International Journal of Nanomedicine
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2023
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IF 8
Dongmei Guo,Yue Huang,Kun Wang,Chenguang Yang,Lili Ma,Yu Zhang,Haiyang Yu,Manhua Cui,Zhaohui Tang
Purpose Cervical cancer (CC) is a highly vascularized tumor with abundant abnormal blood vessel, which could be targeted by therapeutic strategies. Poly(L-glutamic acid)-g-methoxy poly(ethylene glycol)/combretastatin A4 (CA4)/BLZ945 nanoparticles (CB-NPs) have shown great potential as nano vascular disrupting agents (VDAs) in the realm of synergistic cancer therapy.Methods In this study, we investigated the nanocharacteristics of CB-NPs, focusing on active pharmaceutical ingredients (API), as well as lyophilized samples combining API with protective agents (PAs). The in vivo efficacy of final sample (API + PAs) was evaluated.Results The assembled sphere of API with complex core and thin-shell structure was confirmed. PAs were found to significantly influence in vivo efficacy. Collaborative efforts between API and PAs, namely mannitol and lactose, resulted in the most promising lyophilized sample, ie, the final sample (FS2) for CC therapy. Impressively, FS2 demonstrated an exceptional 100% cure rate on the CC U14-bearing mice model.Conclusion FS2 has provided significant insights for cervical cancer therapy. It is also crucial to develop a comprehensive evaluation strategy for the formulation of nanomedicine, which has the potential to serve as a guideline for future clinical trials.
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高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2021
·Vol. 306
·期 10
·2100336
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IF 4.367
Zhiwen Lei,Qi Qiu,Jinlai Shen,Xiaohu Ao,Bingqi Zhang,Yuanfa Guo,Jun Wang,Yonghong Deng,Chaoyang Wang
Solid polymer electrolyte with good thermal stability and flexibility is an excellent candidate for solid-state lithium metal batteries, while its low ionic conductivity caused by high crystallinity limits its application at ambient temperature. Here a metal organic framework (zeolitic imidazolate framework-8, ZIF-8) composited comb-like methoxy poly(ethylene glycol) acrylate polymer electrolyte (MCPE) with high ionic conductivity (9.96 × 10 −5 S cm −1 at 30 °C) is prepared by an in situ UV polymerization method. The as-prepared MCPE exhibits improved mechanical property due to the introduction of porous ZIF-8 nanofillers, which is beneficial to suppress the growth of lithium dendrites. Consequently, the LiFePO 4 ||MCPE||Li cells show a high capacity of 116 mAh g −1 at 30 °C and 0.5 C, and maintain 89.4% of initial capacity after 150 cycles with the average Coulombic efficiency of 99.9%. These results demonstrate that the MCPE shows great potential in solid-state lithium metal batteries near room temperature.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2021
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IF 3.171
Xingzheng Liu,Chuanbo Fu,Manting Wang,Jiexin Wang,Haikui Zou,Yuan Le,Jianfeng Chen
Poly (ethylene glycol)-poly ( n -butyl cyanoacrylate) (PEG-PBCA) is a remarkable drug delivery carrier for permeating blood-brain barrier. In this work, a novel high-gravity procedure was reported to intensify Knoevenagel condensation-Michael addition polymerization of PEG-PBCA. A series of PEG-PBCA containing different block ratios were synthesized with narrow molecular weight distribution of polydispersity indexes less than 1.1. Furthermore, the reaction time reduced 60% compared to conventional stirred tank reactor process. Chemical structures of as-prepared polymers were characterized. In vitro drug delivery performance was evaluated. The cytotoxicity of PEG-PBCA to brain microvessel endothelial cells (BMVEC) decreases with the extension of the PEG chain and the shortening of the PBCA chain. The polymer cellular uptake to BMVECs was better after improving hydrophilicity by PEG block. Results of blood-brain barrier permeability demonstrated that medium length of PBCA chain and short PEG chain are favorable for hydrophobic Nile red permeation, while long PEG chain and short PBCA chain are beneficial to delivery water-soluble doxorubicin hydrochloride (Dox). The average apparent permeability coefficient increased 1.7 and 0.25 times than that of raw Nile red and Dox, respectively. High-gravity intensified condensation polymerization should have great potential in brain drug delivery system.
