ACS Applied Materials & Interfaces
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2017
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IF 7.504
Peng Miao,Yuguo Tang,Lei Wang
Driven by the urgent need to detect trace heavy metal ions in various real water samples, this article demonstrates for the first time an electrochemical biosensor based on DNA modified Fe3O4@Au magnetic nanoparticles (NPs). Three DNA probes are designed to contain certain mismatched base pairs. One is thiolated and modified on the surface of Fe3O4@Au NPs (DNA 1). The other two probes (DNA 2 and 3) are labeled with two independent electrochemical species. Stable structures of cytosine–Ag+–cytosine and thymine–Hg2+–thymine formed in the presence of Ag+ and Hg2+ can assist the hybridization of DNA 1/DNA 2 and DNA 1/DNA 3, which locate corresponding electrochemical species onto the surface of the magnetic NPs. The achieved nanocomposites are then used as selective electrochemical probes for the detection of heavy metal ions by recording the square wave voltammetry signals. Simultaneous detection of Ag+ and Hg2+ is demonstrated without significant interference, and their individual high sensitivities are fundamentally preserved, which meet the requirements of U.S. Environmental Protection Agency (USEPA). Furthermore, the proposed method has been challenged by various real water samples. The results confirm the DNA modified magnetic NPs based sensing method may have potential applications for the monitoring of heavy metal ions in real sample analysis.
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高影响因子
CERAMICS INTERNATIONAL
·
2017
·
IF 2.986
Xiaolin Liu,Yongxin Tao,Huihui Mao,Yong Kong,Jian Shen,Linhong Deng,Linsong Yang
Near-infrared (NIR) light has great potential in biomedical applications due to its advantages of deep penetration depth and low photodamage to biological tissues. In this paper, we constructed a novel core-shell structured drug nanocarrier, Fe 3 O 4 @Au@SiO 2 , for the controlled delivery of etoposide (VP16), a chemotherapeutic drug for cancer patients. The novel core-shell structured drug delivery platform is composed of a mesoporous silica shell and a magnetic Fe 3 O 4 core using Au nanoparticles (AuNPs) as the interlayer, which is characterized by atomic force microscopy (AFM), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, N 2 adsorption/desorption isotherms and the magnetic measurements with vibrating-sample magnetometer (VSM). The synergistic effects of AuNPs, mesoporous silica and Fe 3 O 4 make the core-shell structured nanocomposites an excellent candidate for targeted and NIR light irradiation-controlled drug delivery. For the proposed nanocarrier of VP16, the mesopores in silica can enhance the encapsulation capacity of the nanocarrier and the AuNPs can effectively convert the NIR light into heat to speed up the drug deliver; meanwhile, the incorporation of Fe 3 O 4 with high magnetization to the drug delivery platform realize drug targeting under an applied external magnetic field.
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TALANTA
·
2016
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IF 4.035
Yuhong Liu,Linlin Zhao,Jin Zhang,Jinzha Zhang,Wenbo Zhao,Chun Mao
The work investigates a new fluorescence resonance energy transfer (FRET) system using NaEuF 4 nanoparticles (NPs) and [email protected] 2 S NPs as the energy donor–acceptor pair for the first time. The NaEuF 4 / [email protected] 2 S NPs-based FRET DNA sensor was constructed with NaEuF 4 NPs as the fluorescence (FL) donor and [email protected] 2 S core−shell NPs as FL acceptor. In order to find the matching energy acceptor, the amount of AgNO 3 and Na 2 S were controlled in the synthesis process to overlap the absorption spectrum of energy acceptor with the emission spectrum of energy donors. The sensitivity of FRET-based DNA sensor can be enhanced and the self-absorption of ligand as well as the background of signals can be decreased because of Eu 3+ which owns large Stokes shifts and narrow emission bands due to f–f electronic transitions of 4f shell. We obtained the efficient FRET system by studying suitable distance between the donor and acceptor. Then the FRET-based DNA sensor was used for the design of specific and sensitive detection of target DNA and the quenching efficiency (ΔFL/F 0 , ΔFL=F−F 0 ) of FL was logarithmically related to the concentration of the target DNA, ranging from 100 aM to 100 pM. We can realize an ultrasensitive detection of target DNA with a detection limit of 32 aM. This proposed method was feasible to analyse target DNA in real samples with satisfactory results.
