BIOSENSORS & BIOELECTRONICS
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2026
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IF 11.8
Tiantian Li,Ziwei Chen,Qi Li,Wenqi Tang,Mei Shen,Dongmei Li,Jiayue Zhou,Yinuo Chen,Guanggui Yu,Na Sai
The integration of multiple optical signals with independent responses within a single sensing architecture is of interest for multiplex small-molecule detection. An anole-inspired multi-colored colloidal array (MCA) probe integrating structural reflection (SR), fluorescein isothiocyanate (FITC), and europium acetylacetonate (EU) emissions was developed for simultaneous visual detection of bisphenol B (BPB) and levofloxacin (LVX). The probe consists of a highly ordered non-close-packed (NCP) colloidal array assembled from FITC- and EU-doped molecularly imprinted particles, enabling the coexistence of structural color and dual-emission luminescence within a single architecture. The periodic array generates an additional SR signal via Bragg diffraction, while the enlarged interparticle spacing suppresses aggregation-induced quenching and non-radiative losses, resulting in enhanced FITC and EU emissions. Upon exposure to BPB and LVX, orthogonal optical responses are triggered, producing concentration-dependent multicolor variations that are directly observable by the naked eye, enabling dual-target discrimination. To quantitatively decode these physico-optical responses, a logic-guided physico-optical decoding (LGPD) framework is employed, enabling simultaneous prediction of BPB and LVX concentrations with high correlation coefficients (range from 0.964 to 0.994). The probe exhibits stable tri-color emission over 20 days, with sensitivity low to 1 ng/mL, a linear range of 1-300 ng/mL, and recoveries of 85.4 %-98.61 % in real samples. This multimodal optical encoding and machine-learning-based decoding strategy enables rapid (<30 min) multiplexed detection and provides a generalizable platform for point-of-care analysis in environmental and biomedical applications. This bioinspired integration of optical encoding and machine-learning-assisted decoding provides an alternative strategy for visual and quantitative multiplex sensing.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Tianlong Zhao,Zixin Rong,Demei Wang,Shiyu Liu,Zimei Chen,Yicheng Cai,Tingming Fu
Silybin is a clinically validated adjunct for liver disorders, yet poor absorption and rapid metabolism curtail its wider therapeutic use. Exploiting the distinctive hepatic distribution of glycyrrhetinic acid (GA) receptors, we augmented silybin B (SilB, an isomer of silybin) delivery by encapsulating it within GA-modified liposomes. We constructed a response-surface model to optimize liposome fabrication, identifying the optimal recipe: 5.89:1 lecithin/cholesterol, 100:2.13 lecithin/DSPE-PEG2000, and 12:5.05 lecithin/SilB. DSPE-PEG2000-GA was generated through amidation and substituted for DSPE-PEG2000 to yield GA-modified SilB liposomes (GSL). GSL exhibited 49.34 ± 0.25% encapsulation efficiency, 9.13 ± 0.04% drug loading, 148.881 ± 4.786 nm diameter, 0.269 ± 0.024 polydispersity index, and −23.433 ± 0.775 mV zeta potential. GSL remained stable for 7 days and sustained drug release for 24 h in PBS. GA-modified liposomes displayed accelerated HepG2 uptake and heightened murine hepatic retention, underpinning its superior therapeutic performance. GSL engaged non-alcoholic fatty liver disease on multiple aspects, suppressing lipid accretion, inflammation, and insulin resistance, and significantly surpassed free SilB in therapeutic magnitude. Download: Download high-res image (305KB) Download: Download full-size image
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CHINESE JOURNAL OF CATALYSIS
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2026
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IF 17.2
Fengjuan Guo,Chunyao Ma,Yue Huang,Sitong Hang,Junwei Ma,Hongtao Gao
Electrocatalytic nitrogen reduction reaction (NRR) under ambient conditions offers a sustainable alternative to the energy-intensive Haber-Bosch process. However, the two canonical catalytic pathways face intrinsic limitations: the alternating mechanism suffers from high *NH 2 NH 2 desorption losses, while the distal pathway requires prohibitive activation energy for N 2 protonation. The simultaneous realization of high activity and selectivity thus remains a critical challenge. Here, we demonstrate that boron doping modulates the electronic structure of Mo 2 TiC 2 T x /MoO 2 by upshifting the d -/ p -band center toward the Fermi level, unveiling the dominant a hybrid “distal-alternating” pathway that favors the *NNHH → *NHNH 2 transition rather than the *NNHH → *N cleavage. In addition, the electron-deficient B sites weaken the binding affinity toward Lewis-acidic protons under acidic conditions, thereby effectively suppressing the competing hydrogen evolution reaction. Significant interfacial charge transfer from MoO 2 to the B@Mo 2 TiC 2 T x surface further ensures a sufficient electron supply for N 2 activation and stepwise hydrogenation. As a result, B@Mo 2 TiC 2 T x /MoO 2 delivers an impressive ammonia yield of 121.18 μg h −1 mg cat. −1 with a Faradaic efficiency of 75.94% at a mild potential of –0.2 V vs . RHE. This work unveils the mechanistic feasibility of a non-classical hybrid NRR pathway and establishes a rational strategy for designing next-generation high-efficiency nitrogen reduction electrocatalysts.
