JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 3
·1-12
·
IF 2.8
Huang Kai,Que Tao,Guo Xiang,Wang Rui,Ding Xiang,Zhou Hongqing
The advancement of high-density integration and packaging technologies necessitates the development of packaging materials that possess enhanced thermal conductivity and substantial mechanical strength. In this paper, we present a novel type of CaO–B 2 O 3 –SiO 2 /β-Si 3 N 4 composites synthesized through the solid-state reaction. The effects of β-Si 3 N 4 ceramic content on the sinterability, phase structure, microstructure, and properties of the composites were studied. As an excellent structural and functional material, the rod-like β-Si 3 N 4 ceramic not only enhanced the thermal conductivity (λ) and flexural strength of composite materials but also effectively reduced the thermal expansion coefficient (CTE) of the composite and maintained good high-frequency dielectric properties. The composite sample containing 15wt.% β-Si 3 N 4 demonstrated exceptional performance after sintering at 850 ℃ for 30 min, achieving a bulk density of 2.80 g/cm 3 , a relative permittivity of 6.52 with a dielectric loss of 1.94 × 10 –3 (15 GHz), a λ of 3.5 W/(m·K), a CTE value of 6.40 ppm/ ℃, and a flexural strength of 180.1 MPa. Additionally, the EDS line mapping indicates that there was no diffusion of silver at the interface, thereby affirming the favorable compatibility between the composite and the silver electrode. This characteristic positions the CBS/β-Si 3 N 4 composite as a potentially promising candidate for applications in electronic packaging.
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Acta Pharmaceutica Sinica B
·
2024
·
IF 14.7
Mengyi Yan,Xiayun Chen,Xiaotong Li,Qianqian Liu,Baixue Yu,Yi Cen,Wei Zhang,Yibin Liu,Xinxuan Li,Ying Chen,Tao Wang,Shiying Li
The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects of traditional treatments. In this work, a transferrin receptor (TfR) targeted immunostimulant (PTI) is fabricated for photodynamic immunotherapy against metastatic tumors by interrupting β -catenin signal pathway. To synthesize PTI, the photosensitizer conjugated TfR targeting peptide moiety (Palmitic-K(PpIX)-HAIYPRH) is unitized to encapsulate the transcription interrupter of ICG-001. On the one hand, the recognition of PTI and TfR can promote drug delivery into tumor cells to destruct primary tumors through photodynamic therapy and initiate an immunogenic cell death with the release of tumor-associated antigens. On the other hand, PTI will interrupt the binding between β -catenin and cAMP response element-binding protein (CREB), regulating the gene transcription to downregulate programmed death ligand 1 (PD-L1) while upregulating C–C motif chemokine ligand 4 (CCL4). Furthermore, the elevated CCL4 can recruit the dendritic cells to present tumor-specific antigens and promote T cells activation and infiltration, and the downregulated PD-L1 can avoid the immune evasion of tumor cells and activate systemic anti-tumor immunity to eradicate lung metastasis. This work may inspire the development of antibody antibody-free strategy to activate systemic immune response in consideration of immunosuppressive conditions.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Yong Xie,Qingqing Liu,Jia Shi,Renwei Zhu,Xiong Liu
Thermal processing of barley grains is a useful technique for modelling the physicochemical properties of β-glucans and their food applications. This study investigated the impacts of different thermal processing techniques—including flaking-roasting (FR), stir-frying (SF), steam flash-explosion (SFE), and popping expansion (PE)—on the gelation properties of hulless barley β-glucan. Results showed that PE-β-glucan showed the highest molecular weight ( M w 5243.6 ± 0.3 kDa), water holding capacity, solubility, zeta potential, gel stability, and texture properties, followed by native, SF-, and FR-β-glucan. However, SFE-β-glucan (lowest M w , 89.9 ± 0.2 kDa) failed to gel even at 60 mg/mL. Microstructure observations by atomic force microscope (AFM), confocal laser scanning microscope (CLSM), and transmission electron microscopy (TEM) indicated that PE-induced chain conformation changes primarily augmented cluster stability of β-glucan, strengthening gelation. Hence, β-glucan gel performance is jointly governed by molecular weight and chain conformation, both significantly altered by thermal processing.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Jinlong Qin,Min Sun,Jiajing Cheng,Huici Jiang,Mingchen Lv,Jianxing Jing,Ran Chen,Zhen Fan,Jianzhong Du
Unavoidable damage to the basal layer of the endometrium has a huge negative impact on a woman’s reproductive health and menstrual cycle. However, it is difficult for medicine to penetrate a series of biological barriers toward the basal layer in the deeper area of the endometrium. To meet this challenge, we developed an ultrasound-responsive hydrogel incorporated with a transforming growth factor-beta (TGF-β) mimetic peptide to enhance pregnancy outcomes by restoring the function of a wounded endometrium due to its deep-tissue-penetration capability. In vitro studies revealed that the TGF-β-mimetic-peptide-loaded hydrogel could achieve 64.35% of cell migration under ultrasound stimulation even in phosphate-buffered saline of pH 6.0. Upon in situ sonication at the uterus, carboxymethyl chitosan can be released from degraded hydrogel to open tight junctions with reduced interstitial pressure by ultrasound to promote deep penetration. Rat studies revealed that the penetration capability of TGF-β-mimetic-peptide-loaded hydrogel with sonication was 1.6 times higher than that of the control group. Besides the rat uterine model, ex vivo human uterine tissue was also collected and imaged, demonstrating up to ∼700 μm of tissue penetration depth. In addition, compared to control groups, effective uterus recovery without intrauterine stenosis and endometrial cavity fluid was observed from rats with severe uterine injury treated by TGF-β-mimetic-peptide-loaded hydrogel. In addition, fertility restoration in the endometrial injury model was observed after treatment with such an ultrasound-responsive hydrogel incorporated with TGF-β mimetic peptides. Overall, this work provides an effective approach to treating endometrial injury for enhanced pregnancy outcomes.