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Journal of Materials Chemistry A
·
2016
·Vol. 4
·期 32
·12630-12637
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IF 8.262
Jianjun Ding,Xiangyang Li,Lin Chen,Xian Zhang,Song Sun,Jun Bao,Chen Gao,Xingyou Tian
Au–Pt/CaIn2S4 composites were synthesized for the first time using the photoreduction method by which bimetallic Au–Pt alloy nanoparticles were in situ site-selectively photoreduced on the edges of monoclinic CaIn2S4 nanosteps. The Au–Pt alloy nanoparticles as cocatalysts can spatially separate the oxidation and reduction sites and effectively enhance the photocatalytic hydrogen activity of CaIn2S4 under visible light irradiation. When introducing 0.5 wt% Au–Pt alloy nanoparticles, the rate of hydrogen production could reach 107.6 μmol h−1, which was higher than that of CaIn2S4, Au/CaIn2S4 and Pt/CaIn2S4 by a factor of 18.3, 2.37 and 2.4, respectively. The enhanced photocatalytic activity for hydrogen production could be attributed to the low recombination efficiency of the photogenerated charges and surface-plasmon-resonance-induced effect of Au nanoparticles.
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ELECTROANALYSIS
·
2017
·Vol. 29
·期 9
·2098-2105
·
IF 2.851
Fang Shang,Yuan Liu,Sui Wang,Yufang Hu,Zhiyong Guo
An ultrasensitive electrochemiluminescence (ECL) immunosensor for the detection of tetrodotoxin (TTX) is proposed, which are composed of the branched poly-(ethylenimine) (BPEI) functionalized graphene (BGNs)/Fe 3 O 4 -Au magnetic capture probes and luminol-capped gold nanocomposites (luminol-AuNPs) as the signal tag. Herein, a typical sandwich immunecomplex was constructed on the glassy carbon electrode. The BGNs/Fe 3 O 4 -Au hybrids could efficiently conjugate primary antibody via the Au−S chemical bonds or Au−N chemical bonds and rapidly separate under external magnetic field. The introduction of BPEI to GO could enhance the luminol-ECL intensity. Meanwhile, the multifunctional nanocomposites have been proved with good water-solubility, excellent electron transfer, outstanding stability, etc. The luminescent luminol-AuNPs, a high efficient electrochemiluminescence marker, can be assembled on the second antibody, which can produce the ECL signal to achieve the determination of TTX. This proposed ECL immunosensor with a linear range from 0.01–100 ng/mL can be applied in the detection of TTX in real samples with satisfactory results.
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BIOSENSORS & BIOELECTRONICS
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2016
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IF 7.476
Long Wu,Xiaoyan Xiao,Kun Chen,Wenmin Yin,Qin Li,Pan Wang,Zhicheng Lu,Jing Ma,Heyou Han
Abstrcact Highly sensitive and selective detection of specific DNA sequences is of great importance in clinical diagnosis, environmental and food monitoring, but it still remains challenges to develop a facile method for real sample detection in aqueous solution. Here, a simple and recyclable surface enhanced Raman scattering (SERS) sensor was constructed for Bacillus thuringiensis (Bt) special gene fragment detection by Fe 3 O 4 magnetic beads (MBs) and Au–Ag core-shell nanorods (Au@Ag NRs). A hairpin DNA with sulfhydryl and biotin was attached to Au@Ag NRs as indicator, and MBs with streptavidin (SA) were acted as the capture probe. On the basis of the biotin–SA specific interaction, target sequences were first hybridized with the hairpin DNA and exposed the biotin. Subsequently, the Au@Ag NRs were captured by the streptavidin modified MBs, which reduced the suspended NRs and led to the change of Raman intensity . Under the optimal conditions, the SERS intensity revealed a good linearity with Bt transgene fragment ranging from 0.1 pM to 1 nM with a detection limit of 0.14 pM (S/N=3). To demonstrate the specificity of the strategy, the single-base mismatch in DNA was discussed in the SERS assay. The results showed that the sensitivity and accuracy of the proposed method was acceptable in DNA detection, revealing a great potential in special gene detection.
