NEW JOURNAL OF CHEMISTRY
·
2014
·Vol. 38
·期 8
·3673-3677
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IF 3.159
Xi Juan Zhao,Cheng Zhi Huang
A one step synthesis of water-soluble luminescent copper nanoclusters (CuNCs) reduced and protected by histidine is reported. When excited at 350 nm, the as-synthesized CuNCs exhibit luminescence centered at 456 nm with a quantum yield of 1.6%, which is different from that of histidine alone under the same experimental conditions. Upon addition of guanosine 5′-triphosphate (GTP), the emission of CuNCs is gradually quenched. While other nucleoside triphosphates including ATP, CTP and UTP as well as some inorganic anions such as P2O74−, PO43−, and CH3COO− have no such quenching effect, which indicates that the nucleobase instead of the phosphate anion plays an important role in the emission quenching of CuNCs. The most efficient quenching of the CuNCs induced by GTP can be ascribed to the most reducing ability of guanine among the other nucleobases. This interesting experimental result demonstrates that the as-synthesized CuNCs can be applied to sensing of GTP.
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CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2016
·Vol. 44
·期 8
·1286-1290
·
IF 0.566
Li-Hua DENG,Jin-Bo DAI,Zhen-Lin XU,Jin-Yi YANG,Hong WANG,Zhi-Li XIAO,Hong-Tao LEI,Yuan-Ming SUN,Yu-Dong SHEN
To detect furaltadone metabolite 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ) in fish sample, a Eu 3+ labeling time-resolved fluoroimmunoassay (TRFIA) was developed. The experimental conditions were optimized as follows: the AMOZA-OVA concentration was 0.25 μg mL −1 ; the antibody was diluted by 50000 folds, and the competitive reaction time was 50 min. Under the optimal conditions, the method showed a detection limit of 0.01 ng mL −1 , an IC 50 of 0.26 ng mL −1 and a linear range (IC 20 −IC 80 ) of 0.025−2.83 ng mL −1 . The spiked recoveries of AMOZ in fish at three spiked levels ranged from 78.0% to 86.0%, and the relative standard deviations were less than 15%. Good correlation between ic-TRFIA and high performance liquid chromatography-tandem mass spectrometry was obtained for spiked food samples. The proposed ic-TRFIA method was suitable for the determination of AMOZ residue in food samples.
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Research
·
2021
·
IF 0
Zhuanghe Ren,Xin Zhang,Hai-Wen Li,Zhenguo Huang,Jianjiang Hu,Mingxia Gao,Hongge Pan,Yongfeng Liu
Sodium alanate (NaAlH 4 ) with 5.6 wt% of hydrogen capacity suffers seriously from the sluggish kinetics for reversible hydrogen storage. Ti-based dopants such as TiCl 4 , TiCl 3 , TiF 3 , and TiO 2 are prominent in enhancing the dehydrogenation kinetics and hence reducing the operation temperature. The tradeoff, however, is a considerable decrease of the reversible hydrogen capacity, which largely lowers the practical value of NaAlH 4 . Here, we successfully synthesized a new Ti-dopant, i.e., TiH 2 as nanoplates with ~50 nm in lateral size and ~15 nm in thickness by an ultrasound-driven metathesis reaction between TiCl 4 and LiH in THF with graphene as supports (denoted as NP-TiH 2 @G). Doping of 7 wt% NP-TiH 2 @G enables a full dehydrogenation of NaAlH 4 at 80°C and rehydrogenation at 30°C under 100 atm H 2 with a reversible hydrogen capacity of 5 wt%, superior to all literature results reported so far. This indicates that nanostructured TiH 2 is much more effective than Ti-dopants in improving the hydrogen storage performance of NaAlH 4 . Our finding not only pushes the practical application of NaAlH 4 forward greatly but also opens up new opportunities to tailor the kinetics with the minimal capacity loss.
