CURRENT MICROBIOLOGY
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2025
·Vol. 82
·期 9
·1-14
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IF 2.6
Xiao Mengzhu,Wu Yujia,Li Wanzhen,Wang Jun,Zhang Weiwei,Gui Lin,Ge Fei
Antibiotics, a milestone invention in modern medicine, have significantly improved human quality of life and serve as a primary weapon against bacterial infections. However, antibiotic abuse has led to the emergence and worsening of bacterial resistance, now a major global public health challenge. Therefore, the efficient use of nanoscale antimicrobial peptides (APs) as therapeutic and diagnostic agents offers a novel strategy to replace conventional antibiotics. In this study, we innovatively combined AP with manganese dioxide (MnO 2 ) and zeolitic imidazolate framework-8 (ZIF-8) to develop a novel composite: ZIF-8-encapsulated and AP-loaded MnO 2 (AP-MnO 2 @ZIF-8). This composite exhibited superior properties, including enhanced biocompatibility, excellent aqueous stability, and increased antibacterial activity. Both in vitro and in vivo AP-MnO 2 @ZIF-8 demonstrated potent efficacy against multidrug-resistant (MDR) Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Its minimum inhibitory concentrations (MICs) were 20 μg/ml for E. coli and 39 μg/ml for S. aureus . Furthermore, colony-forming unit (CFU) assays showed that 150-μg/ml AP-MnO 2 @ZIF-8 reduced bacterial survival below 5%, indicating effective growth inhibition. Crucially, it significantly suppressed bacterial activity in S. aureus -infected mouse wound models. Compared to free AP or MnO 2 alone, AP-MnO 2 @ZIF-8 showed significantly enhanced water solubility, bioavailability, and antibacterial activity. This work provides a foundation for developing AP-based antimicrobial strategies and offers a novel nanomaterial approach to combat the increasingly severe antibiotic resistance crisis. Graphical
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CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Xiao Yang,Shuting Huang,Dongyun Chen,Shihong Dong,Najun Li,Qingfeng Xu,Hua Li,Jianmei Lu
Microbial fuel cells (MFCs) offer simultaneous wastewater treatment and energy generation, but their performance is limited by sluggish oxygen reduction reaction (ORR) kinetics at the cathode. To address this, we aimed to develop a low-cost, high-performance catalyst as an alternative to noble metals. We hypothesized that a hollow Zn/multi-heteroatom co-doped carbon structure derived from ZIF-8 could enhance ORR activity by improving active site exposure and charge transport. The catalyst was synthesized via template-guided structural transformation and optimized pyrolysis. The resulting Zn/DAFP-800 exhibited a high surface area (748.62 m 2 g −1 ), a Tafel slope of 71.24 mV dec −1 , and achieved a maximum power density of 2535.32 ± 7.64 mW m −2 in MFCs with 93.62 % retention over 30 days. Additionally, it achieved 92 % chemical oxygen demand (COD) removal in simulated industrial wastewater. These findings demonstrate the catalyst’s promise for practical applications in electrocatalysis and sustainable energy conversion systems.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jun Yang,Guancheng Jiang,Maen M. Husein,Wei Zhang,Shengming Huang,Fuyan Kang,Tengfei Dong,Yinbo He,Lili Yang
Assembling protective metal-organic framework (MOF) coatings for structurally fragile natural enzymes broadens their potential industrial applications. In this study, we developed an enhanced two-step biomimetic mineralization strategy, whereby cellulase acts as a biological template to pre-concentrate Zn 2+ on its surface, subsequently initiating the rapid in situ formation of zeolitic imidazolate framework-8 (ZIF-8). This approach yields a cellulase@ZIF-8 composite that effectively combines enzyme activity retention with the structural robustness of the MOF. Cellulase actively mediated ZIF-8 nucleation and framework construction through precise interfacial coordination with imidazole ligands and Zn 2+ , thus achieving in situ encapsulation. Compared with free cellulase, cellulase@ZIF-8 maintained over 90 % residual activity under acidic conditions and over 60 % activity at 80 °C. Remarkably, under alkaline conditions (pH = 9) or after 30 days of storage, cellulase@ZIF-8 residual activity exceeded twice that of the free enzyme. Even after 10 recycles, cellulase@ZIF-8 retained 60.5 % residual activity, exhibiting outstanding environmental tolerance and reusability. Our results suggest that the spatial confinement provided by ZIF-8, along with its ability to induce conformational rearrangement in the enzyme, underlies the enhanced stability and environmental tolerance observed. We further showed a pH-responsive release of cellulase facilitated by the ZIF-8 framework, enabling burst release of >90 % cellulase in a short time under acidic environment. This work offers valuable insights into enzyme-MOFs design and their applications in biocatalysis, controlled release, and adaptive biomaterials.
