PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
·
2021
·Vol. 20
·期 1
·153-160
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IF 3.982
Chen Wei,Yan Yuyan,Han Renlu,Hu Jun,Hou Yafei,Tang Keqi
A flower-like nanostructured MnO 2 with near-infrared (NIR) light-triggered high photothermal conversion capability of 30% and reactive oxygen species (ROS) generation ability was successfully developed. Different from the reported MnO 2 nanomaterials those were used in the nanomedicine field for only relieving tumor hypoxia and/or imaging, the flower-like MnO 2 inherently acts as a competent agent for simultaneously enhanced photothermal and photodynamic therapy. Graphic abstract A flower-like nanostructured MnO2 with near-infrared (NIR) light triggered high photothermal conversion capability of 30% and reactive oxygen species (ROS) generation ability was successfully developed.
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高影响因子
CELLULAR ONCOLOGY
·
2021
·Vol. 44
·期 3
·557-568
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IF 6.73
Wang Wanyue,Li Xin,Xu Ye,Guo Weikang,Yu Hui,Zhang Lu,Wang Yaoxian,Chen Xiuwei
Purpose Cervical cancer remains a major cause of cancer-related death in women, especially in developing countries. Previously, we found that the acetylation levels of chloride intracellular channel 1 (CLIC1) at lysine 131 were increased in cervical cancer tissues using a label-free proteomics approach. The aim of this study was to further determine the role of CLIC1 expression and its acetylation in cervical cancer. Methods CLIC1 expression and its implications for the prognosis of cervical cancer were analyzed using primary patient samples and cells, and the Gene Expression Profiling Interactive Analysis (GEPIA) database (gepia.cancer-pku.cn). The effect of CLIC1 on cervical cancer cells was evaluated using Cell Counting Kit (CCK)-8, flow cytometry, scratch wound healing, transwell, Western blotting and co-immunoprecipitation (Co-IP) assays. In vivo tumor growth was assessed using mouse xenograft models. Results We found that CLIC1 expression was increased in cervical cancer tissues and cells and that patients with a high CLIC1 expression tended to have a shorter overall survival time. Knockdown of CLIC1 significantly reduced in vitro cervical cancer cell proliferation, migration and invasion, and in vivo tumorigenesis. At the molecular level, we found that nuclear factor kappa B (NF-κB) activity was positively regulated by CLIC1. Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB, attenuated the tumor-promoting effect of CLIC1. Moreover, we found that CLIC1 acetylation at K131 was upregulated in cervical cancer cells, which stabilized CLIC1 by inhibiting its ubiquitynation. Substitution of K131 inhibited CLIC1 ubiquitynation and promoted in vitro cervical cancer cell proliferation, migration and invasion, and in vivo tumor growth. In addition, we found that acetyltransferase HAT1 was responsible for CLIC1 acetylation at K131. Conclusion Our data indicate that CLIC1 acts as a tumor promoter in cervical cancer, suggesting a potential treatment strategy for cervical cancer by regulating CLIC1 expression and/or acetylation.
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JOURNAL OF FLUORESCENCE
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2021
·Vol. 31
·期 2
·509-516
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IF 2.217
Zuo Pengli,Zhang Jingyu,Zhou Yuqing,Xie Ningjie,Xiao Deli
Fluorescent carbon nanoparticles exhibit merits in terms of photochemical stability, functional modification flexibility and excellent biocompatibility. Currently, fluorescent carbon nanoparticles are often obtained by bottom-up or up-bottom strategies. So far, there has been no literature concerning spontaneous formation of fluorescent carbon nanoparticles. However, we have successfully found that fluorescent carbon nanoparticles can form spontaneously in the glutaraldehyde solution. Then further investigations were conducted on the storage time, pH and temperature, which could affect the fluorescence intensity of glutaraldehyde solution. The results indicate that the value of the fluorescence intensity will increase with the extension of the storage time. Moreover, the fluorescence mechanism of the glutaraldehyde solution was studied according to its properties and experiment results. Transmission electron microscopy was used to demonstrate nanoparticles in the glutaraldehyde solution. It’s assumed that such phenomenon is probably attributed to the conjugated structure resulting from the polymerization of glutaraldehyde and the quantum confinement effect owing to the nanoparticles formed by the aggregation of polymers. Therefore, the spontaneous fluorescence produced by glutaraldehyde solution provides a simple and environmentally-friendly way to prepare fluorescent carbon nanoparticles.
