SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Xiaojian Li,Lijun Li,Yangzhi Wang,Xuehui Hao,Changzheng Wang,Zhenshan Yang,Hefu Li
The large-area fabrication of flexible and transparent surface-enhanced Raman scattering (SERS) substrates with high performance by a facile and efficient method is still challenging. Here, we demonstrated a large-scale, flexible and transparent SERS substrate composed of PDMS nanoripple array film decorated with silver nanoparticles (Ag NPs@PDMS-NR array film) prepared by a combination of plasma treatment and magnetron sputtering. The performances of SERS substrates were characterized by rhodamine 6G (R6G) using a handheld Raman spectrometer. The optimal Ag NPs@PDMS-NR array film exhibited high SERS sensitivity, with a detection limitation of R6G reaching 8.20 × 10 −8 M as well as excellent uniformity (RSD = 6.8%) and batch-to-batch reproducibility (RSD = 2.3%). In addition, the substrate showed outstanding mechanical stability and good SERS enhancement by backside illumination, thus it was suitable for in situ SERS detection on curved surfaces. The detection limit of malachite green on apple and tomato peels was 1.19 × 10 −7 and 1.16 × 10 −7 M, respectively, and quantitative analysis of pesticide residues could be realized. These results demonstrate that the Ag NPs@PDMS-NR array film has great practical potential in rapid in situ detection of pollutants.
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APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Ruofei Ma,Hanfei Gao,Yue Wang,Zhangrun Xu,Yuchen Wu
Efficient visible-light photocatalysts are essential for energy and environmental sustainability. Many efforts have been devoted to designing diverse heterostructures in the pursuit of high-performance photocatalysts. However, the effect of morphology of the heterostructures on the photocatalytic performance still needs to be further explored. Here, tunable Au-Ag 2 S heterostructures were synthesized to investigate the morphology-induced photocatalytic performance by surface-enhanced Raman scattering (SERS) spectroscopy. All the Au-Ag 2 S heterostructures possess remarkable visible-light photocatalytic and SERS activity compared with Au or Ag 2 S. Moreover, with increasing exposure of the Au component, the Janus heterostructures display better photocatalytic performance than the heterostructures with other morphologies. The possible mechanism is that the axially separated structure enhances the plasmon-induced electron-hole separation and facilitates interfacial charge transfer in the anisotropic heterostructures, owing to a stronger plasmon-enhanced near field. The photocatalytic degradation efficiency of methylene blue by the Au-Ag 2 S Janus heterostructures reached 93.9% within only 60 s. The photocatalytic degradation rate is 2.38, 1.53 and 1.48 times higher than that of the core–shell, eccentric core–shell-I and eccentric core–shell-II heterostructures. Our work demonstrates that the morphology of the Au-Ag 2 S heterostructures exhibits a significant effect on the visible-light photocatalytic performance, which opens a new pathway toward the design of heterostructures for high-performance photocatalysis.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2023
·Vol. 38
·期 3
·505-513
·
IF 1.6
Wang Wenbo,Xiong Wenhao,Long Yuting,Li Hong
We demonstrated a chemical process in the fabrication of a SERS fiber probe with an ultrahigh sensitivity. The synthesis was carried out by preparing Au@Ag core-shell nanorods (Au@Ag-NRs) self-assembled on polyelectrolyte (PE) multilayers, for which Au@Ag-NRs were controlled by adjusting the silver layer thickness. The effect of silver layer thickness of Au@Ag-NRs on the SERS performance of the fiber probe was investigated. The SERS fiber probe shows the best performance when the silver layer thickness is controlled at 8.57 nm. Under the condition of optimizing silver layer thickness, the fiber probe exhibits ultra-high sensitivity ( i e , 10 −10 M crystalline violet, CV), good reproducibility ( i e , RSD of 3.5%) and stability. Besides, electromagnetic field distribution of the SERS fiber probe was also investigated. The strongest enhancement is found within the core of fiber, whereas a weakened electromagnetic field exists in the fiber cladding layer. The SERS fiber probe can be a good candidate in ultra-trace detection for biomedical and environmental areas.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Weidan Na,Changjin Ou,Yijun Ming,Yuchong Gao,Lin Tian
Surface enhanced Raman spectroscopy (SERS) detection was not as accurate and reproducible as fluorometry due to some uncertainties such as operator's focus adjustment and difference between capillaries. Herein, the weak Raman signal (1640 cm −1 ) from water bending vibration is adopted as a benchmark to improve the practical applicability of Raman detection. Specifically, amygdalin and citrate sodium were applied as reducing and capping agent to synthesize dual-ligand gold nanoparticles (DL-AuNPs). Additionally, the cyano group of amygdalin can attach to the surface of DL-AuNPs and generate a primary SERS signal (2174 cm −1 ), which can be significantly enhanced by Cu(II) as DL-AuNPs aggregates. More importantly, the strong binding affinity between pyrophosphate ions (PPi) and Cu(II) redisperses DL-AuNPs and decreases the signal intensity, making the DL-AuNPs/Cu(II) SERS sensor promising for the detection of PPi. This proposed method presents a reliable SERS analysis with the stable water background calibration and broaden the application of SERS technique in aqueous solution target monitoring.