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JOURNAL OF ELECTRONIC MATERIALS
·
2025
·
IF 2.5
Wang Fangyu,Wen Yijie,Guo Xin,Zhang Xuanhao,Hu Shuai,Yuan Maohui,Han Kai
Upconversion nanomaterials have been extensively applied in many fields owing to their unique optical and electronic properties. In this work, β-NaYF 4 :Yb 3+ /Ho 3+ microcrystals were synthesized by an improved hydrothermal method. The morphology and the composition of the prepared microcrystals were experimentally investigated in detail by scanning electron microscopy (SEM) and X-ray diffraction (XRD). Under the excitation of a 980 nm continuous-wave (CW) laser, the green (541 nm) and red (644 nm) upconversion luminescence (UCL) of Ho 3+ through the energy transfer upconversion processes assisted by the Yb 3+ ions were experimentally studied at the single-particle level. With the gradual increase of excitation intensity in the highly doped Yb 3+ microcrystals, the red UCL was enhanced significantly more than the green UCL and was dominant, resulting in the UCL color finally tuning to pure red. Comparatively, for the lightly doped Yb 3+ microcrystals, the green UCL exhibited a relatively similar increase to the red UCL. The populations of the Yb 3+ and Ho 3+ ions and transitions of the UCL were systematically demonstrated through calculation of the energy levels. Notably, a new UCL at 580 nm was observed, which was ascribed to the transition of 5 F 1 , 5 G 6 → 5 I 7 .
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2024
·
IF 2.9
Wen Jie,Lyu Yanjun,Zhang Lianhong,Ma Yuling,Huang Xia,Zhu Wanyu
A novel method was developed to introduce β-cyclodextrin (β-CD) cage-like macromolecules into acrylic ester resin using metal oxides as a medium, resulting in high-oil-absorption resin composites. β-CD was first grafted onto the surface of cobalt-aluminum bimetallic oxide (CoAl-LDO) via a facile hydrothermal method in an alkaline environment, generating more pore structures. To enhance the hydrophobic properties of β-CD-grafted CoAl-LDO nanoparticles, KH-570 was employed as a modifier to modify nanoparticles. Finally, the β-CD-grafted CoAl-LDO/acrylic ester resin composite was successfully synthesized by suspension polymerization method. The oil absorption performance of the resin composite was evaluated using various solvents. Its saturated capacity reached 18.62 g/g for cyclohexane, 19.92 g/g for toluene, and a remarkable 31.42 g/g for trichloromethane. Even for diesel, a challenging oil due to its viscosity, the absorption reached a noteworthy 16.17 g/g. Further demonstrating its selectivity, the composite strictly adsorbed oil while repelling water. Notably, the impressive capacity remained largely unchanged after eight regeneration cycles.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Jie Liu,Jiang Zhou,Qiang Xi,Shengyuan Yang,Wenfang Du,Fubing Xiao
Bisphenol A (BPA), an endocrine disruptor , is widely used in food packaging materials , including drink containers. Sensitive detection of BPA is crucial to food safety. Herein, we have developed a novel optical-driven hydrogel film sensor for sensitive BPA detection based on the displacement of spiropyran (SP) from β -cyclodextrin ( β -CD) cavity by BPA followed by the photochromism of the released SP. The released SP converts to the ring-opened merocyanine form which shows an enhanced red fluorescence in the dark. The sensor demonstrates a linear detection range from 0.1 to 20 μg mL −1 with a limit of detection at 0.027 μg mL −1 and a limit of quantification at 0.089 μg mL −1 . Notably, the proposed β -CD/SP hydrogel can be reused due to the reversible isomerization of SP and the reversible host–guest interaction. This sensor also shows good performance for BPA determination in real samples, indicating its great potential for food safety monitoring.