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BMC GENOMICS
·
2021
·Vol. 22
·期 1
·1-19
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IF 3.969
Yu Peng,Zhou Li,Yang Wen-Tao,Miao Li-jun,Li Zhi,Zhang Xiao-Juan,Wang Yang,Gui Jian-Fang
Background Loaches of Cobitinae, widely distributed in Eurasian continent, have high economic, ornamental and scientific value. However, the phylogeny of Cobitinae fishes within genera or family level remains complex and controversial. Up to now, about 60 Cobitinae mitogenomes had been deposited in GenBank, but their integrated characteristics were not elaborated.Results In this study, we sequenced and analyzed the complete mitogenomes of a female Cobits macrostigma. Then we conducted a comparative mitogenome analysis and revealed the conserved and unique characteristics of 58 Cobitinae mitogenomes, including C. macrostigma. Cobitinae mitogenomes display highly conserved tRNA secondary structure, overlaps and non-coding intergenic spacers. In addition, distinct base compositions were observed among different genus and significantly negative linear correlation between AT% and AT-skew were found among Cobitinae, genus Cobitis and Pangio mitogenomes, respectively. A specific 3 bp insertion (GCA) in the atp8-atp6 overlap was identified as a unique feature of loaches, compared to other Cypriniformes fish. Additionally, all protein coding genes underwent a strong purifying selection. Phylogenetic analysis strongly supported the paraphyly of Cobitis and polyphyly of Misgurnus. The strict molecular clock predicted that Cobitinae might have split into northern and southern lineages in the late Eocene (42.11 Ma), furthermore, mtDNA introgression might occur (14.40 Ma) between ancestral species of Cobitis and ancestral species of Misgurnus.Conclusion sThe current study represents the first comparative mitogenomic and phylogenetic analyses within Cobitinae and provides new insights into the mitogenome features and evolution of fishes belonging to the cobitinae family.
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2021
·Vol. 413
·期 9
·2553-2563
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IF 4.157
Li Cong,Zi Yuqiu,Xu Dawei,Jiang Dafeng,Qu Fei,Zhao Xian-En
Herein, the self-assembly of 1-dodecanethiol-capped Cu nanoclusters (DT-Cu NCs) is obtained by annealing of dibenzyl ether solution of nanoclusters. These aggregates are composed of small clusters and emit a high level of aggregation-induced emission (AIE) in water. Based on the quenching effect of 4-nitrophenol (4-NP) on DT-Cu NCs, a fluorescence strategy is developed to monitor α-glucosidase (α-Glu) activity and screen its inhibitors from Chinese herbal medicines. 4-Nitrophenyl-α-D-glucopyranoside (NGP) is selected as the substrate, which is further hydrolyzed to yield 4-NP through the catalysis of α-Glu. The quenching efficiency is positively correlated to the concentration of α-Glu. Furthermore, the inhibitory effects of the extracts from four Chinese herbal medicines (i.e., the rind of Punica granatum L., Momordica grosvenorii Swingle., Crataegus pinnatifida Bge., and Lycium barbarum L.) on the α-Glu activity have been studied. The IC 50 values of extracts from the rind of Punica granatum L. and Momordica grosvenorii Swingle are 0.23 and 0.37 g/L, respectively, so they show obvious inhibitory effects on α-Glu. The extracts of Crataegus pinnatifida Bge. and Lycium barbarum L. exhibit relatively weak inhibitory effects. Hence, the proposed strategy can be applicable for screening α-Glu inhibitors from Chinese herbal medicines. Last but not the least, by immobilizing DT-Cu NCs into agarose hydrogels in polyethylene tubes, a visual device is fabricated to screen α-Glu inhibitors with high throughput and sensitivity. Graphical abstract
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Nano-Micro Letters
·
2021
·Vol. 13
·期 1
·1-13
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IF 16.419
Jin Xin,Yang Lin,Wang Xiao-Feng
Two-dimensional (2D) perovskites solar cells (PSCs) have attracted considerable attention owing to their excellent stability against humidity; however, some imperfectness of 2D perovskites, such as poor crystallinity, disordered orientation, and inferior charge transport still limit the power conversion efficiency (PCE) of 2D PSCs. In this work, 2D Ti 3 C 2 T x MXene nanosheets with high electrical conductivity and mobility were employed as a nanosized additive to prepare 2D Ruddlesden–Popper perovskite films. The PCE of solar cells was increased from 13.69 (without additive) to 15.71% after incorporating the Ti 3 C 2 T x nanosheets with an optimized concentration. This improved performance is attributed to the enhanced crystallinity, orientation, and passivated trap states in the 3D phase that result in accelerated charge transfer process in vertical direction. More importantly, the unencapsulated cells exhibited excellent stability under ambient conditions with 55 ± 5% relative humidity.
