International Journal of Electrochemical Science
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2023
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IF 1.5
Van Tu Nguyen,Yue Li Liu,Shah Abdul Hakim,Amr Rady Radwan,Bin Wei,Wen Chen
Fe 2-x Sn x (MoO 4 ) 3 samples were successfully synthesized by wet chemical route. The analytical results of X-ray diffractions indicated that the additions of tin have not destroyed the lattice structure of Fe 2-x Sn x (MoO 4 ) 3 , but increased the units cell volume. Fe 2-x Sn x (MoO 4 ) 3 can be exhibited higher discharge /charge capacities and better cycle-stability than the pristine one. At room temperature, the initial discharge capacity of Fe 1.95 Sn 0.05 (MoO 4 ) 3 is 83.12 mAh g -1 at a discharge rate of 0.5 C and remains 78.81 after 50 cycles. The improved electrochemical properties can be explaining with the presence of tin in the lattice of Fe 2 (MoO 4 ) 3 by improved the structure stability and electrical conductivity.
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JOURNAL OF NANOBIOTECHNOLOGY
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2023
·Vol. 21
·期 1
·1-17
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IF 10.2
He Yiman,Chen Huawan,Li Wenbo,Xu Lu,Yao Huan,Cao Yang,Wang Zhigang,Zhang Liang,Wang Dong,Zhou Di
Background Radiotherapy (RT) is one of the most mainstream cancer therapeutic modalities. However, due to the lack of specificity of the radiation adopted, both normal and cancerous cells are destroyed indiscriminately. This highlights the crucial need to improve radiosensitization. This study aims to address this issue by constructing a multifunctional nanospheres that can sensitize multiple aspects of radiotherapy.Results Nanospheres containing high atomic element Bi can effectively absorb ionizing radiation and can be used as radiosensitizers. Cell viability after Bi2S3 + X-ray treatment was half that of X-ray treatment alone. On the other hand, exposed 3-bromopyruvate (3BP) could reduce the overactive oxygen (O2) metabolism of tumor cells and alleviate tumor hypoxia, thereby promoting radiation-induced DNA damage. The combination index (CI) of 3BP and Bi2S3-based RT in Bi2S3-3BP + X-ray was determined to be 0.46 with the fraction affected (fa) was 0.5 via Chou-Talalay’s isobolographic method, which indicated synergistic effect of 3BP and Bi2S3-based RT after integration into Bi2S3-3BP + X-ray. Under the combined effect of 3BP and RT, autophagy was over-activated through starvation-induced and redox homeostasis dysregulation pathways, which in turn exhibited pro-death effects. In addition, the prepared nanospheres possess strong X-ray attenuation and high near-infrared (NIR) optical absorption, thus eliminating the need for additional functional components and could serve as bimodal contrast agents for computed tomography/photoacoustic (CT/PA) imaging.Conclusion sThe rational design of multifunctional nanospheres with the unique properties provided a novel strategy to achieving high therapeutic efficacy in RT. This was accomplished through simultaneous activation of multiple sensitization pathways by increasing ionizing radiation, reducing tumor oxygen consumption, inducing pro-death autophagy, and providing multiple-imaging guidance/monitoring.
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高影响因子
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
·
2023
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IF 3.3
Shiling Hu,Jue Wang,Haoyun Bai,Chaohua Feng,Zhenqi Zhou,Zhuoyin Xue,Wen Zhang,Yongjing Zhang,Nan Wang,Langchong He
Background Mast cells (MCs) are important effector cells in anaphylaxis and anaphylactic disease. 3’,4’,5,7-tetrahydroxyflavone (THF) presents in many medicinal plants and exerts a variety of pharmacological effects. In this study, we evaluated the effect of THF on C48/80-induced anaphylaxis and the mechanisms underlying its effects, including the role of secreted phosphoprotein 1 (SPP1), which has not been reported to IgE-independent MC activation.Results THF inhibited C48/80-induced Ca2+ flow and degranulation via the PLCγ/PKC/IP3 pathway in vitro. RNA-seq showed that THF inhibited the expression of SPP1 and downstream molecules. SPP1 is involved in pseudo-anaphylaxis reactions. Silencing SPP1 affects the phosphorylation of AKT and P38. THF suppressed C48/80-induced paw edema, hypothermia and serum histamine, and chemokines release in vivo.Conclusions Our results validated SPP1 is involved in IgE-independent MC activation anaphylactoid reactions. THF inhibited C48/80-mediated anaphylactoid reactions both in vivo and in vitro, suppressed calcium mobilization and inhibited SPP1-related pathways.
