HOLZFORSCHUNG
·
2023
·Vol. 77
·期 6
·437-452
·
IF 2.4
Haonan Zhang,Qi Liu,Yanchen Zhu,Zhang Feng,Hao Ren,Huamin Zhai
In this study, representative lignin samples differing in hydroxyl content, molecular weight, linkage composition and lignin units ratio were prepared from eucalyptus wood by different isolation means and modification means: milled wood lignin (MWL), kraft lignin classified at different pH (KL), lignocresol (LC), lignoresorcinol (LR), lignopyrogallol (LP) as well as lignocresol secondary functional switched samples (LC 2 nd deriv). The structure of various lignins was characterized in detail by Fourier transform infrared (FT-IR) spectroscopy, gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR). In order to eliminate the interference of other factors, bovine serum albumin (BSA) with relatively simple protein structure and different kinds of lignin and their derivatives were selected as the research objects. The adsorption/desorption behavior and mechanism between lignin samples and BSA were studied by quartz crystal microbalance with dissipation monitoring (QCM-D). The results showed that the content of phenolic hydroxyl was the main factor affecting the interaction of lignin and BSA, but in addition, the molecular size, linkages composition and the types of lignin units also had important effects on its adsorption behavior. The research will provide theoretical guidance and all-round reliable basic data for the interaction of lignin on lignocellulose hydrolysis enzymes in industrial application.
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International Journal of Nanomedicine
·
2017
·
IF 4.3
Jifu Hao,Tiantian Tong,Kai Jin,Qiannan Zhuang,Te Han,Yanping Bi,Jianzhu Wang,Xiaodan Wang
A folic acid (FA)-functionalized drug vehicle platform based on Pluronic 127 (P127)/D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) mixed micelles was orchestrated for an effective delivery of the model drug resveratrol in order to address the problem of poor water solubility and rapid metabolism of resveratrol and improve its targeted accumulation at tumor site. The FA-decorated mixed micelles were prepared using thin-film hydration method and optimized by central composite design approach. The micelles were also characterized in terms of size and morphology, drug entrapment efficiency and in vitro release profile. In addition, the cytotoxicity and cell uptake of the micelles were evaluated in folate receptor-overexpressing MCF-7 cell line. In vivo pharmacokinetic and biodistribution studies were also performed. The average size of the micelles was ~20 nm with a spherical shape and high encapsulation efficiency (99.67%). The results of fluorescence microscopy confirmed the targeting capability of FA-conjugated micelles in MCF-7 cells. FA-modified micelles exhibited superior pharmacokinetics in comparison with that of solution. Further, the low accumulation of resveratrol-loaded FA micelles formulation in the heart and kidney avoided toxicity of these vital organs. It could be concluded that folate-modified P127/TPGS mixed micelles might serve as a potential delivery platform for resveratrol.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2013
·
IF 3.535
Bang Lin Li,Jun Hua Luo,Hong Qun Luo,Nian Bing Li
A novel electrochemical sensor based on d -penicillamine ( d -PA) molecularly imprinted polypyrrole film on a glassy carbon electrode was fabricated. The complementary cavities located on the surface of molecularly imprinted polypyrrole film were used for subsequent template recognition. It was confirmed that the molecularly imprinted polypyrrole modified glassy carbon electrode (MIP-GCE) showed greater recognition ability than the non-molecularly imprinted polypyrrole modified glassy carbon electrode (NIP-GCE). Considering the electrochemical oxidation of d -PA with ferrocyanide and the specific recognition of molecular imprinting technique, the highly selective determination of d -penicillamine was achieved on the d -PA molecularly imprinted polypyrrole modified glassy carbon electrodes using ferrocyanide as an electrochemical probe. Several factors affecting sensor response, such as film thickness, template concentration, and the pH of phosphate buffer solution, were investigated to achieve optimum electrochemical response to d -PA at the MIP-GCE. The MIP-GCE revealed highly linear behavior in the concentration range of 10.0–480.0 μmol L −1 with the detection limit of 3.5 μmol L −1 for d -PA. The novel sensor has been applied to the determination of d -PA in real biological samples with satisfactory results.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Lujia Ding,Pengcheng Wang,Qiuhan Lin,Dongxue Li,Yuangang Xu,Ming Lu
