RSC Advances
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2024
·Vol. 14
·期 17
·12049-12057
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IF 3.9
Xiaofan Su,Yaqi Lin,Xingyu Hu,Xinzhi Tan,Yao Mai,Minyan Jiang,Ruitao Zhang,Fangjun Huo,Lei Liu,Weidong Tian,Li Xie
A novel sustained chlorine-releasing polydimethylsiloxane/Ca(ClO)2 (PDMS/Ca(ClO)2) material was fabricated by encapsulating Ca(ClO)2 in a PDMS matrix due to its high hydrophobicity and high chemical stability, which showed immediate-responsive and long-lasting antibacterial capabilities in aqueous conditions. Free chlorine could be released from the PDMS/Ca(ClO)2 after immersion in water for 2 min and could also be sustainedly released for 2 weeks, while the released concentration is negatively related to the duration time and positively with the initial Ca(ClO)2 contents. Additionally, Ca(ClO)2 powder as a filler significantly affects the crosslinking and pore size of PDMS. The PDMS/Ca(ClO)2 materials exhibited enduring antibacterial performance against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in both planktonic and multispecies-biofilm status. It is expected that this PDMS/Ca(ClO)2 material and its similar composite would be promising candidates for wide sustainable disinfection applications in biomedical and industrial fields.
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PHYTOMEDICINE
·
2024
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IF 6.7
Huijian Chen,Pengxin Liu,Ruitao Yu,Nabijan Mohammadtursun,Ainiwaer Aikemu,Xinzhou Yang
Background and purpose Swertiamarin (STM), a secoiridoid glycoside from Swertia chirayita (Roxb.) H. Karst , has been shown to decrease body weight, blood glucose, and blood lipids by inhibiting adipose tissue hypertrophy. However, the underlying mechanisms remain unclear. In particular, adipose thermogenesis is a novel avenue for exploring the pharmacological effects of STM. We aim to investigate the efficacy of STM on type 2 diabetes mellitus (T2DM), with a focus on underlying mechanisms, particularly the activation of ADRB3/UCP1 thermogenic signaling pathways. Methods T2DM model was established by a high-fat diet (HFD) and streptozotocin (STZ) in C57BL/6 J male mice. Mice were given to either 100 or 200 mg kg -1 /day of STM, or 200 mg kg -1 /day of metformin (Glucophage) via intragastric administration for 7 weeks. In vitro, 3T3-L1 cells were differentiated into adipocytes. Molecular markers related to ADRB3-UCP1 signals, lipolysis, and mitochondrial function were detected. Results STM-treated diabetic mice showed a reduction of body weight, fat mass, and blood glucose/lipids and an improvement in insulin sensitivity. Bioinformatics analysis indicated STM promoted lipid metabolism and mitochondrial function, features by closely associated with adipose thermogenesis. STM upregulated the lipolysis-related genes and p-HSL protein in inguinal subcutaneous white adipose tissue (igSWAT) and brown adipose tissue (BAT). STM-treated mice processed a more active energy metabolism. Additionally, the ADRB3-UCP1 signals, mitochondrial-related genes, and oxidative phosphorylation were improved in igSWAT and BAT. In vitro , we found STM interacted with ADRB3, increasing glucose uptake, glycerol release, ADRB3-UCP1 signals, p-HSL expression, mitochondrial content, oxidative phosphorylation complex expression with improved mitochondrial Δ ψ m, as well as reduced lipid accumulation in adipocytes. All these effects were reversed upon ADRB3 inhibition. Conclusion This study identifies a previously unknown role of STM activating ADRB3/UCP1 signals in adipose tissue, suggesting a potential strategy for treating T2DM.
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JOURNAL OF FLUORESCENCE
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2024
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IF 2.6
Dai Zhengyuan,Liu Hao,Sun Xuyuan,Wang Ying,Fan Jie,Li Li,Ding Yaping
Using o-phenylenediamine as carbon source and phytic acid as phosphorus source, two P-rich carbon quantum dots RCDs and BCDs were synthesized successfully by changing the reaction temperature and time of hydrothermal method. It was found that RCDs with red emission could realize sensitive detection of 2-methylimidazole, and 2-methylimidazole had no obvious quenching effect on BCDs with blue emission, which made RCDs a sensitive, quick and selective fluorescence sensor for 2-methylimidazole detection. Under the optimal experimental conditions, the fluorescence intensity of RCDs decreased with the increasing of 2-methylimidazole concentration. The detection of 2-methylimidazole concentration by the carbon quantum dots sensor showed a good linear relationship in the range of 5 ~ 110 µM, and the low detection limit was 0.61 µM (S/N = 3). The sensor is able to detect 2-methylimidazole in lake water, enabling the application of real samples. The results show that this work provides a simple fluorescence method to detect 2-methylimidazole in water.
