POLYMERS FOR ADVANCED TECHNOLOGIES
·
2020
·Vol. 32
·期 3
·1262-1271
·
IF 2.578
Qingzhen Zhu,Baogang Zhang,Yuandou Wang,Xinghua Liu,Weiwei Li,Feng Su,Suming Li
Poly( D , L -lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) diblock copolymers with different compositions were synthesized by ring-opening polymerization of D , L -lactide and glycolide, using monomethoxy PEG as macro-initiator. The resulting copolymers were characterized by nuclear magnetic resonance, gel permeation chromatography, and critical micelle concentration analyses. Self-assembly of the copolymers yielded aggregates of different architectures, including spherical micelles and a mixture of spherical and worm-like micelles with Y-junctions. The self-assembled architecture depends on both the hydrophilic/hydrophobic balance and the molar mass of copolymers. Valsartan, a widely used drug in the treatment of hypertension, was loaded in micelles using a co-solvent evaporation method. High drug-loading content was obtained for worm-like micelles. in vitro drug release was performed at 37°C in pH 7.4 phosphate-buffered saline. An initial burst release is detected in all cases, followed by slower release up to 9 days. The overall release rate is strongly dependent on the degradation of micelles. Copolymers with short PLGA blocks exhibit faster drug release due to faster degradation of micelles, and worm-like micelles present slower drug release as compared to spherical ones. Therefore, PLGA-PEG copolymer micelles with high drug-loading capacity, different architectures, and variable drug release rates could be most attractive for sustained delivery of valsartan.
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Foods
·
2025
·Vol. 14
·期 15
·2645
·
IF 5.1
Cong Zhang,Kai Jiang,Yilin Lin,Rui Cui,Hong Wu
In this study, a composite film with dual antioxidant and antibacterial properties was prepared by combining 2% chitosan and 7% gelatin (2:1, w:w), with D-carvone (0–4%) as the primary active component. The effect of D-carvone content on the performance of the composite films was systematically investigated. The results showed that adding 1% D-carvone increased the water contact angle by 28%, increased the elongation at break by 35%, and decreased the WVTR by 18%. FTIR and SEM confirmed that ≤2% D-carvone uniformly bonded with the substrate through hydrogen bonds, and the film was dense and non-porous. In addition, the DPPH scavenging rate of the 1–2% D-carvone composite film increased to about 30–40%, and the ABTS+scavenging rate increased to about 35–40%; the antibacterial effect on Escherichia coli and Staphylococcus aureus increased by more than 70%. However, when the addition amount was too high (exceeding 2%), the composite film became agglomerated, microporous, and phase-separated, affecting the film performance, and due to its own taste, it reduced the sensory quality of the noodles. Comprehensively, the composites showed better performance when the content of D-carvone was 1–2% and also the best effect for freshness preservation in Xinjiang ramen. This study provides a broad application prospect for natural terpene compound-based composite films in the field of high-moisture, multi-fat food preservation, and provides a theoretical basis and practical guidance for the development of efficient and safe food packaging materials. In the future, the composite film can be further optimized, and the effect of flavor can be further explored to meet the needs of different food preservation methods.
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·Vol. 142
·期 14
·e56682
·
IF 2.8
Huili Liu,Luyao Su,Ruihan Li,Liting Wang,Dongyu Bai
In this article, poly(ethylene glycol)-poly( d -lactide) (PEG-PDLA) block copolymers with different PEG chain lengths were synthesized and melt-mixed with poly( l -lactide) (PLLA) and rubber nanoparticles. The role of PEG-PDLA block copolymers in tailoring the microstructures and performances of PLLA/rubber blend were investigated in detail. It was found that high contents of stereocomplex (SC) crystals were generated in PLLA/rubber/PEG-PDLA copolymer blends, which induced rubber nanoparticles to agglomerate and form network-like structures. The size of rubber aggregates and continuity of rubber network-like structures first increased and then declined significantly as the PEG chain length increased. Resultingly, the impact toughness of PLLA/rubber/PEG-PDLA copolymer blends first remarkably increased to 74.1 kJ/m 2 and then decreased to 30.6 kJ/m 2 . Meanwhile, the elongation at break increased with increasing PEG chain length and little loss of tensile strength happened, revealing good stiffness-toughness balance performances of PLLA/rubber/PEG-PDLA copolymer blends. Moreover, the matrix crystallization rate of PLLA/rubber/PEG-PDLA copolymer blends could be greatly increased by increasing PEG chain length and the PLLA/rubber/PEG-PDLA copolymer blends exhibited much higher Vicat softening temperatures than PLLA/rubber blend, which confirmed the excellent heat resistance of PLLA/rubber/PEG-PDLA copolymer blends. These interesting findings suggested that PEG-PDLA block copolymers were highly conducive to prepare PLLA materials with outstanding comprehensive performances.