Fused cyclic energetic compounds are a unique class of large conjugated structures containing two or more rings, and have been identified as promising competitors for traditional energetic materials. In the present work, we investigated 5-amino-6-oxo-4,6-dihydro-[1,2,5]oxadiazolo[3′,4′:5,6]pyrido[4,3- d ][1,2,3]triazine 8-oxide ( 3 ) in detail as a fused amphoteric energetic molecule that can be protonated and deprotonated by acids and bases to obtain its cationic ( 11 – 13 ) and anionic ( 4 – 10 ) salts. All the new compounds were thoroughly characterized by infrared and multinuclear NMR ( 1 H and 13 C) spectroscopy, and elemental analysis. The structural features of 3 – 6 , 9 , 10 , 12 , and 13 were investigated by single-crystal X-ray diffractions and different theoretical techniques (Hirshfeld surfaces analyses, and noncovalent interactions). The aromaticity of compound 3 was studied via localized orbital locator- π and iso -chemical shielding surfaces (ICSS). Their thermal decomposition temperatures were investigated by differential scanning calorimetry and thermogravimetry to be 310–344 °C (onset). In addition, impact and friction tests revealed that these compounds were insensitive. Densities, heats of formation and detonation properties were measured by a gas pycnometer, calculated using the Born-Haber energy cycle and EXPLO5 v6.05.04 program, respectively. The neutral compound 3 and all its non-metallic salts have better detonation properties than HNS and PYX and lower sensitivities. In particular, salt 11 (N + O: 61.74 %, T d : 330 °C, Δ H f : 1.68 kJ g −1 , D : 8.795 km s −1 , P : 36.0 GPa, IS: > 40 J, FS: > 360 N) is a potential candidate for heat-resistant explosives.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2020
·Vol. 34
·期 4
·e5451
·
IF 3.14
Shuang Huang,Xi Hong,Yong Sun,He-Zhen Cui,Quan Zhou,Yue-Jian Lin,Xiu-Feng Hou
Six tridentate NNN ligand precursors derived from 2-(pyridin-2-yl)benzo[d]thiazole(PBT) with different linkers, PBT NN X N (X = NH, NMe, O, S) ( 1a – 1f ), have been successfully prepared. The electronic properties of PBT NN X N ligands are well tunable by differing linkers between PBT skeleton and the pyridine ring, and/or by introducing electron-donating/withdrawing groups on the pyridine ring (R = OMe or F). The ligand precursors and representative complexes Ru ( PBT NN NH N )Cl 2 (PPh 3 ) ( 2a ), Ru ( PBT NN NMe N )Cl 2 (PPh 3 ) ( 2b ), and Ru ( PBT NN S N )Cl 2 (PPh 3 ) ( 2f ) have been characterized by NMR spectroscopy, high-resolution mass spectroscopy, and Fourier transform infrared (FT-IR). The molecular structures of 1f , 2a , and 2f have been determined by X-ray diffraction study. The results indicate that PBT NN NH N ligand in the complex presented coplanar with two five-membered chelating rings. It should be noted that 2a featuring a NH group exhibits superior performance compared to those with other linkers (such as NMe, O, or S). A variety of heterocyclic and aromatic nitriles with aromatic and aliphatic alcohols have been explored in α -alkylation for good to excellent yields. Based on kinetic experiments and mechanistic studies, a proposed mechanism was put forward. Ru-H species and benzaldehyde, which was oxidized from benzyl alcohol, were detected in the catalytic cycle.
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JOURNAL OF LUMINESCENCE
·
2019
·
IF 2.961
Chengjun Wang,Ying Qian
A red emissive fluorescent probe 1,7-dimethyl-3,5-bis(4-methoxyphenyl-vinyl)-8-(10-n-butyl-10H-phenothiazine-3-yl)BODIPY 1,7-dimethyl-3,5-bis(4-methoxyphenyl-vinyl)-8-(10- n -butyl-10 H -phenothiazine-3-yl)BODIPY (avyl-BODIPY-PTZ) with a special orthogonal donor-acceptor structure was designed and synthesized for rapid, sensitive, and selective discrimination of ClO − , over other reactive oxygen species and anions. The probe displays a linear ratiometric absorption (A 578 /A 640 ) and fluorescence (F 599 /F 660 ) response toward ClO − with a fast response velocity (~10 s). The limit of detection (LOD) for ClO − was obtained as 22.6 nM from the fluorescence titration experiment. The fluorescence enhancement of the probe can be observed from the 32-fold enhancement in ratiometric value (F 599 /F 660 ) and the increasement of quantum yield from 0.01 at 660 nm to 0.28 at 599 nm. The oxidation of S atom in phenothiazine by ClO − to form the sulfoxide-type structure was proposed as the recognizing mechanism according to the Mass spectral analysis. The ratiometric enhancement of fluorescence was rationalized by the theoretical calculations. The orthogonal donor-acceptor structure according to optimized calculation and solvent effects of avyl-BODIPY-PTZ illustrated that the ClO − oxidation induced conversion from the nonradiative TICT process to the radiative LE process and caused the fluorescence ratiometric enhancement. The probe with low cytotoxity can successfully permeate into living cells and the cell images can be achieved in single channel. Moreover, after addition of ClO − , another bright red emission channel of the probe switched on and the probe displayed two-channel emission in living cells.