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LANGMUIR
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2024
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IF 3.7
Xue Chen,Yong Xiang,Xiaojing Zhang,Guanlin Li,Sihan Ai,Daoyong Yu,Baosheng Ge
Carbonic anhydrase (CA) plays a crucial role in the CO2 capture processes by catalyzing the hydration of CO2. In this study, we synthesized a bioinspired carbonic anhydrase Zn-MOF (metal–organic framework) incorporating 2-aminoimidazole and Zn2+ as initial constituents. The synthesized Zn-MOF exhibited promising potential for efficiently catalyzing the CO2 hydration. Structural analyses such as SEM, XRD, and BET confirmed that the Zn-MOF crystal consisted of stacked grains with an average size of approximately 36 nm, forming a micron-sized spherical structure. Functionally, Zn-MOF exhibited effective catalytic activity toward both CO2 hydration and ester hydrolysis. The introduction of amino groups significantly enhanced the esterase activity of Zn-MOF to 0.28 U/mg at ambient temperature, which was twice that of ZIF-8. Furthermore, the introduction of amino groups resulted in remarkable hydrothermal stability, with the esterase activity reaching 0.72 U/mg after undergoing hydrothermal treatment at 80 °C for 12 h. Additionally, Zn-MOF exhibited enhanced capability in CO2 hydration at a pH value exceeding 8.5. After six repeated uses, ZIF-8 and Zn-MOF retained approximately 68 and 65% of their initial enzyme activity, respectively, underscoring the potential practical applicability of Zn-MOF in industrial CO2 capture processes. This work showcases the development of a novel Zn-MOF crystal as an efficient CA mimic, effectively emulating the active sites of natural CA using 2-aminoimidazole as a coordinating ligand for Zn2+ coordination. These findings not only advance the field of innovative enzyme mimics but also pave the way for further exploration of industrial CO2 capture catalysts.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Minqiang Xia,Yulu Ye,Zihan Jiang,Yunbo Li
The rapid industrial growth has resulted in a surge in organic coloring agent contaminating water bodies, necessitating urgent environmental remediation. In this work, we present a facile approach for synthesizing degradable thiourea-2-polycaprolactone (T2P) to anchor gold nanoparticles (AuNPs) via filtration, aimed at AuNPs membranes with enhanced efficient catalytic activation. T2P anchored AuNPs membranes demonstrate exceptional stability and catalytic efficiency. They efficiently catalyzes the reduction of 0.1 mM solutions of 4-nitrophenol, methyl orange, and methylene blue in 330 sec, 8.0 min, and 3.0 min, respectively, while achieving the reduction of 10 −4 M 2-nitrophenol takes only 240 sec. Remarkably, even after 15 catalytic cycles, the membrane maintains its original catalytic performance at an efficiency of 100 %, owing to the abundance of active sites facilitated by the preparation method. This novel approach of fabricating degradable T2P anchored AuNPs membranes sets a precedent for sustainable, high-performance catalysts, laying a foundation for economic, eco-friendly catalyst development.
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ChemistrySelect
·
2024
·Vol. 9
·期 3
·e202303342
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IF 1.9
Nianming Jiao,Junjie Cui,Long Liu,Yuan Yao,Yangfeng Xia,Yanqiang Zhang
Graphical Pyridinium trifluoroacetate-based ILs effectively catalyzed the cyclization of 2-propyl ketazine to pyrazolines, achieving conversion and selectivity rates of 98 % and 99 %, respectively. Thermodynamic data were obtained through DFT calculations and calorimeter tests, providing valuable insights for the practical application of ketazine intramolecular cyclization to synthesize pyrazolines. In this work, pyridinium trifluoroacetate ionic liquids, as a protonic acid catalyst, were used to catalyze intramolecular cyclization of ketazine to synthesize 2-pyrazoline. The investigation encompassed the impact of temperature, solvent, dosage of ionic liquid catalyst, and the structure-activity relationship in the cyclization reaction of 2-propyl ketazine. The optimal catalytic performance was achieved at 100 °C with 8 mol % of 3,5-dimethylpyridinium trifluoroacetate in a solvent-free environment. Moreover, thermodynamic and kinetic data were determined through density functional theory calculations and calorimetric experiments. These protonic acid ionic liquids address the issue of excessive traditional protonic acid dosage in the intramolecular cyclization of ketazine, while also presenting a viable pathway for the catalytic synthesis of 2-pyrazolines.