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JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Yuan Meng,Minqi Liu,Yicheng Liao,Junhuai Luo,Xiaoli Fu,Peizhe Sun
This study systematically assessed the performance of a newly developed solid-phase extraction (SPE) material, cellulose-supported aminated β-cyclodextrin polymer (amine-β-CDP@Cellulose), in determining 44 xenobiotics, encompassing endocrine-disrupting chemicals (EDCs), pharmaceuticals, and food additives in urine samples. The primary objective of the research was to synthesize a new sorbent, optimize the extraction protocol, and elucidate the underlying adsorption and desorption mechanisms. Following optimization, it was observed that amine-β-CDP@Cellulose achieved recoveries ranging from 80 % to 120 % for 28 of the 44 targeted xenobiotics, with only three compounds showing recoveries below 50 %. The superior extraction performance of this novel material can be attributed to the synergistic effects of its structural components: charged functional groups introduced via the cross-linking agent, the hydrophobic cyclodextrin cavity that facilitates inclusion complexation, and abundant hydroxyl groups that enhance adsorption. Additionally, the study included a comparative analysis between amine-β-CDP@Cellulose and commercially available HLB resins. This comparative analysis revealed that the amine-β-CDP@Cellulose method effectively mitigated matrix interferences while maintaining comparable extraction efficiency to the HLB-based method. Collectively, these findings suggest that amine-β-CDP@Cellulose could serve as a sustainable and cost-effective material for extracting xenobiotics from complex matrices.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Nannan Cui,Zhikun Wang,Fengting Li,Huiling Su,Wentao Qu,Miantuo Li,Shuangqing Sun,Songqing Hu
Micro/nanocontainers, as smart carriers of corrosion inhibitors, capable of intelligently detecting corroded areas and dispensing inhibitors precisely for targeted corrosion control. Here, pH-responsive chitosan- grafted -β-cyclodextrin (CS- g -β-CD) microspheres (CgCM) loaded with various corrosion inhibitors are prepared via an emulsification cross-linking method. By FT-IR and 1 H NMR characterizations, the successful loading of corrosion inhibitor BTA into β-CD is achieved, with the obtained BTA@β-CD being further grafted on the CS chain by degree 28.8 %. The prepared CgCM possess a size range from 15 to 20 μm, and a surface zeta potential range from positive in acidic solution (33.7 mV at pH = 3) to negative in alkaline solution (−20.4 mV at pH = 10). In addition to loading BTA into β-CD, three compound agents (AIM, AMIM-Cl, and 3-SAMA) are selected to be loaded into the crosslinking gaps of the CgCM, with the loading ratios of BTA, AIM, AMIM-Cl, and 3-SAMA determined to be 31.59 %, 13.85 %, 16.93 %, and 19.30 %, respectively. When subjected to acidic stimulation, the CgCM undergo swelling and dissociation, leading to the responsive release of the four loaded inhibitors into the solution, for which the accumulative release ratios (48 h, pH = 3) are determined to be 93 %, 86 %, 84 %, and 81 %, respectively. Weight loss and electrochemical evaluations firmly establish that these CgCM, laden with inhibitors, are adept at forming dense protective barriers on steel surfaces, achieving a corrosion inhibition efficiency exceeding 90 %. Corrosion morphology, surface elemental distribution, and binding status reveal a compact compounding protective layer formation on the steel/solution interface, by a physicochemical synergistic adsorption pattern. Density functional theory (DFT) calculations and molecular dynamics (MD) simulations reinforce the findings, revealing that all three CgCM systems exhibit targeted, stimulus-responsive release capabilities, coupled with robust adsorption strengths and remarkable corrosion resistance characteristics.
