CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Xiujuan Lin,Yaoting Zhao,Chao Wang,Wenlong Li,Rui Guo,Xiaofang Zhang,Feng Yu,Gensheng Dong,Chungang Li,Shifeng Huang
1-3 piezoelectric composites, as materials with integrated structural/functional characteristics, are typically used to manufacture ultrasonic transducers. As a core sensitive element, the structural dimensions as well as the molding quality of the 1–3 piezoelectric array, will directly affect the transducer's operating performance. In this paper, an improved soft mold process is proposed to prepare lead zirconate titanate (PZT) microscale 1–3 piezoelectric arrays by a soft mold combined with UV curing process. Firstly, the rheological behavior of PZT ceramic suspension and the preparation process of polydimethylsiloxane (PDMS) soft mold were studied. The surface contact angle of the Si master mold modified by trimethylchlorosilane (TMCS) was significantly increased, facilitating the peeling of the PDMS soft mold from the Si master mold surface, thus improving the surface quality of the PDMS soft mold. Then, the sintering process, microstructure, and electrical properties of microscale 1–3 piezoelectric arrays were systematically investigated. The perpendicularity and integrity of the piezoelectric arrays were improved by an optimized sintering process, and the arrays had micropillar diameters as small as 8 μm and aspect ratios over 7.5. The electrical properties of the piezoelectric composites with thicknesses of 55 μm and 42 μm were analyzed to obtain their resonant frequencies f s of 33.8 MHz and 41.3 MHz, respectively. The developed novel soft mold process can realize the preparation of microscale 1–3 piezoelectric arrays with fine structure and large aspect ratios, which are expected to fabricate high-frequency ultrasonic transducers.
✓ 已验证
产品关联
DOI
高影响因子
Aging-US
·
2023
·
IF 5.2
Guang-Zhi Liu,Tian-Tong Niu,Qian Yu,Bao-Lei Xu,Xiao-Qing Li,Bo-Yi Yuan,Guo-Bin Yuan,Ting-Ting Yang,Hui-Qin Li,Yi Sun
The NLRP3 inflammasome is involved in the neuroinflammatory pathway of Alzheimer’s disease (AD). The aim of this study is to explore the roles and underlying mechanisms of ginkgolide (Baiyu®) on amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mice and a murine microglial cell line, BV-2. In the present study, the APP/PS1 mice were administered with ginkgolide, followed by a Morris water maze test. The mice were then euthanized to obtain brain tissue for histological and Aβ analysis. Additionally, BV-2 cells were pretreated with ginkgolide and then incubated with Aβ1–42 peptide. NLRP3, ASC, and caspase-1 mRNA and protein expression in brain tissue of mice and BV-2 cells were quantified by real-time PCR and western blotting, as well as reactive oxygen species (ROS) production, interleukin (IL)-1β and IL-18 levels by lucigenin technique and ELISA. Compared with the APP/PS1 mice, ginkgolide-treated mice demonstrated the shortened escape latency, reduced plaques, less inflammatory cell infiltration and neuron loss in the hippocampi of APP/PS1 mice. The levels of NLRP3, ASC, caspase-1, ROS, IL-1β, and IL-18 were also decreased in the brain tissue of APP/PS1 mice or Aβ1–42-treated BV-2 cells following ginkgolide treatment. Ginkgolide exerted protective effects on AD, at least partly by inactivating the NLRP3/caspase-1 pathway.
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Shanlong An,Xin Huang,Nuo Li,Qiangwei Li,Tieyue Qi,Rujie Wang,Lidong Wang
2-amino-2-methyl-1-propanol (AMP) combines the advantages of the faster reaction rate of primary/secondary amines and the high absorption capacity of tertiary amines, making it a highly promising alternative to monoethanolamine (MEA). However, at high AMP concentrations, the absorption products are prone to solid crystallization, resulting in unstable operation of the carbon capture system. In this work, by adding a small amount of diethylenetriamine (DETA) to AMP, the crystallization of reaction products can be effectively controlled and AMP-DETA absorbent possesses a high absorption rate, low regeneration energy, and low metal corrosion rate. Wetted-wall column tests were performed to comprehensively evaluate the mass transfer kinetics and the effect of crucial conditions, and the diffusion coefficient, gas–liquid mass transfer coefficient, enhancement factor, and mass transfer resistance distribution were obtained. The effect of the addition of DETA on the solubility of HCO 3 − was verified. DETA carbamate was more likely to form intermolecular hydrogen bonds with HCO 3 − , thus reducing the formation of dimeric or multichain macromolecules between HCO 3 − molecules through hydrogen bonds and inhibiting the crystallization of high concentration HCO 3 − . HCO 3 − can accelerate the desorption rate by participating in the deprotonation of protonation amines. The results demonstrated that the average regeneration energy of the AMP–DETA absorption system was reduced by 21.2 % relative to that of 5 M MEA, and its metal corrosion rate was 0.07 mm/a, which was only 7.9 % of MEA under the same conditions. The results contribute to the industrial application of AMP–DETA.