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Journal of Environmental Chemical Engineering
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2024
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IF 7.4
Xiaocong Yu,Jiahui Kan,Jian Han,Kaili Liu,Jihui Li,Huixin Zhang,Jianxin Chen
With the growing public concern for environmental preservation, this work employs environmentally friendly polyaspartic acid (PASP) as the main chain, to develop a green and efficient dual-function inhibitor with scale and corrosion inhibition . The new inhibitor PASP-2-A was synthesized by grafting 2-amino-benzimidazole (2-A) containing nitrogen heterocyclic into polysuccinimide under alkaline conditions. The corrosion inhibition of carbon steel and brass was determined by static test, polarization curve and electrochemical impedance spectroscopy (EIS). It can be found that PASP-2-A had better scale inhibition performance than PASP under different conditions. The addition of 5 mg·L −1 PASP-2-A can almost 100% prevent the formation of CaCO 3 scale. Molecular dynamics simulation results showed that PASP-2-A significantly destroys the crystal structure of CaCO 3 scale due to the coordination between PASP-2-A and Ca 2+ groups. The modified PASP scale inhibitor can prevent the growth of calcite (110) and (104) crystal faces, regulate the transformation of CaCO 3 from stable calcite to more soluble spherical vaterite , making it less deposit. The electrochemical test results showed that the corrosion inhibition of PASP-2-A is greatly improved compared with PASP, and the corrosion inhibition of Q235 carbon steel increased about 40% at the dosage of 200 ppm. The corrosion inhibition efficiency of H62 brass in 3.5 wt% NaCl was 97.97% with 300 ppm PASP-2-A. Notably, due to its degradable nature, low toxicity, and affordability, PASP-2-A serves as an excellent inhibitor, exhibiting remarkable performance in both scale inhibition and corrosion inhibition. Consequently, it presents a promising avenue for further advancements in modified PASP.
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TALANTA
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2024
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IF 5.6
Jing-bo Jiao,Qing Kang,Shu-xin Cui,Jiang-li Cao,Tong Lin,Chen-jing Ma,Ze-hui Xiao,Ting Du,Nan Wang,Xin-jun Du,Shuo Wang
Coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused secondary pandemic, which still poses a serious threat to physical health and economic development. Herein, the target-driven functionalized DNA hydrogel capillary sensor based on cascade signal amplification and carbon coated cobalt manganese modified by prussian blue and platinum nanoparticles (MnCo@C-Pt-PB NPs) has been successfully developed for dual-mode detection of SARS-CoV-2. The cascade signal amplification triggered by target RNA causes the permeability of the DNA hydrogel loaded in the capillary to be destroyed, thereby releasing the embedded MnCo@C-Pt-PB NPs as signal molecules into 3,3′,5,5′-tetramethylbenzidine/hydrogen peroxide (TMB/H 2 O 2 ) solution under the driving of capillarity. The colorless TMB is then catalyzed to blue oxidation products (oxTMB) due to peroxidase-like activity of MnCo@C-Pt-PB NPs, and MnCo@C-Pt-PB NPs and oxTMB with photothermal properties synergistically increase the system temperature under near-infrared irradiation, which are recorded by portable devices to achieve dual-mode detection. Signals intensity are proportional to the logarithm of T-RNA concentration in a wide detection range (100 aM-100 pM), with a detection limit of 100 aM. Moreover, the reliability of the developed method in oropharyngeal swabs samples has also been validated. The signal conversion and amplification function of functionalized DNA hydrogel enhances the convenience, sensitivity and versatility of the developed method, which is promising to be applied in environmental safety, molecular diagnostic assays and disease prevention.
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ENZYME AND MICROBIAL TECHNOLOGY
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2024
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IF 3.4
Bohua Wang,Song Lei,Qingqin Li,Yushuang Luo
Lactulose is a semisynthetic nondigestive sugar derived from lactose, with wide applications in the food and pharmaceutical industries. Its biological production routes which use cellobiose 2-epimerase (C2E) as the key enzyme have attracted widespread attention. In this study, a set of C2Es from different sources were overexpressed in Escherichia coli to produce lactulose. We obtained a novel and highly efficient C2E from Clostridium disporicum (CDC2E) to synthesize lactulose from lactose. The effects of different heat treatment conditions, reaction pH, reaction temperature, and substrate concentrations were investigated. Under the optimum biotransformation conditions, the final concentration of lactulose was up to 1.45 M (496.3 g/L), with a lactose conversion rate of 72.5 %. This study provides a novel C2E for the biosynthesis of lactulose from low-cost lactose.
