Food Bioscience
·
2025
·
IF 5.9
Tao Lu,Zhiguang Suo,Min Wei,Huali Jin,Yong Liu,Baoshan He,Renyong Zhao
β-lactoglobulin (β-LG) is a major allergen in milk what can provoke intense allergic reactions. Therefore, an accurate and efficient method is required for sensitive detection of β-LG. A label-free electrochemical aptasensor utilizing Au/Ag@ZIF-8 and dual amplification strategy has been designed for the detection of β-LG. Au/Ag@ZIF-8 nanocomposite is used as the electrode modification material, which has abundant relative surface area and exceptional conductivity behavior, and it can also serve to immobilize DNA strands. By combining RecJf exonuclease and hybridization chain reaction (HCR) dual amplification strategy, an apparent enhancement of electrochemical signal is obtained. β-LG undergoes target cycling in the effect of RecJf exonuclease, which dislodges complementary strand cDNA and further triggers HCR to provide a large number of sites for methylene blue embedding. The detection range of this aptasensor is 0.01–1000 ng/mL in the optimal detection conditions, with a limit of detection (LOD) of 5.37 pg/mL. The constructed electrochemical aptasensor possesses the superiorities of good specificity, preeminent accuracy and satisfied stability in the detection of β-LG. Moreover, it also demonstrates satisfactory detection performance in the detection of real samples, which indicates that the electrochemical aptasensor has a broad application prospect in protecting food safety and health.
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高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 2
·1-13
·
IF 5.3
Zhang Jiadong,Cui Yaoying,Dou Yanchao,Zhu Jingying,Ma Xiangyu,Guo Liming,Zhang Kai,Hao Nan,Feng Liangdong,Chen Yi
A highly sensitive and selective electrochemical biosensor was developed for the detection of kanamycin using a core-hollow-shell structured peroxidase-mimic nanozyme, CHS-Fe₃O₄@@ZIF-8. The synthesized CHS-Fe 3 O 4 @@ZIF-8 was characterized with scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. It was found that the CHS-Fe 3 O 4 @@ZIF-8 exhibits excellent peroxidase-like activity due to its ultra-thin hollow layer. Besides, CHS-Fe 3 O 4 @@ZIF-8 functionalized with complementary chains of kanamycin aptamer was anchored to the electrode surface via complementary base pairing with the kanamycin aptamer. Upon the presence of kanamycin, a strand displacement reaction was triggered leading to a reduction in the number of the CHS-Fe 3 O 4 @@ZIF-8, which slowed down the catalytic reaction of the substrate 3,3’,5,5’ -tetramethylbenzidine (TMB) facilitated by CHS-Fe 3 O 4 @@ZIF 8. Differential pulse voltammetry (DPV) was employed to measure and record changes in peak current resulting from catalytic oxidation product formation (oxidation product of TMB). The electrochemical signal exhibited a linear relationship with logarithmic variations in kanamycin concentration within a range spanning from 10 to 8000 pM and achieved an impressive detection limit as low as 7.52 pM. Furthermore, successful detection of kanamycin content in serum samples using this sensor demonstrated its good specificity and reproducibility. These findings indicate that the constructed electrochemical kanamycin sensor holds significant potential for practical applications. The biosensor demonstrated high selectivity, distinguishing kanamycin from other antibiotics, and exhibited good reproducibility, making it reliable for practical applications. The successful detection of kanamycin in serum samples further underscores the sensor’s potential for real-world applications, particularly in monitoring antibiotic residues in food products and clinical diagnostics. Graphical
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JOURNAL OF SOLID STATE CHEMISTRY
·
2024
·
IF 3.2
Le Chen,An Xie,Nan Zhang,Jianjun Yin,Qun Chen,Mingyang He,Zhihui Zhang
