CHEMISTRY & BIODIVERSITY
·
2026
·Vol. 23
·期 3
·e03222
·
IF 2.9
Yuhao Zhang,Qi Zhang,Shanshan Yang,Ruofei Bai,Congwei Zhou,Yiqun Wu
Discovery and development of novel antifungal agents featuring distinctive chemical scaffolds are of paramount importance for sustainable plant protection. In this study, a series of twenty-one N '-phenylpicolinohydrazide derivatives was designed and synthesized based on our previous work, characterized by spectroscopic analysis. Their antifungal activity was evaluated against nine plant pathogenic fungi, structure-activity relationships (SARs) were elucidated, and the action mechanism was investigated. The results showed that most of the compounds exhibited excellent antifungal activity, especially compounds B2-1 and B5-5 , among which the EC 50 values for Fusarium graminearum were 1.107 and 0.974 µg/mL, respectively. SAR studies indicated that the carbohydrazide or ─C(Cl) ═ NNH─ fragment in this class of derivatives is the key pharmacophore for antifungal activity. SEM analyses revealed that compound B5-5 can significantly destroy mycelial morphology. Furthermore, molecular docking indicated that B5-5 can bind well with the ubiquinone-binding region of SDH. Thus, N '-Phenylpicolinohydrazide derivatives, especially B2-1 and B5-5, can be considered promising fungicide alternatives for plant protection. Summary A series of twenty-one N '-phenylpicolinohydrazide derivatives were synthesized. Compounds exhibiting potent and broad-spectrum antifungal activity were discovered. The antifungal mechanism of the compound B5-5 was elucidated. Some compounds, especially B2-1 and B5-5 , as promising fungicide alternatives were found. Graphical
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·197
·
IF 36.3
Ma Yuqiang,Li Meng,Zhang Dandan,Wang Cihang,Li Yu,Zhao Zihang,Mu Xiaogang,Hu Jun,Hu Xiang,Li Jiachen,Ma Haixia,Wen Zhenhai
Replacing anodic oxygen evolution reaction with 3,5-diamino-1,2,4-triazole oxidative coupling enables ultra-low-voltage (0.96 V @10 mA cm − 2 ) dual-electrode H 2 production and simultaneous synthesis of energetic 5,5′-diamino-3,3′-azido-1H-1,2,4-triazole (DAAT), achieving 35.8% energy savings.
A Pt single-atom/nanoparticle hybrid on NiS 2 nanosheets (Pt s,n @NiS 2 @CC) exhibits exceptional alkaline hydrogen evolution reaction performance and stability via optimized H* adsorption.
Anodic DAAT formation proceeds via an OH*-mediated N–N coupling pathway, enabling stable (> 300 h @500 mA cm − 2 ), industrial-scale bipolar H 2 production coupled with green DAAT synthesis in an anion-exchange membrane water electrolyzer.
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JOURNAL OF MATERIALS RESEARCH
·
2026
·
IF 2.9
Zhang Zhiwei,Nie Yuhang,Zhang Lianke,Wei Zhiqiang,Li Dandan,Qin Haiying,Ni Hualiang,Li Yangyang,He Junjing
Atomically dispersed catalysts, characterized by their high atom utilization efficiency and distinct catalytic activity, exhibit advantages in reducing fuel cell costs. Herein, we synthesized Co/N/C atomic catalysts by acid leaching of CoO/N/C prepared through carbothermal shock. The resulting Co/N/C-130 demonstrates outstanding performance for the oxygen reduction reaction (ORR) in alkaline media. It displays a half-wave potential ( E 1/2 ) of 0.82 V and a Tafel slope of 47.1 mV dec −1 . Furthermore, it exhibits excellent stability with a positive E 1/2 shift of 6 mV after 40,000 cycles. When applied as a cathode catalyst in a direct borohydride fuel cell (DBFC), Co/N/C-130 achieves a maximum power density of 396 mW cm −2 at 60 °C. Long-term durability test at 50 mA cm −2 reveals a power retention of 90.8% after 24 h and 76.3% after 50 h. These results demonstrate that Co/N/C-130 atomic catalyst is a highly efficient and durable non-precious metal catalyst for ORR. Graphical abstract
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Science China-Materials
·
2016
·Vol. 59
·期 5
·337-347
·
IF 0
Zhang Guoxin,Jin Xiuyan,Li Haoyuan,Wang Lin,Hu Cejun,Sun Xiaoming
The crumpled graphene (CrG) was fabricated by applying defluorination of polyvinylidenefluoride (PVDF) on highly curved surface of CaC 2 particle through bottom-up synthetic strategy. The limited reaction depth between PVDF and CaC 2 leads to the formation of CrG with thin layer (3−6 layer graphene) and reasonable high specific surface area (~324.8 m 2 g −1 ). CrG with N incorporation (N-CrG) was applied as electrode material for reducing oxygen (i.e., oxygen reduction reaction, ORR) in alkaline, showing close onset potential to that of Pt/C and better mass-diffusion behavior. Surprisingly, with increased mass loading of catalysts, N-CrG exhibits steady current increase while Pt/C shows clear current plateau. Meanwhile, the N-CrG sample reveals high cycling stability and tolerance to contaminant, demonstrating its high potential for practical applications. Additionally, the bottom-up synthetic pathway to CrG via polymer dehalogenation on solid alkaline may find more applications which require controlled morphology and thickness of deposited thin graphitic carbon layers.
