JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-23
·
IF 10.2
Pan Yi,Liu Longcai,He Yichen,Ye Luyi,Zhao Xin,Hu Zhiming,Mou Xiaozhou,Cai Yu
Background Triple-negative breast cancer (TNBC) possesses special biological behavior and clinicopathological characteristics, which is highly invasive and propensity to metastasize to lymph nodes, leading to a worse prognosis than other types of breast cancer. Thus, the development of an effective therapeutic method is significant to improve the survival rate of TNBC patients. Results In this work, a liposome-based theranostic nanosystem (ILA@Lip) was successfully prepared by simultaneously encapsulating IR 780 as the photosensitizer and lenvatinib as an anti-angiogenic agent, together with banoxantrone (AQ4N) molecule as the hypoxia-activated prodrug. The ILA@Lip can be applied for the near-infrared (NIR) fluorescence diagnostic imaging of TNBC and its lymph node metastasis for multimodal therapy. Lenvatinib in ILA@Lip can inhibit angiogenesis by cutting oxygen supply, thereby leading to enhanced hypoxia levels. Meanwhile, large amounts of reactive oxygen species (ROS) were produced while IR 780 was irradiated by an 808 nm laser, which also rapidly exhausted oxygen in tumor cells to worsen tumor hypoxia. Through creating an extremely hypoxic in TNBC, the conversion of non-toxic AQ4N to toxic AQ4 was much more efficiency for hypoxia-activated chemotherapy. Cytotoxicity assay of ILA@Lip indicated excellent biocompatibility with normal cells and tissues, but showed high toxicity in hypoxic breast cancer cells. Also, the in vivo tumors treated by the ILA@Lip with laser irradiation were admirably suppressed in both subcutaneous tumor model and orthotopic tumor models. Conclusion Utilizing ILA@Lip is a profound strategy to create an extremely hypoxic tumor microenvironment for higher therapeutic efficacy of hypoxia-activated chemotherapy, which realized collective suppression of tumor growth and has promising potential for clinical translation.
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高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Jinyuan Zhang,Tian Shi,Tong Liu,Fuhua Gao,Da Cai,Pingwei Liu,Shenghong Yang,Yueli zhang
Combining upconversion materials with narrow-wide bandgap semiconductors to construct heterostructured composite photocatalysts effectively improves solar energy conversion efficiency. NYF:Ln 3+ (Ln = Yb,Er,Tm)@BiOX(X = Cl,Br,I) heterostructures were prepared by a two-step hydrothermal method. This work explores the effects of different lanthanide ion doping and narrow-wide bandgap bismuth oxyhalides on the performance of the heterostructures system. Under near-infrared (NIR) light irradiation, NYF:Yb,Er,Tm@BiOI degraded 94 % BPA within 160 min. Significantly, compared with NYF:Yb,Er@BiOCl, NYF:Yb,Er@BiOBr and the NYF:Yb,Er,Tm/BiOI mechanical mixtures, the photocatalytic activity of NYF:Yb,Er,Tm@BiOI was increased by 9.4 times, 3.7 times and 1.8 times, respectively. The enhanced photocatalytic activity is attributed to the doping of Er-Tm double-activated ions, which provides multiple upconversion emissions and forms more overlap in the narrow bandgap BiOI absorption spectrum, making it advantageous to utilize upconversion light fully. Eventually, an underlying mechanism was proposed that the existence of FRET in the NYF:Yb,Er,Tm@BiOI heterostructure leads to enhanced photocatalytic activity. This work provides new insights into the design of advanced structures for NIR-responsive photocatalysts.
