CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Zhaoqi Ye,Zhizheng Sheng,Kexin Yan,Yifan Zhang,Yaxuan Xu,Yahong Zhang,Hongbin Zhang,Yi Tang
Low-water Na + /K + ion switching creates tunable ZSM-5 mesostructures. • A decoupled ZSM-5 platform isolates diffusion and confinement effects. • Mesopore topology governs the MTA lifetime-selectivity trade-off. • Core-shell Z5-Na8@K0 couples transport, confinement, and coke accommodation. • Spatially integrated mesopores break the lifetime-selectivity trade-off. Balancing molecular diffusion and spatial confinement is central to designing ZSM-5 catalysts for methanol-to-aromatics (MTA), yet their individual roles are difficult to disentangle because mesostructural changes often couple with variations in composition or acidity. Herein, we construct a mesostructure-regulated ZSM-5 platform with comparable framework composition, acid properties, and Al siting via a low-water, seed-induced synthesis. By simply switching alkali metal ions (Na + vs. K + ) and introducing trace amounts of TPABr, two continuously adjustable mesostructural regimes are obtained: open mesoporous nanocrystal assemblies (Na + system) and confined intracrystalline mesoporous single crystals (K + system). MTA catalysis reveals that these two mesostructural regimes impose intrinsically competing demands. Open mesopores enhance molecular transport and coke accommodation, extending catalyst lifetime, but promote premature olefin desorption and weaken BTX shape selectivity. Confined intracrystalline mesopores act as reaction reservoirs that retain intermediates, boosting aromatization and BTX selectivity, yet they are more prone to internal coke accumulation. This establishes a diffusion-confinement competition that governs the lifetime-selectivity trade-off. Guided by this mechanistic distinction, we further construct Z5-Na8@K0, an intraparticle integration of a diffusion-favorable nanocrystal-assembly core and a confinement-providing shell. This architecture moves the lifetime-selectivity frontier forward, achieving a more favorable balance of stability, aromatics selectivity, and cumulative target-product productivity. This work provides a decoupled platform for elucidating structure-performance relationships in zeolites and sheds new light on the rational catalyst design for complex reactions governed by coupled transport and confinement. Download: Download high-res image (287KB) Download: Download full-size image
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NUTRITIONAL NEUROSCIENCE
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2026
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IF 3.1
Dawei Xu,Luge Chen,Xiaohu Chen,Weiming Jiang,Lijuan Sun
Background and Objectives Insomnia is a major public health issue that impairs daily functions and quality of life. Sleep-onset difficulty, a common complaint among patients, is accompanied by reduced central serotonin (5-HT) function. β-myrcene from lavender has sedative–hypnotic effects via serotonergic pathways, but most previous studies used intraperitoneal injection, which causes stress and limits clinical translation. Here, we asked whether non-invasive inhalation of β-myrcene produced similar effects in a mouse model of insomnia with low 5-HT function, and explored the underlying mechanisms.Methods β-myrcene was given to PCPA-induced insomnia mice by inhalation (with intraperitoneal injection as a pharmacodynamic control). In the inhalation group, sleep and behavior were evaluated using the amobarbital sodium sleep test and spontaneous locomotor activity test. ELISA, RT-qPCR, Western blot, and 16S rRNA sequencing were applied to study mechanisms.Results Inhaled β-myrcene shortened sleep latency and prolonged sleep duration. It also reduced oxidative stress and modulated GABA, 5-HT, and glutamate levels. These changes were accompanied by upregulation of mRNAs such as GABAARγ2 and 5-HT1A, as well as proteins including GAD65/67 and PKA, suggesting involvement of 5-HT1A/PKA signaling. Additionally, inhalation of β-myrcene was correlated with alterations in gut microbiota composition in PCPA-induced insomnia mice.Conclusions Our findings indicate that inhaled β-myrcene is associated with sedative–hypnotic effects and alterations in gut microbiota composition in PCPA-induced insomnia mice, potentially involving modulation of 5-HT1A/PKA signaling.
