JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2026
·Vol. 34
·期 8
·189
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IF 5.6
Zhang Chen,Meng Kesheng,Liu Wen,Jin Chenlu,Wang Mengying,Meng Jingyu
Marine biofouling poses a significant challenge to marine facilities, increasing ship weight and fuel consumption. Developing efficient and environmentally friendly non-toxic antifouling materials is a current research hotspot to replace traditional toxic coatings. A polyethylene glycol-dimethyldiohexosilane-polymethyl trifluoropropyl siloxane (PEG-DMDES-PMTFPS) polymer was first prepared using a hydrolysis-condensation method. Subsequently, an antifouling coating (PDP) was prepared by physically blending the resulting polymer with polydimethylsiloxane (PDMS). The chemical structure, surface and cross-sectional morphology, mechanical properties, and antifouling performance were comprehensively characterized. The results indicated that PDP was uniformly distributed within the coating, significantly enhancing hydrophobicity with a maximum water contact angle of 105.25°. The coating exhibited optimal antifouling performance at a PDP content of 20 wt%, where the bacterial attachment rate dropped to 1.23%, and the chlorophyll-a content of diatoms was as low as 0.005 mg/L. Mechanistic analysis revealed that the synergistic effect of the hydration layer formed by PEG segments and the low surface energy of fluorinated segments effectively prevented initial microbial adhesion.
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JOURNAL OF MATERIALS SCIENCE
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2026
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IF 4.4
Chen Jiaqi,Gu Hanliu,Wang Ziqi,Ou Mingjun,Luo Wei,Su Yihong,Su Yangxue,Wong Tuck-Whye,Liu Xiaoying,Zheng Yaxin,Wang Li
In breast cancer therapy, the risk of local recurrence and distant metastasis caused by residual tumor cells during this process hinders the clinical application development of this technique. In this study, a drug-loaded multifunctional polyurethane system supporting minimally invasive surgical implantation is introduced, which enables sustained local release of the anticancer drug docetaxel (DTX). The material system employs in situ polymerization and gas foaming techniques from poly(ԑ-caprolactone) diol and polytetramethylene ether glycol, surface modified with polydopamine, and subsequently covalently immobilizes DTX-loaded liposomes onto the modified surface of the porous scaffolds. The resulting scaffold exhibits high porosity as an extracellular matrix and provides good mechanical support, demonstrating excellent shape-memory capability at 37 °C. In vitro monitoring revealed sustained drug release capability from the drug-loaded scaffold, while cellular experiments confirmed its outstanding antitumor activity and fibroblast adhesion behavior. Additionally, in vivo animal experiments show that the drug-loaded scaffold significantly inhibits tumor recurrence and distant metastasis while exhibiting low chemotherapy drug toxicity and causing no damage to healthy tissues. Therefore, this drug-loaded shape-changeable polyurethane scaffold emerges as a novel candidate for post-mastectomy prognosis in breast tumors and effective cancer treatment.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 19
·1481
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IF 3.2
Zhang Xiaomin,Qin Mingjun,Tang Weilei,Pang Juan,Lyu Yue,Chen Cheng
Conductive adhesives (ECAs) are critical for advanced electronic packaging, but the high cost of silver fillers limits their widespread application. This study presents a hybrid filler strategy combining silver-coated copper (Ag@Cu) nanoparticles with a low content of silver flakes to achieve high electrical conductivity at reduced cost. The Ag@Cu particles were synthesized via a two-step wet chemical reduction method, yielding a well-defined core–shell structure with a dense silver coating that prevents copper oxidation. A series of ECAs were prepared with silver flakes and Ag@Cu nanoparticles at a fixed total filler loading of 70%. The results demonstrate that the optimal silver flake content is 4%, at which the ECA exhibits the lowest volume resistivity of 3 × 10⁻ 4 Ω·cm. The prominent conductivity improvement stems from synergistic geometric regulation. Low loading silver flakes serve as conductive bridges to fill interparticle gaps and construct hybrid point-to-face contact, verified by SEM. The silver flake composite retains favorable shear strength and thixotropy for screen printing. A circuit test with printed films lit an LED, validating its feasibility for flexible circuits. This work develops low cost, high-performance ECAs using Ag@Cu nanoparticles and silver flakes, achieving a balance between excellent conductivity and reduced material cost.