Zeolitic-Imidazolate Framework 8 (ZIF-8), a porous crystalline absorbent, could be synthesized from the coordination reaction of zinc ions and 2-methylimidazole (2-mIM). ZIF-8 has a large specific surface area and a high adsorption capacity for n -hexane ( n HEX). However, ZIF-8 suffers from low selectivity for both linear and mono-chain alkanes. Therefore, ZIF-8 was modified through 2-mIM ligand being partly replaced by 2-nitroimidazole (2-nIM) through Vapor-Phase post-synthesis modification. The modified materials were denoted as ZIF-8-2-nIM-X (X = 24h, 48h, 72h). ZIF-8-2-nIM-X has a higher specific surface area and better thermal stability than ZIF-8. Further thermodynamic and kinetic calculations show that the affinity of hexane isomers on ZIF-8-2-nIM-X is spontaneous physical adsorption combined with an exothermic process. In contrast, kinetic studies show that the adsorption of hexane isomers on ZIF-8-2-nIM-X is a pseudo-second-order kinetic model. The batch and dynamic adsorption and separation properties of ZIF-8-2-nIM-X for hexane isomers were studied. The results of the one-component vapor adsorption equilibrium experiment show that ZIF-8-2-nIM-72h has the best adsorption separation coefficient at 293 K. The adsorption capacity of n HEX and 3-methylpentane (3MP) were 211.63 mg/g and 33.91 mg/g, respectively. Compared with ZIF-8 (selectivity coefficient: 1.08), the adsorption selectivity coefficient of the modified material is greatly improved. The adsorption selectivity coefficient of n HEX/3MP is 6.24 (ZIF-8-2-nIM-72h).
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LANGMUIR
·
2025
·
IF 3.9
Yingying Cheng,Yuanye Zhuang,Shiyang Bai,Meng Ge,Jihong Sun,Jingjing Sun,Xufeng Gong
The removal of CO2 from biogas is critically important for environmental protection and energy applications yet remains technically challenging in the chemical industry. In this work, novel composite adsorbents featuring ZIF-8 uniformly dispersed on randomly oriented clinoptilolite lamellae (LCP) were designed and fabricated through a straightforward composite method. The synthesis sequentially incorporated metal precursors into LCP via ion exchange and salt addition and then introduced organic ligands to generate ZIF-8. Comprehensive characterizations, including XRD, FT-IR, N2 adsorption–desorption isotherms, SEM, and TG analyses, confirmed the physicochemical properties and structural features of the composites. The synthesized Zn-LCP/ZIF-8 materials exhibited exceptional CO2/CH4 separation performance, demonstrating ultralow CH4 adsorption capacity (<0.1 mmol/g) coupled with superior CO2/CH4 selectivity (≈28). Complementary molecular simulations using Material Studio software provided mechanistic insights into the adsorption and separation behavior, which further confirmed the superiority of the composite structure in CO2/CH4 separation. These results establish an effective strategy for biogas purification, while offering new perspectives for enhancing the CO2/CH4 adsorption selectivity.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Peiqing Zhang,Sihang Li,Fan Xiao,Yongfang Xiao,Yi Zhang,Zhongguo Shan,Zhenyu Li,Haihua Wang
Membrane distillation (MD) represents a promising advance in wastewater purification, contributing to the mitigation of water scarcity. Hydrophobic poly(vinylidene fluoride) (PVDF) microporous membrane is susceptible to wetting by low surface tension substances, leading to fouling. To address this, PVDF membrane was superhydrophobically modified using modified ZIF-8 to obtain two composite membranes, AZ/PVDF and Z@C/PVDF. AZ/PVDF and Z@C/PVDF composite membranes were prepared by coating more dispersible APTES-ZIF-8 and ZIF-8@MWCNT, respectively, onto the surface of PVDF membrane. The hydrophobicity of the composite membranes was regulated by silane types, fluorination methods, and fluorination time, resulting in reduced surface roughness and increased surface energy. The contact angles of AZ/PVDF and Z@C/PVDF were 154.2 ± 3.4° and 156.8 ± 4.2°, respectively. Both AZ/PVDF and Z@C/PVDF membranes demonstrated outstanding mechanical, thermal, and chemical stability. AZ/PVDF and Z@C/PVDF membranes outperformed PVDF membrane, extending operation times by 2 h and 3 h, respectively, without obvious NaCl crystals. Furthermore, Z@C/PVDF membrane exhibited superior resistance to wetting by SDS than AZ/PVDF and PVDF membranes, treating pickle brine via the direct contact MD (DCMD) process with a recovery rate of 30.2 % within 10 h. Overall, this research offers a promising approach to fabricating superhydrophobic composite membranes for high-salt brine treatment via DCMD.
