ACS Nano
·
2025
·
IF 16
Lifeng Liu,Junmei Zhang,Shihao Wang,Zhirong He,Xiaohu Wang,Limin Tian,Mingxi Li,Guangyu Long,Siqi Zhu,Zhengyu Jiang,Suxin Li
Blocking CD47 effectively stimulates macrophage-mediated phagocytosis of tumor cells, which has emerged as a promising therapeutic strategy but suffers from off-target toxicity. Moreover, despite being specialized in engulfing tumor debris, macrophages are inferior antigen-presenting cells (APCs), leading to attenuated adaptive antitumor immune responses. We find that inhibiting the phosphoinositide-3-kinase γ isoform (PI3Kγ) pathway enhances the macrophage’s ability to function as potent APCs. Mechanistically, PI3Kγ inhibition reduces phagolysosomal acidity and prevents fast degradation of engulfed tumor antigens, thereby skewing tumor-associated macrophages (TAMs) toward an immunopermissive lineage and priming cytotoxic T lymphocyte responses. Building on these insights, we developed a sequential pH-responsive nanomedicine termed NanoAPP to upregulate the “Antigen Phagocytosis-Presentation” cascade machinery and unlock the full antitumor potential of TAMs. NanoAPP comprises a hybrid polymeric micelle system allowing on-demand delivery of (1) αCD47 to the mildly acidic tumor microenvironment to block the “don’t eat me” signal, thus favoring phagocytosis of tumor cells, and (2) PI3Kγ inhibitors in response to more acidic intracellular pH to facilitate antigen processing and presentation by macrophages. This dual-targeting strategy lowers the activation threshold for TAMs compared to αCD47 monotherapy and effectively bridges innate and adaptive immune responses. As a result, NanoAPP suppresses tumor growth and improves survival in established and metastatic murine tumor models. The therapeutic effects are abolished in mice lacking CD8+ T cells or macrophages but not type I conventional dendritic cells. The coordinated nanoimmunomodulation of CD47 and PI3Kγ empowers TAMs with an optimized antigen phagocytosis-presentation cascade for safe and effective cancer therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science Advances
·
2025
·Vol. 11
·期 35
·
IF 12.5
Zhiyong Yu,Qing Yao,Wei An,Hangjun Xu,Jiaqi Su,Juan Wang,Ying Zhang,Huile Jin,Yonggang Feng,Xiaoqing Huang
Electrocatalytic CO 2 reduction (ECR) to formic acid faces challenges in separating and purifying a formate-electrolyte mixture. In situ utilization of this mixture presents a promising yet underexplored solution. Here, we report the synthesis of Bi x Pd 1− x Te nanocrystals (NCs) via a microwave-assisted cation topological exchange approach, enabling the precise tuning of surface oxygen affinities to simultaneously optimize the ECR and catalytic transfer hydrogenation (CTH) of phenol. Optimized Bi 0.1 Pd 0.9 Te NCs achieve a 92% formate Faradaic efficiency at −0.9 volts versus reversible hydrogen electrode and a production rate of 860 millimoles per hour per gram of catalyst at 100 milliamperes per square centimeter. This formate-electrolyte mixture serves as an effective hydrogen donor, enabling 98% selectivity toward cyclohexanone in phenol hydrogenation. Mechanistic studies show uniformly dispersed Bi sites create an oxygen affinity gradient, enhancing *OCHO adsorption for formate production and promoting noncoplanar phenol adsorption for selective cyclohexanone formation. This work pioneers synergistic ECR-CTH integration, establishing an innovative CO 2 valorization and biomass upgrading strategy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Meng Zhang,Yuan Liang,Chao Cui,Xiaoyu Zhao,Tong Zhang
Creating mechanically reinforced ceramic aerogels at ambient pressure to improve their reliability in extreme environments remains a significant challenge. Here we demonstrate an ambient-pressure assembly approach to fabricate sandwich-structured ceramic nanofiber aerogels (S-CNFAs), which have superior structural adaptability compared to CNFAs formed with fibrous membranes or crimped nanofibers. Benefiting from a hierarchical architecture design strategy involving ceramic nanofibers with dense dual-phase structures at the microscale, flake-shaped bonding and arched cellular structures at the mesoscale, and a compact-fluffy-compact stacking structure at the macroscale to enhance stress transfer and dissipation, S-CNFAs achieve exceptional compressive and bending resilience, along with a record-high tensile strength of 565 kPa (more than tenfold enhancement) and specific tensile strength of 22.5 kPa cm 3 mg −1 (over 300 % improvement), and demonstrating exceptional resistance to complex mechanical environments (220 N bursting strength at >30 % strain, knotting capability). Simultaneously, the all-ceramic sandwich architecture confers ultralow thermal conductivity (23.8 mW m −1 K −1 , comparable to still air) and unparalleled thermomechanical stability from cryogenic conditions (−196 °C) to ultrahigh temperatures (∼1300 °C). This ambient-pressure assembly paradigm opens scalable routes to high-performance ceramic aerogels.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