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Nature Communications
·
2026
·
IF 18.1
Chen Yini,Ke Jingwen,Ye Wenbin,Zhou Yuxuan,Song Lei,Hu Weizhao,Geng Zhigang,Hu Yuan
The seawater contains approximately 99% of Earth’s bromide reserves. Therefore, the extraction of bromine from the seawater offers a promising approach to ensure a sustainable supply of bromine. However, the traditional electrochemical extraction method for direct bromine extraction are inapplicable, owing to the low concentration of bromide in seawater (~60 ppm). In this work, we develop an electrolysis-driven styrene enrichment process for efficient bromide recovery from seawater. As for the electrooxidation of bromide, we screen a series of metal phthalocyanines supported on carbon nanotube as the electrocatalysts. Through accelerating the bromine evolution reaction and suppressing the side reaction, nickel phthalocyanine supported on carbon nanotubes exhibit the highest activity with the Faradic efficiency of 97.8% for bromine production among all catalysts. Coupling this catalyst with the ESE process for direct bromine extraction from the Yellow Sea’s seawater, the extraction efficiency of 90.0% is achieved with the product of pure KBr powder. Moreover, the co-produced styrene oxide can be efficiently separated via vacuum distillation, significantly promoting the economic value of this ESE process.
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npj Computational Materials
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2026
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IF 13.1
Chen Le,Li Changlin,Geng Chengzhen,Yu Fengmei,Lu Ai
Predicting the full-range stress–strain behavior of architected elastomers is challenging due to limited data and complex deformation mechanisms. We propose a physics-informed multimodal machine learning framework that embeds domain knowledge at both the data and model levels. At the data level, the Gibson–Ashby law guides targeted augmentation, and energy absorption efficiency segments the curves into distinct stages. At the model level, a multi-branch attention architecture dynamically fuses multimodal inputs and quantifies stage-specific contributions. Our framework achieves high accuracy (R 2 = 0.921), and the learned attention weights reveal a transition in mechanism from structure-dominated collapse to material-dominated densification. This work establishes an interpretable platform for uncovering structure–property relationships and deformation mechanisms in mechanical metamaterials.
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Journal of Coatings Technology and Research
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2026
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IF 3.4
Li Huafeng,Lu Qiuying,Song Weiqiang,Zhang Shuai,Li Wenfeng,Li Junzhuang,Zuo Luoru,Feng Lu,Ji Hanyu,Wang Xiaohui,Wu Liang,Ou Yingjun,Huang Weixin
The influence of intercalated zirconium phosphate (IZP), high-entropy oxide (HEO), ultrafine aluminum oxide (FAO), and their binary hybrid systems on epoxy resin coatings was evaluated through electrochemical, thermal, electrical, and dielectric tests. The results delineated distinct functional profiles for each filler. IZP excelled as an active corrosion inhibitor and high-frequency dielectric stabilizer, FAO provided outstanding long-term barrier protection and electrical insulation, and HEO exhibited a complex role, enhancing thermal stability but impairing corrosion resistance due to its inherent semiconducting. Crucially, significant synergistic and antagonistic effects were identified upon hybridization. The IZP/HEO combination demonstrated a remarkable “catalysis-stabilization” synergy, increasing the char yield to over six times that of neat epoxy. The HEO/FAO hybrid achieved an optimal balance of enhanced thermal stability and superior electrical insulation. Conversely, HEO universally degraded anti-corrosion performance, and an antagonistic effect between IZP and FAO led to increased dielectric loss. This work constructs a clear “filler-structure-property” relationship map, providing scientific strategies for the rational design of next-generation epoxy coatings tailored for specific demanding applications such as electronic packaging, long-term corrosion protection, or high-temperature shielding.
