FOOD CHEMISTRY
·
2025
·
IF 9.8
Kai Huang,Hanwen Liang,Yu Zhang,Sen Li,Hongwei Cao,Hongdong Song,Wenqian Zhao,Xiao Guan
Pea protein isolate (PPI) possesses high nutritional value but inferior emulsifying properties. As a soluble dietary fiber, oat β-glucan (OBG) not only possesses various nutritional functions as well as excellent processing characteristics. Therefore, it can be used as a raw material to modify PPI, enhancing its nutritional value while improving its emulsification properties. This study enhanced the emulsifying properties of PPI by conjugating it with diverse mass ratios of oat β-glucan (OBG). Gycosylation significantly enhanced the emulsifying properties, and the 1:1 group exhibited the most substantial improvement with an emulsifying activity index of 39.52 min and an emulsifying stability index of 120.56 m 2 /g. The confocal laser scanning microscopy (CLSM) and rheological properties of the emulsions indicated the formation of spatial reticular structure after glycosylation. The content of α-helix decreased from 19.6 % to 13.8 %, and β-sheet increased from 31.5 % to 37.6 %. Glycosylation with OBG enhanced the emulsifying properties of PPI by altering the secondary structure, intermolecular forces, and forming a reticular structure. This study provides a theoretical basis for improving the emulsifying properties of PPI and expanding the range of industrial applications for it.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2025
·
IF 7.5
Naidong Li,Chunxia Song,Shaoyun Shan,Hongfei Gao,Xianghong Li,Juan Xu
With the intensification of global energy crises and environmental issues, the development of sustainable, high-energy–density aviation fuels has become a prominent research focus. This study constructs polycyclic high-energy–density aviation fuels using β-pinene and lignocellulose-derived furfural/benzaldehyde as feedstocks through oxidation, aldol condensation, and hydrodeoxygenation reactions. Initially, β-pinene was efficiently oxidized by potassium permanganate to nopinone (achieving 99.2 % conversion with 91.5 % selectivity). Subsequently, nopinone underwent aldol condensation with aromatic aldehydes under solid base catalysts to obtain unsaturated ketone intermediates with high selectivity. Experimental results demonstrated that MgO exhibited optimal catalytic performance (96 % conversion for benzaldehyde condensation, 95 % for furfural condensation), with catalytic activity correlating to catalyst basicity and reaction temperature. The condensation products were successfully converted into polycyclic alkanes through hydrodeoxygenation (HDO) using Pd/C and Hβ catalysts synergistically. Density Functional Theory (DFT) calculations elucidated the regulatory mechanism of aldehyde LUMO energy level differences on reactivity, clarified the energy variations during hydrodeoxygenation, and proposed plausible reaction pathways. The final products exhibited densities of 0.891 and 0.916 g·cm −3 (20°C) with corresponding heating values of 45.18 and 46.81 MJ·kg −1 , respectively, along with a freezing point as low as −64.1°C, demonstrating performance metrics closely approaching those of commercial JP-10 fuel.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Zeyulin Zhang,Dinghe Liu,Yiru Yan,Liru Zeng,Hao Chen,Qingwen Song,Dazheng Chen,Chunxiang Zhu,Chunfu Zhang,Yuming Zhang,Yue Hao
Gallium oxide (Ga 2 O 3 ) film exhibiting the solar-blind absorption cutoff characteristic holds considerable potential for application in UV photodetectors . The material defects in the device will introduce the recombination region for the photodetector, especially at the interface of the Ga₂O₃ heterojunction . The photogenerated carriers , generated within the Ga 2 O 3 film, will inevitably be influenced by these high recombination centers during their transportation. Avoiding or minimizing this region can improve the performance of the photodetector. The p-n junction, with its depletion region , generates an electric field that drives the carriers away from the recombination region. However, due to the Ga 2 O 3 p-type doping difficulty, our work focuses on the growth of single-crystal NiO/β-Ga₂O₃ films by Mist-CVD and the fabrication of field-controlled photodetectors. The hole concentration in the NiO film is adjusted by doping with different concentrations of Li⁺. Compared with a photodetector without the NiO interlayer, the performance of the photodetector with the structure of NiO (1 % Li⁺-doped)/β-Ga₂O₃ exhibits a significant improvement, which achieved the maximum responsivity of 1002.5 A/W, and a high peak detectivity of 3.31 × 10 15 Jones.
