IMMUNITY
·
2024
·
IF 25.5
Bo Wei,Guo Cheng,Qianqian Bi,Cheng Lu,Qihang Sun,Li Li,Ningting Chen,Miner Hu,Haoran Lu,Xuancheng Xu,Genxiang Mao,Shu Wan,Zhechun Hu,Yan Gu,Jiaxin Zheng,Li Zhao,Xiao Z. Shen,Xiaoli Liu,Peng Shi
Hypertension is usually accompanied by elevated sympathetic tonicity, but how sympathetic hyperactivity is triggered is not clear. Recent advances revealed that microglia-centered neuroinflammation contributes to sympathetic excitation in hypertension. In this study, we performed a temporospatial analysis of microglia at both morphological and transcriptomic levels and found that microglia in the hypothalamic paraventricular nucleus (PVN), a sympathetic center, were early responders to hypertensive challenges. Vasculature analyses revealed that the PVN was characterized by high capillary density, thin vessel diameter, and complex vascular topology relative to other brain regions. As such, the PVN was susceptible to the penetration of ATP released from the vasculature in response to hemodynamic disturbance after blood pressure increase. Mechanistically, ATP ligation to microglial P2Y12 receptor was responsible for microglial inflammatory activation and the eventual sympathetic overflow. Together, these findings identified a distinct vasculature pattern rendering vulnerability of PVN pre-sympathetic neurons to hypertension-associated microglia-mediated inflammatory insults.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Siqi Qi,Min Lin,Pengfei Qi,Junjie Shi,Ge Song,Wenxin Fan,Kunyan Sui,Congjie Gao
With the aggravation of pollutants damage to the environment, it is crucial yet rather challenging to design powerful matrixes for nanomaterials with high ions permeability and migration, as well as multiple exposed active sites. However, most of the current nanomaterial matrixes just act as carrier supporters with introduced invalid mass. Here, a gradient natural polycation electrolyte (chitosan) hydrogel was engineered as nanomaterials matrix to boost anionic heavy metals removal such as antimonate (Sb(V)) and arsenate (As(V)) for the first time, based on the generated interfacial and build-in electric potentials due to the diffusion of counterions. The resulting dual electric potentials allow for rapid diffusion and removal efficiency of heavy metal ions. Exemplified by Sb(V) removal, the chitosan gradient hydrogel matrixes with embedded UiO-66 MOFs exhibited a 3-fold higher removal velocity than the homogeneous hydrogel matrix, and their removal efficiencies were also promoted by gathering on the high charge density side of hydrogels. In contrast to the other reported matrix materials without driving force, the gradient polyelectrolyte hydrogel can greatly boost the removal efficiency and shorten the treatment times. This study offers inspirations on eliminating heavy metal contaminations based on self-driving forces stemming from the heterogeneous structure of materials.
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Food Bioscience
·
2024
·
IF 4.8
Xiao Zhang,Miao Yang,Jun Li,Fan Yang,Lei Zhang,Zhang Liu,Aili Wei,Dongao Huo
Despite the high nutritional value and active components present in mungbean sprouts, the influence of different accessions on their nutrition remains unclear. Two accessions with pronounced differences in germination experiments were selected in this study, as the average fresh weight and root length of Shilv 22 (SL22) seedlings were only 47% and 41% of those of Shilv 17 (SL17), respectively. In order to investigate the metabolic changes that occur during mungbean germination, nontargeted metabolomics was performed with different accessions of mungbean sprouts. The results revealed that SL17 and SL22 accessions had extreme differences on metabolic changes, and amino acids including tyrosine, proline, aspartate and asparagine were considered to serve as potential markers to distinguish the two accessions. SL17 accumulated more vitamin B, flavonoids and phenolic acids than SL22 mungbean sprouts after 60 hours, a critical time point of germination. Network pharmacology analysis indicated that caffeic acid, naringenin, kaempferol, apigenin and pinocembrin could be potentially used as crucial active components of mungbean sprouts for future research. This study offers a strong theoretical foundation for producing cost-effective, highly nutritious mungbean sprouts in the market.