·
2025
·
IF 4.7
Aolin Ma,Siqi Liu,Zhixuan Du,Longfei Zhu,Guanping Feng
Sulfonamides, owing to their therapeutic properties and cost-effectiveness, are widely employed in clinical settings and the animal husbandry industry. However, the misuse of these compounds has resulted in severe water pollution, thereby posing significant threats to the growth and development of aquatic plants such as duckweed. Our controlled experiments revealed that sulfonamide exposure disrupts the plasma membrane integrity in duckweed root tip cortex cells and inhibits the root growth. Utilizing ESI-HPLC-MS/MS, we identified that sulfonamide exposure elicits an immune response in duckweed, characterized by the generation of substantial amounts of salicylic acid (SA). The exogenous application of SA exacerbated the sulfonamide-induced growth inhibition, whereas the addition of the SA synthesis inhibitor 1-aminobenzotriazole (ABT) mitigated the stress induced by sulfonamides. A loss-of-function mutant of ICS1, a key enzyme in the SA biosynthesis pathway, exhibited complete insensitivity to sulfonamide exposure. Furthermore, transcription factors SARD1 and CBP60g, which regulate ICS1 gene expression, were induced by sulfonamides, and their double mutant showed insensitivity to sulfonamide exposure. Reactive oxygen species (ROS) detection indicated abnormal accumulation of ROS in duckweed roots under sulfonamide exposure, which is likely to induce SA synthesis. These findings suggest that sulfonamide-mediated growth inhibition in plants is dependent on the ICS1-catalyzed SA biosynthesis pathway, thereby enhancing our understanding of the effects and mechanisms of sulfonamide exposure on aquatic plants.
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2025
·
IF 9.6
Panxianzhi Ni,Dengbinpei Duan,Dan Luo,Mengyi Deng,Meng Zhong,Can Huang,Hongwei He,Jing Shan,Tun Yuan,Jie Liang,Yujiang Fan,Xingdong Zhang
Gastric perforation (GP) is characterized by full-thickness injury of the stomach wall, a severe and potentially life-threatening gastrointestinal disease. However, current treatment, including surgical sutures and endoscopic closure, faces limitations, achieving complete sealing of the perforation and favorable healing remains a great challenge and an acute clinical demand. Here, we report a hydrogel dry powder (PPCL@Mg) for the minimally invasive treatment of GP, which can be delivered to target perforation wounds by spraying via an endoscope, and rapidly absorbing interfacial water and spontaneously forming a hydrogel. This hydrogel was designed with strong adhesion, gastric fluid resistance, good anti-swelling behavior, biocompatibility, anti-oxidation, anti-inflammatory and hemostatic properties, which forms instant, robust and sutureless sealing of GP. In vivo rat GP model results indicated that PPCL@Mg hydrogel effectively sealed the perforation and accelerated healing by promoting cell proliferation and angiogenesis, and regulating inflammation and oxidative stress, and the therapeutic effect surpassed that of surgical suture. Furthermore, the large animal pig GP model further validated the repair efficacy of the PPCL@Mg powder and revealed its superior sealing and repair efficacy compared to titanium clips. Transcriptome sequencing and proteomics analysis further verified the significant therapeutic outcomes and elucidated its mechanism in promoting perforation healing. The proposed PPCL@Mg hydrogel dry powder provides a promising therapeutic approach for GP repair and demonstrates significant clinical translational potential. Statement of Significance As one of the most severe gastrointestinal emergencies, gastric perforation (GP) poses a significant clinical challenge, where reliable perforation sealing and healing are urgently needed. In this work, we introduce PPCL@Mg, a hydrogel dry powder for minimally invasive GP treatment. Delivered endoscopically via spraying, it rapidly absorbs water and spontaneously forms an adhesive hydrogel. Engineered with strong adhesion, gastric-fluid resistance, anti-swelling, biocompatibility, anti-oxidation, anti-inflammatory and hemostatic properties, this hydrogel enables instant, robust, sutureless GP sealing. In vivo rodent and porcine models demonstrated PPCL@Mg hydrogel's efficacy in sealing gastric perforations and accelerating healing. This dry powder system presents a promising strategy for GP repair with significant translational potential.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Dehua Ma,Weiwei Qin,Lin Wang,Benxue Liu,Yongshuai Xie,Guanghui Zhang,Xinqiang Wang,Luyi Zhu,Dong Xu