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Materials Today Chemistry
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2026
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IF 7.4
Tianyu Chen,Bingxin Sun,Xiyun Wang,Wang Zhang,Yuanzhe Piao
CUM encapsulated by β-CDP enhances water solubility and stability, improving its effects. • CUM-β-CDP shows lower MIC on E. coli (40 mg/ml) and S. aureus (5 mg/ml) than pure CUM. • CUM-β-CDP effectively inhibits HepG2 cell proliferation, showcasing potent anti-cancer ability. A pH-responsive delivery system based on supramolecular vesicles was fabricated via a novel host–guest inclusion complex between water-soluble pillar[5]arene (WP5) and cuminaldehyde (CUM). This CUM-WP5 inclusion complex was studied using 1 H NMR, UV-vis, and FT-IR spectroscopy. The resulting inclusion complex could self-assemble into well-defined supramolecular vesicles via host–guest interactions and exhibited significant pH-responsive behavior, which was investigated using dynamic light scattering, transmission electron microscopy, and UV-vis spectroscopy. The preservation time of CUM-WP5 and the molar ratio between host and guest molecules were both significant for the aggregated morphology of the supramolecular vesicles. Furthermore, the CUM complexes demonstrated good antibacterial activity, inhibiting the proliferation of Agrobacterium tumefaciens GV3101 and EHA105. These vesicles therefore present a promising platform for drug delivery and antibacterial applications. The assembly CUM-WP5 through host-guest interaction and the drug release of vesicle in the acid condition, which applied for corn root soaking test. Download: Download high-res image (232KB) Download: Download full-size image
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Communications Chemistry
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2026
·Vol. 9
·期 1
·166
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IF 6.9
Wang Fei,Dong Qi,Liu Yanchao,Li Zhixing,Hao Wenming,Ma Jinghong,Jiao Haijun,Zheng Jiajun,Hedin Niklas,Li Ruifeng
Upcycling plastic waste into valuable resources without solvents, precious metals, or additional H 2 under mild conditions is a formidable challenge that requires new innovations. Herein, we document a catalyst based on Al 2 O 3 beads and zeolite ZSM-5 (ZSM-5#Al 2 O 3 (2 h)). It cracked polyethylene (PE) into gasoline-range C 4 − C 12 hydrocarbons with a selectivity of 98% and a yield of >71% within 1.5 h at 260 °C. Characterization of the catalysts revealed a mesoporous structure and suitable Brønsted acid sites, which promoted the diffusion and catalytic activation of PE. Adjusting the dosage of zeolite supported on Al 2 O 3 beads enables regulation of both the number and strength of acidic sites. Theoretical calculations confirmed that the interfacial interaction between zeolite ZSM-5 and Al 2 O 3 reduces the acid strength of the composite. This is beneficial for the formation of higher hydrocarbons. Remarkably, the process was performed in a 1 L CSTR unit. These results provide instructive guidance for the design of high-performance catalytic materials used in PE waste recycling. The alternative text for this image may have been generated using AI.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
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IF 4.8
Jia Bin Zhang,Wan Hui Guo,Hao Zhang,Wen Pan,Ye Min Guo,Fan-Li Zhang,Cheng Wang,Sheng Hong Liu
5-Hydroxymethylfurfural (5-HMF) is a toxic compound formed during the improper processing or storage of honey, endangering human health. Thus, rapid and accurate detection of 5-HMF is essential. In this study, we fabricated uniform gold nanorod (AuNR) array surface-enhanced Raman spectroscopy (SERS) substrates with high-density plasmonic hot spots by optimizing the AuNR aspect ratio and employing a novel three-phase self-assembly technique, significantly enhancing detection sensitivity and reproducibility. The AuNR array (aspect ratio of 3.5) showed the strongest signals due to the close match between its 781 nm longitudinal LSPR wavelength and the 785 nm excitation laser wavelength, enabling efficient resonant coupling. Leveraging the dual-resonance of the AuNR arrays, tip-induced field focusing and nanogap-mediated plasmon coupling synergistically produced ultrahigh electromagnetic enhancement for SERS detection. Using AuNR array-3.5 as the SERS substrate, the signal intensity demonstrated a positive correlation with a concentration of 5-HMF in the range of 1–50 mg/L, with a limit of detection (LOD) as low as 0.093 mg/L. The substrate revealed excellent uniformity (relative standard deviation, RSD = 3.86%), reproducibility (inter-batch RSD = 2.51%), reusability (RSD = 13.2%) and stability (stored at 4 °C for 30 days). In spiked honey samples, this method achieved an LOD of 35.4 mg/kg, well below the international maximum residue limit (40 mg/kg), and recovery values ranging from 73.32% to 95.92%, confirming its high sensitivity and accuracy. This work provided a rapid, efficient approach for detection of 5-HMF in honey and highlights its application potential in SERS-based food safety monitoring technologies.