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POLYMER
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2020
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IF 4.231
Ke Wang,Qi Liu,Guiyan Liu,Yongfei Zeng
The study of thermoresponsive homopolymers has attracted great attention due to their broad application value. Herein, a series of novel thermoresponsive homopolymers of poly[oligo(ethylene glycol) (acyloxy) methacrylate]s containing oligo(ethylene glycol) (OEG) units and substituent groups of ester have been designed and prepared by RAFT polymerization . The solution properties of these polymers have been investigated in detail, which indicate that most of them exhibit lower critical solution temperature (LCST) in water and upper critical solution temperature (UCST) in alcohols, and their LCST-type or UCST-type cloud point temperature ( T CP L or T CP U ) is closely related to the OEG units and ester groups. Furthermore, the parameters affecting the thermoresponse of these polymers including polymerization degree (DP) and concentration have also been investigated. The present work not only discovers a series of novel thermoresponsive polymers, but also has certain guiding significance on the understanding of molecular structure and thermoresponsive property relationships, which is useful for the design of new thermosensitive polymers.
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JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
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2020
·Vol. 31
·期 7
·1509-1517
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IF 1.399
Wang Dan-Dan,Lu Zhi-Heng,Yang Mei-Nan O.,Guo Hao-Ming,Yang Zhong-Hua
In this study, a novel deep eutectic solvent (DES) containing choline chloride and ethylene glycol was synthesized, and the magnetic polydopamine (PDA) was modified with this deep eutectic solvent to form Fe3O4@PDA-DES. Fourier transformed infrared spectroscopy, scanning electron microscopy, and vibrating sample magnetometer were used to characterize the proposed adsorbent. Then, this magnetic material was used as an adsorbent in the magnetic solid phase extraction process for the extraction of four sulfonylurea herbicides in water samples. The main parameters relevant to this method were investigated. Under the optimum conditions, the linearity was obtained by five points in the concentration range of 1.0-200 µg L-1 and with the correlation coefficients (r) ≥ 0.9927. The enrichment factors were in a range of 495 to 615 and the relative standard deviations were less than 4.3%. The limits of detection varied from 0.0092 to 0.0113 µg L-1. The recoveries of environmental water samples were 61.9 to 100.1%, and the recoveries of drinking water samples were 71.1-101.9%. All results highlighted the excellent potential of magnetic solid phase extraction coupled with ultra-high performance liquid chromatography strategy in selective separation and extraction of sulfonylurea herbicides in water samples.
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JOM
·
2019
·Vol. 71
·期 12
·4547-4555
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IF 2.305
Chen Yan,Liu Yi,Chen Zhengshou,Shi Qian,Gao Junkai,Ding Han,Tang Xi,Liu Yu
Novel mesoporous carbon microspheres (MCMS), which exhibited a large surface area and were developed by the pyrolysis of polydopamine microspheres (PDAMS), were used as a supporting material for polyethylene glycol (PEG) to prepare a new type of efficient form-stable phase-change material (MCMS-PEG). Using a simple vacuum impregnation strategy, the preparation of polydopamine microspheres via a biomimetic method was facile, simple and environmentally friendly. Characterization of MCMS-PEG was performed by scanning electron microscopy (SEM), x-ray diffraction (XRD), x-ray photoelectron spectroscopy (XPS), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA). The results suggested that MCMS-PEG possessed high latent heats of 112.08 J/g during the melting process and 107.34 J/g during the solidification process. Additionally, MCMS-PEG presented an enhanced thermal conductivity and excellent thermal stability. Therefore, the novel mesoporous carbon microspheres developed in this study could be used as efficient supports for the preparation of shape-stabilized phase-change materials.