研究领域:
材料科学
·
电化学
·
纳米材料
·
能量存储与转换
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GLYCOCONJUGATE JOURNAL
·
2012
·Vol. 30
·期 6
·577-583
·
IF 2.117
Zhang Wuxia,Mu Haibo,Zhang Amin,Cui Guoting,Chen Hua,Duan Jinyou,Wang Shunchun
The linear non-sulfated glycosaminoglycan, hyaluronic acid (HA), is widely distributed throughout connective, epithelial and neural tissues etc., and is of great importance in tissue hydration, lubrication and cellular function. Along with the age growth, HA will lose its acetyl groups under action of HA N -deacetylase in vivo . However, the biological consequence of this physiological process remains largely unknown. Herein two highly N -deacetylated HAs, dHA-6 and dHA-10 were generated via the NH 2 NH 2 -HIO 3 procedure. Their molecular weights were estimated to be 24 and 16 kDa by high performance gel-permeation chromatography (HPGPC), and the N -deacetylation degrees were 79.4 % and 93 % respectively, as determined by 1 H nuclear magnetic resonance (NMR). The study on moisture-absorption ( Ra ) and -retention ( Rh ) abilities demonstrated that the Ra values of dHAs under conditions of 81 % or 43 % relative humidity, as well as the Rh values of dHAs under dry condition or 43 % relative humidity, were significantly smaller than that of their respective re- N -acetylated products. The decline of moisture-absorption and –retention capacity after HA N -deacetylation were consistent with the appearance of unsolvated amides remained in the N -deacetylated products, as indicated by circular dichroism (CD) spectroscopy. Our findings implied that HA N -deacetylation, in addition to the decrease of HA contents in the elderly persons, might account for manifestations of naturally aged skin, such as laxity, sagging, and wrinkling.
研究领域:
生物化学
·
皮肤科学
·
糖生物学
·
衰老研究
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POLYMER TESTING
·
2021
·
IF 4.282
Yuanfei Ge,Xiangsong Chen,Xiangqin Wang,Lixia Yuan,Jinyong Wu,Jianming Yao
In this study, CS-NeuAc hydrogel was prepared from chitosan (CS) and N-acetylneuraminic acid (NeuAc) using cyclic freeze/thaw under 1-ethyl-3-(3-dimethylaminopropyl)-carbodiiminde/N-hydroxysuccinimide catalysis. Fourier transformed infrared spectroscopy, X-ray diffraction, and scanning electron microscopy analyses confirmed the successful synthesis of CS-NeuAc hydrogel. CS-NeuAc hydrogels were found to be equipped with suitable swelling behaviour, porosity, water evaporation rate, degradation rate, and good mechanical properties compared to CS. The swelling rate, water evaporation rate, and degradation rate of prepared hydrogel with a CS/NeuAc molar ratio of 10:1 were 710.7 ± 28.6%, 78.2 ± 1.6%, and 58.6 ± 1.5%, respectively. Moreover, CS-NeuAc hydrogel exhibited excellent biocompatibility. The evaluation of CS-NeuAc hydrogels’ antibacterial activity confirmed that they serve as effective antibacterial materials against Escherichia coli and Staphylococcus aureus with antibacterial rates above 95% and 92%, respectively, and the minimum inhibitory concentrations was above 400 μg/ml. In conclusion, CS-NeuAc hydrogel can be a candidate for biological antibacterial materials.
