves a high sensitivity of 863.17 kPa⁻¹, a wide detection range (10 Pa–500 kPa), and a rapid response time of 5 ms, along with excellent flexibility and long-term stability. Notably, FPFCPS enables rapid tactile feedback and material recognition in dynamic robotic operations, offering high-resolution sensing in complex environments. This work represents the first application of LICuG in electric double-layer capacitance-pressure sensors and establishes a new structural design paradigm based on a fully porous architecture. It provides theoretical insights and practical strategies for advancing material development, mechanistic understanding, and implementation of intelligent sensing systems. In this study, femtosecond-laser-induced Cu-composited graphene (LICuG) was successfully synthesized. By incorporating this novel composite material into an electric double-layer capacitance sensing system, a fully-porous flexible capacitive pressure sensor (FPFCPS) was constructed. Through the synergistic regulation of the sensor’s interlayer structural and electrical properties, its overall performance was significantly enhanced. When integrated at key robotic joints, the FPFCPS successfully detected collisions within ~5 ms and was capable of identifying the type of obstacle through tactile contact.
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Scientific Reports
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2026
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IF 4.9
Zhang Kaige,Wang Jing,Chen Yanrong,He Lijun,Zhang Qianchun
Ferrofluids are innovative functional media combing magnetic nanoparticles with liquid fluidity. In this study, a hydrophobic deep eutectic solvent-ferrofluid was prepared by dispersing oleic acid-coated magnetic nanoparticles in hydrophobic deep eutectic solvent composing of DL-menthol and lauric acid, and applied for magnetic assisted liquid–liquid microextraction of trace polycyclic aromatic hydrocarbons (PAHs) from water and food samples. Following microextraction, phase separation was achieved rapidly using an external magnetic field, eliminating the need for time-consuming steps such as centrifugation or ice baths. The material’s structure was characterized by X-ray diffraction and infrared spectroscopy, while its magnetic properties were examined with a vibrating sample magnetometer. Extraction parameters were systematically screened and optimized using Plackett–Burman and Central Composite design experiments. Under optimized conditions, the limits of detection and quantification were 0.05–0.2 µg L − 1 and 0.1–0.5 µg L − 1 , respectively, with intra-day and inter-day relative standard deviations ( n = 5) below 1.6% and 1.7%. The extraction mechanism was further explored using density functional theory. Then, this method was successfully applied to determine of PAHs from environmental water and food samples, achieving spiked recoveries of 85.9–103.0%. Its greenness and practical applicability demonstrate its potential for food analysis and environmental monitoring.
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JOURNAL OF FLUORESCENCE
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2026
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IF 3.4
Liu Xiujin,Lai Gengneng,Shu Zongcheng,Li Wei,Ke Fang
Thyroid-associated ophthalmopathy (TAO) is a complex autoimmune inflammatory disease. There is an urgent clinical need for highly sensitive and minimally invasive biomarkers to enable early diagnosis and dynamic disease monitoring. Among them, miR-320a has been confirmed to be closely associated with oxidative stress regulation, fibroblast activation, and fibrosis progression. However, current detection methods, especially those based on real-time quantitative polymerase chain reaction (RT-qPCR), still suffer from cumbersome procedures, high instrumentation costs, and limited adaptability for rapid point-of-care diagnostics. To address this, we developed a nanozyme-assisted colorimetric biosensing platform integrating target-triggered probe hybridization with Co-g-C 3 N 4 , which exhibits enhanced peroxidase-like activity and stability. The method involves Co-g-C 3 N 4 synthesis, probe-nanozyme interface construction, catalytic optimization, and colorimetric detection via TMB oxidation, validated in spiked serum and with smartphone readout. The platform achieves sensitive miR-320a detection down to picomole levels with excellent linearity and specificity. In spiked human serum analysis, it reliably quantifies endogenous miR-320a with strong recovery rates (94.6-108.9%). However, we acknowledge that direct clinical validation using confirmed TAO patient samples is required for full diagnostic implementation, and this represents a limitation of the current study. Generally speaking, this work provides a portable, cost-effective, amplification-free colorimetric nanozyme platform for miRNA detection, requiring only basic laboratory equipment, and holding significant promise for point-of-care precision diagnostics in autoimmune and fibrotic diseases.