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DESALINATION
·
2025
·
IF 9.8
Onyeagoro Robinson Uzochukwu,Chen Lin,Ruichao Zhu,Jin Wu,Yixuan Zhou,Zhu Liang
Hydrophobic membranes, such as polytetrafluoroethylene (PTFE), are prone to pore wetting during membrane distillation when treating wastewater containing amphiphilic contaminants. In this study, a Janus membrane composed of zeolitic imidazolate framework-8 (ZIF-8) and polyvinyl alcohol (PVA) was fabricated via vacuum filtration and employed in air-bubbling-assisted direct contact membrane distillation (DCMD). The optimal membrane, with a 0.815 mg/cm 2 ZIF-8 loading, achieved a desalination rate of 99 %, a stable vapor flux of 20.53 L/(m 2 ·h), and a permeate conductivity of less than 1.44 μS/cm during 25 h of operation. However, the increasing concentration of SDS in the feed solution over time led to an increase in conductivity, which pointed to a reduction in the membrane's anti-wetting performance, suggesting the limitations of ZIF-8 alone in mitigating wetting. To overcome this, continuous air bubbling was introduced, which significantly enhanced wetting resistance and extended the membrane's operational lifespan to 48 h. Higher airflow rates (5.93 L/min) yielded optimal performance. Furthermore, a Random Forest machine learning model was employed to predict permeate flux and conductivity based on key operational parameters, achieving a coefficient of determination (R 2 ) greater than 0.73. Collectively, this study demonstrates the synergistic potential of the ZIF-8/PVA@PTFE Janus membrane combined with air-bubbling assistance to effectively suppress wetting and enhance the efficiency and durability of membrane distillation for challenging wastewater.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Weimin Liu,Xuerui Zhao,Kefan Huang,Shumei Liang,Jian Li
Magnesium alloys possess significant application potential in various industrial sectors owing to their low density and high specific strength. Nevertheless, their poor corrosion resistance under harsh service conditions remains a critical challenge. In this study, a slippery liquid-infused porous surface (SLIPS), with hydrophobicity, anti-corrosion, and anti-fouling properties, was developed on Magnesium alloy substrates. A robust zeolitic imidazolate framework-8/graphitic carbon nitride (ZIF-8/g-C 3 N 4 ) coating with highly hydrophobic was first constructed on the Mg alloy surface, followed by silicone oil infusion. Within the hierarchical architecture, ZIF-8 nanoparticles are uniformly distributed on g-C 3 N 4 nanosheets, where ZIF-8 serves as anchoring sites to immobilize silicone oil, while g-C 3 N 4 nanosheets act as an effective physical barrier, mitigating both the penetration of corrosive media and the leakage of silicone oil. Benefiting from this synergistic structure, the prepared SLIPS exhibited significantly enhanced anticorrosion performances, with a minimum corrosion current density of 3.49 × 10 - ⁸ A·cm - ² and a maximum corrosion potential of -1.375 V. Furthermore, the ZIF-8/g-C 3 N 4 SLIPS maintained a high impedance modulus of 1.28 × 10⁵ Ω·cm² after 120 h of immersion in NaCl solution, highlighting its long-term stability. This study offers a controllable structural strategy for the development of ultradurable slippery surfaces with long-term corrosion resistance.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Wenyu Li,Hui Yu,Ming Yang,Xiangting Dong,Ying Yang,Tianqi Wang
Photosensitized metal oxide gas sensors have been a research hotspot in the field of gas sensors in recent years, the vast majority of related studies use the ultraviolet light as the excitation light source, there are relatively few related studies on the ceramic gas sensors using a single LED as the excitation light sources, and even fewer studies on using natural sunlight as the light excitation source. In this study, porous ZnO precursor particles were introduced into the channels of ZIF-8 to ensure the integrity of its skeleton after calcination, and ZnO/ZIF-8 derivative was prepared and used to construct gas sensors to detect NO x under the different excitation light source (the natural sunlight, 365 nm LED and xenon lamp). Compared with the test under darkness conditions, the operating temperature was reduced 70℃ under light excitation conditions, the gas-sensitive response of the gas sensor to 20 ppm NO x under the natural sunlight excitation was 7.48 times of the darkness conditions, and the measured detection limit was as low as 50 ppb. Under the excitation of natural sunlight, 365 nm LED or xenon lamp, the room temperature gas sensitive response to NO x gas could be achieved. The prepared gas sensor was used for the actual detection of NO x concentration in vehicle exhaust, which showed the attractive practicality and excellent detection sensitivity.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yiqian Lv,Jingmao Zhao,Baomin Fan,Muhammad Mubeen,Mahmood Mubashar,Fangze Zi,Yinxin Liu,Wanling Wang,Muhammad Jawad,Xuan Wang,Shuai Liu