Ceramic fibers cannot recover from stretching, bending, and compression at high temperatures owing to their inherent brittleness, which severely restricts their practical applications in harsh environments. However, by designing and regulating grain boundary layers, their inherent brittleness can be effectively decreased, endowing them with high toughness and elasticity at high temperatures. Herein, amorphous silica was incorporated into the grain boundary of zirconia nanograins in fibers to successfully prepare chemically bonded zirconia–silicon biphasic fibers (ZSFs) and fibrous membranes (ZSFMs). ZSFMs exhibit excellent tensile strength; excellent resistance to fatigue from buckling, tension, and compression; low thermal conductivity (20.87 mW·m–1·K–1 at −40 °C and 68.53 mW·m–1·K–1 at 1000 °C); and low density (30–50 mg·cm–3). Moreover, ZSFMs exhibit extraordinary thermal insulation performance. The design of flexible, bendable, and high-strength ZSFMs offers a method for using brittle ceramic components in military and civilian applications and many other fields.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Cell Reports Physical Science
·
2025
·
IF 7.3
Weiqiang Wang,Weifeng Zhang,Fengjiao Chu,Tingting Xiao,Dongdong Hu,Pengyi Tang,Jiajia Gao,Honghua Ge
The release of CO 2 has challenged the worldwide environment and led to climate change. An emerging solution is to construct bio-abiotic semiartificial photocatalysis systems for the highly efficient conversion of CO 2 . However, biocompatibility and the narrow product spectrum are challenging these bio-abiotic photocatalysis systems integrating living cells and semiconductors. Living bacterial biofilms can provide a large specific surface area for photosensitizer mineralization, allowing CO 2 fixation, one-carbon product uptake, and further assimilation. Here, we report a living photosensitizer-mineralized biofilm platform with a biocompatible and stable bio-abiotic interface conducting single-enzyme to whole-cell photocatalytic applications. Such engineered photosensitizer-mineralized biofilms not only efficiently implement the regeneration of NADH but also enable the conversion of CO 2 into formate and finally into polyhydroxyalkanoates under light illumination. Thus, this work demonstrates an alternative approach to solar-to-chemical conversion. The proof of concept established in this work might be used for other sustainable photocatalytic applications.
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Shuhan Hui,Yandong Han,Wensheng Yang
This study delves into the impact of the hydrolysis/condensation of 3-mercaptopropyltrimethoxysilane (MPTMS) on the modification of thiol groups on the surface of silica particles. By employing an optimized Stöber method, such as the pH, water content, and quantity of MPTMS in the reaction system, a systematic exploration of the size, shape, and size/shape distribution of the thiol-modified silica particles was carried out. During these investigations, Ellman’s colorimetric method and Raman spectroscopy were utilized to quantitatively analyze the changes in the amount of thiol modification on the surface of silica particles. Furthermore, the synthesized SH-SiO2 particles were employed as adsorption carriers for Au3+ ions, which were then reduced to form SH-SiO2/Au composite particles. Significantly, these prepared SH-SiO2/Au composite particles exhibited remarkable catalytic activity in the reduction reaction of p-nitroaniline.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Jiaqi Zhu,Guoli Zhang,Lu Lin,Tong Qiu,Wenchao Fu,Fengzhi Liu,Baihua Qu,Dianxiao Jiang,Xiaopeng Lu,Yu Song,Xiao-Xia Liu,Xiaoyuan Zhou,Xiaoqi Sun
Rechargeable Mg batteries have gained great interest thanks to the abundant resources and high theoretical capacity of Mg metal anode. However, it suffers from severe passivation and extremely poor plating/stripping kinetics. Herein, a simple salt electrolyte system of Mg(OTf) 2 /MgCl 2 -DME is studied, and the poor Mg affinities on typical metal current collectors are revealed as the key factor for rapid cell failure. Accordingly, an interphase modification on Cu current collector by the in situ generation of a magnesiophilic Cu-thiourea (CuTU) complex is presented. It provides active sites for solvated Mg 2+ as well as Mg. This not only homogenizes Mg 2+ flux but also helps with the release of solvated species to lower the desolvation barrier. The high affinity with Mg further enables the dense and uniform growth of Mg deposits. Thanks to these merits, the facile and reversible plating/stripping of Mg is realized. As a result, the symmetric cells with Mg pre-deposited on CuTU-Cu electrodes stably operate for over 2600 h, which is a 34-fold increase in comparison to the standard Mg foil. Full cells coupling the Mg-CuTU-Cu anode and a PDI-EDA cathode with an N/P ratio of 3 deliver a high capacity of 251 mAh g −1 as well as stable cycling.
