MICROPOROUS AND MESOPOROUS MATERIALS
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2022
·
IF 5.876
Shaokang Jiang,Jian Wang,Zhou Zhu,Shuo Shan,Yilin Mao,Xin Zhang,Xibo Pei,Chao Huang,Qianbing Wan
Bio-MOF-1 is a kind of metal-organic frameworks (MOFs) with bio-derived constitution, self-fabricated by zinc-adeninate secondary building units (SBUs) and may theoretically be endowed with biocompatible behaviors. Its biological applications currently contain several small molecule drugs delivery and in vitro mineralization, yet the related evidence on its biosafety and biocompatibility is still in great need. With the aid of self-modified protocol to synthesize micro/nanoscale bio-MOF-1 (m/n-bio-MOF-1), this study aimed to implement a systematic evaluation based on a series of tests from different dimensions including cell proliferation , oxidative stress, apoptosis and animal experiment, etc. These in vitro & in vivo biosafety and biocompatibility tests are to provide fresh evidence and advice for further applications. The outcomes indicated a concentration-dependent trend that 50 and 20 μg/mL groups proved biofriendly, with n-bio-MOF-1 surpassing m-bio-MOF-1. In conclusion, this work provided systematic evidence for the biosafety of m/n-bio-MOF-1, paved the way for their further exploration, and appealed more emphasis on MOFs toxicity.
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Frontiers in Molecular Biosciences
·
2022
·
IF 6.113
Pan Weimin,Zhou Yong-Ling,Wang Jian,Dai Huai-En,Wang Xiao,Liu Lin
Carotenoid metabolism is critical for diverse physiological processes. The nematode Caenorhabditis elegans has two genes that are annotated as β-carotene 15,15′-monooxygenase (BCMO) and are 17 centimorgan apart on chromosome II, but the function of BCMO-1 and BCMO-2 remains uncharacterized. Sequence homology indicates that the two enzymes belong to the carotenoid cleavage dioxygenase family that share a seven-bladed β-propeller fold with a nonheme iron center. Here we determined crystal structures of BCMO-1 and BCMO-2 at resolutions of 1.8 and 1.9 Å, respectively. Structural analysis reveals that BCMO-1 and BCMO-2 are strikingly similar to each other. We also characterized their β-carotene cleavage activity, but the results suggest that they may not act as β-carotene 15,15′-oxygenases.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Huan Wang,Guo Du,Shaohua Chen,Zhipeng Su,Pingchuan Sun,Tiehong Chen
As an important heterogeneous catalyst , Titanium Silicalite-1 (TS-1) zeolite has been widely applied in various catalytic processes. Here, hierarchical TS-1 single-crystals were successfully synthesized by a steam-assisted crystallization strategy using hierarchically porous titanium-containing silica (Ti-NKM-5) as a precursor. Due to the presence of large mesopores (10–40 nm)， the microporous structure-directing agents penetrated the interstitial structure of silica particles, inducing the dissolution and crystallization process . During crystallization, the generated nanocrystals grew together to form a hierarchical structure. Titanium was fully incorporated into the zeolite framework, and no extra-framework anatase was formed. Compared with the traditional microporous TS-1 zeolite, the synthesized hierarchical TS-1 single-crystal exhibited superior catalytic performance in oxidative desulfurization (ODS) of dibenzothiophene (DBT) and 4, 6-dimethyl dibenzothiophene (4, 6-DMDBT) owing to the hierarchically porous and anatase-free structure. The recycling test revealed the durability of the obtained hierarchical TS-1 catalyst under moderate reaction conditions.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2022
·
IF 5.876
Yongkui Liu,Fumin Wang,Xubin Zhang,Qing Zhang,Yi Zhai,Guojun Lv,Mengyao Li,Mengyue Li
Development of economic routes for synthesis of hollow titanium silicalite-1 (TS-1) zeolite is of great importance in industry. However, there are still challenges to synthesize hollow TS-1 zeolite without anatase TiO 2 . In this work, a one-step strategy without mesoporogen by the solid-phase conversion method was successfully developed to synthesize anatase-free hollow TS-1. The appropriate low amount of TPAOH (TPA/SiO 2 = 0.13) and the suitable crystallization temperature (170 °C) can not merely induce the formation of hollow structures, but also enable more titanium to enter the framework. Moreover, the transformation mechanism based on crystallization rate and dissolution rate was proposed according to the investigation of the transformation process. The hollow TS-1 with large cavities exhibits high catalytic activity and recycle stability in 1-hexene epoxidation. The efficient strategy reported in this paper will provide new opportunities for further promoting the industrial application of hollow TS-1.