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高影响因子
Journal of Food Measurement and Characterization
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2021
·Vol. 15
·期 2
·1747-1753
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IF 2.431
Li Yi-Fang,Lin Zheng-Zhong,Hong Cheng-Yi,Huang Zhi-Yong
A facile colorimetric method for rapid detection of putrescine (Put) and cadaverine (Cad) based on the peroxidase-like activity of (Fe,Co) codoped-CDs was developed. With the enzymatic hydrolysis by diamine oxidase (EC 1.4.3.6, DAO), Biogenic amines (BAs) were decomposed to produce H 2 O 2 which oxidizes 3,3',5,5'-tetramethyl-benzidine with the catalysis of (Fe,Co)-codoped CDs. By means of principal component analysis, Put and Cad were differentiated from BAs and their total amounts were detected by measuring the spectral absorption at 652 nm with a linear range from 0.25 to 10 mg kg −1 . The colorimetric method was applied to the detection of Put and Cad in various fish samples with a detection limit ((3σ/k, n = 9)) of 0.06 mg kg −1 . Besides verifying with HPLC, the recoveries of the colorimetric method were also tested by spiking standards at three levels with the range of 98.2%–115.7%, indicating that the established colorimetric method was accurate and sensitive.
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Nano-Micro Letters
·
2020
·Vol. 13
·期 1
·1-14
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IF 12.264
Huang Jiahui,Wu Peiyi
Complex multiscale assemblies of metal–organic frameworks are essential in the construction of large-scale optical platforms but often restricted by their bulk nature and conventional techniques. The integration of nanomaterials and 3D printing technologies allows the fabrication of multiscale functional architectures. Our study reports a unique method of controlled 3D assembly purely relying on the post-printing treatment of printed constructs. By immersing a 3D-printed patterned construct consisting of organic ligand in a solution of lanthanide ions, in situ growth of lanthanide metal–organic frameworks (LnMOFs) can rapidly occur, resulting in macroscopic assemblies and tunable fluorescence properties. This phenomenon, caused by coordination and chelation of lanthanide ions, also renders a sub-millimeter resolution and high shape fidelity. As a proof of concept, a type of 3D assembled LnMOFs-based optical sensing platform has demonstrated the feasibility in response to small molecules such as acetone. It is anticipated that the facile printing and design approach developed in this work can be applied to fabricate bespoke multiscale architectures of functional materials with controlled assembly, bringing a realistic and economic prospect.
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高影响因子
Nature Communications
·
2020
·Vol. 11
·期 1
·1-12
·
IF 12.121
Zhai Panlong,Zhang Yanxue,Wu Yunzhen,Gao Junfeng,Zhang Bo,Cao Shuyan,Zhang Yanting,Li Zhuwei,Sun Licheng,Hou Jungang
Rational design of the catalysts is impressive for sustainable energy conversion. However, there is a grand challenge to engineer active sites at the interface. Herein, hierarchical transition bimetal oxides/sulfides heterostructure arrays interacting two-dimensional MoO x /MoS 2 nanosheets attached to one-dimensional NiO x /Ni 3 S 2 nanorods were fabricated by oxidation/hydrogenation-induced surface reconfiguration strategy. The NiMoO x /NiMoS heterostructure array exhibits the overpotentials of 38 mV for hydrogen evolution and 186 mV for oxygen evolution at 10 mA cm −2 , even surviving at a large current density of 500 mA cm −2 with long-term stability. Due to optimized adsorption energies and accelerated water splitting kinetics by theory calculations, the assembled two-electrode cell delivers the industrially relevant current densities of 500 and 1000 mA cm −2 at record low cell voltages of 1.60 and 1.66 V with excellent durability. This research provides a promising avenue to enhance the electrocatalytic performance of the catalysts by engineering interfacial active sites toward large-scale water splitting.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2020
·Vol. 31
·期 24
·22028-22038
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IF 2.22
Peng Qirui,Yang Lu,Zhao Qiuying,Ma Yizhou,Ji Hongli,Qiu Jinhao
The development of piezoelectric polymers with superior electromechanical performance is a demand in the areas of flexible sensors, actuators and tissue engineering, among others. In this work, we reported a novel sandwich-structured piezoelectric composites comprising of poly(vinylidene fluoride-hexafluoropropylene) [P(VDF-HFP)] and Prussian blue analogs Co 3 [Co(CN) 6 ] 2 with excellent electromechanical activities. The large specific surface area, unique three-dimensional porous nanostructure and redox behavior of Co 3 [Co(CN) 6 ] 2 appeared to significantly promote the interfacial coupling effect within P(VDF-HFP), resulting in enhanced electromechanical response. Moreover, the sandwich structure topological design would enlarge the interfacial coupling effect, strengthen the breakdown strength and consequently raise the electromechanical performance. For instance, a maximum piezoelectric coefficient d 33 of ~ 41 pC/N can be achieved in the sandwiched composites at a loading of 0.8 wt%, which is 1.78 times that of pure P(VDF-HFP). Furthermore, the sandwiched composites possess superior electromechanical coupling factor k 33 up to 0.215, while that of pure P(VDF-HFP) is only 0.134.
