SEPARATION AND PURIFICATION TECHNOLOGY
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2025
·
IF 9
Xiaojun Ma,Yan Kong,Sinan Wang,Haitao Feng,Lihao Cheng,Yongjuan Chen,Liang Jiang,Jiao He,Jiaqiang Wang
La-based materials are critical for mitigating eutrophication in low-phosphate aquatic environments. However, their practical application is often limited by the trade-off between high La loading and low utilization efficiency. In this study, starch is innovatively employed to immobilize La 3+ , enabling the in-situ formation of La 2 O 2 CO 3 through CO 2 gas generated during one-step pyrolysis, simultaneously, the gas expansion effect is harnessed to create a hierarchically porous architecture. The resulting La 2 O 2 CO 3 /C composite exhibits remarkable adsorption performance, achieving a phosphate uptake capacity of 306.6 mg P/g La and a P/La molar ratio of 1.37. Mechanistic studies indicate that the adsorption is predominantly driven by electrostatic interactions and ligand exchange. Theoretical calculations further reveal that the interfacial electron transfer between La 2 O 2 CO 3 and the carbon matrix enhances La adsorption activity through synergistic effects. This high site accessibility facilitates rapid phosphate diffusion and binding, thereby significantly improving La utilization efficiency. To enable practical application, the powdered adsorbent is immobilized within a chitosan/polyvinyl alcohol double-network aerogel, preserving its high performance while ensuring structural stability and recyclability. This material demonstrates robust performance in removing low-concentration phosphate, when treating real lake water, it achieves 96.8 % removal within 30 min, and in continuous-flow experiments, the cumulative treated water volume reaches 12.84 L. Furthermore, the material exhibits outstanding safety, high selectivity, and reliable reusability. This study advances the understanding of structure–performance relationships in La-based adsorbents and presents a novel design strategy for optimizing rare earth resource utilization in remediating low-concentration phosphate pollution.
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高影响因子
RSC Advances
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2025
·Vol. 15
·期 50
·42443-42449
·
IF 4.6
Hong Zheng,Zhan Wu
Abnormal levels of cytochrome c (Cyt c) are closely associated with various human diseases, including neurodegenerative disorders and cancers. Therefore, the quantitative detection of Cyt c holds significant value for both disease diagnosis and therapeutic efficacy assessment. Herein, we developed two novel label-free fluorescent probes for sensitive Cyt c detection based on upconversion nanoparticles: one functionalized with poly (ethylene glycol) ylated phospholipid (DSPE-PEG) alone, and the other co-functionalized DSPE-PEG combined with triphenylphosphine. The electrostatic interaction generates resulting in a quantifiable fluorescence quenching effect. The proposed method demonstrated excellent performance in the detection of Cyt c in complex matrices, including cell lysates and human blood sample. Notably, it offers significant advantages over conventional assays by simplifying sample preparation, reducing operational steps, and providing rapid response with distinct observable signals, showing great potential for clinical diagnosis and therapeutic monitoring.
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高影响因子
RSC Advances
·
2025
·Vol. 15
·期 50
·42432-42442
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IF 4.6
Baowang Miao,Guidong Zhu,Shimin Lin,Chi Zhang,Yuze Wang,Dongxun Chen,Yanjie Liang,Chengwei Wang
Photothermal therapy (PTT) is limited by its shallow penetration depth, whereas high-dose radiotherapy (RT) can cause significant side-effects. To address these limitations, synergistic therapies integrating RT with PTT have been proposed and investigated as promising treatment strategies. In this study, multifunctional, magnetic-targeting nanoparticles that exhibit high near-infrared absorption and strong photon attenuation were successfully synthesized for the synergistic PTT-RT treatment of glioma. The platform consists of a Bi2S3 core encapsulated within a carbon shell. The nanoparticles were further doped with Fe3O4 to ensure arrival at the tumor site at an effective concentration to achieve optimal therapeutic outcomes, and to enable preferential aggregation at the intracranial tumor site under the guidance of an external magnetic field. The Bi2S3@C/Fe3O4 nanoparticles showed high biosafety and a significant synergistic therapeutic effect in combined RT and PTT, both in vitro and in vivo. The feasibility of Bi2S3@C/Fe3O4 nanoparticles for glioma treatment was systematically evaluated, providing evidence of the applicability of Bi-based nanomaterials in photothermal radiotherapy.
