MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Shuang Lei,Guangyan Liang,Minli Ding,Dali Sun,Zhoubing Huang,Meng-Yi Xie
Conventional solid-phase microextraction fibers are primarily designed for detecting and analyzing of hydrophobic compounds, with limited applicability for hydrophilic compounds. This limitation restricts the in vivo application of solid-phase microextraction technology for hydrophilic substances. In the present study, a novel in vivo SPME fiber, exhibiting superior affinity for neonicotinoids, was developed. The custom-designed fiber exhibited outstanding sampling performance, robust reproducibility with an inter-fiber relative standard deviation of 6.0–10.3 %, and a low detection limit of 0.05 ng mL −1 . The accuracy of the in-house in vivo solid phase microextraction fiber was found to be comparable to that of traditional liquid-liquid extraction methods, while demonstrating superior extraction efficiency. The developed fiber was successfully employed to monitor the degradation kinetics of four neonicotinoid insecticides (acetamiprid, imidacloprid, thiacloprid, and thiamethoxam) in bean sprouts . Differences in the metabolic rates of these insecticides within the bean sprouts were revealed by the elimination kinetics. Also, their elimination half-lives followed the sequence of acetamiprid (0.42 days) > thiamethoxam (0.85 days) > imidacloprid (0.95 days) > clothianidin (1.13 days). The in vivo solid-phase microextraction fiber developed in this study provided operational simplicity and high extraction efficiency, making it a crucial tool for pesticide toxicology research and safety assessment of agricultural products.
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JOURNAL OF THE AMERICAN CERAMIC SOCIETY
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2025
·
IF 3.8
Xiao Zhu,Andrew L. Ogrinc,Qingshan Li,Robert Hengstebeck,Jiaxin Yu,Seong H. Kim,Hongtu He
Surface flaws and defects of glass are known to be sensitive to the environment to which the glass surface is exposed. Previous investigations indicated that the mechanochemical wear of soda lime silicate (SLS) glass in humid air is associated with the presence of sodium ion leaching and interactions with adsorbed water, but the wear of SLS glass in aqueous solutions remains elusive. In this study, the wear of SLS glass was investigated in aqueous solutions with the presence of various electrolyte cation sizes and valences. The results show that the mechanochemical wear of SLS glass decreases as the concentration of sodium ions in the aqueous solution increases. However, the mechanochemical wear of the SLS glass surface increases with the ion size for solutions with monovalent cations, but significantly decreases with the di- and trivalent cations in aqueous solutions. Further analyzes indicate that the sodium ion migration to the glass surface plays important roles in mechanochemical wear of SLS glass in aqueous solutions, in addition to the ion-exchange and hydrolysis of Si–O–Si network. The findings of this study provide further insights into the mechanochemical damage mechanism of silicate glass in aqueous environments.
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ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Dongya Liu,Shaohan Xing,Xiuping Chen
Interface engineering via the construction of heterojunctions to accelerate electron transfer is an effective strategy for enhancing electrocatalytic activity. This study designed and synthesized a NiFe 2 O 4 /CeO 2 Mott–Schottky (M–S) heterojunction for efficient urea oxidation reaction (UOR), which exhibits exceptional activity with a current density of 50 mA cm −2 at 1.40 V (vs. RHE). Spectroscopic analyses validate the formation of the M–S heterojunction, where a significant work function difference drives spontaneous electron transfer from NiFe 2 O 4 to CeO 2 through Ni–O–Ce bridge, thereby establishing a strong built-in electric field. This interfacial charge rearrangement precisely modulates the electronic structure of the Ni sites, enhancing initial urea adsorption and lowering the d -band center. Such modulation weakens intermediate binding and reduces the energy barrier for the rate-determining CO 2 desorption step. The utility of NiFe 2 O 4 /CeO 2 is demonstrated through reduced energy consumption in hybrid water electrolysis along with improved efficiency and longevity in urea-assisted zinc–air batteries. This study elucidates the effectiveness of M–S heterojunction engineering for developing highly efficient catalysts for advanced energy conversion and storage.