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Journal of Inorganic and Organometallic Polymers and Materials
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2025
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IF 4.9
Hou Chengmin,Ren Chuangchuang,Bai Yuan
Industrial pigment wastewater poses a serious threat to ecosystems and human health. This study aimed to develop efficient and recyclable adsorbents for the treatment of such wastewater. Initially, a magnetic carrier, W@Fe 3 O 4 , was synthesized by loading Fe 3 O 4 onto wood fibers (W) via co-precipitation. Subsequently, three types of acrylic-modified magnetic wood fiber adsorbents (W@Fe 3 O 4 -g-pGMA, W@Fe 3 O 4 -g-pAA, W@Fe 3 O 4 - g -pHEMA) were fabricated by grafting poly(glycidyl methacrylate) (pGMA), poly(acrylic acid) (pAA), and poly(2-hydroxyethyl methacrylate) (pHEMA), respectively, onto the W@Fe 3 O 4 surface through surface-initiated polymerization. The successful preparation of the materials was confirmed by FTIR, TG, and SEM. Adsorption experiments demonstrated a significant enhancement in the adsorption performance of all three modified materials for Methylene Blue (MB) and Rhodamine B (Rh B). The optimal adsorption conditions were identified as follows: adsorbent dosage of 10 mg, initial MB concentration of 20 mg/L, initial Rh B concentration of 30 mg/L, pH 7, and temperature of 35 °C. Under these optimal conditions, the removal efficiency of MB by W@Fe 3 O 4 - g -pGMA reached 83.47%, with an adsorption capacity of 16.15 mg g −1 , while the removal efficiency of Rh B by W@Fe 3 O 4 - g -pAA reached 90.08%, with an adsorption capacity of 17.95 mg g −1 . The adsorption kinetics were best described by the pseudo-second-order model. Isotherm analysis indicated that the adsorption of MB onto W@Fe 3 O 4 - g -pGMA was better fitted by the Langmuir model, whereas the adsorption of Rh B onto W@Fe 3 O 4 - g -pAA was more consistent with the Temkin model, suggesting a predominantly chemisorption mechanism. After five consecutive adsorption-desorption cycles, the removal rates for MB by W@Fe 3 O 4 - g -pGMA and for Rh B by W@Fe 3 O 4 - g -pAA remained above 70%, indicating excellent recyclability and stability of the materials. This study provides valuable insights for the design of functional adsorbents and their potential application in the advanced treatment of pigment-containing wastewater.
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Biosensors-Basel
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2025
·Vol. 15
·期 10
·700
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IF 5.6
Yu Qin,Jiali Xie,Shujun Zhen
Fluorescence anisotropy (FA) has been widely used for analyzing biomolecules due to its high throughput, homogeneous detection, and strong resistance to photobleaching. However, the traditional FA method suffers from low sensitivity when the target molecules are small and rotate rapidly, often producing insignificant changes in the FA value. In this study, by combining double signal amplification through the trans-cleavage of CRISPR-Cas12a and DNA tetrahedron assemblies with a large molecular size, a new, fast, simple and highly sensitive FA method was constructed to achieve the quantitative detection of hepatitis B virus DNA (HBV-DNA). The experimental results showed that the linear range of this method was 0.5–9 nmol/L, and the detection limit (LOD = 3σ/k) was 48 pmol/L. In addition, the method demonstrated excellent selectivity and anti-interference, and it was successfully applied to detect HBV-DNA in human serum, indicating that this method has the potential for clinical diagnosis.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Qixin Yang,Zengkun Wang,JingJing Li,Jing Di,Xikun Gai,Yaofeng Zhu
Distinguished by a unique three-dimensional (3D) network structure and commendable electrical conductivity, one-dimensional (1D) carbon nanofibers (CNF) exemplifies a pivotal class of microwave absorption materials. However, their effective absorption bandwidth (EAB) suffers from inadequacy on account of poor impedance matching. To conquer this drawback, a novel in situ dual-doping strategy was employed in this article. Incorporating boron (B) and low-valence-state molybdenum (Mo), this strategy is merged with electrospinning and high-temperature treatment, aimed to fabricate Mo and B co-doped carbon nanofibers (Mo-B/CNF) with superior microwave absorption performance. An array of characterization techniques were leveraged to delve into the microstructure and properties of the Mo-B/CNF. The analysis corroborated a uniform distribution of Mo and B elements within the carbon matrix, alongside the formation of Mo 2 N species. Outstanding microwave absorption was identified for the resulting Mo-B/CNF, accompanied by a minimum reflection loss of -57.7 dB at 10.3 GHz and an EAB of 6.05 GHz. As further demonstrated by radar cross-section simulations, the Mo-B/CNF is capable of attenuating electromagnetic scattering from metallic backplanes and large unmanned aerial vehicles, which highlights their promise in radar stealth applications. Following a structural optimization via 3D electromagnetic simulation software, the metamaterial fabricated from Mo-B/CNF attains an ultra-broad effective absorption bandwidth (EAB) of 32.1 GHz across the 2-40 GHz frequency range. This study delineates the electromagnetic wave absorption traits of Mo-B/CNF, and provides another insight for designing next-generation microwave absorption materials.