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高影响因子
Food Frontiers
·
2025
·Vol. 6
·期 2
·1058-1078
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IF 6.9
Haolin Zhang,Jingjing Zhang,Hui Cao,Petra Högger,Randolph Arroo,Mohamed A. Farag,Avi Shpigelman,Jianbo Xiao,Chunlin Li
A class of flavonoid aminated derivatives that had been consistently overlooked in literature was shown to be formed as artefacts in cell culture medium. In this study, 34 flavonoids from different subclasses were incubated in Dulbecco's modified Eagle's Medium (DMEM) at 37°C for 2 h to identify the reaction mechanism behind aminated derivatives formation from flavonoids. Baicalein, scutellarein, dihydromyricetin, (−)-gallocatechin (GC), (−)-epigallocatechin (EGC), (−)-GC gallate, and (−)-EGC gallate were found to yield corresponding nitrogenous derivatives in both DMEM and amino acid solution. The nitrogen source of these seven flavonoid -aminated derivatives was revealed to be amino acids in DMEM. The pyrogallol group of the flavonoids was a key structural motif, being first oxidized into quinone and then further reacting with amino acids (Strecker degradation) to yield aminated flavonoids and corresponding aldehydes. A slightly alkaline environment accelerated the amination of flavonoids, possibly via the formation of flavonoid quinone. These results provide the mechanistic evidence for the in vitro generation of flavonoid -aminated derivatives, yet to be tested using in vivo assays.
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高影响因子
COMPOSITES COMMUNICATIONS
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2025
·
IF 7.7
Xiaofeng Shi,Lei Wang,Lin Chen,Qiaoling Xu,Zhengting Du,Deqing Shi,Zhenfa Zi,Renchao Che
Chain-like magnetic-dielectric composites have become an ideal choice for electromagnetic (EM) wave absorption materials due to their excellent component adjustment and structural optimization. Here, the chain-like CoNi@C heterojunction was obtained via multi-step reaction combining the solvothermal reaction, polymerization reaction, and annealing treatment. Magnetic chain-like CoNi alloy was firstly synthesized under application magnetic field, where offered the polymerization surfaces for the dopamine monomer. Then, as-prepared CoNi@PDA composites were undergoing the annealing treatment at N 2 atmosphere to obtain the chain-like CoNi@C heterojunction. The EM parameters and impedance match properties of the CoNi@C composites can be efficiently regulated via tunning the carbon shell. Combining with the magnetic-dielectric balance and synergy loss absorption, chain-like CoNi@C heterojunction exhibited outstanding EM wave performance. Optimized CoNi@C-7 heterojunction exhibited the minimum reflection loss (RL min ) value can reach to −50.3 dB at 11.92 GHz when the thickness is 1.95 mm and the effective absorption bandwidth (EAB) can up to 4.16 GHz from 13.84 GHz to 18 GHz at only 1.5 mm thickness. Therefore, the chain-like magnetic-dielectric CoNi@C composites provided a new design ideal to fabricate the EM wave absorption materials.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2024
·
IF 5.8
Jiaying Tian,Hao Guo,Mingyue Wang,Yanrui Hao,Jiaxi Xu,Henglong Ren,Yingfei Hui,Wu Yang
Nickel-cobalt sulfides (NiCo 2 S 4 ) with abundant valence states are promising electrode materials for multiple faradaic reactions in hybrid supercapacitors. However, the slow electron transfer kinetics and lack of active sites restrict its electrochemical activity. Herein, an effective synthesis strategy was proposed to synergistically improve the electrochemical performance of NiCo 2 S 4 through one-step in-situ carbonization-vulcanization method of metal-organic frameworks (MOF). Through rational selection and optimization of the Ni:Co ratio, the fibre-assembled urchin-like 3D nanoflowers (denoted as NCSC) possess abundant sulfur vacancies and appropriate porosity. Interestingly, the S vacancies can expose more redox active sites, while the expandable 3D carbon conductive network can accelerate electron transport. Furthermore, the electrical conductivity and interfacial activity is synergistically enhanced by strong electronic coupling effects. Experimental results reveal that the NiCo 2 S 4 /C exhibit excellent electrochemical performance as a battery-type electrode material. The specific capacitance is 1934 F·g −1 (967 C·g −1 ) at 1 A·g −1 and the capacitance retention is 93.2% after 5000 cycles at 5 A·g −1 . The assembled hybrid supercapacitor device (NiCo 2 S 4 /C//AC) exhibits an exceptionally high energy density of 50.24 Wh·kg −1 at power density of 800 W·kg −1 . These results have significant implications for the optimization of the transition metal compounds for electrochemical energy-storage devices.