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Xinyue Kang,Jiatian Song,Jiuzhou Liu,Siwei Cao,Zhengmeng Lin,Hongyu Jiang,Yiqing Yang,Xiangran Cheng,Yulu Ai,Xuemei Sun,Kaiwen Zeng,Zhengfeng Zhu,Huisheng Peng
Fiber gel dye-sensitized solar cells (FGDSCs) are recognized as an effective solution for high-performance, durable and safe wearable power supply. However, poor and unstable interfaces between fiber electrodes and gel electrolytes are bottleneck problems that have restricted the photovoltaic performances of FGDSCs and their stabilities during deformations. Here, an FGDSC with stable interlaced interfaces is designed by incorporating polymerized gel electrolyte into the aligned channels in fiber electrodes and the gaps between photoanode and counter electrode in situ. The interlaced structure of gel electrolyte in FGDSC improves the interfacial stability and provided stable channels for rapid ion diffusions, offering efficient charge transports at interfaces. The resulting FGDSC thus produced a high power conversion efficiency of 7.95%, and it is further maintained by over 90% after bending for 5000 cycles. These FGDSCs can be integrated with fiber batteries as a self-charging power system, demonstrating an effective power solution for wearables.
✓ 已验证
DOI
高影响因子
Science Robotics
·
2020
·Vol. 5
·期 48
·
IF 18.684
Xiong Yang,Wanfeng Shang,Haojian Lu,Yanting Liu,Liu Yang,Rong Tan,Xinyu Wu,Yajing Shen
Millirobots that can adapt to unstructured environments, operate in confined spaces, and interact with a diverse range of objects would be desirable for exploration and biomedical applications. The continued development of millirobots, however, requires simple and scalable fabrication techniques. Here, we propose a minimalist approach to construct millirobots by coating inanimate objects with a composited agglutinate magnetic spray. Our approach enables a variety of one-dimensional (1D), 2D, or 3D objects to be covered with a thin magnetically drivable film (~100 to 250 micrometers in thickness). The film is thin enough to preserve the original size, morphology, and structure of the objects while providing actuation of up to hundreds of times its own weight. Under the actuation of a magnetic field, our millirobots are able to demonstrate a range of locomotive abilities: crawling, walking, and rolling. Moreover, we can reprogram and disintegrate the magnetic film on our millirobots on demand. We leverage these abilities to demonstrate biomedical applications, including catheter navigation and drug delivery.
✓ 已验证
DOI
高影响因子
POLYMER
·
2025
·
IF 4.5
Hongxi Zhu,Chuanji Ye,Ying Chen,Tianyu Wang,Yiyan Gao,Guanghui Gao
The preparation of water-based, fluorine-free superhydrophobic coatings is of significant importance to the environment. Herein, a series of environmentally friendly products derived from polyethylene wax (PEW) were developed. Initially, polyethylene wax was melt-grafted with itaconic acid (IA) monomers; the resulting grafted product was then used as the oil phase to prepare a water-based emulsion through high-pressure emulsification. Subsequently, alkyl siloxane and hydrophilic nano-silica were incorporated into the emulsion. The interaction between alkyl siloxane and emulsion particles forms an effective bridge connecting organic and inorganic components, while the nano-silica was hydrophobically modified via a coupling reaction. Finally, the mixture was applied to various substrates using a four-sided coating device. Experimental results demonstrate that the composite coating exhibits excellent superhydrophobicity, corrosion resistance, and UV resistance. These results provide new insights for the novel application of polyethylene wax and the development of environmentally friendly superhydrophobic coatings.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）