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Food Chemistry-X
·
2025
·
IF 8.2
Xilu Zhang,Yongxia Fu,Han Wang,Qun Shen,Zhenyu Liu,Yuanlong Chi
The effect of deproteinized Tremella olysaccharide (DTP) on the in vitro digestion of potato starch (PS) was investigated. DTP reduced the hydrolysis rate of PS in a concentration-dependent manner, with digestion rates of 76.99 %, 72.03 %, and 29.73 % after 180 min for 0.3, 0.6, and 1.2 mg/mL DTP, respectively. DTP delayed digestion by shifting the kinetics from single-phase to biphasic behavior. It significantly inhibited pancreatic α-amylase (IC 50 = 5.76 mg/mL) by modifying the enzyme's secondary structure and reducing substrate binding. Additionally, DTP enhanced digesta viscosity, which may have contributed to the reduction in postprandial glucose release, thereby supporting its role as a potential hypoglycemic agent. However, DTP exhibited minimal glucose adsorption, binding only 1.2 % of 100 mM glucose at 1.2 mg/mL. These findings suggest that DTP reduces starch digestion primarily by inhibiting α-amylase activity and increasing digestive viscosity, providing insights into its hypoglycemic potential.
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WATER RESEARCH
·
2025
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IF 12.4
Fang Zhao,Zhao Yang,Yifan Xiao,Ganghua Han,Kim R. Hardie,Mark Bartlam,Yingying Wang
The stereochemistry of antibiotics significantly affects resistance development. With rising antibiotic resistance, nanotechnology is emerging as a promising solution, potentially increasing the likelihood of nanoparticle coexistence with antibiotics in wastewater treatment plants (WWTPs). However, the influence of nanoparticles on chiral antibiotics induced resistance remains unclear. This study employed chemical characterization, metagenomics, and molecular docking to comprehensively elucidate the resistance mechanisms induced by the combination of silver nanoparticles (AgNPs) and chiral antibiotics (ofloxacin: OFL and levofloxacin: LEV). AgNPs significantly altered the abundance and composition of antibiotic and metal resistance genes, as well as the conjugative transfer of the RP4 plasmid among activated sludge communities, with the OFL_AgNPs combination exhibiting a higher resistance potential than LEV_AgNPs. Mechanistic studies revealed that chiral antibiotics selectively interact with AgNPs, promoting Ag + release, enhancing antibiotic uptake, and forming stable complexes. These interactions reshaped microbial functions, including cell membrane permeability, oxidative stress response, quorum sensing, and extracellular secretion, thereby shaping resistance profiles. This study reveals previously overlooked enantiomer-specific risks associated with nanoparticle-antibiotic interactions and provides a foundation for strategies to mitigate ARG dissemination in wastewater treatment and broader environmental systems.
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Small
·
2025
·
IF 12.1
Cheng-Xun Guo,Jing-Hua Chen,Zi-Lin He,Jun-Hua Wei,Dai-Bin Kuang
Methylammonium lead bromide perovskite (MAPbBr 3 ) quantum dots (QDs) have emerged as promising candidates for next-generation optoelectronic applications owing to their exceptional photoluminescent properties. However, their practical applications face significant challenges due to inherent instability issues. Herein, a solvent-induced in situ crystallization method is presented to encapsulate MAPbBr 3 QDs within a crosslinked (cl-) polymethyl methacrylate (PMMA) network. This innovative approach eliminates environmental concerns associated with traditional solvent evaporation methods while enabling uniform dispersion and stabilization of perovskite QDs within the crosslinked polymer matrix. The effects of preparation conditions are systematically investigated on the optical performance of the composite materials. Notably, UV irradiation is found to significantly enhance the luminescent performance. The optimized MAPbBr 3 @cl-PMMA exhibits outstanding optoelectronic performance, featuring a narrow emission profile (full width at half maximum: 24.6 nm), high optical transmittance (91%), and an impressive photoluminescence quantum yield of 98.3%. Benefiting from the protective crosslinked polymer matrix, the composite demonstrates exceptional stability. Furthermore, by integrating MAPbBr 3 @cl-PMMA film with commercial K 2 SiF 6 :Mn 4+ (KSF) red phosphor, a liquid crystal display (LCD) backlight device achieving a wide color gamut of 122.7% National Television System Committee (NTSC) 1953 standard is fabricated. This environmentally friendly and scalable synthesis method offers a promising pathway for large-area manufacturing and practical optoelectronic applications.