研究领域:
生物材料
·
高分子科学
·
抗菌材料
·
组织工程
·
药学
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Small
·
2019
·Vol. 15
·期 46
·1904054
·
IF 10.856
Wenxiang Zhao,Xiang Hu,Suqin Ci,Junxiang Chen,Genxiang Wang,Qiuhua Xu,Zhenhai Wen
Although graphite materials have been applied as commercial anodes in lithium-ion batteries (LIBs), there still remain abundant spaces in the development of carbon-based anode materials for sodium-ion batteries (SIBs). Herein, an electrospinning route is reported to fabricate nitrogen-doped carbon nanofibers with interweaved nanochannels (NCNFs-IWNC) that contain robust interconnected 1D porous channels, produced by removal of a Te nanowire template that is coelectrospun within carbon nanofibers during the electrospinning process. The NCNFs-IWNC features favorable properties, including a conductive 1D interconnected porous structure, a large specific surface area, expanded interlayer graphite-like spacing, enriched N-doped defects and active sites, toward rapid access and transport of electrolyte and electron/sodium ions. Systematic electrochemical studies indicate that the NCNFs-IWNC exhibits an impressively high rate capability, delivering a capacity of 148 mA h g −1 at current density of as high as 10 A g −1 , and has an attractively stable performance over 5000 cycles. The practical application of the as-designed NCNFs-IWNC for a full SIBs cell is further verified by coupling the NCNFs-IWNC anode with a FeFe(CN) 6 cathode, which displays a desirable cycle performance, maintaining acapacity of 97 mA h g −1 over 100 cycles.
研究领域:
材料科学
·
储能
·
电化学
·
纳米材料
·
电池技术
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Small
·
2022
·Vol. 18
·期 44
·2203976
·
IF 15.153
Anding Xu,Qi Zhu,Guilan Li,Caihong Gong,Xue Li,Huaming Chen,Jie Cui,Songping Wu,Zhiguang Xu,Yurong Yan
Metallic Bi, as an alloying-type anode material, has demonstrated tremendous potential for practical application of potassium-ion batteries. However, the giant volume expansion, severe structure pulverization, and sluggish dynamics of Bi-based materials result in unsatisfied rate performance and unstable cycling stability. Here, 2D bismuth@N-doped carbon sheets with Bi O C bond and internal void space (2D Bi@NOC) are successfully fabricated via a self-template strategy to address these issues, which own ultrafast electrochemical kinetics and impressive long-term cycling stability for delivering an admirable capacity of 341.7 mAh g −1 after 1000 cycles at 10 A g −1 and impressive rate capability of 220.6 mAh g −1 at 50 A g −1 . Particularly, the in situ transmission electron microscopy observations visualize the real-time alloying/dealloying process and reveal that plastic carbon shell and void space can availably relieve dramatic volume stress and powerfully maintain structural integrity. Density functional theory calculation and ultraviolet photoelectron spectroscopy test certify that the robust Bi O C bond is thermodynamically and kinetically beneficial for adsorption/diffusion of K + . This work will light on designing advanced high-performance energy materials and provide important evidence for understanding the energy storage mechanism of alloy-based materials.
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高影响因子
Catalysis Science & Technology
·
2023
·Vol. 13
·期 6
·1855-1865
·
IF 5
Shuyi Yang,Jiayi Deng,Jiaying Chen,Qingmei Tan,Tianren Liu,Ke Chen,Dongxue Han,Yingming Ma,Mengjiao Dai,Li Niu
The conversion of N2 and CO2 into urea through a photocatalytic C–N coupling reaction under ambient conditions serves as a novel green avenue for urea synthesis. However, the poor adsorption and C–N coupling capability of inert gas molecules hinder the efficient catalytic activity. Herein, palladium-decorated CeO2 (Pd–CeO2) was demonstrated as an efficient photocatalyst for C–N coupling reaction and delivered a remarkable urea yield rate of 9.2 μmol h−1 g−1, which was superior to that of pristine CeO2 (2.5 μmol h−1 g−1). Comprehensive investigations further endorsed that the emerged space-charge region in the CeO2(111)/Pd(111) interface not only effectively facilitates the targeted capture and activation of inert CO2 and N2 but also stabilizes the formation of key intermediates (*NCON). Besides, the effective inhibition of the endothermic *NNH intermediate is conducive to the subsequent C–N coupling process and the improvement of reaction selectivity. The reaction mechanism was studied in detail by density functional theory (DFT) with the formation of a C–N bond via a thermodynamically spontaneous reaction between *NN* and CO. This work provides novel insights into the conversion of CO2 and N2 into urea.