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高影响因子
Pharmaceutics
·
2020
·Vol. 12
·期 7
·680
·
IF 4.421
Jin Zhang,Xiaoyue Tang,Chuanqing Huang,Zeyu Liu,Yong Ye
Oleic acid (OA) as main component of plant oil is an important solvent but seldom used in the nanocarrier of anticancer drugs because of strong hydrophobicity and little drug release. In order to develop a new type of OA nanomaterial with dual responses to pH and near infrared light (NIR) to achieve the intelligent delivery of anticancer drugs. The novel OA copolymer (mPEG-PEI-(NBS, OA)) was synthesized by grafting OA ando-nitrobenzyl succinate (NBS) onto mPEGylated polyethyleneimine (mPEG-PEI) by amidation reaction. It was further conjugated with NaYF4:Yb3+/Er3+nanoparticles, and encapsulated doxorubicin (DOX) through self-assembly to make upconversion nanomicelles with dual response to pH and NIR. Drug release behavior of DOX, physicochemical characteristics of the nanomicelles were evaluated, along with its cytotoxic profile, as well as the degree of cellular uptake in A549 cells. The encapsulation efficiency and drug loading capacity of DOX in the nanomicelles were 73.84% ± 0.58% and 4.62% ± 0.28%, respectively, and the encapsulated DOX was quickly released in an acidic environment exposed to irradiation at 980 nm. The blank nanomicelles exhibited low cytotoxicity and excellent biocompatibility by MTT assay against A549 cells. The DOX-loaded nanomicelles showed remarkable cytotoxicity to A549 cells under NIR, and promoted the cellular uptake of DOX into the cytoplasm and nucleus of cancer cells. OA copolymer can effectively deliver DOX to cancer cells and achieve tumor targeting through a dual response to pH and NIR.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Chunyan Zhang,Zhendong Fu,Feng Hong,Ge Pang,Tengri Dong,Yunxiao Zhang,Guixia Liu,Xiangting Dong,Jinxian Wang
Broad spectrum response photocatalyst is crucial for making full use of sunlight and widely used in efficient photocatalytic degradation of organic dyes. In this work, upconversion luminescence boosted broadband photocatalysts based on BiF 3 :Yb 3+ , Er 3+ nanoparticles (BFY) and the carbon nitride doped with various masses of barbituric acid (CNB x ) semiconductor materials (BFY/CNB x ) were successfully designed and produced for photocatalysis in UV–Vis–NIR region. Compared with pure g-C 3 N 4 , BFY/CNB 0.5 composites have better photocatalytic performance attributed to the utilization of broadband spectrum energy and effective charge separation. After 30 min illumination by visible light , photodegradation efficiency of RhB reaches about 99.4% by using BFY-2/CNB 0.5 . A plot of C/C 0 versus time indicates that the BFY-2/CNB 0.5 can degrade about 64.7% of RhB in 80 min by NIR irradiation. Under simulated solar light, the sample of BFY-2/CNB 0.5 reaches a maximum degradation efficiency of 98.0% within 15 min. The strengthened photocatalytic activity is due to the synergistic effect of CNB 0.5 and upconversion materials. The active species utilized in the degradation process were examined using capture experiments. After four continuous photocatalytic cycles, about 94.0% of RhB solution is degraded. The photocatalytic mechanism of the composite photocatalysts is also analyzed in detail. The results indicate that the prepared BFY/CNB 0.5 photocatalysts have good prospects in the field of environmental remediation.
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高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Panjun Wang,Shuo Chen,Ziquan Cao,Guojie Wang
Here a novel quadruple-responsive nanocarrier based on reduced graphene oxide/mesoporous silica sandwich-like nanocomposites (rGO@MS) modified by pH- and temperature-responsive poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) with a linker of disulfide was constructed via surface-initiated atom transfer radical polymerization. The polymer chains would be used as gatekeepers to control the release of the loaded cargo molecules under pH, temperature, NIR light and redox stimuli. The cargo molecules (rhodamine B) were demonstrated to release from the polymer-modified nanocomposites triggered by the quadruple-stimuli. It is noted that the release of the loaded rhodamine B from the nanocarriers could be enhanced greatly under the synergistic effect of multiple stimuli. The prepared quadruple-responsive polymer-modified nanocomposites show a bright prospect in the field of smart nanocarriers for controlled release.
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高影响因子
CHEMICAL PHYSICS LETTERS
·
2021
·
IF 2.328
Ziyu Pan,Bin Liu,Bo Wang,Yingchao Liu,Tingyu Si,Wencai Yi,Yangqing Wu,Jinkai Li,Bingqiang Cao
Lead-free double-perovskite Cs 2 SnX 6 (X = Cl, Br, I) containing Sn 4+ is a more stable lead-free photovoltaic material than its homologue CsSnX 3 . However, its stability in air still affects its application. In this Letter, lead-free inorganic Cs 2 SnX 6 (X = Cl, Br, I) nanocrystals (NCs) were synthesized by a hot injection method and in-situ loaded into mesoporous SiO 2 . With the change of halogen content, the PL emission peak of pristine Cs 2 SnX 6 NCs were tuned from 430 nm to 780 nm covering the visible and near infrared spectrum region. Taking Cs 2 SnI 6 /SiO 2 NCs as an example, the optical property stability in solution is obviously improved, and it can be stored in air for over 2 h. Especially, the more stable NIR emission, non-toxicity and easy hydrolysis characteristics of Cs 2 SnX 6 /SiO 2 composite nanoparticles will have potential medical applications like photothermal and photodynamic therapies for cancers.