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BIOORGANIC CHEMISTRY
·
2024
·
IF 4.5
Xiao-Fang Zhang,Hong-Fei Li,Hui Liu,Fang-Lu Wei,Jiao-Xian Du,Ji-Kai Liu,Juan He,Tao Feng
Twenty-nine sesquiterpenoids, including pseudoguaiane-type ( 1 – 11 ), eudesmane-type ( 12 – 23 ), and carabrane-type ( 24 – 29 ), have been identified from the plant Carpesium abrotanoides . Of them, compounds 1 – 4 , 12 – 15 , and 24 – 27 , namely carpabrotins A–L, are twelve previously undescribed ones. Compound 3 possessed a pseudoguaiane backbone with a rearrangement modification at C-11, C-12 and C-13, while compound 4 suffered a carbon bond break between the C-4 and C-5 to form a rare 4,5- seco -pseudoguaiane lactone. Compounds 1 – 3 , 5 , 13 – 16 and 25 – 27 exhibited anti-inflammatory activity by inhibiting NO production in LPS-induced RAW264.7 macrophages with IC 50 values less than 40 μM, while compounds 1 , 2 , 5 , 13 , 14 , 16 , and 25 – 27 showed significant inhibitory activity comparable to that of dexamethasone. The anti-atopic dermatitis (AD) effects of compounds 5 and 16 were tested according to 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in KM mice, and the results revealed that the major products 5 and 16 improved the histological features of AD-like skin lesions and mast cell infiltration in mice. This study suggested that sesquiterpenoids in C. abrotanoides should play a key role in its anti-inflammatory use.
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CHEMICAL RESEARCH IN TOXICOLOGY
·
2025
·
IF 3.8
Xiaomin Ye,Peiqu Zhong,Qiongfang Chen,Dongmei Zhou,Jieyu Luo,Youcai Liang,Jiayuan Zhang,Lijian Zhao
The widespread use of perfluorooctanesulfonic acid (PFOS) has raised concerns regarding its potential on pregnant women, particularly in relation to the development of pre-eclampsia (PE). This study investigates the impact of PFOS exposure on the LncRNA/Rnd3 axis in pregnant mice and its association with trophoblast cell functions in PE. Bioinformatics analysis revealed PFOS-related gene alterations in PE, with pathways enriched in apoptotic signaling and cytokine interactions. Experimental findings showed the downregulation of Oip5os1 and Rnd3, along with the upregulation of miR-155, affecting trophoblast behavior. Animal experiments confirmed that PFOS-induced gene expression changes are linked to PE progression. PFOS exposure impairs trophoblast proliferation and migration via the Oip5os1/miR-155/Rnd3 axis, contributing to PE development.
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Metals
·
2024
·Vol. 14
·期 9
·981
·
IF 2.6
Jialie Liu,Junjie Xu,Chuntao Ge,Jie Pang,Weiliang Jin,Geir Martin Haarberg,Saijun Xiao
To enhance the anticorrosion properties of molybdenum metal in liquid zinc, this study successfully fabricated TiB2coatings on molybdenum substrates via the molten salt electrophoretic deposition technique and investigated their corrosion resistance in molten zinc. Initially, TiB2nanoparticles with a size ranging from 50 to 150 nm were synthesized using the borothermal reduction method in a molten NaF-AlF3bath at 1238 K. Subsequently, the electrophoretic deposition experiment was conducted under a cell voltage of 1.2 V (i.e., 0.6 V/cm) for a duration of 1 h in the melt containing TiB2nanoparticles, resulting in a uniform, continuous, and compact TiB2coating (35 μm thick) on the molybdenum substrate. Moreover, the corrosion resistance of the TiB2-coated molybdenum metal to molten zinc was tested through continuous immersion. After 120 h of immersion, the TiB2coating showed no signs of cracking or peeling off, successfully protecting the molybdenum metal substrate from corrosion by molten zinc. The results confirm that the molten salt electrophoretic deposition technique can be used to prepare TiB2coatings with good resistance to molten zinc corrosion on molybdenum metal.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Jie Wang,Guanshun Xie,Senlin Zhang,Guohao Li,Zhaohui Huang,Xiaohui Li,Xiuqiang Xie,Nan Zhang
Although MXenes have attracted significant attention across diverse fields, they exhibit a pronounced susceptibility to oxidation in aqueous environments, with oxidation significantly accelerated in the presence of transition metal ions (TMI) such as Fe 3+ and Cu 2+ . This limitation impedes the synthesis of transition metal compounds/MXene-based composites and their potential for functional applications. In this study, we elucidate the mechanism of accelerated oxidation of Ti 3 C 2 T x is that Fe 3+ promotes the electron loss in Ti 3 C 2 T x , thus leading to an increased production of hydroxyl radicals ( OH) to oxidize Ti 3 C 2 T x . Furthermore, a rational two-in-one strategy is provided with adding electron-rich ethylenediaminetetraacetic acid disodium zinc salt (ZnNa 2 EDTA) to enhance the stability of Ti 3 C 2 T x by defect filling and electron donation. Consequently, the production of OH is significantly reduced and thus Ti 3 C 2 T x remains well-preserved in the presence of Fe 3+ , which has also effectively enhanced the oxidation stability of Ti 3 C 2 T x in the presence of Cu 2+ . This work is expected to pave a new pathway for targeted applications with coexisting Ti 3 C 2 T x and TMI.