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ChemistrySelect
·
2025
·Vol. 10
·期 28
·e00259
·
IF 2
Bo Yang,Hai Xing,Yang Xia,Xin Wang,Ningning Liu
Graphical ZIF-8 was synthesized through an in-situ growth method within a PVDF membrane matrix. The PVDF/ZIF-8 composite membrane was subsequently prepared via the phase inversion method using immersion precipitation. The ZIF-8 particles were uniformly distributed in the PVDF/ZIF-8 composite membrane. The widespread use of organic dyes in industrial processes has led to increasing environmental pollution due to the discharge of dye-contaminated wastewater, necessitating more efficient dye removal methods. In this study, a poly(vinylidene fluoride) (PVDF)/ZIF-8 composite membrane was fabricated via a phase inversion method using immersion precipitation, with ZIF-8 synthesized via in-situ growth within the membrane matrix. The composite membranes were thoroughly characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and thermogravimetric analysis (TGA). The ZIF-8 particles were uniformly distributed in the PVDF/ZIF-8 composite membrane. The adsorption performance of the PVDF/ZIF-8 composite membrane was evaluated for methyl green (MG) removal. At 313 K with an adsorbent dose of 10 mg, the membrane exhibited an adsorption capacity of 172.30 mg g⁻¹ and a removal ratio of 87.21%, demonstrating that the incorporation of ZIF-8 significantly enhanced adsorption performance. Adsorption isotherm studies revealed that the process followed the Freundlich model, while kinetic analysis indicated a pseudo-second-order mechanism. Additionally, thermodynamic investigations suggested that the adsorption was endothermic and spontaneous. The major driving force for adsorption was identified as electrostatic interactions between the dye and the membrane. These findings highlight the potential of PVDF/ZIF-8 composite membranes for effective dye removal from wastewater.
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Carbon Letters
·
2024
·
IF 5.5
Han Tong,Piao Ying-Ai,Meng Long-Yue,Jin Biao
Food contamination with heavy-metal ions and nitrites poses a serious threat to human health. Consequently, the development of fast and sensitive platforms for detecting these contaminants is urgently needed. In this study, a novel sensing platform was developed by integrating carbon nanotubes generated by the pyrolysis of waste masks (WMCNTs) with ZIF-8 for the simultaneous detection of Cd 2+ , Pb 2+ , and nitrite. Specifically, the electronic structure of the WMCNT backbone was modulated by doping with B and N atoms. Nanoporous ZIF-8 was then grown in-situ on its surface to produce composites with enhanced electrical conductivities and large specific surface areas. This modification provided more active sites for the attachment of heavy-metal ions and nitrites. Under optimized conditions, the sensing platform exhibited a wide linear range with the Pb 2+ , Cd 2+ , and NO 2 − limits of detection of 2.68, 12.12, and 5.94 μM, respectively. Notably, the sensing platform demonstrated excellent anti-interference capabilities and effectively detected nitrites and heavy-metal ions in pickled foods. Graphical abstract
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Chunlei Wang,Dawei Ji,Xuyong Tian,Hongye Lv,Xiuping Li,Tai Zhang,Haolong Xue,Chun Wang,Jingjing Yan,Changfa Xiao
Doping metal-organic frameworks into the casting solution is a common method for preparing mixed matrix membranes. However, metal-organic frameworks are prone to agglomeration and poor dispersion. This can lead to a decline in membrane performance. To address these issues, this work proposed “co-solvent synthesis and in-situ doping” strategy. In this strategy, N,N-Dimethylformamide, which was also the solvent in the casting solution, was chosen as the synthesis carrier for ZIF-8-NH 2 nanoparticles. The prepared ZIF-8-NH 2 suspension could be directly doped into the casting solution in situ. This process eliminated the drying and pre-dispersion steps. Research showed that with 0.5 wt% ZIF-8-NH 2 , the membrane's hydrophilicity significantly improved, with the water contact angle of 72.5°. The pure water flux reached 229 Lm −2 h −1 . Moreover, the retention rates of Congo Red and NaCl were 97.3 % and 3.5 % respectively, demonstrating excellent dye/salt separation. In particular, the flux recovery rate was maintained at more than 91 %, demonstrating good anti-fouling performance. This work provides a promising technical strategy for the efficient treatment of textile dyeing wastewater and resource recovery.