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MOLECULAR AND CELLULAR BIOCHEMISTRY
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2026
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IF 4.7
Jiang Ling,Zhang Xiaolin,Dai Meng,Bi Ying,Han Lingling,Tao Xiaofeng,Wang Qi
Metastasis is the leading cause of death in patients with lung adenocarcinoma (LUAD), highlighting the urgent need to identify novel therapeutic targets. GLIS family zinc finger 1 (GLIS1) is a transcription factor implicated in multiple cancers. However, its role in LUAD remains poorly defined. In this study, we first identified that GLIS1 was significantly upregulated in LUAD tissues. To modulate its expression, lentiviral vectors were constructed to knock down or overexpress GLIS1 in NCI-H1975 and A549 LUAD cell lines, respectively. In vitro gain- and loss-of-function experiments revealed that GLIS1 knockdown significantly inhibited the migratory and invasive capabilities of NCI-H1975 cells. Conversely, GLIS1 overexpression enhanced these malignant phenotypes in A549 cells. In vivo study demonstrated that GLIS1 knockdown substantially reduced liver and lung metastasis of NCI-H1975 cells in mice. Furthermore, we found that downregulation of GLIS1 suppressed LUAD cell migration by inhibiting Homeobox A9 (HOXA9) methylation, which led to the subsequent upregulation of HOXA9 expression. Mechanistically, GLIS1 knockdown transcriptionally suppressed the mRNA level of the DNA methyltransferase DNMT3B, thereby attenuating HOXA9 methylation. Specifically, overexpression of DNMT3B led to DNA hypermethylation and transcriptional suppression of HOXA9, thereby partially rescuing the tumor-suppressive effects resulting from GLIS1 knockdown. Our work is the first to implicate the GLIS1/DNMT3B axis in the epigenetic silencing of HOXA9 in LUAD, highlighting the therapeutic potential of targeting GLIS1.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Zhou Jiangshan,Zhang Shanyuan,Liu Mengfan,Wang Zhonghua,Zhou Zhi
Esophageal squamous cell carcinoma (ESCC) is a highly prevalent malignancy in China. Understanding its metabolic heterogeneity is of great significance for improving the precision of diagnosis and treatment. This study innovatively employed an adult zebrafish xenograft model, combining the spatial metabolomics and in situ derivatization method for fatty acid peroxidation products (FAPPs) based on air flow-assisted desorption electrospray ionization–mass spectrometry imaging (AFADESI-MSI) technology, to elucidate the metabolic patterns associated with ESCC and its differentiation grade. Spatial metabolomic data demonstrated that abundance alterations of glycerophospholipids and acetylated amino acids were statistically correlated with ESCC tumor formation. Levels of lysophospholipids and arachidonic acid-associated metabolites tended to increase with the progressive malignant differentiation of tumor lesions. Profiling of FAPPs showed elevated short- and medium-chain species accompanied by decreased long-chain counterparts in tumor-bearing zebrafish, which may be linked to tumor-initiated alterations in oxidative stress. Specifically, short- and medium-chain FAPPs were enriched in well-differentiated ESCC tissues, while long-chain FAPPs predominated in poorly differentiated tumors, suggestive of disparate lipid peroxidation patterns in ESCC cells at different differentiation stages. Furthermore, distinct signature metabolites were found to be specifically accumulated in the brain providing experimental clues that ESCC may remotely disturb the central nervous system metabolism of host animals. This research uncovers both tumor-induced and differentiation-dependent metabolic heterogeneity of ESCC, and validates whole-body MSI as a transformative approach to unravel tumor-host metabolic interactions. Graphical abstract
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POLYMER BULLETIN
·
2026
·Vol. 83
·期 6
·299
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IF 4.2
Song Kangjia,Liu Jie,Zhang Feifei,Lu Aide,Jin Liqiang,Zhao Zecui,Nian Xinyue,Song Jianan,Zhu Deyi
To mitigate plastic pollution and reduce reliance on fossil fuels, the development of high-performance polymeric coatings from renewable resources to mitigate plastic pollution and reduce reliance on fossil fuels remains a critical challenge. Among them, substituting petroleum-based isocyanates with bio-based 1,5-pentanediisocyanate (PDI) not only significantly reduces the carbon footprint but also provides a key green feedstock for developing high-performance biodegradable polyurethanes. In this study, bio-based poly (lactic acid) polyol (PLA) and PDI were utilized as the raw materials. By incorporating polytetramethylene glycol (PTMEG) into the soft segment of waterborne polyurethane (WPU), a series of PLA/PDI bio-based waterborne polyurethanes (PP-WPU-Ts) were synthesized. The results demonstrate that PP-WPU-3 (n PLA : n PTMEG = 5:5) achieved a high bio-based content of 53.1 wt% along with a balanced combination of mechanical properties, including a tensile strength of 4.02 MPa, an elongation at break of 1118.6%, and a toughness of 26.7 MJ/m 3 . Additionally, PP-WPU-3 exhibited outstanding wear and yellowing resistance, reaching 80,000 abrasion cycles and a grade 1 yellowing resistance (ΔE = 2.8). Most importantly, the material exhibited controllable degradation across various environments: rapid disintegration in alkaline media (65% weight loss in 6 h), efficient biodegradation in soil (54.3% in 120 days), and synergistic mineralization by Bacillus sp. (19.3% in 15 days), offering a promising end-of-life solution. The optimized PP-WPU-3 possesses balanced mechanical properties while also exhibiting excellent yellowing resistance and degradation capabilities. These characteristics validate its potential as an eco-friendly alternative for organic coatings.