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Journal of Molecular and Engineering Materials
·
2021
·
IF 0
Lili Feng,Pengyu Wang,Hansen Yang,Zhuo Chen,Shuhui Bo
A charge transfer dye with the D– π –A structure was synthesized by Pd catalyzed Hartwig–Buchwald coupling and Knoevenagel condensation reaction, using N, N-dihexylbenzo[b]thiophen-6-amine as donor and 2-(3-cyano-4, 5, 5-trimethylfuran-2 (5H)-ylidene)malononitrile (TCF) as acceptor. The solvatochromic and pH switch properties of the as-synthesized dye were investigated through UV-vis absorption and fluorescence emission spectra. A positive solvatochromism of the dye in different polar solvents was observed along with a visible color change of the solution. By adding acid/base into the DMSO solution of the dye, the color as well as the absorption and emission spectra of the solution exhibited outstanding characteristics of pH switch.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
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IF 5.6
Na Wang,Ye Zhang,Wen Huang,Wei Du,Chunhua Ma,YuQiang Fang,Chunyu Zeng
Salvianolic acid B (SaB) demonstrates significant cardioprotective effects against myocardial ischemia–reperfusion injury (I/R). However, its clinical application is limited by rapid metabolism and poor bioavailability. To address this, we synthesized SaB-loaded organic quantum dots (SaB@qd) via a hydrothermal method and functionalized them with the near-infrared (NIR) dye cypate (SaB@qd@Cy). Proteomic analysis of cardiac tissues from I/R model rats identified SIRT2 as a key downregulated protein. Molecular docking and cell membrane chromatography confirmed SaB as a natural SIRT2 agonist, binding specifically to the SER-263 residue. SaB@qd@Cy enhanced myocardial SaB accumulation by 3.2-fold compared to free SaB (P<0.01). In vivo, SaB@qd@Cy reduced the infarct area by 41% (compared to 28% reduction by mitochondrial-targeted CoQ10 nanoparticles) and attenuated inflammatory cytokine expression (IL-1β, TNF-α) via the SIRT2/NLRP3 pathway. Additionally, cypate enabled real-time NIR imaging of ischemic borders, with a temperature increase of 15.3±1.2°C under 808 nm laser irradiation. This study presents a novel theranostic nanoplatform that integrates natural compounds with photoresponsive quantum dots for targeted therapy and intraoperative imaging in I/R management.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Zuocheng Luo,Qingfeng Zhang,Wei Xie,Tong Yuan,Qisheng Zang,Ning Wang,Hanxiao Fan,Shuhong Xie,Xiaoping Ouyang
Potassium ion hybrid capacitors (PIHCs) have attracted widespread attention as combining the advantages of potassium ion batteries (PIBs) with supercapacitors . However, the sluggish kinetics caused by the large radius of K + hinder the practical application of PIHCs. Herein, we synthesized a boron and fluorine co-doping interlaced network porous carbon nanofibers (BF-PCNFs), which was used as the freestanding anode of PIHCs the freestanding anode of PIHCs to alleviate large volume expansion and increase conductivity. Benefiting from the B, F co-doping and porous interlace nanostructure of BF-PCNFs, the anode shows 185 mA h g −1 under a load of 12.6 mg cm −2 , a reversible capacity of 176 mA h g −1 at 1000 mA g −1 after 6000 cycles, and the capacity retention from 100 mA g −1 to 5000 mA g −1 is 62%. Furthermore, the PIHCs based on BF-PCNFs as anode and activated carbon as cathode exhibit an energy density of 87 Wh kg −1 and a power density of 393 W kg −1 . The capacity retention is as high as 78% over 4000 cycles. Considering the exceptional rate performance, long cyclability and high-mass-loading, our work may supply a new strategy for designing novel energy storage devices with outstanding performance.