✓ 已验证
产品关联
DOI
高影响因子
RESPIRATORY RESEARCH
·
2023
·Vol. 24
·期 1
·1-14
·
IF 5.8
Liu Jin,Chen Yuqian,Chen Huan,Wang Yan,Li Danyang,Zhang Qianqian,Chai Limin,Qiu Yuanjie,Zhang Jia,Shen Nirui,Wang Qingting,Wang Jian,Li Manxiang
Background Macrophage migration inhibitory factor (MIF) and GTPase dynamin-related protein 1 (Drp1)-dependent aberrant mitochondrial fission are closely linked to the pathogenesis of asthma. However, it is unclear whether Drp1-mediated mitochondrial fission and its downstream targets mediate MIF-induced proliferation of airway smooth muscle cells (ASMCs) in vitro and airway remodeling in chronic asthma models. The present study aims to clarify these issues. Methods In this study, primary cultured ASMCs and ovalbumin (OVA)-induced asthmatic rats were applied. Cell proliferation was detected by CCK-8 and EdU assays. Western blotting was used to detect extracellular signal-regulated kinase (ERK) 1/2, Drp1, autophagy-related markers and E-cadherin protein phosphorylation and expression. Inflammatory cytokines production, airway reactivity test, histological staining and immunohistochemical staining were conducted to evaluate the development of asthma. Transmission electron microscopy was used to observe the mitochondrial ultrastructure. Results In primary cultured ASMCs, MIF increased the phosphorylation level of Drp1 at the Ser616 site through activation of the ERK1/2 signaling pathway, which further activated autophagy and reduced E-cadherin expression, ultimately leading to ASMCs proliferation. In OVA-induced asthmatic rats, MIF inhibitor 4-iodo-6-phenylpyrimidine (4-IPP) treatment, suppression of mitochondrial fission by Mdivi-1 or inhibiting autophagy with chloroquine phosphate (CQ) all attenuated the development of airway remodeling. Conclusions The present study provides novel insights that MIF promotes airway remodeling in asthma by activating autophagy and degradation of E-cadherin via ERK/Drp1 signaling pathway, suggesting that targeting MIF/ERK/Drp1 might have potential therapeutic value for the prevention and treatment of asthma.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2023
·
IF 3.9
Qiang Ma,Lijun Jiang,Bowen Yang,Bowen Xu,Qingyuan Wang,Qihong Wu,Ping Ning,Yingjie Zhang,Jin Huang,Jiming Hao
Gaseous thallium (Tl) pollution events, primarily caused by non-ferrous mineral refineries and fossil fuel combustion, have increased over the past few decades. To prevent gaseous Tl distribution from flue gas, MnO2/CeO2@HKUST-1 (MCH) was synthesized and found to achieve a gaseous Tl(I) removal level of up to 90% at 423 K, a weight hourly space velocity (WHSV) of 2000 h–1/mL with an Mn dose of 10%, maintained over 10 h. The best Mn/Ce ratio was found to be 9:1. To further investigate surface kinetic behavior, four commonly used kinetic models were applied, including the Eley–Rideal (ER) model, Langmuir–Hinshelwood (LH) model, Mars–van Krevelen (MVK) model, and pseudo-first-order (PFO) model. While the ER and LH models had the slightest deviation, the MVK model was the most reliable. The CatMAP software was also used to match the simulation deviation. This work demonstrated the Tl removal mechanism and provided insights into the accuracy of kinetic models on minor-radius heavy metal. Thus, this research may help promote the design of reactors, heavy metal removal rates, and flue gas purification technology selection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Asia-Pacific Journal of Chemical Engineering
·
2023
·
IF 1.8
Kai Sun,Xinbao Li,Ye Yuan,Yucheng Wang,Ying Chen,Yingying Zhu,Junliang Lu
Adsorption of volatile gasoline components at oil terminal by using metal organic frameworks (MOFs) is a prospective technology in reducing environment pollution and increasing oil resource recovery. In this study, a typical MOF of HKUST-1 was facile prepared by solvothermal method and tested in the adsorption of volatile gasoline components. Isobutylene was selected as a model compound. The effects of preparation parameters Cu 2+ /H 3 BTC molar ratios, Cu 2+ precursors, and solvent compositions on the structure of HKUST-1 and its subsequent adsorption performance were systematically studied. The synthesized samples were characterized by XRD, SEM, and N 2 physisorption. It was found that the HKUST-1 prepared by using DMF as the unique solvent obtained the highest specific surface area (1076.7 m 2 /g) and the largest pore volume (0.90 cm 3 /g). Furthermore, the maximum isobutylene adsorption capacity of 31.9 mg/g was found on the HKUST-1 which prepared under the conditions of Cu 2+ /H 3 BTC = 2, Cu (CH 3 COO) 2 as the Cu 2+ precursor, and a solvent composition of DMF:EtOH:H 2 O = 0:4:3.