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Meijiao Duan,Qiyue Sun,Jiaqi Duan,Zhuo Chen,Chunyan Yang,Cui Zhai,Meng Cao,Huan Liu,Mengqian Wei,Yunong Chen,Lei Lei,Xingchun Gou,Liujiao Bian,Jing Luan
This study presents a groundbreaking investigation into the molecular interaction between microRNAs (miRNAs) from the traditional Chinese medicine Astragali Radix and the anti-angiogenic protein Kringle 5 (K5). We successfully screened and identified 10 highly enriched miRNAs that exhibit a significant binding affinity to K5. Through a combination of bioinformatics and experimental techniques, including molecular docking and affinity chromatography, we found that specific miRNAs, particularly miR1, act as natural aptamers, binding to K5 with high selectivity and an association constant ( K a ) of approximately 5.80 × 10 4 L/mol. Our findings reveal that the conserved stem-ring structure of these miRNAs is crucial for their recognition and binding to K5, mediated by electrostatic, hydrophobic, and hydrogen bond interactions. Functional assays in vitro demonstrate that miR1 effectively neutralizes K5-mediated inhibition of endothelial cell proliferation and restores the HIF-1α/VEGF signaling pathway. This research provides a novel biochemical perspective suggesting that Astragalus -derived miRNAs may function as natural molecular decoys to modulate K5 activity, thereby supporting angiogenesis. These findings offer new insights into the bioactive landscape of traditional Chinese medicine and providing a strong foundation for the development of novel nucleic acid-based drugs. Download: Download high-res image (114KB) Download: Download full-size image
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Jiawen Lu,Yangchun Shen,Xingtao Zhou,Yuting Wang,Hui Ye,Qiang Yu,Jianhua Xie,Yi Chen
Acrylamide (AA) and 5-hydroxymethylfurfural (HMF) are processing-derived contaminants that frequently co-occur in environmental and dietary exposure, yet the health effects of their co-exposure remain poorly understood. Here, we show that co-exposure to AA and HMF induces duodenal injury in mice, whereas neither toxin alone causes significant damage. Macrophage depletion using clodronate liposomes significantly attenuates this pathology, identifying macrophages as important mediators of the intestinal injury. Co-exposure promotes macrophage polarization toward a pro-inflammatory phenotype. Notably, direct exposure of intestinal epithelial cells to AA and HMF produces limited cytotoxicity. In contrast, conditioned medium from AA+HMF-treated macrophages compromises epithelial viability and barrier integrity in both intestinal epithelial cells and mouse intestinal organoids. These findings indicate that macrophage-mediated inflammatory responses, rather than direct epithelial toxicity, contribute substantially to AA+HMF-induced intestinal injury. Mechanistically, AA and HMF co-exposure triggers mitochondrial dysfunction and elevated mitochondrial reactive oxygen species (mtROS) production in macrophages, accompanied by enhanced glycolysis and hypoxia-inducible factor-1α (HIF-1α) activation. Pharmacological inhibition or genetic silencing of HIF-1α attenuates metabolic and inflammatory responses, while scavenging mtROS or iNOS inhibition reduces macrophage activation. Collectively, these findings reveal an immune-mediated mechanism underlying AA and HMF co-exposure-induced intestinal injury and highlight macrophage responses as a determinant of contaminant mixture toxicity.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Hanyu Shi,Hongliang Fu,Shaocong Zhan,Yue Lian,Yong Dai,Yongfeng Hu,Yang Zang,Zhifeng Wang,Jing Zhao,Huaihao Zhang