To overcome the inherent limitations of epoxy (EP) coatings in terms of barrier performance, active protection, and weathering resistance, this work presents a multifunctional composite strategy based on hierarchically engineered nanohybrids. Polyaspartic acid (PASP), in coordination with Ca 2+ , was co-functionalized on zeolitic imidazolate framework-8 (ZIF-8) nanoparticles that were in-situ grown on α-ZrP platforms. The resulting PASP-Ca@ZIF-8/ZrP nanohybrids exhibited excellent dispersibility and interfacial compatibility within EP matrix, enabling the fabrication of an advanced PCZZ/EP coating with robust mechanical properties (adhesion strength of 6.7 MPa and tensile strength of 52.3 MPa) and an exceptional barrier performance (| Z | 0.01Hz of 7.1 × 10 10 Ω·cm 2 after 90 days of immersion in 3.5 % NaCl solution). The nanohybrids endowed the coating with pH-responsive release of inhibitory species (PASP, Ca 2+ , Zn 2+ , and 2-MI) imparting a dynamic self-repairing function that effectively mitigated localized corrosion, as validated by salt spray and filiform corrosion tests. During 144 h of accelerated UV exposure, the | Z | 0.01Hz value of PCZZ/EP coating retain over 1 × 10 8 Ω·cm 2 , demonstrating its excellent weathering-resistance. Molecular dynamics simulations further revealed the highest crosslinking density (96 %) and the lowest Cl − diffusion coefficient (0.0159 cm 2 /s) of PCZZ/EP model, indicating a dense internal network that restricted ion transport. This work establishes a scalable and versatile design framework for developing high-performance smart epoxy coatings, offering both mechanistic insight and practical solutions for the long-term protection of steel infrastructures in severe marine and industrial environments.
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POLYMER ENGINEERING AND SCIENCE
·
2025
·
IF 3.2
Yudong Lian,Cuicui Wang,Zhaolong Sun,Quan Ji,Jinglong Tang,Xiaomei Ma
Hydrogels of exopolysaccharide gellan gum (GG) show great potential in biomedical areas. However, their weak mechanical properties and lack of functionality impede the practical applications. To address this, zeolitic imidazolate framework-8 (ZIF-8) nanoparticles were integrated into GG hydrogels via physical blending. X-ray diffraction confirms the successful incorporation and even distribution of ZIF-8 within the GG matrix. The novel composite hydrogels exhibit excellent mechanical properties without compromising the GG hydrogel's inherent thermoreversibility. Specifically, they achieve a maximum compressive strength and fracture energy of 0.85 MPa and 6.91 kJ·m −3 , and tensile strength and fracture energy of 95.09 kPa and 12.89 kJ·m −3 , respectively. They also display outstanding elasticity, resilience, and fatigue resistance, recovering approximately 86% after 10 compression cycles at 70% strain and over 70% after 10 stretching cycles at 200% strain. Notably, the composite hydrogels exhibit excellent swelling resistance in physiological saline, good biocompatibility, and enzymatic degradation by specific enzymes, with the equilibrium ratio lower than 56% and the minimum NIH3T3 cell viability higher than 86% after 24 h' incubation in the hydrogel extract. The excellent mechanics, eco-friendliness, and unique thermoreversibility and rheological properties suggest their suitability for applications in biomedical fields like 3D printable and repairable tissue engineering materials. Highlights ZIF-8/gellan gum composite hydrogels were fabricated via physical blending. ZIF-8 promotes the strength, toughness and resilience of gellan gum hydrogels. The composite hydrogels show good dimensional stability in physiological saline. They demonstrate good biocompatibility and can be degraded by specific enzyme. They are thermoreversible but with a lower transition temperature than GG hydrogel.
