IONICS
·
2023
·Vol. 29
·期 12
·5491-5503
·
IF 2.8
Ren Shufang,Cao Li,Liu Xiaohang,Cui Wangyong,Lv Rui,Guo Tong,Wang Qingtao,Zheng Zhixiang
The detection of norfloxacin (NOR) is crucial because the overdoes and accumulation may result in residues in environment in animal-derived foods, which can destroy ecology and cause disease for people. A molecularly imprinted electrochemical sensor based on g-C 3 N 4 /Cu-MOF was constructed for the selective detection of norfloxacin in this paper. The g-C 3 N 4 /Cu-MOF was synthesized by melamine pyrolysis and solvothermal method followed by ultrasonic mixing. After drop casting g-C 3 N 4 /Cu-MOF on glassy carbon electrode, the molecularly imprinted film was synthesized by electropolymerization. The composite was analyzed by powder X-ray diffractometer, field emission scanning and transmission electron microscope, and Fourier transform infrared spectroscopy. The electrochemical properties of the sensor were characterized by cyclic voltammetry, electrochemical impedance spectroscopy, and pulse voltammetry. The results show that the composite of g-C 3 N 4 /Cu-MOF efficiently decreased the charge transfer resistance of electrode and improved the electron transfer kinetic between analyte and electrode with the improved current response and increased active area. After optimizing conditions of the ratio of functional monomers to template molecules, the number of polymerization cycles, accumulation time, electrolyte pH, and the sensor exhibits excellent response toward NOR with the linearity range of 0.02–0.1 μmol/L and 1–120 μmol/L and the limit of detection of 6.67 nmol/L. Moreover, it shows good selectivity, anti-interference, and reproducibility properties. In the real sample detection of pharmaceutical formulations, serum and milk, the sensor shows an acceptable recovery rate and standard deviation.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-22
·
IF 10.2
Zhang Shushan,Huang Yongquan,Pi Songying,Chen Hui,Ye Feile,Wu Chaoqun,Li Liujun,Ye Qing,Lin Yuhong,Su Zhongzhen
Incomplete radiofrequency ablation (IRFA) triggers mild protective autophagy in residual tumor cells and results in an immunosuppressive microenvironment. This accelerates the recurrence of residual tumors and causes resistance to anti-PD-1/PDL1 therapy, which bringing a great clinical challenge in residual tumors immunotherapy. Mild autophagy activation can promote cancer cell survival while further amplification of autophagy contributes to immunogenic cell death (ICD). To this regard, we constructed active targeting zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (NPs) loaded with STF62247 or both STF62247 and BMS202, namely STF62247@ZIF-8/PEG-FA (SZP) or STF62247-BMS202@ZIF-8/PEG-FA (SBZP) NPs. We found that SZP NPs inhibited proliferation and stimulated apoptosis of residual tumor cells exposed to sublethal heat stress in an autophagy-dependent manner. Further results discovered that SZP NPs could amplify autophagy in residual tumor cells and evoke their ICD, which dramatically boosted the maturation of dendritic cells (DCs). Through vaccination experiments, we found for the first time that vaccination with heat + SZP treatment could efficiently suppress the growth of new tumors and establish long-term immunological memory. Furthermore, SBZP NPs could remarkably promote the ICD of residual tumor cells, obviously activate the anti-tumor immune microenvironment, and significantly inhibit the growth of residual tumors. Thus, amplified autophagy coupled with anti-PD-1/PDL1 therapy is potentially a novel strategy for treating residual tumors after IRFA.Graphical Abstract
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Scientific Reports
·
2023
·Vol. 13
·期 1
·1-12
·
IF 4.6
Li Tao,Tian Yuan,Zhong Quliang,Chen Peng,Zhang Junhao,Du Guangshi,Li Lei,Jiang Yiting,Jiang Kehua