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APPLIED SURFACE SCIENCE
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2025
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IF 6.9
Lang Wu,Zhineng Zhou,Qiaogang Song,Na Yu,Xinghuan Hu,Ying Zhang,Xu Su,Xintong Zhao,Shurong Wang
SnO 2 has attracted significant attention as a potential replacement for TiO 2 in perovskite solar cells (PSCs) due to its high optical transmittance, stable physicochemical properties, and ability to process at low temperatures. However, when an SnO 2 electron-transport layer is prepared using solution gel spin coating, many oxygen vacancy defects are generated in the SnO 2 bulk and on its surface. These defects may result in nonradiative recombination at the SnO 2 /perovskite interface. This study proposes a novel and effective multibottom interfacial modification strategy that introduces 1,2-propanediamine hydroiodic acid (1,2-PDADI) molecules with multiple functional groups at the SnO 2 /perovskite interface. The incorporation of 1,2-PDADI molecules effectively passivates the oxygen vacancy defects at the SnO 2 surface and considerably improves the electronic properties of SnO 2 by reducing nonradiative recombination. Additionally, the interaction between the –NH 3 group in 1,2-PDADI and PbI 2 substantially reduces the PbI 2 content, thereby inhibiting defects forming in perovskite films. As a result, PSCs modified with 1,2-PDADI achieve a higher efficiency of 24.70% and demonstrate reduced hysteresis characteristics compared to the control (22.86 %). Thus, this study offers a cost-effective, straightforward, and effective approach for realizing high-efficiency PSCs.
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INTERMETALLICS
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2025
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IF 4.8
Liangcai Du,Xiaoqing Liu,Qianqian Kong,Lichao Gong,Zhenhua Yao
Understanding the intricate phase transformations and their impact on the mechanical properties holds paramount importance in developing high entropy alloys (HEAs) with ideal properties, yet it remains challenging and underexplored. In this study, a series of novel CrFeMnNi (2-x) Ti x (x = 0, 0.5, 1, and 1.5 at.%) HEAs were meticulously designed based on the established Valence Electron Concentration (VEC) rule, with the VEC values systematically varied as the atomic composition (Ni, Ti) changed. The microstructure, phase transformation behavior, mechanical properties, and strengthening mechanisms were systematically investigated. We found that the HEA powders exhibited phase behavior consistent with the VEC rules. The spark plasma sintered (SPSed) HEA bulk samples exhibited a phase transformation attributed to the precipitation of Cr and Mn within the matrix, resulting in the formation of the σ phase. Quantitative calculation of the strengthening mechanisms revealed that grain boundary strengthening and precipitation strengthening were the primary contributors to the high strength of the HEA bulk samples. These findings not only advance the utilization of the VEC rules in HEA material design but also contribute to the understanding of the phase behavior and mechanical properties of HEAs, facilitating the design of high performance HEAs.
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SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Yue-Yang Zhang,Le-Yu Huang,Huiling Wang,Sixuan Meng,Fei Yang,Shi-Yu Liu
Carboxylesterase 2 (CES2), an extensively expressed serine esterase which widely distributed in various organs and tissues, exerts important roles in maintaining normal physiological function while abnormal expression of CES2 was correlated with many metabolic diseases and cancers. Thus, to develop efficient tool for detection of CES2 activity is of great importance in related clinical diagnosis and research of physiological function of CES2. To date, several enzyme-activated fluorescent probes were developed for CES2 sensing. Among which regulation of CES2 in diseases such as diabetics, colitis, cancers and liver injury could be visualized. However, even though CES2 displayed relatively high expression level in kidney, its regulation in pathological process of kidney injury was rarely studied, and thus related preliminary investigation is in urgent demand. Herein, by rational design and construction of an enzyme-activated fluorescent probe (named as DDXB ) with high catalytic efficacy, sensitivity and specificity toward CES2, down-regulation of CES2 activity in acetaminophen (APAP)-induced liver injury and dextran sulfate sodium (DSS)-induced colitis model was successfully visualized. Most importantly, aberrant up-regulation of CES2 in streptozotocin (STZ), renal ischemia reperfusion (IR) injury (RIRI) and cisplatin (CDDP)-induced kidney injury model was first revealed via DDXB- based fluorescence imaging and further confirmed by immunohistochemistry (IHC) staining. Thus, preliminary evidence for identifying CES2 as potential biomarker of kidney injury were first provided, and the newly developed probe could serve as an efficient tool for related diagnosis or further investigation of CES2 physiological function in more diseases.
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