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FIBERS AND POLYMERS
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2026
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IF 3.1
Zhu Wenju,Peng Wei,Wang Shuolong,Xu Shuang,Ma Kai,Liu Jiarui,Yang Xiaokang,Chen Jia,Cheng Bowen
In this study, according to the design principle of intumescent flame retardant, rapeseed meal was modified into a phosphorus-nitrogen flame-retardant HPRm by using H 2 O 2 –H 3 PO 4 system, and L9(3 4 ) orthogonal experiment was designed to optimize the modification conditions. Cotton fabric was durably flame-retarded with HPRm via an optimized pad-dry-cure process. With only a 12.74% weight gain, the treated fabric achieved an LOI of 39.4% and a 34 mm damage length in the VFT. In CCT, the PHRR and THR of HPRm cotton decreased significantly. In addition, since HPRm can form multiple covalent bonds with cotton fibers, the LOI of HPRm cotton remained at 35.7% after 50 washing cycles and self-extinguished in VFT. At the same time, the results of TG, TG-IR and char residue analysis confirmed that HPRm changed the pyrolysis pathway of cotton fabric, reduced the production of combustible gas and formed a stable P/N char layer on the surface of cotton fiber, which effectively interrupted the combustion of cotton fabric. HPRm finishing somewhat reduced the fabric’s mechanical properties and softness. This work provides a feasible method for realizing the resource utilization of traditional agricultural by-products and the environmentally friendly and durable flame retardant of cotton fabrics.
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FOOD SCIENCE AND BIOTECHNOLOGY
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2026
·
IF 3.9
Wang Chunjing,Liu Xingyu,Chen Xiumei,Che Jinxin,Tao Nengguo,Pan Fei
Experiments were conducted to evaluate the antifungal activity of chain aldehydes with potent antifungal properties against Penicillium italicum ( P. italicum ) resistant to prochloraz. The results showed that trans,trans -2,4-nonadienal and trans,trans -2,4-octadienal possessed the strong antifungal activity with MIC values of 0.10 μL/mL for both compounds. Density functional theory (DFT) revealed that compounds with highly delocalized electron systems exhibited significantly stronger antifungal potency. Machine learning (ML) techniques were used to build regression models for identifying the influential structure features of aldehydes, and the random forest (RF) model had lower error levels. We can conclude that the DFT coupled with ML is a reliable, fast and inexpensive tool for solving problems related to the structure properties and antifungal activity. The strategy can be extended to find safe and effective novel inhibitors of P. italicum resistant to prochloraz for the development of green inhibitors of postharvest diseases in fruits and vegetables.
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WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2026
·Vol. 42
·期 10
·555
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IF 4.7
Wang Yuhao,Zhou Dongming,Chen Qiong,Wang Changjun,Li Wenhao,Sun Xuewei,Tang Chengliang,Jiang Zhiqiang,Zhang Xuefei,Wang Wenjing,Yang Zhan,Cui Qian
Enterohemorrhagic Escherichia coli O157:H7 (EHEC O157:H7) is a globally significant foodborne pathogen. Infection disrupts the gut microbiota and exacerbates host immune dysfunction. Reuterin, a broad-spectrum antimicrobial metabolite produced by Limosilactobacillus reuteri during glycerol fermentation, exhibits potent antibacterial activity in vitro; however, its in vivo preventive efficacy and underlying mechanisms remain incompletely understood. This study aimed to comprehensively evaluate the protective effects of reuterin prophylaxis and to investigate its potential mechanisms in mitigating EHEC O157:H7 infection through gut microbiota modulation. In a murine infection model, prophylactic administration of reuterin (60 mM) conferred pronounced protection, as evidenced by alleviation of colonic pathology, oxidative stress, and systemic inflammation, together with restoration of intestinal barrier integrity. 16S rRNA sequencing and fecal microbiota transplantation (FMT) demonstrated that reuterin alleviated EHEC O157:H7 infection through gut microbiota remodeling, which was associated with elevated abundances of Ligilactobacillus and Alloprevotella and increased short-chain fatty acids (SCFAs) production. Exogenous SCFAs supplementation was associated with attenuated colonic damage and inflammation, consistent with a potential contribution of these metabolites to the observed protection. Furthermore, our data are compatible with a model wherein SCFAs-mediated activation of the intestinal receptor GPR43 may suppress NF-κB signaling. Collectively, this study provides a foundation for the further development of reuterin as a prophylactic agent against EHEC O157:H7 infection. Graphical abstract Reuterin pretreatment exerted direct antimicrobial effects and was associated with shifts in gut microbial taxonomy and increased SCFAs production. These changes coincided with upregulated GPR43 expression and attenuated NF-κB activation in colonic tissues, correlating with ameliorated oxidative stress and inflammation in EHEC O157:H7-infected mice. While these findings are consistent with a potential role for the SCFAs–GPR43–NF-κB signaling axis in mediating protection, causality regarding specific microbial mediators remains to be established.
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