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Sustainability
·
2024
·Vol. 16
·期 10
·4231
·
IF 3.3
Ke Ren,Fangjie Ding,Lijun Zhang,Fengping Peng,Jianzhong Guo,Chunzheng Wu
The food industry is responsible for generating considerable amounts of waste, such as excess fruits and leftover sugars, which contribute to resource depletion and pose environmental challenges. This research delves into the application of gold-modified graphitic carbon nitride nanosheets (Au/CN) as a potent catalyst for the transformation of these food wastes into H2via piezoelectric reforming during sonication. Au/CN demonstrated a superior rate of H2evolution compared to pristine g-C3N4(i.e., 1533.3 vs. 364.9 µmol/g/h) and it maintained its efficiency through multiple cycles of use. The catalytic activity was found to be optimal at a neutral pH level and with increased sugar concentrations. The enhanced catalytic performance of Au/CN was ascribed to the efficient segregation of charge carriers as well as the reduced charge transfer distance. This study underscores the viability of using Au/CN as a means for converting food wastes into a sustainable source of H2energy.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2025
·
IF 8.4
Junzi Huang,Mengjie Lu,Min Liu,Yahong Xie,Peng Wei,Huihui Xie,Liang Li,Weitao Han,Zhiwei Zhang,Ying Qi
The residues of tetracyclines (TCs) antibiotics present significant challenges in terms of contamination and pose a threat to human health. In this study, a cost-effective n-type semiconductor, CeO 2 , were loaded with small amounts of Au nanoparticles were fabricated by one-step hydrothermal method under alkaline conditions in the presence of the surfactant CTAB. Characterization tests revealed that Au/CeO 2 had significant visible light absorption capacity and good e − /h + separation efficiency. Photocatalytic degradation results of TC showed that 2% Au/CeO 2 -CTAB had the highest photocatalytic activity, achieving a degradation rate of 86.4% within 90 min. These values were 3.8 and 2.6 times higher than those of pure CeO 2 and CeO 2 -CTAB (without Au loading), respectively. Loading Au nanoparticles substantially increased the visible light absorption range, reduced bandgap width, and lowered photo-generated carrier recombination rate. Residual e − /h + on the semiconductor surface activating functional groups, further promoting photocatalytic degradation of pollutants such as TC. Au-loaded CeO 2 nano-photocatalysts have potential applications in the environments polluted by antibiotic residues.
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TALANTA
·
2024
·
IF 5.6
Siyu Wu,Hongyun Ma,Xiaoyan Chen,Wen Zhong,Yingying Gu,Yuqing Miao,Yarui An
Here, a label-free immunosensor was conducted using rGO/Collard-like Bi 2 S 3 @Au nanocomposite system to detect carbohydrate antigen 19-9 (CA19-9) as a diagnostic biomarker for Pancreatic cancer. The unique morphology of Collard-like Bi 2 S 3 increases its specific surface area, which allows it to immobilize more materials and biomolecules on its surface. To realize the covalent bonding of bismuth-based materials with biomolecules, bismuth-based materials were functionalized by Au NPs. Besides, the superior electrochemical activity and large specific surface area of Bi 2 S 3 @Au improved the stability of the sensor, which made it an ideal candidate for regulating the sensing interface in this study. Meanwhile, reduced graphene oxide (rGO) with remarkable electrical conductivity to improve the current response of the sensing interface, thus broadening the linear range of the immunosensor. Based on the above materials, a label free electrochemical immunosensor was constructed for detecting CA19-9. Under optimal conditions, it displays good linear relationship within the range of 0.01 U mL −1 to 100 U mL −1 , the detection limit being 0.0012 U mL −1 . Additionally, the immunosensor prepared in this work is characterized by superior interference immunity, reproducibility and storage stability, and has yielded satisfactory recovery rate in testing the serum samples of patients.
