INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Ying Fang,KangRui Wang,Qin Li,ChengHong Huang
Carboxylation chitosan achieved by alkalization linked with ethyl vanillin to obtain Chitosan-ethyl vanillin (EV-CMCS) compound through Schiff base reaction and confirmed by FT-IR, UV, XRD, TG and NMR. EV-CMCS refluxed with GNRs for acquisition of EV-CMCS@GNRs nanocomposites for PTX Loading and release. Results demonstrated that both EV-CMCS and EV-CMCS@GNRs are nanoscale composites with excellent solubilization due to their micelle structure taking CMC values of 0.06683 mg/mL and 0.06537 mg/mL. It was found that the loading and encapsulation rate of EV-CMCS and EV-CMCS@GNRs for PTX are 19.59~37.64% and 60.36~80.79% as well as 20.99~37.02% and 58.78~79.77%. Compared with only the delayed release of EV-CMCS that it have 11.5% and 18.7% accumulative release amount for 24 h and 14.9% and 23.7% for 48 h under both pH 6.8 and 7.4, the EV-CMCS@GNRs represent sudden release that it have an accumulative release amount of 90.2% for 24 h and 96.0% for 48 h at pH 6.8. It deduced that the broken Schiff base under acidic condition can increase CMC of EV-CMCS@GNRs, which offered an alternative way for paclitaxel delivery for tumor therapy.
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高影响因子
JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2022
·Vol. 46
·期 3
·e16407
·
IF 2.609
Runan Zhao,Yu Zhang,Huanle Chen,Rong Song,Yan Li
A green chitosan-based coating was prepared by incorporating chitosan-stabilized eugenol emulsions into chitosan solution. The physical, mechanical, rheological, and stability property of chitosan coatings were characterized and then the effect of chitosan coatings on the shelf-life of fresh meat was investigated. Emulsion incorporation greatly improved the performance of chitosan coating, including stronger anti-corrosion against pH and UV-light resistance and lower water vapor permeability. Emulsion incorporation greatly increased the inhibition zone for Escherichia coli and Staphylococcus aureus by 6.9 and 8.7 mm, respectively. After the application of coating, meat kept a bright red appearance within 14 days and its spoilage was prevented. After 14-day storage, pH value, the total number of colonies, and TVB-N of meat still met the quality standard, demonstrating that the shelf-life of meat was prolonged from 6 to 14 days. The knowledge provides a green coating to extend the shelf-life of fresh meat. Novelty impact statement Chitosan-stabilized emulsions were added into chitosan-coating materials. Eugenol-loaded chitosan coating had a good protection effect on the color of meat. Shelf-life of fresh meat was prolonged to 14 days by eugenol/chitosan coating.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2013
·Vol. 131
·期 4
·
IF 1.395
Ruihua Huang,Bingchao Yang,Qian Liu,Yanping Liu
Activated carbon/chitosan composite has been used as an adsorbent to remove aniline and Cr(VI) ions from aqueous solutions simultaneously. The effects of preparation conditions such as the ratio of activated carbon to chitosan, crosslinking reagents, crosslinking time, and adsorption conditions including adsorbent dosage, pH value of solution, and contact time on simultaneous adsorption of aniline and Cr(VI) ion were investigated. Experimental results showed that epichlorohydrin was the proper crosslinking reagent, and the ratio of activated carbon to chitosan was kept at 1. When the adsorbent dosage was 4.0 g/L, and the concentrations of aniline and Cr(VI) were lower than 50 and 100 mg/L, respectively, both aniline and Cr(VI) were simultaneously removed at natural pH with high removals (>95%). The presence of Cr(VI) enhanced the adsorption of aniline, while the presence of aniline almost had no influence on the adsorption of Cr(VI). The adsorption processes of both aniline and Cr(VI) followed the pseudo-second-order kinetics model, but the sorption of Cr(VI) was preferential to that of aniline by this composite. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 39903.
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Materials Today Communications
·
2022
·
IF 3.662
Zhe Huang,Shenghua Li,Lung-Chang Tsai,Tao Jiang,Ning Ma,Fang-Chang Tsai
A single molecule intumescent flame retardant was synthesized through in-situ polymerization by chitosan-based ammonium polyphosphate microencapsulated by melamine-formaldehyde resin. The multiple reactive hydroxyl and amino groups in its molecular chain made it a positively charged polymer with excellent coordination. The decomposition of melamine-formaldehyde resin produced a large amount of incombustible gas, which reduced the heat absorption on the surface of the composite material and inhibited its decomposition. Through thermogravimetric analysis , it was found that its thermal stability was better at high temperatures. Due to the decomposition of melamine-formaldehyde resin, a large amount of incombustible gas was produced, which reduced the heat absorption on its surface and inhibited its decomposition, so that polypropylene composites containing the flame retardant had a smooth decomposition process. The burning results showed that the limiting oxygen index and vertical combustion grade of the polypropylene composites containing the flame retardant had been improved, which the vertical combustion rating was V-1, and the limiting oxygen index was 25.7%. At the same time, it was clearly observed that composites containing the single-molecule intumescent flame retardant had an excellent anti-dripping effect. The surface temperature of the composite material was greatly reduced during combustion, from 343.7 ℃ to 156.9 ℃. Raman spectra and SEM of the surface carbon layer of the burned spline revealed the composite containing the flame retardant with a lower ID/IG value, indicating that the carbon layer it formed had more excellent crystallinity. Therefore, its carbon layer had a better structure and stability. It could be borne out that our single-molecule intumescent flame retardant had a good flame retardant effect on PP.