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ANALYTICAL CHEMISTRY
·
2019
·
IF 6.35
Yu Cao,Pei Liang,Qianmin Dong,Dan Wang,De Zhang,Lisha Tang,Le Wang,Shangzhong Jin,Dejiang Ni,Zhi Yu
Recently, more and more attention has been given to a semiconductor oxide-based surface-enhanced Raman spectroscopy substrate for its great stability and biocompatibility. However, its poor SERS sensitivity limits the applications of semiconductor oxide SERS substrates. In this paper, we provide a facile reduction method to modulate oxygen vacancy concentrations in oxide SERS substrates. Using MoO2 as an example, the resonance coupling as well as charge transfer between the semiconductor oxide SERS substrate and the target molecules were promoted for the reason of artificial oxygen vacancy embodied in the Raman signals being improved. By using the TEM, SEM, and XPS measurements, we confirmed that we successfully prepared defective MoO2–x with a polycrystalline surface. MoO2–x modulated oxygen vacancy treated with 6 wt % Li shows a very high detection sensitivity of 10–8 M (4.79 ug/L) for R6G, and the intensity of the Raman signal was highly enhanced. Because of the existence of defective energy levels, resonance coupling, as well as charge transfer between semiconductor and molecules, was obviously promoted. More importantly, the method of modulating oxygen vacancy can be widely used in semiconductor oxide materials for its chemical enhancement capacity can be promoted by artificial oxygen vacancy.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 2
·1-9
·
IF 5.479
Jiang Ningjing,Hu Yongjun,Wei Wei,Zhu Tingfeng,Yang Kang,Zhu Guichi,Yu Meng
A surface-enhanced Raman scattering (SERS) method is described for the determination of microRNA that is associated with various forms of cancer. The substrate consists of functionalized gold-silver bimetallic structure, and the sensitivity is strongly enhanced by making use of a re-circulated enzymatic amplification system (REAS). Poly-dopamine acts as both a reductant and a protective of the substrates. It was employed to link the gold core and silver satellite. The unique “hot spots” consisting of a Au@PDA@Ag nanocomposite improve the Raman signal and sensitivity. The reductive feature of PDA can prevent the susceptible oxidation of metallic silver to maintain the high Raman activity. To improve the sensitivity of the assays, a re-circulated enzymatic amplification system was developed in which the nicking endonuclease triggers the nucleic acid reaction system to enter an amplified cycle. By integrating the bimetallic nanosubstrate and magnetic separation into the REAS, microRNA can be detected by SERS (best at the Raman band of 1586 cm −1 ) with a limit of detection as low as 0.2 fM. In our perception, the assay provides an exciting new avenue to study the expression of tumor genes. Thus, it holds vast promise in cancer diagnosis.