✓ 已验证
产品关联
DOI
高影响因子
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
·
2021
·
IF 1.455
WanFu Wang,Qiang Xu
Recently, halide hybrid perovskites have emerged as an attractive material for radiation detection due to their high atomic numbers and resistivity, large μ
τ product ( μ is the carrier mobility ; τ is the carrier lifetime). However, the sensitivity and stability of perovskite X-ray detectors were limited by ion migration in the perovskites. In this paper, the guanidinium ionic (Gua + ) doped MAPbI 3 single crystals were successfully obtained with the solution-processed method. (Gua) 0.06 (MA) 0.94 PbI 3 single crystal shows an activation energy of 589 meV. The X-ray detector with Au/(Gua) 0.06 (MA) 0.94 PbI 3 /Ga structural exhibited a high X-ray sensitivity of 2903 μ C Gy air − 1 cm −2 and a low limit of detection of 7.2 nGy air s − 1 . This work shows that a certain amount of Gua + doping into MAPbI 3 could inhibit the ion migration, and significantly improve the X-ray detection performance.
✓ 已验证
产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2021
·
IF 3.08
Yue Li,Linna Guo,Tiesheng Li,Bowen Yang
The ultra-small Lu6O5F8: 1%Er3+/10%Yb3+ up-conversion nanoparticles (UCNPs) were prepared via a co-precipitation method and used for detection of metal ions . Compared with other metal ions (Na+, Mg2+, Al3+, Fe2+, Co2+, Cd2+, etc), the up-conversion luminescence (UCL) intensity was reduced by 90% in the presence of Cu2+. Moreover, Strong quenching (65%) of the emission was observed upon the addition of Cu2+ in the concentration range of 0–10 μM. Meanwhile, the Cu2+ luminescence quenching mechanism was studied in detail. Under the 980 nm (1550 nm) excitation, the red UCL intensity of (Lu0.79Y0.1)6O5F8: 1%Er3+/10%Yb3+ and (Lu0.85Gd0.04)6O5F8: 1%Er3+/10%Yb3+ UCNPs enhanced about 4.67 (19.3) times and 3.95 (8.89) times than that of Y3+, Gd3+-absent samples, respectively. The temperature-sensing effect of Lu6O5F8: 1%Er3+/10%Yb3+ was also studied in detail, including not only this thermally coupled level (Er3+ 2H11/2, 4S3/2), but also the non-thermally coupled levels (Er3+ 2H11/2, 4F7/2). The absolute (S a ) and relative sensitivity (S r ) of Lu6O5F8: 1%Er3+/10%Yb3+ based on non-thermally coupled levels is much higher than that based on thermally coupled levels in the 293–473 K range. The maximum S a and S r is 0.087 and 0.0185 K −1 at 293 K. These meaningful results indicate that Lu6O5F8: 1%Er3+/10%Yb3+ materials have broad prospects in UCL multifunctional applications.