Oily wastewater discharge severely endangers ecology and human health, driving demand for oil-water separation materials with high efficiency and environmental friendliness. In this study, the H-ZSM-5 molecular sieves were incorporated into PVA matrix and loaded onto stainless steel mesh (SSM) to construct H-ZSM-5/PVA@SSM composite hydrogel separation material. H-ZSM-5 builds continuous water transport channels for large water flux, increases surface roughness on composite hydrogels to form stable hydration layers and improve oil resistance, while hydrogen bonding reinforces adhesion with PVA matrix. Meanwhile, the SSM as rigid supporting framework offers steady mechanical support for hydrogel coating, and effectively improve material mechanical strength and reusability. The optimal H-ZSM-5/PVA-0.5@SSM sample achieves markedly increased water flux rising from 113.04 L m −2 h −1 (PVA@SSM) to 735.82 L m −2 h −1 , while maintaining separation efficiency above 96% after 30 cycles. Besides, the material gains oil-in-water emulsion separation efficiency up to 99.80% with water flux of 1.086 × 10 5 L m −2 h −1 bar −1 . Also, the H-ZSM-5/PVA-0.5 composite hydrogel gains tensile strength enhancement from 22.16 MPa to 26.97 MPa compared to pristine PVA hydrogel. By integrating H-ZSM-5 porous transport merit, PVA hydrophilicity and SSM rigid support, the H-ZSM-5/PVA-0.5@SSM achieves efficient purification of oily wastewater and emulsions.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
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IF 5.9
Weiguang Su,Jianbin Liang,Dawei Wang,Siegfried Yeboah,Jiemeng Ding,Tian Lan,Ruirui Zhang,Qing Xu,Li Wang
Monodisperse 5-ASA microcapsules (CV < 3%) are engineered via microfluidics. • Nanocrystal-in-microcapsule architecture yields high drug loading (20.4 wt%). • pH 6.1 threshold enables release in the acidic IBD microenvironment. • Moving-boundary kinetics map single-particle to macro-scale release. The performance of targeted oral delivery systems for hydrophobic drugs like 5-aminosalicylic acid is limited by variable release kinetics and premature release in the upper gastrointestinal tract. To address this challenge, monodisperse 5-aminosalicylic acid nanocrystal-in-hydroxypropyl methylcellulose acetate succinate (5-ASA NCs@HPMCAS) composite microcapsules were prepared via microfluidic interfacial assembly and antisolvent precipitation. Droplet-templated solidification yielded microcapsules with an average diameter of 28.33 μm, a coefficient of variation < 3%, a drug loading of 20.4 wt% and an encapsulation efficiency of 83.3%. Driven by the pH-dependent transition of the HPMCAS shell, the microcapsules remained structurally intact under simulated gastric and proximal intestinal conditions (pH < 6.0) but underwent rapid interfacial erosion around pH 6.1. The model payload was released within approximately 3 min at pH 7.2 under quiescent in vitro conditions, while 5-ASA release reached 88.5% at pH 6.5 over 4 h. Ex vivo GI imaging of DiR-labeled microcapsules provided preliminary evidence of upper-GI retention and lower-GI localization after oral administration. Residual ethyl acetate was approximately 217 ppm, while dimethyl sulfoxide was below the assay’s quantification range. A 24-hour Caco-2 assay showed cell viability above 90%, supporting preliminary in vitro cytocompatibility under the tested conditions. The uniform particle size also enabled comparison between single-particle moving-boundary kinetics and macroscopic release behavior, providing a physicochemical basis for pH-responsive oral delivery.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Cheng Gu,Yakun Qu,Ya Chen,Yunlong Wang,Chaowen Liu,Le Zhang,Xiangyang Cui,Xiaoguang Zhao,Enhui Xing,Yibin Luo,Zhen Chen,Junhua Li
Framework Fe-ZSM−5 was developed for catalytic CO 2 desorption from MEA. • Isolated tetrahedral Fe 3+ sites were incorporated into the MFI framework. • Framework Fe reduced Fe dissolution in MEA by more than 88% over 120 °C for 15 days. • Fe-ZSM−5 increased the average CO 2 desorption rate by 35% over the blank case under continuous operation. • Lewis acid-base pairs promote H 2 O-assisted carbamate decomposition. Catalytic CO 2 desorption from aqueous amine solvent is a promising strategy for energy-saving CO 2 capture from industrial flue gas. As an important candidate, conventional zeolite catalysts often suffer from insufficient activity, while metal incorporation can effectively regulate acidity but also causes metal-site dissolution. Herein, we prepared an excellent ZSM-5 zeolite with framework-incorporated Fe (Fe-ZSM−5) through feasible hydrothermal method. The coordination characterizations