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CRYSTENGCOMM
·
2023
·Vol. 25
·期 6
·981-987
·
IF 3.1
Nan Li,Minghao Shi,Wei Zhan,Wenjing Shen,Mianmian Wu,Guifang Sun,Qingfei Li,Jiangquan Ma
Ru-based catalysts are potential substitutes for Pt in the hydrogen evolution reaction (HER). It is worth noting that the Se ions in RuSe2 can modulate the electronic structure of the Ru metal, thus effectively improving the HER kinetics of RuSe2. However, single electronic structure modulation is hard to complete due to the electron deficiency of active Ru atoms. Herein, we prepare and design a novel RuSe2/Co–N–C (RuSe2 nanospheres supported on Co–N–C nanosheets) electrocatalyst with two-electron modulation by a hydrothermal and thermal annealing method. Benefiting from the uniform distribution of RuSe2 nanospheres on Co–N–C nanosheets and Co–N–C nanosheets acting as additional electron donors to make up for the electron deficiency of the Ru metal, RuSe2/Co–N–C exhibits excellent HER performance with a low overpotential of 26.4 mV at 10 mA cm−2 and a low Tafel slope of 53.2 mV dec−1. This work offers an effective method for the synthesis of high catalytic performance electrocatalysts by constructing an interaction between the carrier and the active metal.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Ruige Yang,Zhiyan Liu,Meiyue Han,Liping Cui,Yong Guo
To discover novel natural-product-based insecticide candidates, herein, a variety of osthole-derived N-benzoylthioureas were synthesized and assessed for their insecticidal activities against three insect pests. An insecticidal assay showed that most of the target osthole-derived N-benzoylthioureas displayed a more potent and broad-spectrum insecticidal effect than the parent osthole after the introduction of N-benzoylthioureas on the C-3′ position of osthole. Compound B24 displayed the most potent growth inhibitory (GI) effect on Mythimna separata Walker, with a final corrected mortality rate of 82.1% when treated with a concentration of 1 mg/mL, which was 1.64- and 1.53-fold higher in comparison to osthole and the botanical insecticide toosendanin, respectively. Compounds B22, B23, and B25 displayed a more promising aphicidal effect on Myzus persicae Sulzer, and their LD50 values were 0.015, 0.017, and 0.019 μg/larvae, respectively, superior to the commercially available insecticide rotenone (0.024 μg/larvae). Derivatives B19, B20, B23, and B25 displayed more potent larvicidal activity against Plutella xylostella Linnaeus, with LC50 values of 0.22, 0.26, 0.15, and 0.30 mg/mL, respectively, exceeding that of rotenone (0.37 mg/mL). Furthermore, both compounds B19 and B23 against P. xylostella were found to be more effective than rotenone in a control efficacy assay under greenhouse conditions. The structure–activity relationship (SAR) suggested that osthole-derived N-benzoylthioureas are more active in most cases when the R group is an electron-withdrawing group than when it is an electron-donating group, especially for halogenated groups. Additionally, the potent compounds B19 and B23 possessed good selectivity and were less toxic to non-target organisms. This study suggests that these osthole-derived N-benzoylthioureas could be further studied in depth as eco-friendly natural product pesticides in crop protection.
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高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2022
·
IF 7.693
Jieyu Sun,Xiuyi Lin,Yuhan Qiu,Runyu Wang,Yanfei Zhang,Chuanshuang Hu,Weiwei Zhang
Bamboo is an eco-friendly and sustainable material but with limited application due to its susceptibility to mold infection. N -methylol acrylamide (NMA) is a cross-linking monomer with bifunctional groups, here NMA was used to modified bamboo to enhance its anti-mold property through in situ polymerization and cross-linking reaction. When the monomer concentration was 6% and above, no mold germinated at the NMA treated bamboo surface. SEM/EDX, FTIR was used to explore the anti-mold mechanism of NMA modified bamboo. The primary reason for the improvement in the anti-mildew property was the coating effect of PNMA on starch as well as the antimicrobial properties of PNMA. Thermal stability of bamboo before and after modification was almost unchanged. Results also indicated that the mechanical properties of modified bamboo are improved by around 50%, which was mainly attributed to more compact structure of cell wall obtained in the neutral reaction condition. The NMA in situ polymerization was proved to be a potential modification for bamboo to broaden its application.
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