✓ 已验证
产品关联
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2020
·Vol. 76
·期 9
·3264-3272
·
IF 3.75
Shuang Gao,Yanyan Liu,Jingyu Jiang,Xiaoming Li,Lixia Zhao,Ying Fu,Fei Ye
BACKGROUND Thiabendazole (TBZ) is a poorly water-soluble benzimidazole fungicide. However, the water solubility of TBZ can be significantly enhanced by inclusion complexation with cyclodextrins. In this study, a thiabendazole/hydroxypropyl- β -cyclodextrin (TBZ/HP β CD) complex was synthesized and electrospinning was performed to produce a TBZ/HP β CD nanofibrous (TBZ/HP β CD-NF) complex that improved water solubility and antifungal activity. RESULTS The formation of TBZ/HP β CD-NF was characterized by Fourier transform infrared spectroscopy, X-ray diffraction and nuclear magnetic resonance. The morphology of TBZ/HP β CD-NF was studied by scanning electron microscopy. A phase solubility experiment showed that HP β CD exerted a great solubilization effect on TBZ, and TBZ/HP β CD-NF had better antifungal activity compared to that of TBZ alone. CONCLUSIONS In summary, the solid fungicidal nanodispersion prepared in the present study is a new type of formulation that can enhance the water solubility of TBZ. This formulation, which demonstrated potential as a new fast dissolving formulation type with increased efficacy, is expected to be conducive to the sustainable development of agriculture. © 2020 Society of Chemical Industry
✓ 已验证
DOI
高影响因子
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2018
·Vol. 90
·期 3
·321-329
·
IF 1.316
Deng Shanxia,Liu Huijun,Qi Caixia,Yang Aohui,Li Zhendong
In the paper, the two chemically modified β-cyclodextrin derivatives of 4,4´-diaminodiphenyl ether-bridged-bis-β-cyclodextrins (ODA-bis-β-CD) and p -aminobenzenesulfonic acid-β-cyclodextrin (ABS-β-CD) were synthesized, and then these two β-cyclodextrin derivatives were respectively formed into inclusion complexes with benzophenone (BP) by co-precipitation method. The structure of the inclusion complexes were characterized by UV/vis spectroscopy, FT-IR spectroscopy, elemental analysis, 1 H NMR spectroscopy and XRD. Spectral titration was performed to study the inclusion behavior of the inclusion complexes. These experiments indicated that two inclusion complexes were formed at a stoichiometric ratio of 1:1 and the inclusion stability constants at different temperatures were calculated using the Benesi–Hildebrand (B–H) equation. The thermodynamic parameters (ΔG°, ΔH°, ΔS°) were obtained. As a result, it was found that the two chemically modified β-cyclodextrins containing BP were exothermic and spontaneous process (ΔG° < 0), and the processes of inclusion complexation were mainly enthalpy driven with negative or minor negative entropic contribution.
✓ 已验证
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2024
·
IF 3.3
Wanyin Ge,Maohao Yang,Honglei Yin,Shifan Shang,Zili Luo,Xin Xie,Ye Tian
SiAlON-based phosphors have garnered considerable attention in the field of white lighting owing to their excellent thermal stability, and rare earth doped SiAlON-based phosphors are expected to be used in a new generation of lighting sources. In this work, Eu 2+ or Ce 3+ doped Si 3 Al 3 O 3 N 5 phosphors were synthesized by high temperature solid phase method. The microstructure of the phosphors exhibited irregular grain. The two phosphors exhibit green and cyan luminescence under 365 nm excitation, which are derived from the 5 d -4 f transitions of Eu 2+ and Ce 3+ , respectively. The quenching concentrations are 3 % and 4 % for Eu 2+ and Ce 3+ doped phosphors , respectively. The fluorescence intensity of Eu 2+ and Ce 3+ activated SiAlON powders decreased to 50 % of the room temperature intensity at 179 °C and 170 °C, respectively. The thermal activation energy values of the two phosphors were 0.35 eV, and the coordinate configuration diagram was constructed to comprehensively analyze the thermal quenching behavior of phosphors. Finally, the two phosphors powders were mixed with red and blue fluorophore to obtain white LEDs, showing low color temperature, high color rendering, high power unsaturation and long half-life. The SiAlON-based phosphors with excellent thermal stability obtained in this work achieve different wavelengths of luminescence in the green region. The results show that the β -Si 3 Al 3 O 3 N 5 phosphor can be used as a candidate material for high-quality green light supplement for wLEDs .