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Nature Communications
·
2026
·
IF 18.1
Feng Rumeng,Xu Wenyu,Wang Hongwei,Wang Binfen,Li Jialin,Chang Zelin,Huang Zhaodong,Chen Ze,Li Xinliang
Conversion-type static bromine batteries demonstrate promise in high output voltage and large capacity for rechargeable energy storage due to the inherent polyvalent reaction potential. Nevertheless, the combination of the limited two-electron 2Br - /Br 2 redox couple and the redox-inactive organic ligands presents a fundamental bottleneck for the overall specific energy. Herein, ethyl viologen dibromide is developed as an energetically active positive electrode for organic lithium-bromine batteries by efficient coordination chemistry, featuring an advanced six-electron redox mechanism triggered by both intercalation and conversion reactions. The activated redox couple of 2Br - /2Br + incubates a collaborative increase in capacity (632.8 mAh g −1 Br ) and discharge voltage (3.7 V). Besides, ethyl viologen undergoes reversible two-step intercalation and extraction of Li + ions, contributing to additional energy storage. Reciprocal spectroscopic characterizations and computational electrochemistry indicate the chemisorption effect and interhalogen confinement and detail the dynamic mass-charge transfer pathway. This work sets a paradigm worth emulating for designing high-performance halogen batteries.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Sheng Ding,Siyu Liu,Shaoyang Kang,Shuwei Wang,Nan Jiang,Yuwei Li,Chunxiao Zhou,Hantao Lou,Chuangnian Zhang,Pingsheng Huang,Wenshuai Liu,Zujian Feng,Weiwei Wang,Deling Kong,Ningbei Yin
Diabetic wound healing poses a major clinical challenge. One of the promising therapy, the flap transplantation surgery exhibited unsatisfactorily low flap survival due to the intertwined pathological barriers: impaired angiogenesis, excessive oxidative stress, and persistent inflammation, leading to poor tissue repair. While the therapeutic platforms based on extracellular vesicles (EVs) emerges as a promising treatment, its efficacy is often limited by the inadequate yield and rapid in vivo clearance. To address this challenge, this study developed a strategy centered on preconditioning human umbilical vein endothelial cells (HUVECs) with high glucose (HG) stress to produce HG-preconditioned extracellular vesicles (hEVs), which significantly improve production, enrich regenerative cargoes (e.g., HIF-1α, VEGF), and enhance homologous cellular internalization. The hEVs derived from HUVECs were encapsulated by microfluidically fabricated gelatin methacryloyl (GelMA) microgels to create GelMA@hEVs. The biodegradable and biocompatible GelMA microgels enabled a sustained hEVs release profile. Therefore, GelMA@hEVs exhibited significant efficacy improvement in promoting endothelial cell proliferation, migration, and tube formation critical for vascularization, mitigating reactive oxygen species, and modulating macrophage polarization toward a pro-reparative phenotype. Mechanistically, these therapeutic effects relied on activating the HIF-1α/VEGF pathway, a core axis for angiogenesis dysregulated in diabetes. In diabetic ischaemic flap models, GelMA@hEVs significantly improved flap survival, restored vascular perfusion, and facilitated tissue regeneration without systemic toxicity. Altogether, this work provides a generalizable strategy for diabetic ischaemic flap repair by combining engineered EVs as bioactive cargo with a microgel scaffold for sustained delivery, offering a promising in situ tissue engineering solution.
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Nature Communications
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2026
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IF 18.1
Li Zeheng,Wu Zhuoying,Qian Shangshu,Lv Xucheng,Dai Chengjun,Lin Zheng,Zheng Mengting,Liu Tiefeng,Song Ting-Lu,Lin Zhan,Lu Jun
The pursuit of high-energy-density lithium-ion batteries demands high-silicon silicon-graphite composite negative electrodes, yet their commercialization remains hindered by interfacial incompatibility and mechanical instability. While an ideal binder must simultaneously achieve robust adhesion to both silicon and graphite, accommodate substantial silicon volume changes, and maintain high binder bulk stability, existing systems fail to harmonize these requirements. Here, we present a molecularly engineered binder that resolves this trilemma through interfacial-mechanical synergy. By integrating a hydrophobic-soft copolymer and hydrophilic-hard copolymer, our design enables amphiphilic interfacial adhesion and provides mechanical properties specifically tailored to accommodate silicon volume changes. A supramolecular crosslinker further reinforces interchain cohesion, ensuring binder bulk stability during long cycling life. This design enables a 2 Ah-level pouch cell to sustain 500 cycles at 0.3 C with 99.83% average Coulombic efficiency. At a commercial binder loading of 5 wt%, 1 Ah cells deliver over 2000 cycles at 1 C with an average Coulombic efficiency of 99.93%. Our work has the potential to not only resolve the long-standing trade-off between interfacial and mechanical stability in silicon-based negative electrodes but also provide a practical framework for designing next-generation binders targeting energy-dense, durable batteries.
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