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高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
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2022
·Vol. 147
·期 20
·11467-11475
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IF 4.755
Ma Xiao‑Hua,Hu Jie,Li Quan‑Guo,Li Peng,Liu Xuan,Yan Xiao-Min,Cheng Chun-Sheng,Li San-Xi
This study describes the apparent thermodynamics and reaction kinetics of the synthesis of [(5,6-dimethyl dicarboxylate-3-pyridine) methyl]-trimethyl ammonium bromide (DPTAB) and established a reaction kinetics model firstly. Simultaneous thermal analysis coupled with Fourier transform infrared and mass spectrometry (STA-FTIR-MS) was utilized to study the mechanism of the decomposition reaction of DPTAB firstly also. The finding is that the apparent activation energy of the synthesis reaction of DPTAB is 69.27 kJ mol −1 , and the apparent reaction heat is –74.46 kJ mol −1 (based on the moles of dimethyl 5-bromomethylpyridine-2,3-dicarboxylate). Under thermal runaway conditions, the adiabatic temperature rise is 8.87 K. The synthesis reaction kinetic equation is \(r=5.876\times {10}^{13}\cdot \mathrm{exp}\left(-69.27/RT\right)\cdot {C}_{\mathrm{CMPE}}^{ 0.893}\cdot {C}_{\mathrm{TMA}}^{ 1.136}\) . Under a nitrogen atmosphere, the decomposition of DPTAB undergoes an endothermic melt accompanied by an exothermic decomposition process. The decomposed products, trimethylamine reacts with bromomethane further to form tetramethylammonium bromide salt that undergoes an endothermic sublimation at 583 K, and the enthalpy of sublimation is 72.92 kJ mol −1 .
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JOURNAL OF MATERIALS SCIENCE
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2022
·Vol. 57
·期 35
·16965-16973
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IF 4.682
Wang Tao,Lu Yang,Xu Lin,Chen Zheng Jian
Surface-enhanced Raman scattering (SERS) has drawn attention to broad applications. Here, we investigate the SERS property of the π-conjugated poly(3-hexylthiophene-2,5-diyl) (P3HT) for molecule detection. The crystal structure of π-conjugated P3HT thin films is of the great significance to its SERS property. Our results show that the optimized crystal structure can significantly improve its SERS property. The SERS substrate has an excellent signal reproducibility (RSD < 10%). In addition, the SERS substrate still remains a good Raman enhancement after one year and shows excellent long-term stability compared with those of other types of SERS substrate. The result of our theory calculation shows that significant π-stacking of the probe molecules with the thiophene π-cores molecules plays an important role in the large SERS enhancement by the charge transfer mechanism. The increase in the crystallinity of the P3HT film can improve the charge transfer of the substrate molecules and the methylene blue (MB) molecules via more effective chemisorption of the probe molecules with the substrate molecules. The study contributed to the rational design of the organic semiconductor polymer SERS substrate with high sensitivity, selectivity, and long-term stability. Graphical abstract
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Journal of Physical Chemistry C
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2022
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IF 4.177
Jiarui Zhao,Junhong Fu,Jian Wang,Kaixin Tang,Qi Liu,Jiahui Huang
The Pd/TiO2 catalysts with varying Pd nanoparticle sizes are used to study the control of selectivity toward the hydrogenation of 3-nitrostyrene (3-NS). Our results show the selectivities of 3-vinylanilline (3-VA) rise by decreasing the particle size, while the selectivity of 3-ethylnitrobenzene (3-EN) is the opposite. However, over the Pd/SiO2 catalysts, 3-EN moieties are the dominant product regardless of their differences in particle size. We find that the electronic interactions between Pd NPs and the TiO2 support rise by decreasing particle size, as a result, creating more admetals on the Pd NPs in contact with TiO2, which favorably adsorb the nitro group of 3-NS, thus resulting in enhanced selectivity of 3-VA. However, the classical strong metal–support interactions (SMSI) induced by reduction at elevated temperatures play no significant role in the controlling of selectivities of 3-VA and 3-EN. The SiO2-supported Pd NPs without electronic metal–support interactions (EMSIs) prefer the reduction of the vinyl group of 3-NS. This work underlines the importance of EMSI governing the selectivity for hydrogenation of unsaturated nitroarene reactions.