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JOURNAL OF LIPOSOME RESEARCH
·
2025
·
IF 4.3
Han Chen,Jin Su,Wenhui Cheng,Linwen Wen,Meiqi Huang,Xuejiao Li,Wei Cai,Qian Ning,Liangjun Guan
5-Fluorouracil (5-Fu) is a chemotherapy drug that can treat various cancers. However, its short plasma half-life and severe adverse reactions limit its wide application in clinical utility. To overcome these drawbacks, in this study, 5-Fu long-circulating liposomes (SSL-5-Fu Lip) were prepared by the film hydration method. DSPE-PEG2000-FA was conjugated to the surface of SSL-5-Fu Lip through amidation reaction, resulting in the successful preparation of FA-SSL-5-Fu Lip. The particle size and zeta potential were measured. The encapsulation efficiency of 5-Fu was determined by high-performance liquid chromatography (HPLC), and the drug loading was calculated. The stability of FA-SSL-5-Fu Lip was evaluated at 4 °C based on particle size and PDI. Pharmacokinetic studies were conducted in male Sprague-Dawley (SD) rats. The average particle size of the liposomes was 139.11 ± 3.1 nm, and the zeta potential was −4.30 ± 0.91 mV. The encapsulation efficiency and drug loading of 5-Fu were 76.88 ± 4.23% and 24.14 ± 0.97%, respectively. The half-lives of 5-Fu and FA-SSL-5-Fu Lip were 0.319 h and 1.059 h, respectively. It can be preliminarily proved that FA-SSL-5-Fu Lip has the effect of prolonging circulation time. Compared with free 5-Fu, it prolongs the circulation time of the drug in the body, laying a foundation for its clinical application.
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CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Jiaqi Li,Dongfeng He,Ruize Zhang,Binbin Tan,Jiang Wang,Jing Wang,Junrong Chen,Hui Wang,Wenlei Wang
5-Hydroxymethylfurfural (HMF) serves as a key platform molecule for green photocatalytic oxidation to produce high-value-added chemicals. Addressing the critical need for efficient photocatalytic conversion of HMF to 2,5-furan dicarboxylic acid (FDCA) under mild conditions, this study proposes and constructs a synergistic ternary composite photocatalytic system. By incorporating porous organic polymers (POPs) into oxygen-vacancy-rich MnO 2-x /Cu 2 O, the MnO 2-x @POPs@Cu 2 O composite photocatalyst was synthesized. This composite catalyst demonstrated remarkable photocatalytic performance under ambient conditions, achieving 71.8% conversion of HMF and 18.5% yield of FDCA. Results indicate that POPs not only selectively enrich reactants by forming dynamic imine bonds with HMF via its surface (–NH 2 ) functional groups, but also significantly enhance interfacial charge separation and transport through a locally embedded electric field generated by its highly negatively charged triazine framework, thereby accelerating the Mn-Cu bimetallic redox cycle. Furthermore, electron paramagnetic resonance (EPR) and density functional theory (DFT) calculations confirmed that introducing POPs effectively reduces O 2 adsorption energy, promotes molecular oxygen activation, and enhances reactive oxygen species generation. This study provides a novel strategy for designing low-cost, high-efficiency multicomponent photocatalysts for biomass refining.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Yinze Yang,Pengxiao Wei,Yan Du,Shiyu Huang,Dongyang Li,Haiyang Cheng,Fengyu Zhao
The sustainable synthesis of primary amines from renewable biomass is a key goal of green chemistry. Reductive amination of furfural (FAL), a representative biomass platform molecule, provides a direct route to furfurylamine (FAM), yet noble-metal catalysts remain dominant in this field, limiting large-scale application due to high cost and scarcity. Herein, we report non-noble Ni/HZSM-5 catalysts with tunable SiO 2 /Al 2 O 3 ratios that achieve up to 99% yield of FAM with a high generation rate (10.8 mmol FAM mmol Ni −1 h −1 ) under mild conditions (90 °C, 1 MPa H 2 , 0.8 MPa NH 3 ). Mechanistic studies reveal that the synergistic interface between metallic Ni and Brønsted acid sites facilitates hydrogen activation and spillover, enhances imine adsorption, and stabilizes gem- diamine and is beneficial for its ammonolysis. The catalyst also demonstrates excellent recyclability and broad substrate scope, affording >90% yields of primary amines for the reductive amination of the various aldehydes and ketones. This work provides mechanistic insights into Brønsted acid–metal synergy and establishes a sustainable, cost-effective strategy for the green synthesis of primary amines.