✓ 已验证
DOI
高影响因子
CURRENT ISSUES IN MOLECULAR BIOLOGY
·
2026
·Vol. 48
·期 10
·1066
·
IF 4.1
Taomei Yang,Xiangyun Chen,Chunwei Chu,Yonghu Wan
Limited docetaxel efficacy in triple-negative breast cancer (TNBC) necessitates chemosensitizers. Baicalein is a potential chemosensitizer, but its synergy with docetaxel in TNBC is unclear. Here, we investigated the combined effects and underlying mechanisms. The concentrations of baicalein (80 μM) and docetaxel (20 nM) were tested on TNBC cells; synergy was assessed by CCK-8 and Chou–Talalay analysis. Proliferation, migration, invasion, and apoptosis were assessed by colony formation, wound healing, Transwell, Matrigel, and flow cytometry assays. Protein levels of p-AKT, p-GSK3β and β-catenin were determined by western blot, and HSP90AA1 mRNA by qPCR. Baicalein–HSP90AA1 binding was analyzed by molecular docking. The prognostic value of HSP90AA1 was analyzed by Kaplan–Meier Plotter. The combination exhibited synergistic anti-tumor activity (CI < 0.9), significantly suppressed proliferation, migration and invasion, and enhanced apoptosis. Mechanistically, the combination reduced p-AKT, p-GSK3β, and β-catenin protein levels without affecting HSP90AA1 mRNA. Molecular docking indicated a potential interaction between baicalein and HSP90AA1. High HSP90AA1 expression correlated with shorter distant metastasis-free survival (HR = 1.71,p= 0.0046) and worse overall survival (HR = 2.15,p= 0.021). Thus, baicalein synergizes with docetaxel to suppress TNBC in vitro, accompanied by suppression of AKT/GSK3β/β-catenin signaling, potentially through interaction with HSP90AA1, a proposed upstream target.
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Jiangtao Guo,Junjie Liu,Mingwei Wang,Yuhua Zhang,Ziyu Zhang,Martien Cohen Stuart,Junchao Chen,Weiping Tang,Xuhong Guo,Dahu Qi,Tao Liu
Spinal cord injury (SCI) is a serious neurological disease accompanied by neuroinflammatory responses. Recently, nanosized drug delivery systems have attracted attention for SCI treatment by improving solubility and bioavailability and providing sustained drug release. Protein-based nanoparticles can be biocompatible but often require chemical cross-linkers for structural stability, raising biosafety concerns. Here, we introduce a β-sheet-driven physical cross-linking approach to fabricate nanoparticles without chemical cross-linkers, namely by employing gelatin (Gel) and silk fibroin (SF) as proteins. This coassembly approach ensures structural integrity, enables enzyme-responsive degradation, and allows precise size control with narrow size distributions. Gel/SF particles can load dexamethasone (DEX) with a high drug loading (∼72%), exhibiting long-term stability and enzyme-triggered release. In vitro, these nanoparticles suppress pro-inflammatory cytokines and promote M2 phenotype microglial polarization, suggesting their neuroinflammation-regulating potential. Gel/SF particles may be a biocompatible, cross-linker-free protein-based drug delivery system, offering a promising platform for SCI treatment and broader applications in neuroinflammatory disorders.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Xing-Jie Dai,Leipeng Xue,Ying Liu,Shu-Wu Wang,Ying Li,Jia-Yi Yin,Hao-Zhe Long,Hui-Min Liu,Ning Wang,Guo-Liang Lu,Yan Li,Hong-Min Liu,Bo Wang,Yi-Chao Zheng
Lysine-specific demethylase 1 (LSD1) is a validated cancer therapeutic target, critically implicated in maintaining cancer stem cells (CSCs) across leukemia and solid tumors. Although numerous potent LSD1 inhibitors have been developed, none have reached clinical approval, underscoring the need for novel agents with improved efficacy. Using a scaffold-hopping strategy, we designed and synthesized a novel class of phenoxazine-based LSD1 inhibitors. Among them, X-1 (IC50 = 0.082 μM) emerged as the most potent, exhibiting a 3-fold improvement in activity over the previously reported compound 3s (IC50 = 0.247 μM). Mechanistic studies revealed that X-1 suppressed the stemness of gastric cancer cells by interrupting the β-catenin-mediated transcriptional program, thereby reducing the expression of stemness-related proteins. In vivo studies confirmed its robust antitumor efficacy by inhibiting tumor proliferation and stemness without significant toxicity. Our findings identify X-1 as a promising LSD1-targeted inhibitor, offering a potential therapeutic strategy for gastric cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2026