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Pharmaceutics
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2022
·Vol. 14
·期 11
·2307
·
IF 6.525
Xueyan Gou,Fenglin Ran,Jinru Yang,Yanrong Ma,Xin’an Wu
Background: Organic anion transporter 1 (OAT1) and OAT3 have an overlapping spectrum of substrates such that one can exert a compensatory effect when the other is dysfunctional. As a result, the knockout of either OAT1 or OAT3 is not reflected in a change in the excretion of organic anionic substrates. To date, only the mOAT1 and mOAT3 individual knockout mouse models have been available. Methods: In this study, we successfully generated aSlc22a6/Slc22a8double-knockout (KO) rat model using CRISPR/Cas9 technology and evaluated its biological properties. Results: The double-knockout rat model did not expressionmRNAfor rOAT1 or rOAT3 in the kidneys. Consistently, the renal excretion ofp-aminohippuric acid (PAH), the classical substrate of OAT1/OAT3, was substantially decreased in theSlc22a6/Slc22a8double-knockout rats. The relativemRNAlevel ofSlco4c1was up-regulated in KO rats. No renal pathological phenotype was evident. The renal elimination of the organic anionic drug furosemide was nearly abolished in theSlc22a6/Slc22a8knockout rats, but elimination of the organic cationic drug metformin was hardly affected. Conclusions: These results demonstrate that this rat model is a useful tool for investigating the functions of OAT1/OAT3 in metabolic diseases, drug metabolism and pharmacokinetics, and OATs-mediated drug interactions.Keywords:OAT1/OAT3;CRISPR/Cas9;gene knockout;pharmacokinetic
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Materials Today Energy
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2022
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IF 9.257
Can Luo,Ruyun Qiu,Gen Li,Xiaojun Shi,Zhifei Mao,Rui Wang,Jun Jin,Beibei He,Yansheng Gong,Huanwen Wang
Sodium-ion hybrid capacitors (SIHCs) are promising technology for energy storage because they combine the merits of high-energy batteries and high-power capacitors as well as naturally abundant sodium resource. However, conventional SIHCs consume a mass of electrolyte during the charge process, thus generating some side reactions at high potentials. In this work, we report a novel rocking-chair SIHC using Na 3 V 2 (PO 4 ) 3 /carbon composite nanofibers (denoted as “NVP@CNF”) as binder-free cathodes and SiO 2 -templated hollow carbon nanofibers (HCNF) as the capacitive anode. Resulting from the unique carbon-encapsulation configuration, the NVP@CNF cathode demonstrates excellent rate capability (105.8 mAh/g at 0.5C; 66.9 mAh/g at 100C) and long-term cycling stability (98% capacity retention after 2000 cycles) in sodium half-cells. The as-fabricated HCNF||NVP@CNF SIHC device delivers a high energy density of 216.4 Wh/kg at a power density of 381.8 W/kg. Even at an increased power density of 15272.7 W/kg, the energy density is still as high as 123.0 Wh/kg (based on the total mass of active materials in both electrodes). These results provide a new route to design various flexible self-supporting composite fiber electrodes through a simple electrospinning encapsulation strategy, which finally pushes the development of next-generation hybrid energy storage devices.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2022
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IF 6.371
Hongxia Chen,Yutian Yang,Rihuang Nie,Cheng Li,Shuangwu Xu,Mengcheng Zhou,Xinyu Zhang,Hongming Zhou
Na 3 V 2 (PO 4 ) 3 has been widely studied due to its stable three-dimensional transmission channel structure as a cathode electrode of sodium ion batteries , but its micro particle size and low intrinsic electronic conductivity limit its further development. Therefore, hierarchical porous micro-nano NVP/C materials were successfully prepared using a metal-organic frameworks (MOFs) precursor. Because of the unique hierarchical porous micro-nano structure, 3D highly conductive network between surface and particles, and high specific surface area, M-NVP/C exhibits outstanding rate capability (95.0 mAh g −1 at a current density of 10 C) and extraordinary stable cycle life (the capacity decays from 111.2 mAh g −1 to 108.8 mAh g −1 after 500 cycles at 1 C, with a capacity retention rate of 97.8 %). This method provides a promising pathway for the application of MOFs in battery materials and promotes the development of SIBs in large-scale energy storage systems.