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Polymers
·
2022
·Vol. 14
·期 24
·5466
·
IF 4.967
Changcai Teng,Xiongyan Meng,Yeqin Hu,Hongzhao Mao,Huiting Li,Jing Yang,Tiantian Sun,Shuai Meng,Chengli Zong
Small synthetic TLR7/8-agonists can be used as vaccine adjuvants to enhance cell and humoral-mediated immune responses to specific antigens. Despite their potency, after local injection they can be dispersed to undesired body parts causing high reactogenicity, limiting their clinical applications. Here we describe a vaccination strategy that employs the covalent conjugate of a mannose and TLR7/8 agonist as a vaccine adjuvant to take advantage of mannose binding C-type lectins on dendritic cells to enhance the vaccine’s immunogenicity. The mannose-TLR7/8 agonist conjugate can self-assemble into nanoparticles with the hydrophilic mannose on the outside and hydrophobic TLR7/8 agonist inside. Although its ability to stimulate HEK-BlueTMhTLR7/8 cells dropped, it can efficiently stimulate mouse bone marrow-derived dendritic cells as indicated by the up-regulation of CD80 and CD86, and higher cytokine expression levels of TNF-α, IL6, and IL-12p70 than the native TLR7/8 agonist. In vivo, vaccination using the SARS-CoV-2 RBD trimer as the antigen and the conjugate as the adjuvant induced a significantly higher amount of IgG2a. These results suggest that the mannose-TLR7/8-agonist conjugate can be used as an effective vaccine adjuvant.Keywords:adjuvants;mannose;TLR7/8 agonist;immune responses;cytokines;antibody
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PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Shupei Liu,Huan Zhou,Lichao Wan,Yi Chen,Xinfang Zhang,Yao Ding,Jinsong Rao,Sibo Kang,Changhao Wu,Yuxin Zhang
Anti-corrosion coating with corrosion detection ability will provide more efficient protection for metal equipment. In this work, the microencapsulated filler (Ni-Co/8-HQ@DE) with both anti-corrosion and corrosion detection ability was prepared by in-situ growth and vacuum impregnation assembly technology. The load of 8-HQ was determined to be 23.68 % by thermal decomposition test. The combination of test and simulation is used to quantify the ability of Ni-Co/8-HQ@DE to capture Cl − and verify the persistence of 8-HQ release. VASP simulated the reaction mechanism between 8-HQ and iron ions, and electrochemical data calculated that the thickness of the passivation film produced by 8-HQ was 3.1 nm. In addition, the impedance modulus of the prepared EP/Ni-Co/8-HQ@DE coating is three orders of magnitude higher than that of the EP coating, and the water absorption is reduced by 98.27 %. The 14 day salt spray test and 90 day salt water immersion test showed obvious corrosion detection effect.
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SENSORS
·
2025
·Vol. 25
·期 22
·
IF 3.5
Canjie Hu,Pengjia Qi,Lichao Liu,Yang Chen,Jijun Tong
To meet the demand for rapid and accurate glucose determination in clinical diagnostics, food testing, and related fields, this study developed a high-performance electrochemical glucose biosensor based on multi-walled carbon nanotubes/Prussian blue/zeolitic imidazolate framework-8@glucose oxidase/chitosan (MWCNTs/PB/ZIF-8@GOx/CS). The MWCNTs/PB conductive network significantly accelerated electron transfer and catalytic activity, while the ZIF-8, with its regular pore structure and high specific surface area, provides an efficient microenvironment for the immobilization and conformational stabilization of glucose oxidase (GOx), thereby improving substrate diffusion and maintaining enzyme activity. The MWCNTs/PB/ZIF-8@GOx/CS sensor demonstrates excellent sensing performance, featuring a wide linear response to glucose concentrations ranging from 4.8 μM to 2.24 mM, a high sensitivity of 579.57 μA/mM/cm2, and a low detection limit of 0.55 μM (S/N = 3). In addition, the sensor performs excellent repeatability (RSD = 1.49%) and retained 86.23% of its initial response after 3 weeks of storage at 4 °C, highlighting its strong potential for practical application in glucose detection.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2021
·
IF 3.517
Caiyun Liu,Zhenzu Bai,Jiayu Lin,Kai Jiang,Shan Huang,Weijia Zheng,Ruifen Chen,Yang Xiang,Xiaoyan Wang,Long Liu
The application of 3 D printing technology in tissue engineering has become increasingly important. However, due to the limitations of bio-ink, there are still some remaining problems. For example, the major challenge for ideal bio-ink is to maintain stable 3 D structure and good biocompatibility in the meantime while conventional gels are week and nearly unprintable. So, the development of new bio-ink material with improved rheological and mechanical properties is highly demanded to avoid compromising biocompatibility for tissue engineering. Silk fibroin (SF), a natural degradable polymer, is considered to be a proper material for the preparation of bio-inks. We used SF, gelatin, and polyols as raw materials to fabricate bio-inks and scaffolds. We evaluated the rheological properties and printability of bio-inks with a rotational rheometer and a 3 D printer. The scaffolds were prepared by crosslinking and freeze-drying technologies. The biocompatibility and osteoinductive functions of scaffolds were investigated by evaluating proliferation, osteogenic differentiation and related cell signaling of cultured MC3T3-E1 cells. The results showed that the scaffolds using SF, Gel and propanediol (PG) not only had good rheological properties and storage modulus, but also could better enhance osteogenic specific genes expression mediated by Smad1/5/8 and Runx2 pathways. What is more, morphological characterization showed that α-mem incubation could help scaffold form porous structure on its surface, which could shed a light on a new 3 D bio-printed bone repair scaffold with both naturally emerged and CAD-designed porous structure. Our findings provide a potential biomaterial for the treatment of bone tissue regeneration.
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