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TALANTA
·
2026
·
IF 6.1
Mengjun Wang,Fanjie Xue,Miao Chen,Zheng Liu,Yi He
Herein, a colorimetric/fluorescence dual-mode sensor was developed for ultrasensitive detection of glyphosate, utilizing a Cu-based quasi-metal-organic framework NENU-5 (QN-5) and green-emissive carbon dots (GCDs). QN-5 mimics laccase activity by catalyzing the conversion of oxygen (O 2 ) into superoxide radical (·O 2 − ), which then oxidizes the phenolic substrate 2,4-dichlorophenol (2,4-DP) in the presence of 4-aminoantipyrine (4-AP) to generate a distinct red quinone imine (λ Abs = 510 nm, QI). The generated QI quenches the fluorescence of GCDs via the inner filter effect. However, the strong complexation between glyphosate and Cu 2+ inhibits the catalytic activity of QN-5, thereby reversing the colorimetric and fluorescence signals. The developed dual-mode sensor exhibits excellent sensitivity, achieving detection limits of 11 nM in fluorescence mode and 17 nM in colorimetric mode, with recoveries ranging from 92.50 % to 102.85 %. This sensor also exhibits satisfactory selectivity and anti-interference in real samples of soybean, soil, and river water.
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APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Yan Zhao,Yang Gao
The microstructure of plasma-sprayed nanostructured yttria-stabilized zirconia (YSZ) coatings may change during high-temperature exposure, which would influence the coating performance and service lifetime. In this study, the phase structure and the microstructural evolution of 3YSZ (zirconia-3 mol% yttria) and 5YSZ (zirconia-5 mol% yttria) nanostructured coatings were investigated by means of sintering at 1400 °C for 50–100 h. The microhardness, elastic moduli, and thermal shock cycles of the 3YSZ and 5YSZ nanostructured coatings were also investigated. The results showed that the redistribution of yttrium ions at 1400 °C caused the continuous increase of monoclinic-phase zirconia, but no obvious inter-splat cracking formed at the cross-sections, even after 100 h. Large voids appeared around the nanoporous zone because of the sintering of nanoscale granules upon high-temperature exposure. The microhardness and elastic moduli of the nanostructured coatings first increased and then decreased with increasing sintering times. The growth rate of the nanograins in the 3YSZ coating was lower than that in 5YSZ, which slowed the changes in 3YSZ coating porosity during sintering. Although the 3YSZ coating was prone to monoclinic phase transition, the experimental results showed that the thermal shock resistance of the 3YSZ coating was better than that of the 5YSZ coating.
研究领域:
材料科学
·
表面工程
·
陶瓷涂层
·
热障涂层
·
高温材料
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Mengyu Wang,Shuhan Zhang,Chaoyue Meng,Fenglei Han
To enhance the conversion efficiency and product selectivity in CO2 hydrogenation to methanol, we prepared a series of Cu–Fe bimetallic catalysts with varied Cu/Fe ratios supported on HZSM-5 by an initial impregnation method and evaluated them in a dielectric barrier discharge (DBD) nonthermal plasma reactor. Among these, the Cu7Fe3/HZSM-5 catalyst achieved a CO2 conversion of 12.1% and a methanol selectivity of 9.6% in plasma-assisted CO2 hydrogenation, with activity decay below 3% over 400 min of continuous operation. The catalyst structure and surface properties were systematically investigated by SEM, XRD, BET, XPS, H2-TPR, CO2-TPD and CO-TPD. Catalytic performance was assessed under optimized plasma reaction conditions (CO2/H2 = 1:3, total flow 70 mL·min–1, discharge power 20 W, circulating water temperature 30 °C). Furthermore, in situ DRIFTS indicated an oxygen vacancy-dominated formate pathway: oxygen vacancies in FeOx strengthened CO2 chemisorption and induced polarization of the C═O bond; Cu+ sites facilitated sequential hydrogenation of formate intermediates (HCOO*); and the Cu0-HZSM-5 interface optimized H* spillover, collectively suppressing CH4 formation. These results underscore that vacancy engineering and metal–zeolite interfacial effects are pivotal in steering plasma-catalytic CO2-to-methanol selectivity.