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JOURNAL OF HAZARDOUS MATERIALS
·
2025
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IF 11.3
Zulqarnain Haider Khan,Han Yu,Hui Li,Syed Shabi Ul Hassan Kazmi,Ruixia Han,Muhammad Azeem,Xin Sun,Zia Ur Rehman,Gang Li
Reactive oxygen species (ROS) are critical mediators of soil biogeochemical processes. While the production of ROS with biochar (BC) in the rhizosphere has not been explored. We demonstrate that BC and Fe-modified biochar (FeBC), prepared at 400°C and 600°C, influence ROS generation in paddy soil containing biodegradable (polybutylene succinate: PBS) and conventional (polystyrene) microplastics (MPs). FeBC, particularly FeBC prepared at 600°C, enhance ROS (O 2 •− , H 2 O 2 , • OH) production in paddy soil. The results of rhizosphere-focused pot experiment simulating field-like flooded conditions highlight that FeBC significantly increased O 2 •− , H 2 O 2 , • OH concentrations, especially with PBS (25.63, 27.69, 35.82 µM/kg, respectively) surpassing control by 3.1–3.6-folds. Iron plaque formation, water-soluble phenols, and microbial activity further influenced ROS dynamics and accelerated MP degradation via oxidative fragmentation (SEM surface fissures), dissolved organic carbon release (484 mg/kg), and SUVA 254 decline (4.6 folds). Microbial shifts toward Actinobacteria (37–43 %) and Firmicutes (25–28 %) correlated with ROS dynamics, linking biotic-abiotic degradation pathways. This work reveals the novel role of FeBC in rhizosphere ROS generation and the environmental behavior of MPs in BC-treated agricultural systems.
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Food Science & Nutrition
·
2025
·Vol. 13
·期 9
·e70862
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IF 3.8
Lu Jin,Yuanquan Ran,Nian Yang,Lanlan Yang,Xiaoyan Jia,Huan Zhao,Qiong Hu,Bing Yang,Dongxin Tang,Minyi Tian
α-Caryophyllene is a natural condiment and flavoring additive. Herein, we first study the in vivo and in vitro anti-lung cancer efficacy of α-caryophyllene and its potential mechanism. In antitumor activity in vitro, α-caryophyllene exhibited obvious selective cytotoxicity, and its cytotoxicity against lung cancer A549 cells (IC 50 = 22.94 ± 0.56) was superior to the elemene injection (EI, positive control), while its toxicity against normal cell lines was lower (MRC-5: IC 50 = 76.66 ± 2.60 μg/mL, L929: IC 50 = 44.04 ± 0.72 μg/mL). α-Caryophyllene blocked the cell cycle in the G1 phase via reducing cyclin E2-CDK2 and cyclin D3-CDK 4/6 complexes and increasing p21, thereby suppressing A549 cell proliferation. Simultaneously, α-caryophyllene activated the mitochondrial apoptotic pathway through elevating the Bax/Bcl-2 ratio, lowering ΔΨm, releasing Cyt c, activating caspase 9 and caspase 3, and triggering PARP fragmentation. In addition, α-caryophyllene downregulated N-cadherin and MMP-2 levels, thereby preventing the metastasis of A549 cells. In antitumor activity in vivo, α-caryophyllene effectively suppressed transplanted tumor growth by inducing apoptosis of transplanted tumor cells and was superior to the positive control EI. Therefore, α-caryophyllene has outstanding anticancer properties in vitro and in vivo, showing great potential to become a new anticancer drug in the pharmaceutical field.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2025
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IF 3.4
Ya-Xin Yao,Xue Lu,Zhao Li,Hao-Yu Liao,Zhi-Bing Liu,Hui Zhao,Hua Wang,De-Xiang Xu,Zhu-Xia Tan
Accumulating data demonstrate that bleomycin (BLM), a clinically used antineoplastic drug, induces pulmonary interstitial fibrosis. However, the specific mechanism remains unclear. This study was carried out for the purpose of evaluating the effect of mitochondrial dysfunction-associated senescence on BLM-induced pulmonary fibrosis. Adult C57BL/6 J mice were intratracheally instilled with BLM (2.5 mg/kg). Pulmonary α-SMA and Vimentin, two indicators of epithelial-mesenchymal transition (EMT), were increased, and pulmonary collagen deposition was shown in BLM-treated mice. Pulmonary p16 and p21, two biomarkers of cell cycle arrest, were elevated, and pulmonary SASP indicators were up-regulated in BLM-treated mice. The reduction of mitochondrial area in BLM-treated mouse lungs was revealed by transmission electron microscopy. ATP content was reduced in BLM-treated mouse lungs. Pulmonary SOD2 and IDH2, two enzymes located in mitochondria, were decreased in BLM-treated mice. Sirtuin3 (SIRT3), an NAD + -dependent deacetylase located in mitochondria, was down-regulated in BLM-treated mouse lungs. Interestingly, Sirt3 gene knockout aggravated BLM-evoked mitochondrial dysfunction-associated senescence in mouse lungs. Sirt3 gene knockout exacerbated BLM-induced lung fibrosis. Conversely, nicotinamide mononucleotide (NMN), an NAD + precursor, weakened BLM-induced down-regulation of mitochondrial SIRT3 activity in mouse lungs. NMN pretreatment attenuated BLM-induced mitochondrial dysfunction-associated senescence in mouse lungs. Finally, NMN pretreatment alleviated BLM-induced EMT and lung fibrosis. These results indicate that mitochondrial dysfunction-associated senescence partially contributed to BLM-induced pulmonary fibrosis.