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FREE RADICAL BIOLOGY AND MEDICINE
·
2021
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IF 7.376
Yue Zhang,Shibo Sun,Weiping Xu,Rui Yang,Yijia Yang,Jianli Guo,Kun Ma,Jianqiang Xu
Shikonin , a naturally occurring naphthoquinone with potent anti-tumor activity, has been reported to induce cancer cell death via targeting selenoenzyme thioredoxin reductase 1 (TrxR1; TXNRD1). However, the interaction between shikonin and TrxR1 remains unclear, and the roles of the cellular antioxidant system in shikonin induced cell death are obscure. Here, we found that shikonin modified the Sec 498 residue of TrxR1 to fully inhibit its antioxidant activity , however, the shikonin-modified TrxR1 still remained intrinsic NADPH oxidase activity, which promotes superoxide anions production. Besides, TrxR1 efficiently reduced shikonin in both selenocysteine dependent and selenocysteine independent manners, and the oxygen-coupled redox cycling of shikonin also generates excessive superoxide anions. The inhibitory effects and the redox cycling of shikonin towards TrxR1 caused cancer cell ROS-dependent necroptosis. Interestingly, as we evaluated, some cancer cell lines were insensitive to shikonin, especially kelch-like ECH associated protein 1 (KEAP1)-mutant non-small cell lung cancer (NSCLC) cells, which harbor constitutive activation of the nuclear factor-erythroid 2-related factor 2 (NRF2). NADPH bankruptcy caused by glucose starvation or glucose limitation (inhibiting glucose transporter 1 by BAY-876) could efficiently overcome the resistance of KEAP1-mutant NSCLC cells to shikonin. Glucose-6-phosphate dehydrogenase (G6PD), was known as a rate-limiting enzyme in the pentose phosphate pathway , however, the pharmacological inhibition of G6PD by 6-aminonicotinamide (6-AN), enhanced the shikonin-induced cytotoxicity but has no selectivity on KEAP1-mutant NSCLC cells. This study will be helpful in applying shikonin for potential chemotherapy, and in combinational treatment of KEAP1-mutant NSCLC.
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Catalysts
·
2023
·Vol. 13
·期 6
·969
·
IF 3.9
Srinivasan Vinju Vasudevan,Jin Cai,Junming Xu,Hongjian Lin,Hongliang Wang,Quan Bu
In this work, the microwave-assisted reaction of 5-hydroxymethylfurfural (5-HMF) into valuable ether and acylated production formation was investigated with the help of molybdophosphoric acid encapsulated dendritic fibrous silica (KCC-1) as a catalyst. XRD, N2adsorption-desorption, SEM, FT-IR, NH3-TPD, and TEM were used to analyze the physicochemical and structural properties of the synthesized catalysts. The microwave etherification of 5-HMF with ethanol was tested using synthesized catalysts. The effects of the reaction temperature, reaction time, catalytic amount, and microwave power were investigated. The resulting MPA-KCC-1 and IMPA-KCC-1 catalysts demonstrated excellent activity for the etherification of 5-HMF with ethanol, producing 5-(hydroxymethyl) furfural diethyl acetal (HMFDEA) and 5-(ethoxymethyl)furfural diethyl acetal (EMFDEA) products selectively. The significant advantages of the work are the selective production of EMFDEA at 82%, the catalyst can be easily removed via filtration, and the catalyst activity remains nearly intact even after five reaction cycles.Keywords:biomass;acetylation;5-HMF;etherification;heteropolyacid;fibrous silica
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2023
·
IF 5.2
Ge Yang,Yanjiao Wang,Mengling Sun,Panpan Xu,Chunzheng Wang,Ke Huang,Heqing Jiang,Svetlana Mintova,Hailing Guo
The amino-modification of the filler material is one of the most common strategies for optimization of the performance of mixed matrix membranes, aiming to enhance the interactions between the filler and the organic matrix and accelerate the adsorption of gas molecules by the filler. Herein, we found that the in-situ introduction of amino groups into the HKUST-1 filler would have negative effects on the gas separation performance of the MMMs following the “diffusion-adsorption coupling control” mechanism, which suggests that using MOFs fillers with large aperture size to accelerate the diffusion of small H 2 molecules and slow the diffusion of polar CO 2 molecules through the adsorption-desorption process. The NH 2 -HKUST-1 filler caused the blockage and loss of the pore structure , and the interfacial interactions in the PEI-based mixed matrix membranes were not improved. Therefore, the in-situ synthesized NH 2 -HKUST-1 did not support H 2 /CO 2 separation. This work further investigates the possible “diffusion-adsorption coupling control” mechanism of fillers with large aperture size and contributes to the development of MMMs materials.