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PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
·
2024
·
IF 1.4
Wenhe Yu,Xiaowen Wu,Dingyi Zhang,Ruiyu Mi,Minghao Fang,Xin Min,Zhaohui Huang
In this work, single-phase ZSM-5 zeolite was synthesized using solid waste coal fly ash (CFA) as raw material, providing a potential alternative for creating high-value-added products from this waste. X-ray diffraction (XRD), scanning electron microscopy, X-ray fluorescence, Fourier transform infrared spectroscopy, N2 physisorption, and other techniques were used to evaluate the crystallization and morphology of the ZSM-5 obtained. The results indicated that ZSM-5 can be synthesized by the simple method of mixing, stirring, and heating. A well-defined hexagonal shape of ZSM-5 with a specific surface area of 162 m2/g and mesoporous structure was obtained at the temperature of 160 °C during hydrothermal treatment for 72 h. Theoretically, the mechanism of crystal growth of ZSM-5, i.e. the liquid phase nucleation and step growth models, was clarified. These results open the possibility of exploring the crystallization of ZSM-5 and the utilization of CFA. Simultaneously, the critical roles of silicon in framework formation and crystallization control during the formation and growth of zeolites were elucidated.
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LANGMUIR
·
2026
·
IF 4.4
Siyao Zhang,Si Liu,Linling Yu,Yan Sun
Aminotransferases (ATAs), essential enzymes for the synthesis of chiral amine drugs, play a crucial role in the synthesis of sitagliptin. The catalytic process of ATAs relies on the effective synergistic action of the cofactor pyridoxal 5′-phosphate (PLP). However, practical applications face challenges such as the poor stability of ATAs and the inefficient recovery of the expensive cofactor PLP. To address these issues, this study proposes a high-efficiency and stable catalytic nanoreactor, ATA&PLP@PAH-BioHOF-1, fabricated by polyelectrolyte poly(allylamine hydrochloride) (PAH)-mediated coencapsulation of both ATA and PLP in a hydrogen-bonded organic framework, BioHOF-1, for the synthesis of sitagliptin. This immobilization system overcomes the limitations of traditional single immobilization methods that were unable to simultaneously maintain enzyme activity and sustainably reuse the cofactor. The system exhibits excellent loading capacity and catalytic performance, achieving a sitagliptin yield of over 95% within 4 h. Additionally, the system demonstrates outstanding stability, retaining 78.3% of its initial sitagliptin yield (95%) after 18 consecutive catalytic cycles (4 h each), with a total PLP turnover number of 175. This study has thus provided an efficient nanoreactor system for the sustainable production of sitagliptin with in situ PLP recycling.
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ACS Catalysis
·
2026
·Vol. 16
·期 15
·14434-14449
·
IF 13.6
He Tianli,Chen Haoxi,Li Senyuan,Jin Yanshuo,Yu Xiang,Huang Wenyu,Xie Fangyan,Chen Jian,Pan Dingjie,Wang Nan,Meng Hui,Chen Shaowei
Oxidation of 5-hydroxymethylfurfural (HMF) has been proposed as a promising alternative to the oxygen evolution reaction to enhance hydrogen production in alkaline media. However, the mechanistic understanding of the HMF oxidation reaction (HMFOR) has remained limited. In this study, CoSe 2 -Cu 2−x Se heterostructure composites are synthesized via a two-step hydrothermal method using cobalt(II) acetate, cupric acetate, and selenium powders as the starting materials, and the sample with a 0.4 mmol initial feed of cupric acetate stands out as the best HMFOR catalyst among the series, achieving a current density of 10 mA cm −2 at a potential of +1.265 V vs RHE and a 97% Faradaic efficiency for the production of 2,5-furandicarboxylic acid at +1.5 V vs RHE. The catalytic activity is attributed to the lattice oxygen within the amorphous hydroxyl oxide layer formed via surface reconstruction of the catalyst, which can directly and indirectly participate in HMFOR during the indirect oxidation of CoOOH/CoO 2 . Such a lattice oxygen-mediated indirect oxidation mechanism of CoOOH/CoO 2 is supported by in situ spectroscopic characterizations, 18 O-isotope labeling experiments, and density functional theory calculations. The findings of this work provide new insights into the electro-oxidation of small organic molecules, an important process for advancing electrochemical energy technologies.
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