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Theranostics
·
2025
·Vol. 15
·期 10
·4481
·
IF 13.3
Yupeng Sun,Rui Li,Yike Cai,Yan Liu,Peiyuan Wang,Ming Wu,Xiaolong Zhang,Naishun Liao,Cuilin Zhang,Aixian Zheng,Haipo Xu,Rui Zeng,Yongyi Zeng,Xiaolong Liu
Tumor-infiltrating CD8 + T cells and programmed death-1 (PD1) levels are critical indicators for tumor immunophenotyping and therapeutic decision-making. Noninvasive optical imaging in the second near infrared window (NIR-II) is particularly well-suited for investigating the biological processes within tumors in live mammals, thanks to its deep-tissue penetration and superior spatiotemporal resolution. However, in vivo NIR-II imaging has primarily been restricted to a single probe at a time. Methods: Herein, we developed a two-plex NIR-II molecular imaging method utilizing the non-overlapping fluorescence emission of indocyanine green (ICG) in the NIR-IIa window (1000-1200 nm) and PbS/CdS core-shell quantum dots (QDs) in the NIR-IIb window (1500-1700 nm). By integrating PD1 aptamer-labeled ICG (ICG-Apt-PD1, targeting PD1) and CD8 aptamer-labeled QDs (QDs@Apt-CD8, targeting CD8 + T cells), our two-plex NIR-II molecular imaging enabled simultaneous and noninvasive monitoring of the number of CD8 + T cells and PD1 levels in tumors. Results: QDs@Apt-CD8 demonstrated the excellent ability for in vivo imaging of tumor infiltrating CD8 + T cells, owing to its strong NIR-IIb luminescence and the high selectivity and specificity. This two-plex in vivo molecular imaging allowed for dynamic monitoring for PD1 levels and the number of CD8 + T cells in tumors. We observed the heterogeneous bio-distributions of PD1 and CD8 + T cells across different tumor types and revealed the tumor immunophenotypes. Moreover, our findings indicated that the low PD1 and high CD8 + T cells levels in tumors predicted a better anti-tumor effect. Conclusions: Such in vivo noninvasive NIR-II molecular imaging would complement ex vivo biopsy-based diagnostic techniques, and it could contribute to developing an in vivo tumor immune-scoring algorithm to offer a more precise prediction for immunotherapeutic response.
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JOURNAL OF HYDROLOGY
·
2024
·
IF 5.9
Dan Zhang,Wenke Wang,Zhengyu Zhang,Fengjia Liu,Yufei Ma,Shengke Yang
Knowledge of the transport and fate of nanobubbles (NBs) in groundwater is decisive to assess their remediation scope. In this work, based on the exploration of the stability of NBs in groundwater environmental conditions, the transport behavior and mechanism of NBs under physical (grain size, NBs concentration and flow velocity) and chemical conditions (pH, iron strength (IS) and types and dissolved organic matter (DOM)) were investigated by the column experiment and numerical simulation. The results showed NBs were more stable under alkaline and humic acid (HA) environment. NBs transport increased with the increase of grain size, NBs concentration, pH and HA, respectively. However, NBs transport was inhibited with the increase of acidity, electrolytes and L-Tryptophan (L-Trp) concentration, which was mainly due to these unfavorable factors will lead to an increase in the NBs size and a stronger electrostatic attraction at the interface between NB and sand, resulting in more retention of NBs in porous media. This was demonstrated by the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory and straining calculations. The two–site deposition model showed a better fit. The straining rate (k str ) was greater than attachment rate (k att ), which proved the main retention mechanism of NBs in groundwater was a synergistic mechanism dominated by pore straining and supplemented by attachment (electrostatic attraction and blocking). These findings provided a theoretical basis for the application of NBs technology in groundwater.