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高影响因子
Research
·
2023
·
IF 11
Jiaxiang Bai,Yonghai Feng,Wenming Li,Zerui Cheng,Jessica M. Rosenholm,Huilin Yang,Guoqing Pan,Hongbo Zhang,Dechun Geng
Nanozymes are considered to represent a new era of antibacterial agents, while their antibacterial efficiency is limited by the increasing tissue depth of infection. To address this issue, here, we report a copper and silk fibroin (Cu-SF) complex strategy to synthesize alternative copper single-atom nanozymes (SAzymes) with atomically dispersed copper sites anchored on ultrathin 2D porous N-doped carbon nanosheets (CuNx-CNS) and tunable N coordination numbers in the CuNx sites (x = 2 or 4). The CuNx-CNS SAzymes inherently possess triple peroxidase (POD)-, catalase (CAT)-, and oxidase (OXD)-like activities, facilitating the conversion of H2O2 and O2 into reactive oxygen species (ROS) through parallel POD- and OXD-like or cascaded CAT- and OXD-like reactions. Compared to CuN2-CNS, tailoring the N coordination number from 2 to 4 endows the SAzyme (CuN4-CNS) with higher multienzyme activities due to its superior electron structure and lower energy barrier. Meanwhile, CuNx-CNS display strong absorption in the second near-infrared (NIR-II) biowindow with deeper tissue penetration, offering NIR-II-responsive enhanced ROS generation and photothermal treatment in deep tissues. The in vitro and in vivo results demonstrate that the optimal CuN4-CNS can effectively inhibit multidrug-resistant bacteria and eliminate stubborn biofilms, thus exhibiting high therapeutic efficacy in both superficial skin wound and deep implant-related biofilm infections.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Shuhui An,Xiaoyi Zhang,Muqing Si,Huihui Shi,Peng Wei,Jianwei Shen,Wei Lu,Tao Chen
Luminescent polymeric gels (LPGs) are promising for wide high-tech applications due to their hydrated state, tunable emission and similarity to bio-tissues. However, most LPGs only exhibit visible luminescence below 630 nm and cannot emit the preferred near-infrared (NIR) luminescence (650 ∼ 900 nm). Herein, we report red-to-NIR aggregation-induced emissive LPGs based on supramolecular co-assemblies of cationic terpyridine platinum(II) luminogen (TPY-Pt) and anionic alginate (Alg) with unexpected large red emission shift (∼100 nm). Combined analyses of UV–Vis/emission spectra, transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential results, and density functional theory (DFT) calculations suggested that such large red-shifted emission derived from coupling of the dyes’ transition dipole moments in TPY-Pt/Alg co-assemblies. Interestingly, red-to-NIR luminescence was well-preserved after TPY-Pt/Alg co-assemblies were physically incorporated into crosslinked poly(vinyl alcohol) (PVA) networks. Consequently, PVA organohydrogels and hydrogels with red-to-NIR emission bands respectively centered at 698 nm and 708 nm were obtained. After further mechanical training to induce anisotropic orientational structures, these PVA organohydrogels were able to bear a high stress of 1.4 MPa. They also had pH-responsive emission, self-healing and remolding capacities, and biocompatibility. The developed red-to-NIR luminescent organohydrogels with these integrated merits have been seldom reported and are expected to find many potential applications.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Qunling Fang,Jing Wang,ShanShan Wu,Ken Cham-Fai Leung,Yunqi Xu,Shouhu Xuan
Pathogenic bacteria and difficult-to-degrade pollutants in water have been serious problems that always plague people. Therefore, finding a “one stone-two birds” method that can quickly catalyze the degradation of pollutants and show effective antibacterial behavior become an urgent requirement. This work reports a facile one-step strategy for fabricating a Rambutan-like Fe 3 O 4 @AgAu@PDA (Fe 3 O 4 @AgAu@Polydopamine) core/shell nanosphere with both catalytic and antibacterial activities which can be critically improved by externally applying an NIR laser irradiation (NIR, 808 nm) and a rotating magnetic field. Typically, the Rambutan-like Fe 3 O 4 @AgAu@PDA nanosphere have a rather rough surface due to the AuAg bimetallic nanorods sandwiched between the Fe 3 O 4 core and the PDA shell. Owing to the penetrated PDA shell, AgAu nanorods show high and magnetically recyclable photothermal-enhanced catalytic activity for the reduction of 4-nitrophenol to 4-aminophenol and they can also be applied to initiate TMB oxidation under the help of NIR heating condition. Moreover, Fe 3 O 4 @AgAu@PDA shows a moderate antibacterial activity due to the weak release of Ag + . Under applying a rotating external magnetic field, the rough-surface Fe 3 O 4 @AgAu@PDA nanospheres produce a controllable magnetolytic force on the bacterial due to their good affinity. As a result, the Fe 3 O 4 @AgAu@PDA nanospheres show a "magnetolytic-photothermal-Ag + " synergistic antibacterial behavior against E. coli and S. aureus .