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BLOOD
·
2025
·Vol. 145
·期 10
·1074-1088
·
IF 23.1
Yong Long,Qianqian Zhang,Ling Ling,Yuan Zhuang,Xiaolei Wei,Haoyang Huang,Zhanping Lu,Yushan Huang,Xianming Chen,Yuhua Ye,Xiaoqin Feng,Haokun Zhang,Binbin Huang,Yueyan Huang,Yidan Liang,Mingyan Fang,Yukio Nakamura,Bin Lin,Xinhua Zhang,Daru Lu,Xin Jin,Xiangmin Xu
Accumulation of free α-globin is a critical factor in the pathogenesis of β-thalassemia. Autophagy plays a crucial role in clearing toxic free α-globin, thereby reducing disease severity. However, the impact of natural mutations in autophagy-related genes (ATGs) on the phenotypic variability of β-thalassemia remains unclear. In this study, we systematically investigated the relationship between variants in ATGs and disease phenotypes in a cohort of 1022 patients with β-thalassemia, identifying 4 missense mutations in the autophagy and beclin 1 regulator 1 (AMBRA1) gene. Disruption of the Ambra1 gene in β-thalassemic mice was found to reduce autophagic clearance of α-globin in red blood cell precursors, exacerbating disease phenotypes. Functional characterization of the AMBRA1 gene and these mutations in patient-derived CD34+ cells, edited human umbilical cord blood–derived erythroid progenitor 2 (HUDEP-2) cells, and engineered HUDEP-2 β-thalassemic cells confirmed that AMBRA1 facilitates the autophagic clearance of free α-globin in human erythroid cells. Functional studies demonstrated that AMBRA1 missense mutants destabilize Unc-51-like kinase 1 protein, inhibit light chain 3 protein lipidation, and subsequently hinder autophagic flux, leading to increased α-globin deposition. Additionally, these mutations were associated with erythrotoxic effects in vitro, including increased intracellular reactive oxygen species levels, higher apoptosis rates, and impaired erythroid differentiation and maturation. This study sheds light on the molecular association between mutations in ATGs and the exacerbation of β-thalassemia, highlighting the potential role of the AMBRA1 gene as a promising diagnostic and therapeutic target for β-hemoglobinopathies.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Javzan Gankhuyag,Munkh-Amgalan Gantumur,Yves Harimana,Akhunzada Bilawal,Blessing Titilayo Ajala,Shuang Zhang,Yang Li
This study investigated the interactions between soybean protein isolate (SPI) and β-cyclodextrin (β-CD), focusing on structural changes and functional enhancements. Results revealed that β-CD induces SPI conformational changes by decreasing α-helix, increasing β-structures, and enhancing flexibility via non-covalent interactions. Redshift in the negative peak from 203 to 214 nm as β-CD concentration increased from 0.1 to 1.0 mg/mL. Fluorescence quenching confirmed spontaneous complexation driven by hydrophobic forces. Moderate β-CD concentrations improved the functional and interfacial properties of SPI, whereas higher levels promoted aggregation and diminished performance. Increasing β-CD concentration elevated SPI-β-CD particle size from 197.6 to 310.7 nm and zeta potential from −15.52 to −24.27 mV. SEM confirmed structural rearrangement without compromising material integrity, while molecular docking showed stable complex formation through hydrogen bonding and van der Waals forces. These findings highlight the potential of SPI-β-CD complexes for enhanced functionality in emulsions, delivery systems, and various applications.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Chenxiao Chu,Mingli Wei,Che Bian,Xiaoshuang Bi,Yaxin Deng,Peifu Xiao,Jiansong Zhao,Yuying Wang,Haibing He,Jingxin Gou,Tian Yin,Xing Tang,Li Yang,Hongbo Zhang,Yu Zhang
Type 2 diabetes mellitus (T2DM) persists as a global health challenge, with current therapies inadequately addressing the intertwined pathologies of hyperglycemia, oxidative stress, and β-cell dysfunction. Here, an oral nanotherapeutic platform, MOP@T@D, engineered to restore glucose homeostasis and rejuvenate pancreatic β-cells is developed. The platform is constructed by co-loading insulin and glucose oxidase (GOx) into diselenide-bridged mesoporous organosilicon nanoparticles (MON), followed by sequential coating with transferrin (Tf) and functionalization with deoxycholic acid (Dc). MOP@T@D demonstrates efficient intestinal absorption and liver-targeted delivery, achieving an oral bioavailability of 10.6%. Under hyperglycemic conditions, GOx-generated H 2 O 2 cleaves the diselenide bonds in the MON framework, resulting in rapid insulin release with 8.7-fold higher cumulative release compared to normoglycemic conditions. Simultaneously, the metabolized selenium derivatives progressively upregulate key selenoproteins, enhancing glutathione peroxidase (Gpx) activity by 31%, which effectively neutralizes oxidative stress and suppresses NF-κB-mediated inflammation. In a T2DM rat model, this therapy increases the islet area by 26.7% and restores insulin secretion to 74.6% of the physiological level. Notably, the system maintains normal blood glucose levels for two weeks after cessation of administration. In summary, through a simple oral dose, MOP@T@D not only stabilizes glycemic fluctuations but also addresses the root pathophysiology of T2DM.
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