Schematic presentation of the SERS method based on poly-dopamine mediated bimetallic SERS substrate and re-circulated enzymatic amplification.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Xiaozhou Li,Tianyue Yang,Youtao Song,Jinghai Zhu,Deli Wang,Wei Li
Here we describe a surface-enhanced Raman scattering (SERS)-based immunochromatographic assay (ICA) method for the dual detection of two pyrethroid pesticides cypermethrin and esfenvalerate. In the proposed ICA-SERS methods, antibody conjugated gold nanoparticles (AuNPs) were used as the SERS substrate while fluorescence tags labeled on AuNPs were used as the Raman reporters for SERS. Through the immuno-specific combination of antigen and antibody, Raman reporter labeled AuNPs were immobilized on the test line of the ICA strip and facilitated the SERS measurement. And by immobilizing two test lines designed for the detection of two pesticides, a simultaneous dual detection was accomplished. The LODs of the ICA-SERS system was 2.3 × 10 −4 and 2.6 × 10 -5 ng/mL for cypermethrin and esfenvalerate, respectively. The sensitivity was 3 to 4 times higher than ELISA and fluorescent-based ICA methods using the same indirect competitive immunoassay methods. For the three types of samples (tap water, river water, and milk), the recoveries ranged from 94.9% to 112%, with RSD values ranged from 1.3% to 13.5%. The research reveals that this ICA-SERS method possesses high specificity, sensitivity, and reproducibility, and can be reliably used to detect dual pesticides in real samples. An R Shiny-based application 2plex-speclysis was built and used for all the data analyses in this paper. The application was designed to incorporate all the analyses including spectral preprocessing, performance evaluation, and PCA analysis, and make the spectral analysis accessible for people without programming experience.
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Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 27
·8432-8441
·
IF 6.641
Jing Zhao,Chen Wu,Lipeng Zhai,Xiaofeng Shi,Xin Li,Guojun Weng,Jian Zhu,Jianjun Li,Jun-Wu Zhao
A surface-enhanced Raman scattering (SERS)-based sandwich type immunoassay was developed for the detection of α-fetoprotein (AFP) with high sensitivity, reproducibility and selectivity. In the immunoassay, an antibody immobilized nitrocellulose (NC) membrane was employed to capture AFP and antibody conjugated silica coated gold/silver core–shell nanostars (AuNS@Ag@SiO2) were used as SERS probes. AuNS@Ag was synthesized by the direct deposition of Ag on the AuNS. The Ag shell grew outward from the center towards the tips and adopted a polyhedral shape. The AuNS@Ag nanoparticles were shown to have higher SERS activity than gold nanostars (AuNSs), and their LSPR wavelengths could be finely tuned across a wide spectrum ranging from visible to near-infrared by simply adjusting the Ag shell thickness. The silica coating improved colloidal stability of the nanostructure and provided functionality for antibody conjugation. By using 4-mercaptobenzoic acid (4-MBA) as a Raman reporter molecule, the proposed SERS sensor is able to detect AFP with a low limit of detection (LOD) of 0.72 pg mL−1 and a wide and clinically relevant linear detection range from 3 pg mL−1 to 3 μg mL−1. Hence, this SERS-based immunoassay provides a strategy for the detection of trace AFP and has potential to assist in the monitoring of prognosis for hepatocellular carcinoma (HCC) patients.
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Advanced Materials Interfaces
·
2019
·Vol. 6
·期 16
·1900659
·
IF 4.713
Qingyun Liu,Ping Chen,Yongqin Ye,Ying Wan,Bin Wang,Zhiqiang Luo
Developing plasmon-assisted semiconductor nanocomposites as multifunctional surface-enhanced Raman scattering (SERS) substrate for detection as well as photodegradation of toxic organic pollutants appears to be a crucial step in upgrading the SERS technique to a quantitative analytical level. However, conventional photocatalytic semiconductor scaffolds are confined in ultraviolet-light-active metal oxide nanostructures (TiO 2 , ZnO, etc.). Herein, the scope of semiconductor scaffold is expanded to visible-light-active oxynitrides by developing a robust and ultrasensitive recyclable SERS substrate based on 3D hierarchical gallium oxynitrides (GaON) nanosheets loading with Ag nanoparticles (Ag NPs). Significantly, the bandgap of GaON nanosheets shrinks to 2.9 eV to enable visible-light adsorption. The as-fabricated SERS substrate shows a high sensitivity with enhancement factor of 5.2 × 10 7 in R6G detection, and yields a wide detection range of 1.0 × 10 −6 –1.0 × 10 −12 mol L −1 . Assisted with the enhanced charge transfer by generating the Schottky contact at the metal/semiconductor interface and the electron traps played by the residue oxygen, the Ag/GaON nanocomposites show attractive recyclability at visible-light irradiation with well-maintained SERS activity after four cycles. This work demonstrates the superiority of taking advantage of plasmon-assisted oxynitride semiconductors as a high-performance SERS platform and provides new opportunities for developing robust visible-light-driven recyclable SERS substrates.