Penile size is closely concerned and short penis contributes serious sexual dysfunction and tremendous psychological problems to couples. Androgen is essential for penile development and testosterone replacement is recommended to patients with micropenis. We previously proved that inhibiting activity of lysyl oxidase (Anti-lysyl oxidase, Anti-LOX) combined with vacuum erectile device (VED) lengthened penis by remodeling tunica albuginea. We thus explored whether HCG supplement could accelerate tunica albuginea remodeling (induced by Anti-LOX + VED) to promote penile growth. Forty-two SD male rats (4 weeks old) were purchased and divided into 7 groups: control, Anti-LOX, HCG, VED (with a negative aspirated pressure of − 300 mmHg), Anti-LOX + VED, HCG + VED, and Anti-LOX + HCG + VED. After an intervention for 4 weeks, all rats’ penile length, exposed penile length, and erectile function were measured. Serum samples were collected to detect hormone levels and penile corpus cavernosum were harvested for histo-pathological analysis. All intervention groups showed significantly longer penis than controlled rats. Anti-LOX sharply increased penile length and exposed length by 15% and 9% respectively, this lengthening effect was more obvious in Anti-LOX + VED group (26% and 19%, respectively). Although HCG promoted penile length by 8%, this effect was slight for exposed length (3%). Moreover, Anti-LOX + HCG + VED dramatically increased penile length and exposed length by 22% and 18%, respectively, which was similar with that in Anti-LOX + VED (26% and 19%, respectively). HCG dramatically stimulated testosterone and dihydrotestosterone secretions than control group, whether with or without Anti-LOX and VED; while it induced more AR expression than other groups. Finally, all procedures did not improve or deteriorate normal erectile function. Although we verified that Anti-LOX + VED lengthened penis by inducing tunica albuginea remodeling, however, HCG supplement did not synergize with Anti-LOX + VED to accelerate albuginea remodeling to facilitate penile growth.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2023
·
IF 3
Sun Ziyi,Zhang Gaoning,Li Xiaoru,Cui Qingqi,Gong Lili,Tian Zhenhua
This study investigated the chemical and volatile characteristics of sea buckthorn fruits from three different regions in China. The chemical composition of the volatile oil was determined by using a non-targeted gas chromatography and mass spectrometry (GC/MS) method and the differences in chemical composition among the three producing areas were compared by heatmap providing a visual basis for researchers. A total of 93 compounds were identified, including 52 compounds from the Northeast China, 51 from the Xinjiang region, and 37 from Inner Mongolia region. Then, the in vitro antioxidant activity of sea buckthorn fruit oil was measured using DPPH, ABTS, and SOD inhibition tests, and the results showed that sea buckthorn fruit oil in northeast China was the strongest antioxidant, followed by Inner Mongolia and Xinjiang. The results of the CCK-8 experiment indicated that within the tested concentration, there is no cell cytotoxicity of the essential oil in human umbilical vein endothelial cells (HUVECs) cells. The results could supply reference to distinguish sea buckthorn fruit from different production areas and, meanwhile, clarify the activity and safety of sea buckthorn oil.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 54
·115896-115906
·
IF 5.8
Liu Wenjuan,Wang Zihan,Chai Guoli,Deng Wenbo
The extensive application of carbon nanomaterials (CNMs) has attracted increasing studies concerned about its environmental impact. These studies focus on single exposure to CNMs, but repeated exposures with relatively low concentration are more likely to occur under actual exposure scenario. In this study, we studied the metabolic functional and structure of soil microorganism community under single and repeated exposures to multiwalled carbon nanotubes (MW), graphene (GR), and fullerene (C 60 ) by Biolog EcoPlates and high-throughput sequencing. Our findings revealed that repeated exposures to CNMs significantly increase the metabolic activity and diversity of the soil microbial community as compared with single exposure. Principal component and similarity analysis not only indicated that GR exerted a stronger effect on soil microbial diversity among three exposures compared to C 60 and MW, but also revealed that the metabolic activity of the soil microbial community was more affected by the exposure scenarios of CNMs than the type of CNMs. These findings elucidated the effect of CNMs under different exposure scenarios on soil microorganism community, providing a new perspective on the risk assessment of nanomaterials.