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JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 14
·8528-8543
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IF 4.22
Wang Junchao,Zhang Zetian,Xie Taoling,Sun Liying,Yang Kaifeng,Liu Yang,Li Zhengjun
Polyhedral oligomeric silsesquioxanes (POSSs) can be utilized to prepare nanocomposites to improve their physical and mechanical properties significantly by physical interaction and chemical cross-linking. The purpose of this work is to prepare a kind of water-dispersive POSS containing multiple epoxy groups and then use it to prepare gelatin/POSS nanocomposites to enhance their thermal and mechanical properties. Accordingly, 3-glycidyloxypropyl-POSS (G-POSS) was synthesized by a complete hydrolysis and condensation method. Then, G-POSS was modified with polyetheramine to obtain a derivative material of POSS, denoted as P-G-POSS, which possess better water dispersion and flexibility. Importantly, the chemical structure of both G-POSS and P-G-POSS was confirmed by FT-IR, NMR, XPS and EDS analyses. Subsequently, POSS/gelatin nanocomposites were prepared in accordance with 1:1, 2:1 and 3:1 of epoxy/amino mole ratios in alkaline aqueous medium. The microscope porous structure, thermal stability, mechanical properties, along with water absorption of the composites containing various contents of P-G-POSS, were emphatically studied and discussed. The results indicated that composites possessed the maximum denaturation temperature up to 80.1 °C, as well as the increased initial decomposition temperature and residual mass at 700 °C, and particularly improved mechanical properties after incorporation of P-G-POSS into gelatin matrix. The reason is likely that the cross-linking reaction of epoxy groups in P-G-POSS with amino groups in gelatin macromolecules, along with hydrogen bonding, played an important role in the as-prepared gelatin/POSS composites. This study would be helpful to promote the application of POSSs in bone tissue regeneration and leather cleaner production.
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Reaction Kinetics Mechanisms and Catalysis
·
2021
·Vol. 132
·期 1
·301-315
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IF 2.081
Hu Yi-Ming,Zheng Wan-Bin,Jia Ai-Ping,Luo Meng-Fei,Tang Cen,Lu Ji-Qing
A series of Ir/BN catalysts with same Ir contents (2 wt%) were calcined at different temperatures and tested for gas phase selective hydrogenation of crotonaldehyde. It was found that the thermal treatment exerted significant impacts on the structural and electronic properties of the 2Ir/BN catalysts. The catalyst calcined at 500 °C (2Ir/BN-5) showed the best performance, with a steady state of conversion of ca. 21% and a crotyl alcohol selectivity of ca. 83% at reaction temperature of 80 °C. Kinetic analysis indicated that the enhanced activity on the 2Ir/BN-5 catalyst was related to its higher surface coverage of crotonaldehyde because of the presence of small Ir particles (with a mean diameter of 3.4 nm) compared to those in the catalyst calcined at 600 °C (2Ir/BN-6, with a mean diameter of 4.4 nm). Also, the surface of the Ir species in the 2Ir/BN-5 catalyst are more electron-enriched compared to that in the 2Ir/BN-6, which suppressed the adsorption of C=C bond and thus improves the selectivity to CROL.
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