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 14
·B1364
·
IF 3.12
Nana Feng,Jie Zhang,Wei Li
The development of a reliable electrochemical sensor for detecting melamine is crucial given the adverse effect of melamine on the health of humans, especially infants. Here, a chitosan (CS)/graphene oxide (GO) nanocomposite was prepared and used as an electrochemical sensor. The morphology of this nanocomposite was characterized by scanning electron microscopy and transmission electron microscopy, and its structure was investigated using Fourier transform infrared spectroscopy and Raman spectroscopy. Electrochemical experiment results showed that CS/GO nanocomposites exhibit excellent sensing properties to melamine and have an ultrahigh sensitivity of 54.6 μA μM−1 cm−2, a linear range of 4–2300 ppb, and a calculated limit of detection of 0.83 ppb. This material also exhibits positive anti-interference property and fairly accurate measurement in real milk, thus ensuring that the present sensing platform can be utilized for practical applications, such as food inspection.
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高影响因子
Coatings
·
2021
·Vol. 11
·期 8
·914
·
IF 2.881
Zihao Dong,Ran Li,Yan Gong
With chitosan, nano-TiO2and nano-Ag as raw materials, nano-TiO2and nano-TiO2-Ag were modified by a surface modifier-sodium laurate. Chitosan (CTS), chitosan-nano-TiO2(CTS-TiO2), and chitosan-nano-TiO2-nano-Ag (CTS-TiO2-Ag) composite materials and corresponding films were prepared by a solution co-blending method. Then, the antibacterial performances of the above three types of materials againstEscherichia coli,Staphylococcus aureus, andBacillus subtiliswere compared. Moreover, potato and strawberry weight loss rates, peroxidase activity, and vitamin C contents after different film coating treatments were measured. Compared with CTS films, the CTS-TiO2-Ag and CTS-TiO2composite films both showed better physical properties, and both demonstrated higher antibacterial effects, especially forE.coli. Measurement of physiological indices in fruits and vegetables showed that the freshness-preserving effect of CTS-TiO2-Ag coating films was the most significant. In all, the CTS-TiO2-Ag coating films can actively contribute to the storage of fruits and vegetables at room temperature, and better ensure product quality. Thus, such films are meaningful for research and development of new fruit freshness-keeping techniques and materials.
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高影响因子
Applied Materials Today
·
2020
·
IF 8.352
Yipeng Chen,Baokang Dang,Qingfeng Sun
The concept of replicating the laminated ternary structure of natural nacre with coordinating strength and toughness has generated much interest in exploring future structural materials. Here the ternary lignocellulosic nacre with high performance is fabricated via synergistic toughening of delignified nano-lignocellulose (DNLC) and molybdenum disulfide (MoS 2 ) through freezing-induced assembly followed by hot-pressing process. The high mechanical performance of the lignocellulosic nacre due to lubrication of MoS 2 combine with intermolecular hydrogen bonding between DNLC and chitosan (CS) has effectively verified the synergistic toughening effect. The MoS 2 -CS lignocellulosic nacre exhibits an exceptional balance of strength and toughness, which exceed to other conventional lignocellulosic composites and natural materials. Furthermore, these composites show superior photocatalytic activity. This approach of fabricating the MoS 2 -CS lignocellulosic nacre supplies an imaginative door in the near future for devising and manufacturing the ultra-strong and ultra-tough lignocellulosic nacre for the photooxidation of volatile organic.
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高影响因子
Journal of Renewable Materials
·
2022
·Vol. 11
·期 1
·291-307
·
IF 2.115
Long Li,Yanan Lu,Yu Chen,Jiayi Bian,Li Wang,Li Li
Silver nanoparticles (Ag NPs) are an effective antibacterial agent, but their application in food packaging is limited due to their easy agglomeration and oxidation. In this study, antibacterial microcapsules were fabricated using Ginkgo biloba essential oil (GBEO) as core material and chitosan and type B gelatin biopolymer as capsule materials. These antibacterial microcapsules were then modified with green-synthesized Ag NPs, blended into the biopolymer polylactic acid (PLA), and finally formed as films. Physicochemical properties and antibacterial activity against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) were evaluated. Results showed that the prepared antibacterial PLA films exhibited excellent antibacterial activity against foodborne pathogens. Its TVC exceeded the limit value of 7 log CFU/g at 7 days compared with the 5 days of pure PLA films. Therefore, these films can extend the shelf life of grass carp fillets by 2–3 days under refrigeration.