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Nano Research
·
2023
·
IF 9.9
Chen Tanlin,Tian Yingrui,Guo Zihao,Chen Yao,Qi Qing,Meng Fanbin
In order to meet the requirements of the marine environment for microwave absorption (MA) materials, we put forward the strategy of constructing multi-functional composite materials, which integrate microwave absorption, anti-corrosion, and antibacterial properties. Herein, graphene oxide (GO) was used as a template to induce the growth of zeolitic imidazolate framework-8 (ZIF-8), simultaneously as a two-dimensional (2D) nanocontainers to load corrosion inhibitors to achieve pH-responsive and self-healing properties. Finally, quaternary ammonium salt (dimethyl octadecyl(3-trimethoxylsilyl propyl) ammonium chloride (DMAOP)) and sodium ascorbate (VCNa) were introduced to achieve synergistic antibacterial activity and the reduction of GO. The 2D strip-like structure of ZIF-8 was due to the confined growth induced by the electrostatic attraction between ZIF-8 and GO sheets. The as-obtained reduced GO (RGO)/ZIF-8/DMAOP 5 exhibited excellent microwave absorption (MA) properties, with a minimum reflection loss (RL) value of −47.08 dB at 12.73 GHz when the thickness was 2.8 mm. Moreover, the effective absorption bandwidth reached 6.84 GHz. After soaking in 3.5% NaCl solution for 35 days, the RGO/ZIF-8/DMAOP 5 −0.7% coating still achieved an impedance value of 4.585 × 10 7 Ω·cm 2 and a protective efficiency of 99.994%, providing superior anti-corrosion properties. In addition, fantastic antibacterial activity was obtained, with the antibacterial rates of RGO/ZIF-8/DMAOP 10 reaching 99.39% and 100% against Escherichia coli and Staphylococcus aureus . This work could open new avenues towards the development of a new generation of multifunctional MA materials.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-15
·
IF 16.6
Lu Xiangyu,Kuai Le,Huang Fang,Jiang Jingsi,Song Jiankun,Liu Yiqiong,Chen Si,Mao Lijie,Peng Wei,Luo Ying,Li Yongyong,Dong Haiqing,Li Bin,Shi Jianlin
Psoriasis is a common inflammatory disease of especially high recurrence rate (90%) which is suffered by approximately 3% of the world population. The overexpression of reactive oxygen species (ROS) plays a critical role in psoriasis progress. Here we show that biomimetic iron single-atom catalysts (FeN 4 O 2 -SACs) with broad-spectrum ROS scavenging capability can be used for psoriasis treatment and relapse prevention via related gene restoration. FeN 4 O 2 -SACs demonstrate attractive multiple enzyme-mimicking activities based on atomically dispersed Fe active structures, which are analogous to those of natural antioxidant enzymes, iron superoxide dismutase, human erythrocyte catalase, and ascorbate peroxidase. Further, in vitro and in vivo experiments show that FeN 4 O 2 -SACs can effectively ameliorate psoriasis-like symptoms and prevent the relapse with augmented efficacy compared with the clinical drug calcipotriol. Mechanistically, estrogen receptor 1 (ESR1) is identified as the core protein upregulated in psoriasis treatment through RNA sequencing and bioinformatic analysis. Together, this study provides a proof of concept of psoriasis catalytic therapy (PCT) and multienzyme-inspired bionics (MIB).
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Nano Research
·
2023
·
IF 9.9
Nie Zhidong,Sun Yingzhi,Zhou Tianxu,Kong Shengwen,Liu Linxing,Zhao Chuangqi,Liu Mingjie
One-dimensional (1D) aramid nanofiber (ANF) based nanocomposite films have drawn increasing attentions in various applications due to their excellent mechanical properties and impressive chemical and thermal stabilities. However, the large-area fabrication of aramid nanocomposite films with ultrastrong mechanical properties under mild conditions remains a great challenge. Here we present a facile superspreading-assisted strategy to produce aramid nanofiber based oriented layered nanocomposites using phase inversion process that occurs at the fully swollen hydrogel surfaces. The nanocomposite films based on ANF, carboxylation carbon tube (CNT –COOH ), poly(vinyl alcohol) (PVA), and MXene nanosheet exhibit a tensile strength of up to 870.8 ± 85 MPa, a Young’s modulus of 21.8 ± 2.2 GPa, and outstanding toughness (up to 43.2 ± 4.6 MJ/m 3 ), which are much better than those conventional aramid nanofiber based materials. Electrical conductivity of our nanocomposite films reaches the maximum of about 1100 S/m. The fabulous mechanical properties combination and continuous production capability render our strategy representing a promising direction for the development of high-performance nanocomposites.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·
IF 4.3
Han Luodan,Chen Zhiwei,Yu Chunxiao,Tang Keren,Wang Yonghao,Sun Weiming,Zhang Xi,Yao Xu,Chen Jinghua,Wu Fang,Lan Jianming