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ANALYST
·
2019
·Vol. 144
·期 22
·6533-6540
·
IF 4.019
Ziyi Cheng,Rui Wang,Yanlong Xing,Linlu Zhao,Jaebum Choo,Fabiao Yu
Cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) are important diagnostic biomarkers for acute myocardial infarction (AMI). Many efforts have been undertaken to develop highly sensitive detection methods for the quantitative analysis of these dual targets. However, current immunoassay methods are inadequate for accurate measurement of cTnI and CK-MB, due to their limited detection sensitivity. Thus, there is still an urgent demand for a new technique that will enable ultrahigh sensitive detection of these biomarkers. In this study, we developed a surface-enhanced Raman scattering (SERS)-based sandwich immunoassay platform for the ultrasensitive detection of cTnI and CK-MB. In this study, a monoclonal-antibody-immobilized gold-patterned chip was used as a SERS active template. Target samples and polyclonal-antibody-conjugated Au@Ag core–shell nanoparticles were then added. Using this SERS platform, the concentration of biomarkers could be quantified by monitoring the characteristic Raman peak intensity of Raman reporter molecules. Under optimized conditions, the limits of detection (LODs) were estimated to be 8.9 pg mL−1 and 9.7 pg mL−1 for cTnI and CK-MB, respectively. Thus, the proposed SERS-based immunoassay has great potential to be an effective diagnostic tool for the rapid and accurate detection of cTnI and CK-MB.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Yiran Tian,Hongmei Liu,Ying Chen,Canliang Zhou,Yong Jiang,Chenjie Gu,Tao Jiang,Jun Zhou
Along with the fast development of synthesis technique of nanomaterial, surface-enhanced Raman scattering (SERS) has emerged as an attractive tool for molecule sensing in the field of food safety and environmental monitoring. In this paper, a novel seedless one-spot strategy was firstly used to synthesize a series of 3D and 2D Ag nanostructures by simply modulating the injection rate of Ag source under different temperature. Through monitoring their morphology evolution under various synthesis conditions, the formation mechanism of these nanostructures was investigated in detail. Especially, the as-prepared 3D hierarchical Ag nanoflowers exhibited superior SERS performance with an enhancement factor of 3.77 × 107 and a limit of detection (LOD) as low as 1.45 × 10-9 M for 2-naphthalenethiol. In addition, the practical SERS-based monitoring of para-aminothiophenol in gas and sodium saccharin in commercial red wine with ultra-low LOD of 7.08 × 10-6 M and 0.0018 mg/mL was subsequently realized using this Ag nanostructure, demonstrating their intriguing prospect in sensitive direct detection of food additives and environmental contaminant.
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ANALYTICAL SCIENCES
·
2018
·
IF 1.355
Qiang Zou,Xin Li,Tao Xue,Shentong Mo,Qi Su,Jia Zheng
A surface-enhanced Raman scattering (SERS) platform for the selective trace analysis of Hg2+ ions was reported, based on poly-thymine (T) aptamer/2-naphthalenethiol (2-NT)-modified gold nanoparticles (AuNPs), which was an oligonucleotide-functionalized nanosensor and SERS chip. 2-NT was used as a Raman reporter, and T aptamer could form a T-Hg2+-T structure with Hg2+ ions making an SERS nanosensor absorbed to the SERS chip. The optimum concentrations of DNA and 2-NT were obtained. An average of 960 DNA molecules attached to each AuNP were measured. The limit of detection (LOD) was 1.0 ppt (1.0 × 10−12 g/mL), which is far below the limit of 10.0 ppb for drinking water, stipulated by the World Health Organization. The sensor has the advantages of low detection cost, a simple sample pretreatment, a green solution and reducing false positives. Furthermore, the nanosensor was used for the determination of trace Hg2+ in the water of a lake; a reliable result was obtained accurately.
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