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
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2023
·
IF 6.2
Fen Xiong,Kaiyuan Jiang,Yali Wu,Cong Lou,Chengjie Ding,Wenli Zhang,Xi Zhang,Chen Li,Hong Zheng,Hongchang Gao
Intermittent fasting (IF) is an ecological strategy to control various metabolic disorder symptoms, but its protective effect on type 1 diabetes (T1D)-induced cognitive dysfunction and the underlying mechanisms remain poorly defined. Herein, we examined the efficacy of IF in altering the behaviors and brain metabolome in T1D mice and investigated the potential molecular mechanisms. We demonstrated that IF remarkably improved frontal cortical-dependent memory in T1D mice and reduced the loss of neuronal cells. Metabolomics and targeted mass spectrometry assays showed that IF reprogrammed the composition of the frontal cortical metabolome in T1D mice, including activating the aspartate and glutamate pathway and reversing glycerophospholipid and sphingolipid depositions. Mechanistically, IF attenuated the levels of oxidative stress proteins, like NOX2, NOX4, 8-OHdG, and 4-HNE, and inhibited the levels of pro-apoptotic factors Bax and cleaved Caspase-3, ultimately improving the memory ability of T1D mice. In vitro studies confirmed the protective effect of the supplemented N -acetylaspartate, a pivotal metabolite involved in IF-regulated T1D-induced cognitive dysfunction, in high glucose-stimulated SH-SY5Y cells by eliminating toxic lipids accumulation, oxidative stress, and apoptosis. To conclude, the frontal cortical metabolites mediated the protective effects of IF against T1D-induced cognitive dysfunction by attenuating oxidative stress and apoptotic signaling. Thus, IF can be a potential therapeutic strategy for T1D-induced cognitive dysfunction.
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JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Yanjiao Wang,Ge Yang,Hailing Guo,Xianglong Meng,Guodong Kong,Zixi Kang,Rémy Guillet-Nicolas,Svetlana Mintova
HKUST-1 nanocrystals (50–80 nm) were homogeneously dispersed in a polyetherimide (PEI) polymer matrix . The use of a capping agent (sodium formate) prevented the agglomeration of HKUST-1 nanocrystals in the casting solution. The highly dispersed HKUST-1 nanocrystals were found to strengthen the interactions with the PEI and minimize the interfacial holes by providing more accessible Cu unsaturated metal sites for the C O bonds on the five-membered rings of the PEI matrix. The PEI membrane loaded with 30 wt % HKUST-1 nanocrystals (30-N-HKUST-1/PEI) showed a high H 2 permeability (193.3 Barrer at 25 °C under 1.5 bar) and good ideal H 2 /CH 4 and H 2 /CO 2 selectivity factor of 101.7 and 20.6 in a single gas test, respectively. In the gas mixture test, it also showed a good separation performance, i.e., a H 2 /CH 4 and H 2 /CO 2 selectivity factor of 82.4 and 16.5 was measured, respectively. The 30-N-HKUST/PEI membrane was tested in a gas mixture at different temperatures (25–100 °C), different pressures (0–3 bar) and various time (5–72 h) to study the performance in more realistic conditions thus to be further considered in the separation of syngas.