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CARBOHYDRATE POLYMERS
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2018
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IF 5.158
Abishek Jung Poudel,Feng He,Lixia Huang,Lin Xiao,Guang Yang
A supramolecular hydrogel system was prepared by the host-guest interaction between the α-cyclodextrin (α-CD) and poly (ethylene glycol) (PEG) chains of the poly (ethylene glycol)- block -poly (lactic acid) (PEG- b -PLA) micelles. The formation of inclusion complex (IC) crystals between α-CD and the PEG chains of the micelles was verified by different techniques. Rheological studies indicated that the gelation kinetics and the mechanical strength of the hydrogels could be modulated by the α-CD concentration. Also, the shear-thinning and self-healing properties of the hydrogels were confirmed. Doxorubicin (DOX) could be encapsulated into the hydrogels via the micelles and be released from the hydrogels sustainably, with the release rate dependent on the α-CD concentration. The released DOX showed higher inhibition efficacy against HeLa cells compared with the free drug. These attractive features, together with the superior biocompatibility, make the present hydrogels an potential injectable drug delivery system for tumour treatment.
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Asian Journal of Organic Chemistry
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2018
·Vol. 7
·期 10
·2039-2044
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IF 2.496
Qian-Qian Huang,Wei-Qiang Yu,Xiao-Lin Luo,Jin Gao,Jie Xu
Graphical An alternative method for glycerol hydrogenolysis to CH 4 and ethylene glycol that proceeds through preferential C−C bonds cleavage catalyzed by highly-dispersed Ru catalysts with tunable particle sizes via carbothermal reduction has been reported. An alternative method for the conversion of crude glycerol was proposed to produce renewable energy methane and high-value chemical ethylene glycol through preferential cleavage of C−C bonds, catalyzed by highly dispersed Ru-based catalysts prepared by carbothermal reduction. It was found that the Ru particles size could be tuned by adjusting the reduction temperature, and the size firstly decreased then increased with raising of the temperature of carbothermal reduction. This resulted in the opposite tendency of catalytic performance against the Ru particle sizes in hydrogenolysis of glycerol, in which the glycerol conversion and yield of C−C bond cleavage increased firstly and then decreased. Ru catalysts carbothermal reduced at 450 °C possessed highly dispersed Ru nanoparticles with uniform particle sizes about 1.0 nm that showed high hydrogenation activity and selectivity of C−C bond cleavage as well as good stability that could be recycled in aqueous phase hydrogenolysis of glycerol.
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JOURNAL OF POLYMER RESEARCH
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2012
·Vol. 19
·期 12
·1-8
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IF 1.733
Ma Chi,Wang Bing,Xiong Cheng-Dong,Chen Dong-Liang,Xiong Zuo-Chun
Control of dimensional stability is crucial for using electrospun membranes in biomedical and tissue engineering applications. In this study, the contraction of electrospun membranes of poly( l -lactide-co-glycolide) (PLLGA) after stretch was investigated. Then, by adding PLLGA-b-polyethylene glycol (PLLGA-PEG), the contraction of the membranes was controlled. In addition, the mechanical properties of the membranes were investigated. On the basis of the strain–stress behavior of the membranes, an elongation of 50 % was used to investigate the orientation degrees of the membrane fibers. On the basis of the morphology of the stretched membranes, the contraction was found to depend on the orientation degree of fibers after stretch. A linear relationship between the contraction and degree of orientation after stretch was confirmed. Two-dimensional fast Fourier transform (2D FFT) analysis of the scanning electron microscopy (SEM) images of the membranes was used to quantify the orientation degree. It was surmised that the different orientation degrees were responsible for the different morphologies and thermal behaviors of the membranes.