In this work, an upconversion luminescence (UCL) nanosensor for fast detection of ferric ion (Fe 3+ ) and phosphate ion (Pi) is developed based on the inner-filter effect (IFE) between NaYF 4 :Yb/Er upconversion nanoparticles (UCNPs) and Fe 3+ -hypocrellin B (HB) complex. Fe 3+ -HB complex has strong absorption band (450–650 nm), which overlaps with the green emission peak of UCNPs at 545 nm. By adding Fe 3+ and Pi, the UCNPs-HB system produces the red-shift change of absorption spectrum, which leads to the “on–off-on” process of IFE. So, with the specific recognition ability of HB for Fe 3+ and the competitive complexation of Pi for Fe 3+ , the proposed nanosensor utilizes the UCL change to achieve the detection of the targets. For the detections of Fe 3+ , the linear range is 10–600 μM with a limit of detection (LOD) of 2.62 μM, and for Pi, the linear range is 5–100 μM with a LOD of 1.25 μM. The results for selectivity, precision, and recovery test are also satisfactory. Furthermore, the real sample detection shows that the proposed nanaosensor has a great potential in environmental and biological systems. Graphical Abstract An upconversion luminescence (UCL) nanosensor based on the inner-filter effect (IFE) between upconversion nanoparticles (UCNPs) and Fe 3+ -hypocrellin B (HB) complex for the detection of Fe 3+ and phosphate ion has been proposed, which is promising to be a convenient and sensitive assay for monitoring Fe 3+ and phosphate ion in different environments and biological systems.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2023
·
IF 2.5
Yu Hao,Sun Junru,Wang Zirui,Ren Manman,Yang Zhizhou,Liu Weiliang,Yao Jinshui,Zhang Changbin,Zhao Hui
Compared to lithium-ion batteries, aqueous rechargeable zinc-ion batteries (ZIBs) are of interest for their high safety and low cost. Manganese-based oxide materials as an attractive cathode candidate for ZIBs However, the low conductivity of manganese oxide materials leads to poor electrochemical performance. Herein, manganese sesquioxide/Nitrogen-doped reduced graphene oxide (Mn 2 O 3 /N-rGO) composite has been synthesized by hydrothermal method. The Mn 2 O 3 /N-rGO composite as ZIBs cathode material provides high electrical conductivity, which facilitates charge transfer and improves the overall electrochemical performance. The electrode provides 222.3 mA h g −1 of high reversible capacity with a current density of 100 mA g −1 . A robust cycle stability with over 90% of initial capacity retained and 98% coulombic efficiency was observed following 500 cycles. Its excellent electrochemical behavior can be explained by the higher electrical conductivity, faster Zn 2+ transfer, and stronger structural stability of N-rGO. In addition, the energy storage mechanism of H + and Zn 2+ coinsertion was also tentatively studied, which provides inspiration for future design and research on high-performance manganese-based materials cathodes of ZIBs. Graphical Abstract
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Journal of Analysis and Testing
·
2023
·Vol. 7
·期 4
·369-376
·
IF 4.7
Chen Shuoran,Chen Fuming,Li Yanling,Wang Yuyang,Wang Xiaomei,Ye Changqing
A derivative of fluorescein, fluorescein O,O-diacrylate (FODA), was utilized in a triplet–triplet annihilation upconversion (TTA-UC) system to develop a composite ratiometric chemosensor capable of detecting cysteine (Cys). FODA acted as both the probe for Cys and the energy acceptor for upconversion (UC) emission, thereby making UC a responsive signal to Cys. In addition, the phosphorescence signal of the sensitizer in the TTA-UC system remained constant and did not respond to Cys, making it an ideal internal reference signal for constructing a ratiometric sensor. Through this simple strategy, traditional fluorescent probes can be combined with TTA-UC system to establish a ratiometric sensing platform, which can be applied in more scenarios due to the longer wavelength excitation.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 10
·1-9
·
IF 5.7
Yang Weiqing,Li Dandan,Li Yunlong,Zheng Yuan,Shan Jiajia
Abstract A method is proposed to fabricate a novel capillary surface-enhanced Raman scattering (SERS) substrate integrating sampling and detection based on meniscus evaporation self-assembled technology, named Meniscus@AgNPs@Capillary substrate. Ag nanoparticles (AgNPs) were arranged in the inner wall of the capillary through meniscus evaporation. The parameters which might affect the deposition of AgNPs during evaporation were investigated, including the evaporation temperature, self-assembly time, the ratio of silver sol to ethanol, and capillary length. The enhancement effect of SERS under different fabrication conditions was investigated using rhodamine 6G (R6G) as a Raman probe. Moreover, the optimal fabricated Meniscus@AgNPs@Capillary substrate was applied to the detection of several environmental pollutants such as polystyrene nanoplastics (PSNPs) and various antibiotics, with limits of detection (LOD) of 10 µg/L and 1 µg/L, respectively. The Meniscus@AgNPs@Capillary substrate presented the advantages of time and effort saving, high sensitivity, and on-site sampling and testing. Graphical Abstract
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