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ACS Omega
·
2025
·
IF 4.3
Mingmin Li,Liang Qi,Jin Huang,Haonan Li,Wei Cheng,Zihan Shi,Xianxing Jiang,Yifeng Zhou,Wanxiang Jiang
Liver fibrosis can progress to cirrhosis and hepatocellular carcinoma. Currently, there is no effective drug for liver fibrosis. The peptide 6 (T6) is an endogenous peptide derived from human intrauterine adhesion tissues and has antifibrotic potential. Here, to improve the long-term efficacy and activity of T6, we conducted the rational modified of T6 through studying structure–activity, and synthesized a series of analogues. Among them, S6 and S6-FA exhibited optimal antihepatic fibrosis activity, and S6-FA had a stronger long-acting effect than T6 and S6. The two analogues inhibited the expression of α-SMA and Collagen 1 in TGF-β-induced LX2 cells model and CCl4-induced mouse model of liver fibrosis. Besides, we discovered that S6 and S6-FA remarkably reduced the AST and ALT serum levels. Mechanistic studies have demonstrated that analogues inhibited liver fibrosis through inhibiting Erk, Smad and P65 pathways. This study provided that the novel peptide S6 and S6-FA is potential candidate compounds for treating liver fibrosis.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2024
·
IF 8
Shinan Wang,Yue Yuan,Erping Bi
Coexisting tetracycline (TC), dissolved organic matter (DOM), and metal cations in aqueous environments might form complexes and consequently affect the environmental fate of TC. In this study, the interactions among coexisting humic acid (HA), TC, and Mg(II) in solutions were investigated by equilibrium dialysis batch experiments and nuclear magnetic resonance hydrogen spectroscopy ( 1 H NMR) characterization. In the binary systems, the dimethylamine (4Me 2 NH + ) functional group on the A-ring of TC bound to the oxygen-containing functional groups of HA via hydrogen bond. The solution pH affected the agglomeration morphology and dissociation of the oxygen-containing functional groups of HA as well as protonation and spatial conformation of TC, which in turn affected the HA-TC interactions. The complexation sites and ratio of Mg(II) on TC affect the binding mode in the ternary system. When the TC-Mg(II) complexation ratio is 1:1, the B, C, and D rings of TC preferentially complex with Mg(II), resulting in the change of TC from an extended to a twisted conformation. At this time, Mg(II) had a weaker inhibitory effect on binding affinity between HA and TC. When the complexation ratio was 1:2, the second Mg(II) complexation deactivated the 4Me 2 NH + on the A ring and further stabilized TC twisted conformation, resulting in a stronger inhibitory effect on the binding of TC to HA. Under acidic conditions, the solution pH mainly caused the difficulty in forming TC-Mg(II) complexes. The inhibitory effect of Mg(II) on the binding between HA and TC is weaker than that under alkaline conditions.
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Natural Product Communications
·
2024
·
IF 1.5
Meng S. Cheong,Lutfun Nahar,Satyajit D. Sarker,Hui Cao,Wai S. Cheang,Jianbo Xiao
Piceatannol is a stilbenoid, which has shown bioactivities in various cell culture models. However, its stability in cell culture medium is not clear. Here, UPLC-MS/MS was applied in situ to analyze the degradation products of piceatannol in Dulbecco's Modified Eagle's Medium (DMEM) and cell culture to investigate the compound's stability in DMEM. During the incubation with cell culture medium (at 4 and 37 °C), several piceatannol derivatives, such as an oxidation product (m/z 243.06), a reduction product (m/z 247.09), dimers (m/z 485.12 and 487.14) and trimers (m/z 727.18) were detected, which demonstrated the instability of piceatannol in cell culture conditions. To confirm if the new products during the incubation were generated due to the instability of piceatannol, ascorbic acid was added. The presence of ascorbic acid could significantly slow the degradation rate of piceatannol and the generation of piceatannol derivatives, which proved that the new products were generated by the degradation of piceatannol and indicated that the instability of piceatannol might be related to its antioxidant activity.
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