·
IF 6.8
Jiaen Chen,Kedi Yang,Yidan Wang,Jiaxing Yang,Qiang Lu,Xiaolu Mao,Li Ge
The separation of enantiomers is crucial in the pharmaceutical industry. Herein, a novel polymeric adsorbent was developed through the single-step cross-linking of [6-DHAA-6-deoxy]-β-CD, a dehydroabietylamine (DHAA) modified β-CD using epichlorohydrin. The resulting polymer demonstrates exceptional chiral recognition for the S-enantiomer of valsartan, a model chiral pharmaceutical, with a high adsorption capacity 20 mg·g −1 at 25 °C. Thermodynamics and kinetics studies reveal that S -valsartan adsorption onto poly-[6-DHAA-6-deoxy]- β -CD follows the Langmuir isotherm model and the pseudo-second-order kinetics, respectively. Molecular simulations suggest that chiral recognition arises from differing orientations and specific binding energies of the two enantiomers on the [6-DHAA-6-deoxy]-β-CD host. Under optimized conditions, racemic valsartan is successfully resolved with an excellent enantiomeric excess, leading to a high enantiopurity of 99.5% for the S -valsartan product. The current study not only presents a high–performance adsorbent for the enantioseparation of valsartan enantiomers, but more importantly, outlines a versatile pathway for developing sustainable separation media from natural, chiral resources.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Chi Lei,Qixiu Weng,Ping Song,Yingchun Zhu,Liangzhi Li,Lingzhao Kong,Lishi Yan
β-Glucosidase (BGL) is limited by the catalytic efficiency and environmental tolerance in the biomass biorefinery process. In this study, maleimide and its derivatives were used to modify BGL. FT-IR, circular dichroism, ζ-potential, ultraviolet, and fluorescence were used to characterize the conformational alteration of the thiol-modified enzyme and induced the enhancement of rigidity and substrate affinity. Molecular docking revealed that the modified BGL, especially Moc-Mal-BGL, had lower binding energy (−6.8 kcal mol–1) and shorter average hydrogen bond length (2.018 Å) with the substrate. The activity of Moc-Mal-BGL increased by 110.6% compared with native BGL and realized a 2.6-fold increase in catalytic efficiency kcat/Km (13.92 s–1/mM). The corresponding cellobiose conversion rate increased by 19.0%. Thermal stability, storage stability, solvent (GVL and DMSO) tolerance, and glucose tolerance of Moc-Mal-BGL were significantly improved. This work provides a rapid strategy to improve the catalytic efficiency and environmental tolerance of BGL and investigates the mechanism in depth.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Qiaochun Chen,Yuanyuan Chen,Qian Zhou,Mingfu Wang
Galangin (Gal), a hydrophobic flavonoid prevalent in galangal, exhibits remarkable inhibitory effects against the formation of β -carboline, a subclass of heterocyclic amines. However, its poor aqueous water solubility hinders its application in water-based food systems, such as braised meats. To address this issue, Gal-loaded zein/pectin nanoparticles (ZGP-NPs) were designed to integrate the potential inhibitory effects of Gal and pectin against HAs formation while improving Gal dispersion in aqueous systems. The nanoparticle formulation was optimized, achieving high encapsulation efficiency (96.07%) and loading capacity (7.93%) at a Gal concentration of 2 mg/mL. Microstructural and physicochemical characterization revealed successful encapsulation, yielding uniform spherical particles with an average size of 123.42 nm. ZGP-NPs demonstrated satisfactory stability across different chemical and physical conditions. In brine models and braised lamb applications, ZGP-NPs significantly suppressed β -carboline formation, achieving 35.43–68.30% (free type) reductions in β -carbolines in brine model systems, and 10.58–28.24% (free type) and 31.72–55.22% (free + bounded type) reductions in braised lamb. Mechanistic insights suggest that ZGP-NPs may suppress β -carboline generation via trapping of aldehydes (precursors for β -carboline formation), free radical scavenging, and direct binding of β -carbolines. This work demonstrates a pioneering strategy for mitigating HAs using polyphenol-encapsulated nanoparticles, providing a novel, efficient, and cost-effective approach for improving meat safety.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）