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JOURNAL OF CHEMICAL PHYSICS
·
2024
·Vol. 161
·期 11
·
IF 3.1
Ran Xunan,Chen Zhihua,Ji Hongzhou,Ma Zhaoyu,Xie Yuxi,Li Wenping,Zhang Junying
With advantages such as low cost, high stability, and ease of production, visible light photocatalytic C 3 N 4 with a unique microscopic layered structure holds significant potential for development. However, its hydrogen production efficiency remains low due to the pronounced recombination of photo-generated charge carriers and limited surface reaction sites. Normally, the photocatalytic performance of C 3 N 4 can be enhanced by loading noble metals with surface plasmon resonance. It is worth noting that the size of noble metal nanoparticles has a great influence on photocatalytic performance. In this study, accurate controlling of the size and distribution of Au nanoparticles was achieved on the surface of C 3 N 4 by introducing amino groups to improve photocatalytic performance. Results show that uniformly distributed Au nanoparticles in the range of 2–6 nm can be obtained on C 3 N 4 with a remarkable enhancement of hydrogen production efficiency, which is about 114 times the property of pure C 3 N 4 . The small-sized and uniformly distributed Au nanoparticles can provide more reaction sites and increase the separation of photo-generated charge carriers, in turn improving Au/NH 3 –C 3 N 4 photocatalytic hydrogen release rate to 6.85 mmol g −1 h −1 . This work offers a facile way to enhance photocatalytic performance by controlling the size of metal nanoparticles on C 3 N 4 precisely.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Chong Sun,Muhan Zhang,Qiqi Fei,Daoying Wang,Zhilan Sun,Zhiming Geng,Weimin Xu,Fang Liu
In this paper, a novel immunosensor was built for quantitative detection of heat shock protein 90 (HSP90) based on graphite-like carbon nitride nanosheets (g-C 3 N 4 NSs) hybridized with gold-F127 nanoparticles (g-C 3 N 4 -F127-Au NSs) modified electrode. The transmission electron microscope (TEM) was used to observe the structure and morphology of g-C 3 N 4 -F127-Au NSs. The successful preparation of g-C 3 N 4 -F127-Au NSs was characterized by UV–vis spectra, fourier transform infrared spectra (FTIR) and Raman spectra. Meanwhile, the electrochemical properties were measured by linear sweep voltammetric (LSV) and differential pulse voltammetry (DPV). Under the optimized conditions, the peak currents were linear with the concentration of HSP90 ranging from 3.5 μg/mL to 2.43 mg/mL. The linear regression equation was I (μA) = 10.31–10.05logc (R 2 = 0.9986, n = 9) with the detection limit of 2.67 μg/mL. Finally, the immunosensor exhibited good selectivity performance and provided a new approach for meat quality evaluation.
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RARE METALS
·
2025
·
IF 11
Zhao Zhi-Hua,Ma Shi-Xin,Pan Ya-Fang,Rahmatullah Abu-Bakker-Md,Shen Xiao-Qing,Shao Zhi-Gang,Wu Lan
To facilitate real-time monitoring and recording of humidity in the environment and to satisfy the requirement for strain performance in certain applications (such as wearable devices), this paper proposes an in-situ method for synthesising Au nanoparticles on ZIF-67. In this study, an Au@ZIF-67 composite humidity-sensitive material was combined with flexible polyethylene terephthalate interdigitated electrodes to create an Au@ZIF-67 flexible humidity sensor. The prepared samples were characterised using X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy. The humidity-sensitive properties of the sensor were investigated, and its monitoring capabilities in applications involving respiration, gestures, skin, and baby diapers were tested. The experimental results indicate that compared with a pure ZIF-67 humidity sensor, the Au@ZIF-67 (0.1Au@Z) flexible humidity sensor exhibits a 158.07% decrease in baseline resistance and a 51.66% increase in sensitivity to 95% relative humidity, and the hysteresis, response time, and recovery time are significantly reduced. Furthermore, the sensor exhibits excellent characteristics such as high resolution, repeatability, and stability. The obtained results regarding the material properties, humidity sensitivity, and practical application of non-contact humidity monitoring demonstrate that the prepared sensors exhibit excellent and comprehensive performance, indicating their broad prospects in wearable medical devices, wireless Internet of Things, humidity detection in complex environments, and intelligent integrated systems. Graphical abstract
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危险品化学品经营许可证（带存储）