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Materials Today Chemistry
·
2025
·
IF 6.7
Henigul osman,Xiaohui Tang,Dong Zhang,Bo Liu,Jie Gao,Xin Chen,Tao Jiang,Haobo Pan,Yingbo Wang
To address the dual challenges of controlled drug delivery and microenvironment modulation in repairing osteoporotic bone defects, we developed a multifunctional poly(l-lactic acid) (PLLA)-based composite fibrous scaffold (PLLA/PDA/ZIF-8@Qu). The scaffold was fabricated via electrospinning, followed by in situ polydopamine (PDA) polymerization to robustly immobilize ZIF-8 nanocarriers loaded with quercetin (Qu) on the fiber surface. The mussel-inspired PDA coating served as an adhesive interlayer between ZIF-8 and PLLA. Additionally, it provided near-infrared (NIR) responsiveness and surface functionalization capability. Under osteoporotic acidic conditions (pH 5.0–6.0), the scaffold exhibited pH-triggered release behavior, ZIF-8 degradation accelerated Zn 2+ release, and cumulative Qu release reached 90 %. Zn 2+ contributed to antibacterial activity, while the PDA coating enabled NIR-driven photothermal/photodynamic synergy, achieving 100 % inhibition against both E. coliand S. aureus. Quercetin (Qu) exerted antioxidant effects via the Nrf2/ARE pathway and promoted macrophage polarization toward the M2 phenotype, thereby ameliorating the local inflammatory microenvironment. In vitro , the scaffold enhanced osteogenic differentiation of bone marrow mesenchymal stem cells, as indicated by a 2.3-fold increase in alkaline phosphatase activity, a 1.85-fold increase in mineralized nodule formation, and upregulated Runx2 expression. In a rat femoral defect model, the scaffold group at 8 weeks post-implantation showed increased bone mineral density (BMD) from 0.454 to 0.935 g/cm 3 and trabecular number (Tb.N) from 0.694 to 0.923 mm −1 , with the defect largely filled by newly formed bone. Collectively, these results demonstrate that the PDA-enabled, ZIF-8/Qu-integrated PLLA scaffold couples pH-responsive release with antibacterial, anti-inflammatory, and pro-osteogenic functions, supporting its potential as a bone repair material responsive to pathological microenvironments.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Wenxiang Hu,Jiangyu Zong,Jiajun Gong,Rong Xue,Yangbin Lv,Biao Liu,Wenting Dai,Yajun Wang,Chu Chu
Lipase immobilization plays a pivotal role in enhancing enzyme stability, reusability, and practical applicability in ligand fishing, a technique used to identify bioactive compounds from traditional Chinese medicine (TCM). However, conventional methods often lead to significant activity loss due to suffering from enzyme leakage, conformational distortion, and mass transfer resistance. In this study, we present a dynamic defect-engineering (DDE) strategy within zeolitic imidazolate framework-8 (ZIF-8) to overcome these limitations. The DDE process enables adaptive formation of transport channels driven by enzyme–framework interactions, facilitating the migration of lipase from surface adsorption to intracrystalline encapsulation. Brunauer–Emmett–Teller (BET) analysis confirmed successful encapsulation, showing a reduced specific surface area of 565.1 m 2 /g for lipase@ZIF-8, indicative of enzyme incorporation within the defect-engineered framework. This structural optimization significantly improved biocatalytic performance, achieving 82 % activity retention and 65 % immobilization yield, compared