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JOURNAL OF MATERIALS CHEMISTRY
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2012
·Vol. 22
·期 41
·22265-22271
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IF 5.968
Xiang Zuo,Xiao-Min Liu,Feng Cai,Hui Yang,Xiao-Dong Shen,Gao Liu
A novel graft copolymer solid electrolyte with a relatively high ionic conductivity, 10−3.9 S cm−1 at 30 °C and 10−3.1 S cm−1 at 80 °C, is prepared by free radical polymerization in this study. The polymer consists of methacrylate as the backbone and a mixture of hexadecal (C16)–methoxyl terminated oligo(ethylene oxide) at a certain ratio as side chains. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis reveal that non-polar unit (C16) end-modification not only greatly increases the mobility of the ethylene oxide (EO) chains, but also suppresses their local crystallization behavior by interrupting the regular arrangement, therefore improving the conductivity of the obtained electrolyte.
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RSC Advances
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2014
·Vol. 4
·期 97
·54268-54281
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IF 3.708
Yinwen Li,Huilong Guo,Jian Zheng,Jianqun Gan,Yan Zhang,Xiaoxiao Guan,Kun Wu,Mangeng Lu
Novel macromolecular star polymers with triazole and cyclodextrin (CD) segments as branch points and poly(oligo(ethylene glycol)methacrylate) (POEGMAs) as dense hydrophilic branches were synthesized via a combination of azide–alkyne click chemistry and atom transfer radical polymerization (ATRP). Firstly, a tetrafunctional linking agent (PETP) was prepared by the reaction of pentaerythritol (PE) and propargyl bromide, and then a four arm β-CD terminated star polymer (PE-CD) was obtained through the click chemistry reaction. Finally, thermally-responsive star polymers (PE-CD–POEGMAs) with PE as the central core, triazole and CD segments as branch points, and POEGMAs as side branches were synthesized by the ATRP of MEO2MA and OEGMA using PE-CD terminated with bromines as macroinitiators. A study on the thermoresponsivity and morphology of PE-CD–POEGMAs indicated that polymeric nano-aggregates existed as multimolecular micelles and behaved with tunable thermosensitivity, which were driven by the strong hydrophobic–hydrophilic interactions in the inner core and outer shell. The encapsulation capacities towards multi-guest molecules were investigated and the results indicated that water soluble guests could be encapsulated by PE-CD–POEGMAs, and the guest encapsulation capacities were derived from the special star molecular structure properties of PE-CD–POEGMAs and the synergistic encapsulation phenomenon of different guest molecules. This unique amphiphilic star polymer illustrated the potential applications in supramolecular science, drug delivery and other nanotechnology applications.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2013
·Vol. 18
·期 4
·1087-1097
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IF 2.279
Yan Zhenhua,Wang Min,Lu Youqin,Liu Renmin,Zhao Jinsheng
Three carbon-supported Pt–Co alloys with varying Pt to Co atom ratio (Pt 2 –Co/C, Pt–Co/C, Pt–Co 2 /C) were prepared by NaBH 4 reduction in ethylene glycol at room temperature. As supported by X-ray diffraction, all the prepared Pt–Co nanoparticles have a single-phase face-centered cubic structure. Transmission electron microscopy indicates that all nanoparticles have small particle-size range and are highly dispersed on carbon support. Catalytic properties of the synthesized Pt–Co alloy catalysts were analyzed using cyclic voltammetry and linear sweep voltammetry methods, and the results suggested that Pt–Co/C catalysts exhibit the best Pt mass activity and the highest stability for the oxygen reduction reaction (ORR) when compared with Pt/C catalyst and other Pt–Co alloy catalyst in both acidic and neutral media. Kinetic analysis reveals that the ORR on Pt–Co alloy follows the four-electron pathway leading to water. As the cathode catalyst, the single-chamber microbial fuel cell tests indicated the much better performance of Pt–Co alloy than that of commercial Pt/C.
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