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JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Chi Wu,Kai He,Huizhen Li,Lan Zhang,Liangang Mao,Lizhen Zhu,Jinhua Jiang,Xingang Liu
The transgenerational impacts of pesticide mixture on Daphnia magna ( D. magna ) following long-term exposure, particularly regarding transcriptomic effects, remain poorly understood. We analyzed 470 irrigation water samples from various Chinese provinces. Imidacloprid (IMI, 71.1 %), clothianidin (CLO, 60.43 %), and tebuconazole (TEB, 64.68 %) were the most frequently detected pesticides, with nearly 50 % of samples showing mixtures of TEB with IMI or CLO. D. magna were exposed to environmentally relevant concentrations (0.89–1.62 μg/L) over 12 generations. Key effects included reduced fecundity, delayed development, and smaller body size, with these impacts exacerbating across generations. A Leslie matrix model revealed declines in population size, intrinsic rates of increase, and age structure. Notably, mixed pesticide exposures induced specific pathways related to oocyte meiosis, resulting in greater toxicity than single exposures. Additionally, disrupted lipid metabolism and feeding behaviors were linked to insufficient energy for growth and reproduction, affecting ovarian development. These findings highlight the ecological risks of long-term pesticide exposure and offer insights for mitigation strategies in aquatic ecosystems.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Fengwei Huang,Xiaoyun Dong,Yuexin Wang,Xianjun Lang
Conjugated microporous polymers (CMPs) have evloved into versatile visible light photocatalysts. Narrowing the bandgaps of CMPs could capture more visible light without shifting the suitable position with an established electron acceptor like thiazolo[5,4- d ]thiazole (TzTz). Here, benzene-1,3,5-tricarbaldehyde (Bz-CHO) and benzo[1,2-b:3,4-b':5,6-b'']trithiophene-2,5,8-tricarbaldehyde (BTT-CHO) are adopted to undergo condensation with dithiooxamide, preparing two TzTz-bridged CMPs, namely TzTz-Bz and TzTz-BTT. Thereby, TzTz-BTT could capture visible light more substantially than TzTz-Bz due to narrowing the bandgap. Endowed by TzTz, both TzTz-BTT and TzTz-Bz possess similar positions for the activation of O 2 and can drive the subsequent formation of imines. However, TzTz-BTT, with a narrower bandgap, could capture more green light to drive the electron and proton transfer for the selective formation of imines with higher conversions than TzTz-Bz. This work suggests that CMPs can be equipped with extensive visible light absorption for photocatalytic selective oxidations.
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Advanced Powder Materials
·
2025
·
IF 24.9
Yang Li,Bin Sun,Ying Li,Chong Zhang,Pu-Jun Jin,Xin Wang,Bao Yu Xia,Yu Chen,Xuan Ai
The large-scale implementation of direct ethylene glycol fuel cells (DEGFCs) relies on the design of catalysts that possess exceptional activity, durability, and efficient C–C bond breaking ability. However, Pt and Pd-based nanomaterials continue to face challenges of low selectivity and slow reaction kinetics in driving the complete oxidation of ethylene glycol to CO 2 . In this work, a facile one-pot reduction method is reported for controllable synthesis of PtBi nanodendrites (PtBi-NDs) composed of ultrathin bimetallene subunits. In alkaline media, the composition optimized PtBi-NDs demonstrate outstanding activity and strong resistance to CO poisoning during the ethylene glycol oxidation reaction (EGOR). The PtBi-NDs show 5.8-fold higher mass activity, enhanced stability, and superior C1 selectivity relative to commercial Pt nanoparticles (Pt c-NCs). Most strikingly, PtBi-NDs deliver a higher power density (8.3 mW cm –2 ) than Pt c-NCs in DEGFCs. The theoretical analysis and experimental measurements explain that the introduction of Bi element into Pt induces d–p orbital hybridization and promotes electron transfer from Bi to Pt, thereby facilitating C–C bond cleavage and boosting EGOR kinetics. This work establishes an effective strategy for constructing Pt-based ultrathin bimetallenes and offers fundamental insights into boosting EGOR performance via d-p orbital hybridization.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Jiaying Ai,Jiajun Yan,Yuxin Zhang,Fuping Lu,Shuhong Mao,Yixun Jiang,Lei Li,Hui-Min Qin