✓ 已验证
产品关联
DOI
高影响因子
Food & Function
·
2021
·Vol. 12
·期 10
·4471-4483
·
IF 5.396
Siqi Jiang,Na Deng,Bisheng Zheng,Tong Li,Rui Hai Liu
The effects of Rhodiola extract (RE) on longevity and stress resistance in Caenorhabditis elegans (C. elegans), and the underlying molecular mechanisms were explored in the present study. Results showed that the lifespan of C. elegans was remarkably prolonged by 37.1% after treated with high-dose RE (480 μg mL−1). Intervention with RE alleviated aging-related declines in the C. elegans model, and enhanced the stress resistance against heat shock, ultraviolet radiation and paraquat. Moreover, RE reduced the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the activities of superoxide dismutase (SOD) and catalase (CAT). RE also upregulated the gene expression of sod-3, gst-4, daf-16, skn-1 in C. elegans, downregulated the gene expression of daf-2 and age-1, and accelerated the translocation of DAF-16 and SKN-1 into the nucleus. Furthermore, the daf-16(mu86) and skn-1(zu169) mutants reversed the extension of lifespan triggered by RE, indicating that these genes were involved in RE-regulated longevity. These results demonstrated that RE could enhance lifespan extension, healthspan and stress resistance of C. elegans via insulin/IGF signaling and SKN-1 pathways. Therefore, the present findings suggested Rhodiola as a potential candidate to ameliorate the symptoms of aging.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Yangjinghua Yu,Runjun Sun,Zhong Wang,Mu Yao,Guohe Wang
Graphene oxide (GO) composite materials as adsorbent have been widely researched in the adsorption various heavy metal contaminated water . In order to improve its structural stability and adsorption properties, self-support GO/Sodium Alginate (SA)/1, 2-Propanediamine (PDA) composite membrane was prepared by vacuum filtration. The performance of amino functional groups in composite membranes was observed using X-ray photoelectron spectrum (XPS). The X-ray diffraction (XRD) was used to characterize the interlayer spacing. The Pb 2+ adsorption properties of composite membranes were discussed by intermittent adsorption experiments. Intermittent adsorption experiments include the subject of the pH, contact time, adsorption film weight, concentration of metal ion and temperature change. The Pb 2+ adsorption on the composite membrane strongly depends on pH. After 20 min of adsorption, the membrane reached the adsorption equilibrium, and the adsorption rate was fast. The maximum adsorption capacity of the composite membrane to Pb 2+ was 189.25 mg g −1 . The adsorption process of the membrane was consistent with the chemisorption process and mono-layer adsorption process. The GO/SA/PDA membranes can be used to the adsorption of Pb 2+ , which might give contribution to environmental protection.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2021
·Vol. 9
·期 26
·14710-14721
·
IF 12.732
He Huang,Wanyue Ye,Caicheng Song,Yingcen Liu,Xiaotong Zhang,Yu Shan,Yuzhen Ge,Shufen Zhang,Rongwen Lu
The selective oxidation of primary carbon–hydrogen bonds in the methyl group of toluene to corresponding oxygenates is of immense significance. This transformation, however, remains challenging and often requires either extensive optimization of the present chemical operating processes or, more importantly, the design and development of novel catalysts. In this paper, we achieve the confinement of uniform Au nanoparticles by using Silicalite-1 (Au@Silicalite-1) via an improved impregnation method for solvent-free oxidation of toluene by oxygen to benzaldehyde. In situ Ar+ etching XPS experiments revealed that in the evolution of Au0 and Au3+ species in a single Au@Silicalite-1 crystal the proportion of the Au3+ species becomes enriched from 0 on the surface to >80% in the center. In the synergetic catalysis between Au0 and Au3+ species, it was observed that the electron-rich Au0 species activated oxygen to form superoxide anion radicals, while the electron-deficient Au3+ species promoted activation of the primary carbon–hydrogen bond in toluene and enabled efficient desorption of the desired product benzaldehyde with selectivity >90%. For comparison, Silicalite-1 or SiO2 supported Au0-rich catalysts exhibited strong adsorption of benzaldehyde, generating overoxidized benzoic acid as the main product.
✓ 已验证
产品关联
DOI
高影响因子
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2020
·
IF 1.687
Jiang Gao,Lin Gao,Baoqiang Zhang,Haoyu Wang,Weihua Ma
Titanium silicalite-1 (TS-1) has unique catalytic properties for oxidation reactions due to the titanium atom in the framework. To increase the Ti content in the framework, polyvinylpyrrolidone (PVP) was added as a surfactant to modify TS-1 (PTS-1). The titanium content in PTS-1 as the active site in the catalytic reaction increased to 0.87 wt%, compared with the traditional TS-1 which has a titanium content of 0.64 wt%. Simultaneously, the average particle size of PTS-1 is reduced to 180 nm, compared with TS-1 (230 nm). The increase in Ti content makes the Au loading increase; thus, Au/PTS-1 shows higher catalytic performance for propylene epoxidation, and the propylene oxide (PO) formation rate increases from 95 g PO h −1 kg Cat −1 with Au/TS-1 to 190 g PO h −1 kg Cat −1 with Au/PTS-1. In addition, the mechanism for the modification of Ti content by PVP is proposed.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）