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高影响因子
Advanced Optical Materials
·
2021
·Vol. 10
·期 4
·2102229
·
IF 9.926
Leqi Yao,Qiyue Shao,Meiling Shi,Tianqi Shang,Yan Dong,Chao Liang,Jinhua He,Jianqing Jiang
Near-infrared (NIR) phosphor-converted light-emitting diodes (pc-LEDs) hold great potential for applications ranging from night vision to non-destructive detection. However, it remains a long-standing challenge to develop NIR phosphors simultaneously with longer-wavelength broadband emissions and higher efficiency. Herein, ultra-broadband Ga 4 GeO 8 :Cr 3+ (GGO:Cr 3+ ) phosphors are developed, with the NIR emission covering 700–1300 nm. Furthermore, tunable emission bands peaking from 835 to 980 nm are achieved simply by varying the Cr 3+ concentration. Particularly, emission maxima (λ max ) of GGO: x Cr 3+ shift from 850 to 900 nm without intensity loss when increasing x values between 0.02 and 0.10. An internal quantum yield of 60% is achieved for GGO:0.02Cr 3+ (λ max ≈ 850 nm, full width at half maximum (FWHM) ≈215 nm). The origin of tunable ultra-broadband emissions of GGO:Cr 3+ is revealed on the basis of structural and time-resolved spectroscopic analysis. The pc-LED fabricated by GGO:0.02Cr 3+ exhibits a maximum NIR output power of ≈56 mW at 400 mA drive current, and its application in high-penetration quality analysis of fruits is also demonstrated. The results indicate that GGO:Cr 3+ phosphors have high promise for practical applications in NIR pc-LED devices.
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高影响因子
Advanced Science
·
2022
·Vol. 9
·期 16
·2200732
·
IF 17.521
Huiling Zhou,Dongsheng Tang,Xiaoxu Kang,Haitao Yuan,Yingjie Yu,Xiaolu Xiong,Nier Wu,Fangzhou Chen,Xing Wang,Haihua Xiao,Dongsheng Zhou
Photothermal therapy based on conjugated polymers represents a promising antibacterial strategy but still possesses notable limitations. Herein, degradable pseudo conjugated polymers (PCPs) containing photothermal molecular backbones and reactive oxygen species (ROS)-sensitive thioketal bonds are designed. Triphenylphosphine (PPh 3 ) is introduced into PCPs to generate phosphonium-based PCPs (pPCPs), which further assembled with hyaluronic acid into pPCP nanoparticles (pPCP-NPs). pPCP-NPs with quaternary phosphonium cations selectively anchor on and destroy bacterial cell membranes through electrostatic action. Under 1064 nm laser irradiation, pPCP-NPs (pPCP-NPs/+L) produce near-infrared-II (NIR-II) photothermal antibacterial effect, thereby killing bacteria in a sustained manner. pPCP-NPs are readily degraded upon ROS abundant at infection sites, therefore exhibiting enough biosafety. pPCP-NPs/+L display an almost 100% bacterial inhibition rate in vitro and resultin a nearly complete recovery of bacteria-induced mouse wounds. A further metabolomics analysis denotes that pPCP-NPs/+L work in a concerted way to induce bacterial DNA damage, inhibit bacterial carbon/nitrogen utilization and amino acid/nucleotide synthesis. Taken together, degradable pPCP-NPs with both NIR-II photothermal effect and cationic phosphonium structural bacteriostasis provide a new avenue for antibiotics-alternative anti-infection therapy.
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DOI
PubMed
高影响因子
PROGRESS IN SOLID STATE CHEMISTRY
·
2025
·
IF 10.5
Zhiwei Wang,Yinan Shen,Liangsheng Tian,Suwit Suthirakun,Wongsathorn Kaewraung,Qi Menghang,Hang Zhao,Xin Xin,Ruoxiu Xiao,Peng Jiang,Qu Li,Tingting Lu
The coating optimized with high near-infrared reflectance pigments can effectively reduce the energy consumption for heating and cooling in buildings, thereby alleviating the pressure on global energy consumption. Using a high-temperature solid-state method, blue-violet pigments with high near-infrared reflectance, Ca 2 Zn 1- x M x Si 2 O 7 (M = Mn, 0 ≤ x ≤ 0.4 and Ni, 0 ≤ x ≤ 0.2) solid solutions, were synthesized for the first time, with a maximum solar reflectance of 82.67%. Using XPS analysis, it was determined that the oxidation state of Ni in the pigment is +2, while Mn exists in mixed oxidation states of +2 and +3. UV-VIS-NIR spectroscopy analysis indicates that the blue-violet color of the pigment originates from the d-d transitions of the transition metal ions. As the doping concentration increases, the near-infrared reflectance of the pigment decreases. The DFT calculations have also confirmed that the color of pigments originates from transition metal ions. The as-synthesized pigments were incorporated into acrylic to create colored coatings. Improving the near-infrared solar reflectance of the acrylic coating. The excellent high near-infrared solar reflectance and coating property optimization make the synthesized pigment a potential energy-saving coating.
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