Chemical tethering NAD + to GfADH enhances enzyme-cofactor spatial proximity. • The application of conjugate and NOX reduced the NAD + demand by 13-fold. • The NAD + -GfADH conjugate and NOX were co-fixed via sequential recruitment. • Co-immobilization enhanced enzyme stability with improved cofactor regeneration. The green biomanufacturing of high-value compounds is limited by enzyme instability and cofactor dependence. Herein, we developed a tailored multi-module immobilization strategy that integrated cofactor tethering with sequential multi-enzyme co-immobilization to facilitate the efficient conversion of allitol into D-allulose catalyzed by the Gluconobacter frateurii -derived dehydrogenase (GfADH). In this strategy, nicotinamide adenine dinucleotide (NAD + ) was covalently tethered to the surface of GfADH via a flexible linker, creating an NAD + -GfADH conjugate. Coupling the conjugate with NADH oxidase (NOX) established an efficient cofactor self-regenerating system, reducing the external NAD + demand by 13-fold. Furthermore, this conjugate was encapsulated within hybrid nanoflowers, thereby improving its reusability. To facilitate cofactor transfer, NOX was directionally recruited and colocalized with GfADH using the SpyTag/SpyCatcher system. The co-immobilized enzyme exhibited a high D-allulose yield of 88.7% from 110 mM allitol and retained 85.0% of its initial activity after 6–8 cycles. This work provides a valuable integrated strategy for cofactor regeneration and enzyme stabilization in cofactor-dependent biosynthesis. Download: Download high-res image (169KB) Download: Download full-size image
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SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yongfei Huang,Li Zhang,Zhefeng Fan
Photodynamic therapy (PDT) holds great promise for tumor treatment, but its clinical translation is greatly hindered by the drawbacks of conventional photosensitizers (PSs), such as insufficient reactive oxygen species (ROS) generation, exclusive type‑II photoreaction, poor subcellular targeting, and compromised efficacy in hypoxic tumors. Herein, we rationally designed and synthesized a mitochondria‑targeted near‑infrared (NIR) photosensitizer Mito‑IsTp with a classic D-π-A architecture, using isophorone as the electron acceptor, methoxy‑modified triphenylamine as the electron donor, benzene as the π‑bridge, and triphenylphosphonium as the mitochondrial‑targeting group. Mito‑IsTp displays a maximum emission peak at 770 nm within the NIR‑I window, together with satisfactory photostability and solvent‑dependent optical performance. Upon 660 nm NIR light irradiation, Mito‑IsTp can simultaneously produce type‑I (•OH, O 2 -• ) and type‑II ( 1 O 2 ) ROS with much higher efficiency than commercial Rose Bengal and Chlorin e6 (Ce6). Confocal imaging verifies its excellent mitochondrial targeting ability in HeLa cells with a Pearson correlation coefficient of 0.97. In vitro experiments reveal negligible dark toxicity and efficient phototoxicity to induce cancer cell apoptosis through ROS-mediated mitochondrial damage. In vivo studies on HeLa tumor‑bearing nude mice further show that Mito‑IsTp ‑mediated PDT significantly suppresses tumor growth without obvious systemic toxicity or organ injury, confirmed by body weight recording, H&E staining, blood routine tests, and hemocompatibility assessment. This work presents a high‑performance NIR PS with dual‑pathway ROS generation and precise mitochondrial targeting, establishing a feasible paradigm for hypoxia‑resistant and mitochondria‑targeted tumor PDT.
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Chem
·
2025
·Vol. 12
·期 3
·
IF 19.6
Yu-He Liang,Jia-Xin Kang,Yan Wang,Yi-Ge Li,Hou-Ji Cao,Qianyi Zhao,Xuenian Chen,Yan-Na Ma
The selective B–H functionalization of carboranes has received considerable attention because of their wide applications in functional materials, catalysis, and pharmaceuticals. Deuterium-labeling experiments and kinetic-isotope-effect experiments are two important tools for mechanistic studies on the selective B–H activation of carboranes. Thus, developing an effective method for the synthesis of perdeuterated carboranes is highly desirable. Herein, we present a practical method for synthesizing perdeuterated carboranes via Pd(II)-catalyzed B–H activation by using D 2 O as a deuterium source. This protocol features extraordinary functional-group tolerance, high levels of deuterium incorporation, and ease of scaling. Mechanistic studies illustrate that the deuteration reaction proceeds via Pd(II)-catalytic electrophilic H/D exchange and subsequent intermolecular Pd migration. The same degree of deuterium incorporation across all boron vertices indicates that the Pd-migration step is faster than the electrophilic palladation step. Additionally, the versatility of this method is reflected in the deuteration of other boron clusters.
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