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GREEN CHEMISTRY
·
2024
·
IF 9.3
Lin Fan,Shangshang Sun,Zhidan Zhang,Yanmei Qin,Peter Ruhdal Jensen,Chun You
In conjunction with the pressing global issue of climate change and the associated concern over global warming, increasing interest has emerged in the exploration of carbon dioxide (CO2) as a resource for the generation of a diverse array of products intended to serve societal needs. This study presents the development of an ATP-free and NAD-balanced in vitro synthetic enzymatic biosystem (ivSEB), which comprises only five cascade thermophilic enzymes, designed for the synthesis of L-malate through CO2 fixation powered by the utilization of D-glucose as a substrate. This designed ivSEB yields two moles of L-malate from one mole of D-glucose and two moles of CO2. Through meticulous refinement of reaction conditions and enzyme loading amounts, this ivSEB has demonstrated its capability to produce 6.85 mM of L-malate via CO2 fixation from an initial 5 mM of D-glucose with a molar product yield of 68.5%, and 2.45 mM of L-lactate as a byproduct. In the pursuit of assessing the industrial feasibility of this ivSEB, the study further subjected the system to the utilization of a high concentration (45.70 mM) of D-glucose. Although this endeavor necessitates additional optimization for enhanced efficiency, the present findings herald the emergence of an alternative avenue for the sustainable production of L-malate through CO2 fixation, thus bearing substantial promise for addressing ecological and industrial imperatives.
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JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Yirou Wang,Yi Liu,Ji Chen,Zeyang Ge,Jing Wang,Dehua Li
Peri-implantitis, caused by bacterial biofilm on dental implants, leads to bone loss and tissue inflammation, ultimately causing oral health decline. Traditional methods to remove biofilm are ineffective in promoting reosseointegration on implant surfaces. This phenomenon can be attributed to two factors: incomplete removal of biofilm from hard-to-reach areas and alterations in the physicochemical properties of implant surfaces caused by decontamination procedures. To address this problem, we developed D-arginine-loaded chitooligosaccharide-capped pH-responsive mesoporous silica nanoparticles (Dar@MSN-COS) for improving the efficacy of decontamination of Water Jet (WJ). Dar@MSN-COS particles exhibit a targeted approach towards the extracellular polymeric substance (EPS) in order to disrupt the biofilm, and possess the capability to infiltrate confined areas between implant screws. Following this, the WJ treatment effectively removed residual biofilm and demonstrated improved cleaning efficacy. Furthermore, the decontamination of the Dar@MSN-COS combination with WJ promotes effective cell cytocompatibility on the titanium surface. The results of mechanistic experiments indicate that Dar@MSN-COS may act on biofilms by releasing a significant quantity of reactive oxygen species (ROS), suggesting it as a key contributing factor. In summary, our novel therapeutic protocol shows promise as an alternative solution for addressing the clinically complex aspects of peri-implantitis.
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ENERGY & FUELS
·
2024
·
IF 5.2
Li Zhao,Hao Fu,Yuan-gu Xia,Ji Liu,Bin Hu,Zhan-jun Cheng,Xi Luo,Dan Yan,Ji-hong Li,Qiang Lu
Pyrolysis is a promising thermochemical conversion technology, which can convert biomass and cellulose into value-added products. Herein, a new approach of oxalic acid-assisted staged fast pyrolysis (OASFP) of cellulose was developed, achieving the coproduction of 1,4:3,6-dianhydro-α-d-glucopyranose (DGP), furfural (FF), and formic acid (FA) in separated pyrolysis stages. The lab-scale tests demonstrated that a selectivity of 71.6% and a yield of 31.5 wt % for FA in the aqueous phase, as well as a selectivity of 55.6% and a yield of 1.2 wt % for FF in the organic phase, were achieved in the primary pyrolysis stage under the optimized conditions (primary pyrolysis temperature of 220 °C and cellulose-to-oxalic acid (OA) ratio of 1:3). During the subsequent secondary pyrolysis process at 400 °C, the decomposition of the solid residue achieved a yield of 7.2 wt % and a selectivity of 32.7% for DGP. The interaction between OA and cellulose during the primary pyrolysis stage was essential for DGP generation. The formation mechanism of major products and the role of OA were revealed based on experiments and density functional theory calculations. In total, the OASFP of cellulose offers new possibilities and opportunities for biomass utilization.