confirm that Fe-ZSM−5 contains isolated, tetrahedrally coordinated Fe 3 + within the MFI framework. Compared to impregnated Fe, the dissolution rate of framework Fe species in ethanolamine absorbent was reduced by more than 88%, which can effectively enhance catalytic performance and simultaneously avoid solvent degradation. Meanwhile, the incorporation of framework Fe modifies the acidic environment of the zeolite by generating Si-OH-Fe Brønsted acid sites and Fe-related Lewis acid sites. Fe-ZSM−5 exhibited high catalytic activity for CO 2 -rich MEA solution, with a peak desorption rate of 4.306 mmol·min −1 (48% higher than the blank case); the catalytic rate constants reach 2.0–2.4 × 10 −4 min −1 . This work proposes a novel design strategy for high-performance acid catalysts, representing a durable and efficient catalyst for reducing regeneration energy in amine-based CO 2 capture. Download: Download high-res image (299KB) Download: Download full-size image
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Journal of Physical Chemistry C
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2025
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IF 3.2
Youmin Cao,Geoffrey I. N. Waterhouse,Yan Li
In this study, a highly active NiAl-GCN non-noble-metal catalyst was developed for the selective catalytic oxidation of 5-hydroxymethylfurfural (HMF) to furandicarboxylic acid (FDCA). NiAl-layered double hydroxide (NiAl-LDH) was first synthesized via a hydrothermal method and then blended with dicyandiamide (2-fold by mass) and heated at 550 °C for 6 h to obtain the NiAl-GCN catalyst (consisting of a NiAl mixed metal oxide and g-C3N4). The prepared catalyst was then characterized using X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), N2 physisorption measurements, and X-ray photoelectron spectroscopy (XPS) to explore its structure, morphology, chemical composition, and physicochemical properties. Next, HMF oxidation tests were carried out, and the effects of reaction time, reaction temperature, amount of oxidant, and amount of catalyst on HMF conversion and product distribution were investigated to optimize the reaction conditions. In batch tests under the optimized testing conditions (acetonitrile as solvent, t-BuOOH as the oxidant, 120 °C, 12 h), the NiAl-GCN catalyst achieved a HMF conversion of 100%, FDCA selectivity of 80.6%, and good stability during recycling experiments. The synergistic electron transfer between GCN and NiAl-MMO enhances the adsorption of HMF and activation of oxidants, leading to superior catalytic efficiency and FDCA selectivity compared to single-component catalysts.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Yu Hu,Hongchen Song,Zhenghua Qu,Jun Dong,Fengxing Jiang,Congcong Liu,Xiaofang Liu,Qinglin Jiang,Cheng Liu,Jingkun Xu,Peipei Liu
LaNiO 3 , as a promising pseudocapacitive material, exhibits multiple valence states (Ni²⁺/Ni³⁺) and adjustable conductivity. However, the poor cycle life and limited electrolyte accessibility of LaNiO 3 currently restrict its potential applications. To address these challenges, poly(5-nitroindole) is loaded on LaNiO 3 /carbon cloth by a simple electrodeposition method as a novel electrode for supercapacitors. The electron-withdrawing nitro (-NO 2 ) group in poly(5-nitroindole) not only enhances surface hydrophilicity but also introduces additional redox active sites, substantially boosting the pseudocapacitance performance. Furthermore, the synergistic combination of LaNiO 3 with high conductivity and poly(5-nitroindole) with porous nano-network structure establishes an efficient conductive framework, significantly reducing charge transfer resistance and enhancing the stability of composite electrodes. As a result, the composite electrode delivers a high areal/gravimetric capacitance of 594.4 mF cm −2 /807.6 F g −1 at 0.5 mA cm −2 and long cycling stability with 76.0 % retention of its initial capacitance after 10,000 cycles. Moreover, the electrochemical behavior analysis has confirmed the simultaneous effect of surface storage capacitance and diffusion processes of the prepared composite electrode, and the porous nano-network structure of poly(5-nitroindole) effectively optimizes the adsorption/diffusion pathways of electrolyte ions. This work provides a feasible strategy for designing high-performance supercapacitor electrodes by integrating conductive perovskites with functionalized conducting polymers.
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