研究领域:
材料科学
·
电化学
·
能源存储
·
纳米科技
·
功能材料
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CRYSTAL GROWTH & DESIGN
·
2024
·
IF 3.2
Juhe Liu,Yuwei Chen,Mengran Sun,Wenhao Liu,Xianghe Meng,Jiyong Yao
Na3LuB8O15, the first sodium lutetium borate in the Na–Lu–B–O system, was prepared by the spontaneous crystallization method. Na3LuB8O15 is crystallized in the centrosymmetric triclinic space group P1¯ with the following cell parameters: a = 6.4047(12)Å, b = 7.3342(13)Å, c = 13.081(2)Å, α = 88.999(7)°, β = 78.631(8)°, γ = 66.622(7)°, and Z = 2. The general configuration of Na3LuB8O15 can be characterized as a network structure created by infrequent multiboron anion chain skeletons [B8O17] and [LuO7] polyhedra shared by oxygen atoms, where Na ions are filled in the pores to balance charges. According to a UV–vis-NIR spectrum investigation, the chemical has a short ultraviolet cutoff edge (185 nm). Thermal analysis reveals incongruent melting compound properties. In addition, a first-principles calculation was conducted to delve deeper into the correlation between the performance and the structure.
研究领域:
材料科学
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无机化学
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晶体学
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光学材料
·
固态化学
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8
Yongxing Li,Haiyu Ji,Shuang Yang,Wenhao Cao,Jiarong Zou,Zhangliang Zhu,Jinfang Zhang,Mei Li
Interactions between polyphenols and starch are critical for modulating starch functionality through structural reorganization. This study systematically compared the interaction of young apple polyphenols (YAP) with A-type (corn starch, CS), B-type (potato starch, POS), and C-type (pea starch, PES) under autoclaving. Multi-technique analysis confirmed the formation of starch-YAP complexes and structural reorganization into A+V- and B+V-type crystalline polymorphs. Distinct differences in complex properties were observed among the crystal types. CS-based complexes (CSY_4) demonstrated the highest loading capacity (785.61 ± 0.37 mg/g) and long-range crystallinity (9.35%), yet exhibited the lowest short-range order (0.885 ± 0.044); PES-based complexes (PESY_4) showed the highest encapsulation efficiency (97.40 ± 0.02%) alongside the lowest swelling power (1.63 ± 0.01 g/g) and solubility (0.36 ± 0.01 g/g); whereas POS-based complexes (POSY_4) presented the lowest amylose content (13.71 ± 0.17%). These structural modifications led to markedly suppressed digestibility, with resistant starch content increasing to 52.02 ± 2.41% (CSY_4), 56.55 ± 0.43% (POSY_4), and 57.19 ± 1.80% (PESY_4), and POS demonstrated the greatest efficacy in lowering the estimated glycemic index (eGI) (ΔeGI = 14.83). The study elucidates a crystal-type-dependent strategy for designing slow-digesting starch-based functional foods through polyphenol-mediated structural engineering.
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Biomaterials Science
·
2026
·
IF 5.7
Meilin Qiao,Licheng Gao,Ruibing Yu,Jian-Wei Chen,Xuanrong Sun,Yue Cai
The emergence of multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) infections, particularly those involving biofilm formation, poses a critical challenge to global healthcare. While polymyxin B (PMB) remains a last-line antibiotic against such infections, its efficacy is severely limited by poor biofilm penetration and adaptive resistance mechanisms. In this study, we developed a biomimetic nanoplatform (PMφ-PLGA-NOR) comprising a poly(lactic-co-glycolic acid) (PLGA) core loaded with norharmane (NOR), coated with PMB-modified P. aeruginosa cytoplasmic membrane (PMφ). This design utilizes the homologous targeting of bacterial membrane components and PMB's affinity for gram-negative pathogens to achieve efficient biofilm penetration. NOR, a βcarboline compound, has been shown to disrupt quorum sensing (QS) by inhibiting PqsA, resulting in significant reduction in biofilm formation. In vitro investigations have demonstrated that PMφ-PLGA-NOR disrupts the integrity of biofilms, thereby enhancing the bactericidal efficacy of PMB by facilitating its deep penetration into the biofilm matrix. In vivo, intraperitoneal administration of Mφ-PLGA-NOR combined with PMB achieved a 2-log reduction in bacterial lung burden. This study underscores the promise of bacterial plasma membrane-based pathogen-mimetic nanoplatforms in potentiating the efficacy of antibiotic adjuvants in conjunction with biofilmpenetrating strategies.
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