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Journal of Energy Chemistry
·
2025
·
IF 14.9
Dengqi Zhou,Ke Zeng,Liqiang Wang,Feiying Tang
The development of highly efficient non-noble metal catalysts for the hydrogenation of N-heteroarenes under mild condition is of great importance for both theoretical and industrial applications, which can efficiently reduce energy consumption and environmental pollution. In this work, we found that the prepared CoCu nano-alloy catalyst after exposed in the air over 24 h (named Co 1 Cu 1 /C) exhibited a dramatically improved catalytic performance (yield from trace to >99%) for quinoline hydrogenation under mild reaction conditions (60 °C, 3 MPa H 2 ). According to the characterization, the catalyst Co 1 Cu 1 /C exhibited the strong interaction between Co and Cu. Meanwhile, it was endowed with a stable partial oxidation surface. The unsaturated oxygen coordinated surface of Co 1 Cu 1 /C presented a moderate binding for quinoline and 1, 2, 3, 4-tetrahydroquinoline, which could efficiently avoid the deactivation of catalyst and favor the hydrogenation kinetics. The density functional theory (DFT) calculations coupled with X ray-based structural analyses suggested that the unsaturated oxygen coordinated surface could lower the diffusion energy of the active hydrogen species and the reaction barrier for quinoline hydrogenation which resulted from the d - p orbital electron coupling. This work revealed that the catalytic performance of nano-alloy catalysts might not only be ascribed to the interaction between metals, while the unsaturated oxygen coordination of metallic surfaces played an important role.
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Journal of Functional Foods
·
2019
·
IF 3.197
Ming Li,Shuo Wang,Xianjie Li,Qiong Wang,Zhidan Liu,Ting Yu,Ruirui Kou,Keqin Xie
Diallyl sulfide (DAS) is an effective bioactive organosulfur compound extracted from garlic. This study aimed to explore whether the protective effect of DAS on lipopolysaccharide (LPS)/ d -galactosamine ( d -GalN) induced acute liver injury was associated with the regulation of Kupffer cell (KC) activation. The results indicated that DAS administration protected mice from LPS/D-GalN-induced histopathological damage and serum aminotransferase elevation and also showed more pronounced beneficial effects than GdCl 3 administration. The F4/80 + or CD11b + KC immunohistochemistry results showed that DAS administration suppressed LPS/D-GalN-induced KC activation. DAS administration also suppressed LPS/D-GalN-triggered production of TNF-α, IL-1β, MCP-1 and NO in the liver or serum, which was in line with the mRNA expression of TNF-α, IL-1β, IL-6, MCP-1 and iNOS in the liver. Taken together, these findings reveal that the protective effects of DAS on LPS/D-GalN-induced acute liver injury may be achieved by inhibiting the activation of KC, thereby suppressing the secretion of various proinflammatory mediators.
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Oxidative Medicine and Cellular Longevity
·
2022
·
IF 7.31
Debo Gao,Pingli Li,Fei Gao,Yangjun Feng,Xiaolin Li,Delong Li,Yuqin Li,Yuliang Xiao
Previous studies have demonstrated that both CS and LiCl possess anti-Alzheimer's disease (AD) activities. We prepared chondroitin sulfate-Li (CS-Li) and investigated its effect on AD and explored the possible mechanisms both in vitro and in vivo . We found that CS-Li could inhibit amyloid β (A β ) aggregation and protect SH-SY5Y cells from A β 1-42 -induced cytotoxicity in vitro . In D-gal and AlCl 3 -induced AD mouse model, CS-Li improves the spatial learning and memory abilities of AD mice, reverses the nuclear pyknosis and cell edema, and increases the survival rate of neurons in hippocampus of mice. Moreover, CS-Li significantly increased the levels of GSH-Px, Na + /K + -ATPase, and ChAT and decreased the levels of MDA and AchE in AD mice. Western blot results demonstrated that CS-Li could decrease the hyperphosphorylation of tau (Ser396/Ser404) by regulating the expression of p-GSK-3 β (Ser9) and PP2A and inhibit the expression of proinflammatory factors through inhibiting NF- κ B nuclear translocation by activating the MAPK signaling pathways. In a word, CS-Li can delay AD development through multitarget processes, including A β aggregation inhibition, oxidative stress damage, tau hyperphosphorylation, and inflammatory response, thereby improves learning and memory abilities.