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高影响因子
Chemistry-An Asian Journal
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2025
·
IF 3.3
Boyu Jia,Li Ju,Fancang Meng,Huan Wu,Kexiang Li,Qingmin Ji
The chemical modification and self-assembly capability of fullerenes offer advantageous conditions for tailoring Fe/N-doped carbon-based catalysts. However, their strong π–π stacking tendency may partially restrict metal loading and the generation of active Fe species. Therefore, how to utilize the distinctive features of fullerenes to precisely regulate and optimize Fe–N active sites along with their local coordination environment remains challenging. In this work, water-soluble C 60 (wsC 60 ) was synthesized via a facile interfacial oxidation process. The presence of –OH on the C 60 cage may strengthen its binding affinity with Fe 3+ ion and effectively modulate the incorporation of Fe/N into the C 60 -derived carbon electrodes. By varying the wsC 60 /Fe 3+ mixing ratios followed by pyrolysis under NH 3 , we obtained Fe/N-doped carbons (FeN@wsC 60 -900) with distinct Fe/N-doping states, including FeN 4 , O–FeN 4 /Fe cluster, and FeN 4 /Fe cluster. The abundant –OH in wsC 60 also promoted the formation of a highly porous network, enhancing active site accessibility. The resultant FeN@wsC 60 -900 exhibited excellent oxygen reduction reaction (ORR) activity, outperforming both conventional C 60 -derived carbons and commercial Pt/C. Structural characterizations and density functional theory (DFT) simulations revealed that the O-coordinated Fe–N 4 with adjacent Fe cluster could optimize the coordinate geometry and adsorption energies of key ORR intermediates.
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高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Jing Cao,Yu Sun,Cong Zhang,Xue Wang,Yiqing Zeng,Tao Zhang,Pintong Huang
Sonodynamic therapy (SDT) represents a viable approach to overcoming the limited ability of photodynamic therapy to penetrate biological barriers. However, pancreatic tumors contain a hypoxic microenvironment that limits the efficacy of oxygen-dependent type II SDT, complicating efforts to develop reliable, stable, and hypoxia-tolerant sonosensitizer. Herein, a tablet-like TiO 2 /C nanocomposite with a metal-organic-framework (MOF)-derived carbon structure was designed and found to be hypoxia-tolerant and stable in response to repeated ultrasound irradiation, enabling the TiO 2 /C-mediated generation of large quantities of reactive oxygen species (ROS) and thereby achieving efficacious type I SDT. Importantly, this nanocomposite continued to generate ROS in response to repeated ultrasound irradiation, and was able to induce tumor cell apoptosis via SDT-induced DNA damage in vitro and in vivo . This TiO 2 /C nanocomposite also exhibited good biocompatibility and did not induce any apparent toxicity in vitro and in vivo . Together, these data highlight TiO 2 /C as a valuable nanocomposite capable of facilitating repeated type I SDT, making it a promising tool for the treatment of hypoxic solid pancreatic tumors. Statement of significance In this research, a tablet-like TiO 2 /C nanocomposite with a metal-organic-framework (MOF)-derived carbon structure was designed, which exhibited great stability upon repeated ultrasound irradiation, hypoxic-tolerant ability and good biocompatibility. After ultrasound irradiation, TiO 2 /C could efficiently generate reactive oxygen species in an oxygen-independent manner, which overcame the limitation of pure TiO 2 nanoparticles . Therefore, it was applied to repeated type I sonodynamic therapy of hypoxic pancreatic tumor.
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高影响因子
JOURNAL OF ORGANIC CHEMISTRY
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2025
·
IF 3.6
Huanhuan Cui,Chunyu Hu,Xiulin Qiao,Tiesheng Shi,Chao Chen,Wei Wei,Zu-Li Wang,Zhuoming Ma
An efficient visible-light-induced EDA strategy has been developed for constructing 3-difluoroalkylated quinoxalin-2(1H)-ones through the C–H difluoroalkylation of quinoxalin-2(1H)-ones with fluoroalkyl bromides. This transformation could provide a series of 3-difluoroalkylated quinoxalin-2(1H)-ones in moderate to good yields under mild and metal-free conditions. Mechanistic studies revealed that the formation of the EDA complex between fluoroalkyl bromide and TMEDA was essential to initiate this transformation.