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FOOD CHEMISTRY
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2022
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IF 9.231
Shurong Wang,Haohao Wang,Shuqin Liu,Hongyuan Guo,Junlong Meng,Mingchang Chang,Suozhu Wu
A novel electrochemical method for detecting fluoride was developed based on gold electrode modified by layer-by-layer (LBL) assembly of poly(3-aminophenylboronic acid)-reduced graphene oxide (PAPBA-RGO) multilayers. The PAPBA-RGO multilayer-modified gold electrode was constructed by using alternating LBL assembly of RGO and PAPBA on a bare gold electrode by one-step electrodeposition. Fluoride was electrochemically determined based on the proposed modified electrode by evaluating the changes in peak current for potassium ferricyanide reduction caused by the conjunction of fluoride and boronic acid groups of PAPBA. The results indicated that the peak current for potassium ferricyanide reduction obviously decreased with the increasing fluoride concentration. The response range of our method for fluoride was 1 × 10 –8 to 1 × 10 –1 M with a detection limit of 6 × 10 –10 M and high sensitivity and selectivity. This method was applied to detect fluoride in tap water, rice, apple, and edible fungi samples.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2022
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IF 6.371
Xiaohui Wu,Qin Zhang,Fangyi Huang,Xingyu Huo,Fuyu Li,Yulan Jing,Yuanxun Li,Hua Su
In this work, a new low loss Ba 3 Ti 4- x (Mn 1/3 Nb 2/3 ) x Nb 4 O 21 (MN-BTN, 0 ≤ x ≤ 12 mol%) ceramics configuration was presented through preparing by the solid-state route. The XRD patterns, Rietveld refinement , microstructure, and microwave properties were systematically analyzed. All the fabricated MN-BTN ceramics belonged to the hexagonal structure with a P 6 3 / mcm space group. More specifically, the 6MN-BTN ceramic exhibited a high relative density of ~92.3 %, homogeneous grains distribution with an average size of ~71.95 µm, and several excellent microwave dielectric properties : ε r = 59.67, Q× f = 16,226 GHz, τ f = +103.9 ppm/℃ sintered at 1220 ℃. The incorporation of 1.5 wt % BaCu(B 2 O 5 ) (BCB) compound within the 6MN-BTN ceramic not only effectively reduced the sintering temperature from 1220 ℃ to 950 ℃, but also the excellent microwave dielectric properties were maintained: ε r = 42.33, Q× f = 11,300 GHz, τ f = +24.7 ppm/℃. Interestingly, the 6MN-BTN + 1.5 wt % BCB ceramic showed better chemical compatibility with Ag. The proposed 6MN-BTN + 1.5 wt % BCB ceramic configuration could be regarded as a promising material for LTCC applications.
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Journal of CO2 Utilization
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2022
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IF 8.321
Nicui Yuan,Yuxin Mei,Yuwei Liu,Yating Xie,Baining Lin,Yonghua Zhou
The development of efficient and highly selective photocatalysts is a key point for the photocatalytic conversion of CO 2 . In this paper, a composite catalyst UiO-66-NH 2 /Ce(HCOO) 3 (simplified to UNH/Ce(HCOO) 3 ) was fabricated by one pot method with CeCO 3 OH as the precursor. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) characterizations results confirmed that UNH was dispersed on the surface of Ce(HCOO) 3 and strongly interacted with it via Ce-N bond. The yield of CH 4 on the optimal UNH/Ce(HCOO) 3 catalyst reached 3 times of that on pristine UNH, up to 128.81 μmol g −1 , with the CH 4 selectivity of 71.9 %, and the R electron reached 286.46 μmol g −1 h −1 . The UV–vis diffuse reflection spectra and photoelectrochemical tests results confirmed that the improved photocatalytic CO 2 reduction performance and high CH 4 selectivity could be attributed to the formation of the type-Ⅱheterojunction of UNH/Ce(HCOO) 3 with abundant Ce 3+ , which expanded the visible light absorption range, accelerated the separation and transfer rates of photogenerated charges, and thus efficiently promoted the multi-electron reduction reaction of CO 2 to CH 4 . In addition, the reaction temperature affected profoundly the cycle performance of the catalyst. The results presented here illustrated the possibility for improving the stability of UNH/Ce(HCOO) 3 -1.80 by decreasing reaction temperature.
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