to 44 % activity retention in conventional in situ encapsulation. Utilizing the preserved catalytic activity, we established a lipase-based ligand fishing platform, which successfully identified 20 potential inhibitors (10 anthraquinones and 10 flavonoids) from Cassiae Semen and Citri Reticulatae Pericarpium using HPLC-Q-TOF-MS/MS analysis. Overall, this work demonstrates the effectiveness of the DDE strategy in enhancing lipase immobilization within ZIF-8, offering a robust and efficient platform for the high-throughput screening of lipase inhibitors from natural products and advancing the application of enzyme-based ligand fishing in TCM research.
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高影响因子
Small
·
2025
·
IF 12.1
Yan Gao,Xiayu Lia,Shuai Huang,Na Zhao,Jianshe Zhao
Three-dimensionally ordered macro-microporous 3DOM-ZIF-8-based peroxophosphotungstate (DIL-PW 4 ) is constructed to break the limitation of micropores inherent in traditional supported catalysts. The presence of ordered macropores expose more active sites and significantly enhance mass diffusion, thereby boosting catalytic activity, especially in reactions involving larger molecules. The prepared composite DIL-PW 4 @3DOM-ZIF-8 is verified by various characterization techniques and used as a catalyst for the extraction oxidation desulfurization of multi-component simulated fuel. The results showed that heterogeneous catalyst DIL-PW 4 @3DOM-ZIF-8 has a remarkable catalytic effect, with 97.03% total sulfides removal in 120 min. In addition, the stability and reusability of the catalyst DIL-PW 4 @3DOM-ZIF-8 are evaluated as important parameters for industrial applications. In addition, a possible mechanism based on experimental studies are proposed.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yunfei Shen,Huaiqi Shi,Keying Qu,Zuopeng Li,Bolong Yang,Zhansheng Wu
Multifunctional cotton fabric holds significant promise for domestic and healthcare applications. A key challenge remains developing sustainable fabrication routes for mechanically durable cotton textiles integrating intrinsic and photothermally amplified antibacterial functions. Herein, we prepared ZIF-8/67-loaded Ag nanoparticles on cotton fabric using in-situ reduction technology (ZIF-8/67-Ag@CCT). Subsequent dip-coating with polydimethylsiloxane (PDMS) produced ZIF-8/67-Ag@CCT@PDMS, enhancing superhydrophobicity. The modified fabric exhibited exceptional superhydrophobicity (water contact angle: 148.55 ± 0.21°) and UV-blocking capabilities (UPF value: 186). The surface demonstrated excellent self-cleaning properties against dyes and maintained robust stability after 30 washing cycles and immersion in acidic/alkaline solutions (>97.0% antibacterial efficacy retention). Critically, the fabric exhibited excellent biocompatibility, as validated by human induced pluripotent stem cell-derived skin organoid assays showing no adverse effects on cell proliferation, apoptosis, or survival rates. Antibacterial effects originated from the penetration of AgNPs and Ag⁺/Zn²⁺/Co²⁺ ions into bacterial structures, disrupting metabolism via reactive oxygen species (ROS) generation. The multifunctional ZIF-8/67-Ag@CCT@PDMS fabric presents a highly promising solution for durable antibacterial medical textiles, offering combined antibacterial activity, exceptional stability, self-cleaning, UV resistance, and biocompatibility.
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