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MATERIALS CHEMISTRY AND PHYSICS
·
2021
·
IF 4.094
Xianhao Min,Qifei Xie,Zhiguo Wang,Xinzhong Wang,Mingxiang Chen
As traditional capping ligands like oleic acid (OA) and oleylamine (OLA) cannot efficiently maintain the optoelectronic properties and stability of iodide perovskite nanocrystals (NCs), post synthesis surface modification with some other ligand is a convenient and valid method to solve these problems to some extent. Here we promote a long carbon chain ligand with a thiol group, 1-Octadecanethiol (ODT), to realize the passivation of the surface of CsPbI 3 NCs after the synthesis process. After modification, our ODT-CsPbI 3 NCs exhibit excellent optical properties with a high PLQY of 93% and outstanding stability under different conditions compared to the untreated samples.
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Aging-US
·
2018
·
IF 5.179
Xingting Liu,Xin Lin,Siyu Zhang,Changquan Guo,Jian Li,Yuling Mi,Caiqiao Zhang
After 480 days of age, high-producing hens are likely to be subject to ovarian aging, mainly due to oxidative stress. In this study, the amelioration of ovarian aging in chickens, using a plant antioxidant, lycopene, was investigated. The activity of the Nrf2/HO-1 pathway in chicken ovaries at different ages (90, 150, 280 and 580 days old) were compared to elucidate any age-related changes. Subsequently, the putative attenuating effect of lycopene (100 ng/mL) on ovarian aging was evaluated through the establishment of a D-gal-induced aging ovarian culture model. The cultured ovarian tissues of young (280 days) and old (580 days) hens were treated with lycopene for 72 h to verify protective effects of lycopene on naturally aged ovaries. Results showed that the Nrf2/HO-1 pathway was down-regulated during the ovarian aging process. Lycopene rescued the decreased antioxidant capacity by increasing the activities of antioxidases and activating the Nrf2/HO-1 pathway in both D-gal-induced and naturally aged ovaries. Moreover, lycopene promoted cell proliferation and inhibited apoptosis in both D-gal-induced and naturally aged ovaries. Lycopene also alleviated D-gal-induced mitochondrial damage in the living granulosa cells. In conclusion, lycopene can effectively ameliorate the oxidative stress in aging hen ovaries via the activation of the Nrf2/HO-1 pathway.
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高影响因子
ChemistrySelect
·
2023
·Vol. 8
·期 45
·e202303724
·
IF 2.1
Ping Chen,Yu Ling,Hongkai Tong,Ke Dong,Xu Liu,Xiao Chen,Changhai Liang
Graphical 4-Methyl-1-pentene as a branched chain α-olefin can be efficiently synthesized via propylene dimerization on the K−Cu SCALMS catalyst that presents an excellent selective C−C linkage, as well as limits the isomerization of products. The urgent need for branched-chain α-olefin (4-methyl-1-pentene) with excellent characteristics promotes the development of efficient catalysts for the selective dimerization of propylene to it. Based on the concept of supported catalytically active liquid metal solutions (SCALMS), the highly efficient K−M/K 2 CO 3 (M=Fe, Co, Ni, Cu, and Zn) catalysts are prepared by the melting method for the dimerization of propylene. The K−Cu SCALMS catalyst presents highly efficient and excellent selective C−C linkage, as well as limits the isomerization of C6 products. The highest conversion of propylene (64.3 %) with 80.6 % selectivity to 4-methyl-1-pentene with thermodynamic instability is reached at 160 °C, 6 MPa and 20 h. Furthermore, the post-reaction K−Cu SCALMS catalyst can be successfully reactivated in the H 2 atmosphere. Therefore, it is proposed that it may be achieved the continuous selective dimerization of propylene to 4-methyl-1-pentene over K−Cu SCALMS catalyst by the application of fluidized bed technology.
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