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高影响因子
THERMOCHIMICA ACTA
·
2021
·
IF 3.115
Chen Cheng,Jun Yan,Yanling Lu,Weining Ma,Chen Li,Shiguo Du
Chitosan (CH) and chitosan/lignosulfonate composite (CH/LS) were selected as shell materials for microencapsulated red phosphorus (MRP). MRP samples of RP@CH and RP@CH/LS were prepared and applied as flame retardants for epoxy resin (EP). The microstructure, chemical composition and thermal decomposition of the as prepared samples were systematically characterized. The effects of red phosphorus (RP), RP@CH and RP@CH/LS on the flame retardance performance of EP and the mechanism were investigated in detail. The results showed EP containing 7wt% RP@CH/LS got the limited oxygen index value of 30.6 %, and passed V-0 degree in the vertical burning tests. The peak heat release rate of EP/7wt% RP@CH/LS decreased 59.7 % compared with that of neat EP in the cone calorimeter tests. The shell structures also improved the interfacial compatibility between RP and the organic substrates, which was illustrated by tensile strain tests and scanning electron microscope (SEM) observation.
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高影响因子
RSC Advances
·
2024
·Vol. 14
·期 16
·11311-11321
·
IF 3.9
Tong Wan,Qianqian Zhang,Guocheng Jin,Shiai Xu
This work aims to determine the optimal conditions for emulsion cross-linking of chitosan (CHS) with various molecular weights using glutaraldehyde as a cross-linking agent to produce 5-fluorouracil-loaded CHS microspheres (5-FU/CHS). Their drug loading and encapsulation efficiencies are found to be in the range of 3.87–12.35% and 20.13–70.45%, respectively. The dynamic light scattering results show that 5-FU/CHS microspheres are micron-sized with a uniform size distribution, and the scanning electron microscopy results show that they are spherical. The results of thermogravimetric analysis, X-ray diffraction, and Fourier transform infrared spectroscopy demonstrate that 5-FU is successfully incorporated into the microspheres. The in vitro release tests show that 5-FU/CHS have a prolonged, pH-responsive release pattern of 5-FU, and the cumulative release rate under acidic condition is much larger than that under neutral conditions. The drug release kinetic analysis further demonstrates that the release of 5-FU can be well described by the Fickian diffusion model.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Meiyi Wu,Jingfei Wang,Yue Wang,Ruiting Zhang,Chongruihan Li,Shuangling Zhong,Yan Gao,Xuejun Cui
Polysaccharides, as a natural biomolecule, are abundantly available in nature and have good bioactivity. They contain several functional groups such as hydroxyl, carboxyl, and amino groups, which can exhibit different fluorescent property after modification. In this work, the chitosan (CS) was selected as a raw material and grafted with methotrexate (MTX) to prepare a nitrite sensor. The sensing material exhibited obvious aggregation-induced emission (AIE) properties and could react with nitrite under acidic conditions to form diazo compounds that could enhance fluorescence. This “enhanced-luminescent” mode fluorescence probe for nitrite (NO 2 − ) displayed superior sensing performance, such as excellent sensitivity, good selectivity, a low detection limit (0.22 μM) and wide detection range from 0 to 120 μM. Moreover, this sensor was effectively applied to detect nitrite in sausage samples. Finally, CS-MTX also showed excellent biocompatibility, good water solubility and outstanding antibacterial performance against Gram-positive Staphylococcus aureus ( S. aureus ) and Gram-negative Escherichia coli ( E. coli ). These results demonstrated that it may be a potent multifunctional material for nitrite detection and anti-bacteria in food industry.
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yuhe Dong,Tong Wu,Tao Jiang,Wanying Zhu,Linyan Chen,Yuantong Cao,Ying Xiao,Ye Peng,Ling Wang,Xi Yu,Tian Zhong
As an anti-infection antibiotic delivery route, a drug-controlled release system based on a specific condition stimulus response can enhance drug stability and bioavailability, reduce antibiotic resistance, achieve on-demand release and improve targeting and utilization efficiency. In this study, chitosan-coated liposomes containing levofloxacin (Lef@Lip@CS) were prepared with lysozyme in body fluids serving as an intelligent “switch” to enable accurate delivery of antibiotics through the catalytic degradation ability of chitosan. Good liposome encapsulation efficacy (64.89 ± 1.86 %) and loading capacity (5.28 ± 0.18 %) were achieved. The controlled-release behavior and morphological characterization before and after enzymatic hydrolysis confirmed that the levofloxacin release rate depended on the lysozyme concentration and the degrees of deacetylation of chitosan. In vitro bacteriostatic experiments showed significant differences in the effects of Lef@Lip@CS before and after enzyme addition, with 6-h inhibition rate of 72.46 % and 100 %, and biofilm removal rates of 51 % and 71 %, respectively. These findings show that chitosan-coated liposomes are a feasible drug delivery system responsive to lysozyme stimulation.
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PubMed
高影响因子
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