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FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Wei Liang,Xuhui Huang,Marat Muratkhan,Zhu Tian,Yikun Wei,Shuyao Li,Chengrong Wen,Lei Qin
Understanding how alternative sweeteners and proteins regulate starch gelatinization is critical for developing low-sugar and functional food systems. However, the effects of D-psicose (D-psi) and yeast protein (YP) on the gelatinization behavior and multi-scale structure of wheat starch gels remain unclear. Herein, binary and ternary wheat starch (WS) gel systems containing D-psi and YP at different addition levels (1%, 3%, and 6%) were systematically investigated. The results demonstrated that the incorporation of D-psi and YP significantly altered the pasting behavior of the gels, leading to reduced viscosity parameters and increased gelatinization temperature. SEM and CLSM observations revealed that the WS-D-psi-YP systems formed a more homogeneous and compact network structure, whereas excessive D-psi induced structural collapse and heterogeneity. Meanwhile, the addition of D-psi and YP increased the short-range molecular order, decreased the relative crystallinity, and enhanced the ΔH values of the systems. Furthermore, the composite gels exhibited reduced water mobility and improved water distribution uniformity. Moderate D-psi incorporation maintained relatively stable viscoelasticity and stress relaxation behavior, while decreasing RDS and increasing SDS and RS contents. These findings provide new insights into the development of low-sugar and functional starch-based gel foods.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2026
·
IF 7.3
Han Wang,Weiming Liao,Yunzhe Li,Aiping Guo,Zhenyu Liu,Xinyu Guo,Kexin Wang,Yulin Zheng,Zihan Wang,Wei Wang,Xiaowei Wang,Liangren Zhang,Qi Sun,Zhuo Huang
Activation of extrasynaptic δ-GABAARs represents a promising strategy for rapid-acting antidepressant therapy in major depressive disorder (MDD). Here, we report the discovery and pharmacological characterization of a novel series of thiazolo[4,5-d]pyrimidin-7(6H)-one derivatives as potent positive allosteric modulators selective for δ-GABAARs. Systematic SAR exploration identified compound 12i as a lead candidate, which demonstrated high potency on the extrasynaptic receptor subtype (α4β3δ: 950% current enhancement at 10 μM, EC50 = 0.8 μM) while maintaining favorable modulation of synaptic subtypes. In vivo, 12i exerted rapid-acting antidepressant effects in both the mouse tail suspension test and the chronic restraint stress-induced depression model, with no addictive behaviors observed. These effects were completely abolished in δ-subunit knockout mice, confirming target engagement. Furthermore, 12i significantly enhanced NREM sleep in a p-chlorophenylalanine-induced insomnia model, highlighting potential dual efficacy in MDD with comorbid sleep disturbance. Collectively, these findings position 12i as a promising clinical candidate for next-generation rapid-acting antidepressant therapy.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Jiaying Ai,Jiajun Yan,Yuxin Zhang,Fuping Lu,Shuhong Mao,Yixun Jiang,Lei Li,Hui-Min Qin
Chemical tethering NAD + to GfADH enhances enzyme-cofactor spatial proximity. • The application of conjugate and NOX reduced the NAD + demand by 13-fold. • The NAD + -GfADH conjugate and NOX were co-fixed via sequential recruitment. • Co-immobilization enhanced enzyme stability with improved cofactor regeneration. The green biomanufacturing of high-value compounds is limited by enzyme instability and cofactor dependence. Herein, we developed a tailored multi-module immobilization strategy that integrated cofactor tethering with sequential multi-enzyme co-immobilization to facilitate the efficient conversion of allitol into D-allulose catalyzed by the Gluconobacter frateurii -derived dehydrogenase (GfADH). In this strategy, nicotinamide adenine dinucleotide (NAD + ) was covalently tethered to the surface of GfADH via a flexible linker, creating an NAD + -GfADH conjugate. Coupling the conjugate with NADH oxidase (NOX) established an efficient cofactor self-regenerating system, reducing the external NAD + demand by 13-fold. Furthermore, this conjugate was encapsulated within hybrid nanoflowers, thereby improving its reusability. To facilitate cofactor transfer, NOX was directionally recruited and colocalized with GfADH using the SpyTag/SpyCatcher system. The co-immobilized enzyme exhibited a high D-allulose yield of 88.7% from 110 mM allitol and retained 85.0% of its initial activity after 6–8 cycles. This work provides a valuable integrated strategy for cofactor regeneration and enzyme stabilization in cofactor-dependent biosynthesis. Download: Download high-res image (169KB) Download: Download full-size image
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