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高影响因子
PLoS Pathogens
·
2019
·Vol. 15
·期 5
·e1007759
·
IF 6.463
Longxing Cao,Bowen Yu,Dandan Kong,Qian Cong,Tao Yu,Zibo Chen,Zhenzheng Hu,Haishuang Chang,Jin Zhong,David Baker,Yongning He
Hepatitis C virus (HCV) is a member of Hepacivirus and belongs to the family of Flaviviridae . HCV infects millions of people worldwide and may lead to cirrhosis and hepatocellular carcinoma. HCV envelope proteins, E1 and E2, play critical roles in viral cell entry and act as major epitopes for neutralizing antibodies. However, unlike other known flaviviruses, it has been challenging to study HCV envelope proteins E1E2 in the past decades as the in vitro expressed E1E2 heterodimers are usually of poor quality, making the structural and functional characterization difficult. Here we express the ectodomains of HCV E1E2 heterodimer with either an Fc-tag or a de novo designed heterodimeric tag and are able to isolate soluble E1E2 heterodimer suitable for functional and structural studies. Then we characterize the E1E2 heterodimer by electron microscopy and model the structure by the coevolution based modeling strategy with Rosetta, revealing the potential interactions between E1 and E2. Moreover, the E1E2 heterodimer is applied to examine the interactions with the known HCV receptors, neutralizing antibodies as well as the inhibition of HCV infection, confirming the functionality of the E1E2 heterodimer and the binding profiles of E1E2 with the cellular receptors. Therefore, the expressed E1E2 heterodimer would be a valuable target for both viral studies and vaccination against HCV.
Hepatitis C virus (HCV) is an enveloped virus that infects millions of people worldwide and may lead to cirrhosis and hepatocellular carcinoma. HCV has two envelope proteins, E1 and E2, which form heterodimers on viral surface and are critical for HCV cell entry. However, current studies of HCV E1E2 are often limited by the poor quality of the in vitro expressed E1E2 heterodimers. Here we express the ectodomains of HCV E1E2 with different tags, and are able to isolate soluble E1E2 ectodomains suitable for structural and functional studies. Then we generate the 3D reconstruction of E1E2 heterodimer by electron microscopy and also model the E1E2 structure by the coevolution based strategy with Rosetta, showing the potential interactions between E1 and E2. Moreover, the E1E2 heterodimer is applied to examine the interactions with the HCV cellular receptors, neutralizing antibodies as well as the inhibition of HCV infection. These results suggest that the expressed E1E2 heterodimer would be a promising target for both viral studies and vaccination against HCV.
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高影响因子
ChemElectroChem
·
2019
·Vol. 6
·期 5
·1574-1581
·
IF 3.975
Pu Wang,Shuang Hou,Fang Pang,Miao Liu,Yanxin Li,Tiezhong Liu,Yizhen Luo,YaMeng Fan,Lingzhi Zhao
Graphical In the mill : Unique hierarchical mosaic-structure SiO x /C@CoO nanosheets, with both SiO x and graphite particles embedded in a CoO layered structure, are successfully fabricated through a high-energy ball-milling process and through a one-step hydrothermal process to form a 3D hierarchical mosaic structure. The unique combination of the CoO and SiO x /C can accommodate the large volume changes and retain the structural integrity of the nanosheets, maintaining the cycling stability and rate capability of SiOx/C@CoO electrode materials. Unique hierarchical mosaic-structure SiO x /C@CoO nanosheets were successfully synthesized from SiO x /C nanospheres embedded in CoO nanosheets through a high-energy ball milling and hydrothermal self-assembly process. The SiO x /C@CoO material exhibited good cyclic performance with a reversible discharge capacity of 1079 mAh g −1 over 250 cycles at a current density of 1000 mA g −1 . It also displayed an excellent rate capability (with an average specific reversible discharge capacity of 777.8 mAh g −1 at 2000 mA g −1 and 480 mAh g −1 at 5000 mA g −1 ). The stable skeleton structure of SiO x /C-embedded CoO nanosheets and the synergistic effect between the two materials should be responsible for the improvement of the lithium storage. This work proposes a feasible approach to promote CoO application in lithium-ion batteries.
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Industrial Chemistry & Materials
·
2023
·
IF 0
Yu Chen,Chang-Long Tan,Jing-Yu Li,Ming-Yu Qi,Zi-Rong Tang,Yi-Jun Xu
Photocatalytic hydrogen (H2) production coupled with selective oxidation of organic compounds into high-value-added organic intermediates has expansive prospects in the utilization and transformation of solar energy, which meets the development requirements of green chemistry. In this work, high-efficiency hole cocatalyst PdS-decorated In2S3 flower-like microspheres are fabricated for the effective visible-light-driven C–N coupling of amines to imines coupled with H2 evolution. Owing to the establishment of the internal electric field, which further boosts the transfer of photoexcited holes to PdS, PdS–In2S3 exhibits distinctly enhanced photocatalytic redox performance, which is 39.8 times higher for H2 and 14.3 times higher for N-benzylidenebenzylamine than that of the blank In2S3, along with high selectivity and stability. Furthermore, the practicability of dehydrogenation coupling of various aromatic amines to the corresponding C–N coupling products on PdS–In2S3 has been demonstrated and a plausible reaction mechanism has been proposed. This work is anticipated to stimulate further interest in establishing an innovative photoredox platform for selective organic synthesis coupled with H2 evolution in a green and sustainable way.
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