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ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Guozhen He,Tao Dong,Zhaochu Yang,Bjo̷rn Torger Stokke,Zhuangde Jiang
Biofouling deteriorates the performance of sensors operated in biofluids. Protein adsorption is believed to be the first step of biofouling, which also reduces biocompatibility by further inducing cell adhesion, platelet activation, and even inflammation. Current studies of antifouling coatings are focused on polymers and hydrogels, which have succeeded in remaining resistant to protein adsorption, but their application on sensor electrodes is limited due to low conductivity and biocompatibility. Here, we report a spontaneous antibiofouling strategy for sensor electrodes by controlling oxygen vacancies in WO3 nanosheets. Irreversible adsorption of proteins was reduced by 76% in unprocessed human plasma when electrodes were coated with WO3 rich in surface oxygen vacancy. These electrodes maintained 91% of the initial current density after 1 month of incubation in human plasma.
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Yongquan Wang,Fuhao Guo,Lihua Hu,Wen Lv,Mengyuan Zhang,Xuanbo Liu,Yibin Zhou,Wenjia Yan,Lijun Yin
This study evaluated the effects of internal aqueous phase gelation on water-in-oil-in-water (W/O/W) emulgel stability and their potential for controlled soymilk coagulation to produce soft tofu. Incorporating gelatin or κ-carrageenan gelled the internal aqueous phase, leading to a decrease in droplet size. For κ-carrageenan, this incorporation also resulted in a ζ-potential more negative than –30 mV. All emulgels displayed elastic characteristics, showing higher G' values compared to G''. Emulgels containing over 2.5% κ-carrageenan showed the highest G' values and apparent viscosity, consistent with enhanced thermal, storage and centrifugal stability. The incorporation of gelatin suppressed creaming and droplet size increase in the emulgels during storage and freeze-thawing. The encapsulation efficiency (EE) of MgCl 2 was increased to over 88%, and its release rate was significantly slowed. The yield and hardness of tofu coagulated with emulgels were, respectively, 32%–74% higher and 36%–66% lower than those of tofu coagulated with MgCl 2 solution. This was in accordance with the increased water content, which is semi-bonded water within the gel network. Microstructure analysis indicated that the controlled coagulation resulted in a homogeneous protein network with uniformly distributed micropores. The increased proportion of β-sheet structure implies more extensive interactions between amino acid residues, contributing to a more ordered conformation. The delayed coagulation time and the lower G′ values of soymilk coagulated with emulgels further confirmed the controlled coagulation. These findings indicated that internal aqueous phase gelation enhances emulgel stability and controls soymilk coagulation, demonstrating their potential as coagulants for producing soft tofu with high yield.
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CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
·
2025
·Vol. 52
·期 8
·e70050
·
IF 2.5
Zibo Xiong,Zhiwei Lai,Sanmu Li,Hua Zhang,Yongqiang Wang,Lishan Tan,Guang Yang,Zuying Xiong
Omeprazole is a widely used proton pump inhibitor and anti‐ Helicobacter pylori drug; however, its nephrotoxicity has been controversial. This study aimed to explore the effects and mechanisms of omeprazole on the kidney. In HK2, HPC, NRK and 293 T cells, omeprazole‐induced alterations in cell morphology, density and viability in a concentration‐dependent manner. Excessively high concentrations (> 50 μM) led to a significant increase in cell death. Interestingly, NRK seemed insensitive to omeprazole. RNA sequencing revealed significant alterations in the genomic expression profile when HK2 cells were incubated at a concentration of 5 μM, including the inhibition of proliferative, metabolic and cytokine receptor gene expression. This alteration augments the environmental susceptibility of HK2 when exposed to H 2 O 2 . Animal studies have shown that omeprazole (10.4 mg/kg × day, 28 days) has no significant effect on body weight, kidney or heart weight or kidney or liver function, as well as plasma calcium and vitamin D. Tissue staining revealed increased expression of the macrophage marker F4/80 in response to omeprazole. In conclusion, therapeutic‐dose omeprazole administration in the short term shows no clinically relevant nephrotoxicity. However, omeprazole decreases cell proliferation and viability by disrupting gene expression; thus, the long‐term use of omeprazole may increase inflammation and environmental susceptibility. These findings provide valuable insights for the clinical use of omeprazole, highlighting the need for careful consideration of its effects in the kidney. Omeprazole decreases cell proliferation and viability by disrupting gene expression; thus, the long‐term use of omeprazole may increase inflammation and environmental susceptibility. These findings provide valuable insights for the clinical use of omeprazole, highlighting the need for careful consideration of its effects in the kidney.
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