INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jiawen Liu,Song Li,Jie Shen,Jun Mei,Jing Xie
The direct application of essential oils in food systems faces challenges due to their volatility, strong odor, and instability. This study developed nanoemulsions encapsulating laurel ( Laurus nobilis ) essential oil (LEO) using sodium caseinate (SC) and octenyl succinic anhydride (OSA) modified α-cyclodextrin (α-CD) as composite stabilizers, aiming to enhance emulsion stability and bioactive efficacy. The results demonstrated that a 1:1 SC/OSA-α-CD ratio formed a dense reticular structure with minimal turbidity. NE-S1O1-8 M displayed uniform droplets, the smallest particle size (317.23 nm), and an 86° contact angle. Furthermore, under storage, centrifugation, or heating, NE-S1O1 showed superior stability with negligible changes in particle size or appearance. The encapsulation efficiency, antibacterial and antioxidant activities primarily depended on LEO concentration. The NE-S1O1-8 M emulsion exhibited optimal integrated bioactivity, demonstrating inhibition zones of 18.9 mm against S. putrefaciens and 17.1 mm against S. aureus , along with DPPH and ABTS radical scavenging rates of 79.2 % and 82.8 %, respectively. Although the encapsulation efficiency under this condition was slightly lower than that at 4 × MBC, it remained at a high level above 80 %. This study provides a novel approach for stabilizing active compound-loaded nanoemulsions suitable for food preservation applications.
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高影响因子
NATURAL PRODUCT RESEARCH
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2025
·
IF 1.6
Tengfei Zhao,Jia Wang,Chunshuai Huang
Dehydroamino acids are a class of noncanonical unsaturated amino acids commonly found in various naturally occurring peptides and proteins. In this study, we successfully cloned and heterologously expressed the cda biosynthetic gene cluster from Streptomyces nitrosporeus ATCC 12769 in Streptomyces lividans TK24, leading to the identification of three α,β-dehydroamino acid derivatives, designated as catedehas A–C (1–3). Among these, compound 2, although previously reported, lacked any detailed characterisation data. Their structures were elucidated by high-resolution electrospray ionisation mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, along with other spectroscopic techniques. Compounds 1–3 exhibited remarkable antioxidant activity in DPPH· free radical scavenging assay, with IC50 values of 27.52, 12.51, and 8.32 μM, respectively.
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ACS Nano
·
2025
·
IF 16
Hengdong Ren,Chensi Zhou,Ka Wang,Ximing Zhang,Lei Feng,Wenqing Wei,Yuqing Sun,Yukang Liu,Jun Dai,Xiaobing Xu,Zhiyong Zhang,Xinglong Wu
Interface polarization (one of the slow polarizations) is considered the primary mechanism driving microwave absorption (MA), but limitations in material composition and microstructure design often lead to weak interfacial polarization relaxation. In this work, we developed an interesting heterostructure consisting of carbon nanotube-encapsulated α-Fe2O3 nanocolumns (CNTs@α-Fe2O3). The curvature effects of CNTs induce a built-in electric field between CNTs and α-Fe2O3 nanocolumns, facilitating effective interface polarization. Under microwave irradiation, electron accumulation at the interfaces, driven by the energy-level mismatch between the two materials, further strengthens interface polarization, leading to a highly efficient MA performance. This heterostructured material achieves a minimum reflection loss of −74.1 dB at a thickness of 1.8 mm and an effective absorption bandwidth (reflection loss ≤ −10 dB) of 5.2 GHz (11.9 ∼ 17.1 GHz) at a thickness of only 1.5 mm. X-ray photoelectron spectroscopy and Raman scattering show a distinct blueshift in the Fe 2p binding energy and the A1g mode energy (exclusively associated with Fe atom vibrations), suggesting substantial charge transfer and redistribution at the interface associated with enhanced interface polarization. This work provides insights into interface polarization through the strategic design of energy levels and materials.
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CRYSTENGCOMM
·
2025
·
IF 2.6
Kaiwen Wu,Jichao Shi,Daqing Wang,Honghao Ni,Runping Jia,Yufeng Liu,Lin Lin,Dandan Wu,Shufang Chang,Yaqi Wang,Qing Xin
Magnetic iron oxide is a typical narrow-band gap semiconductor photocatalyst, but its inherent magnetic aggregation effect and high electron–hole recombination rate seriously affect its photocatalytic performance. Here, α-Fe2O3/SiO2 composite aerogels were prepared by combustion technology for the first time. The unique structure of α-Fe2O3/SiO2 composite aerogels with amorphous silica coated with nanocrystalline iron oxide was confirmed. The composite aerogels exhibited a high specific surface area (479 m2 g−1 when calcined at 500 °C), so that they have excellent adsorption properties for organic pollutants (MB, RhB and TC) and Cr(VI). The composite aerogels with a Fe : Si molar ratio of 1 : 2 showed the best visible light photocatalytic properties for MB, RhB and TC. Based on the study of the band gap width, photocurrent density, transient photocurrent response, impedance of photocatalysts, and the unique structure of the composite aerogels, the mechanism of photocatalytic enhancement of composite aerogels was proposed. Finally, the mechanism of the preparation of α-Fe2O3/SiO2 composite aerogels by combustion synthesis was analyzed. It is a potential technology for preparing high performance composite aerogel photocatalysts by high efficiency combustion technology.
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Theranostics
·
2022
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IF 11.6
Yong Luo,Zishan Zeng,Ting Shan,Xiaoyu Xu,Jie Chen,Yuanfeng He,Tao Zhang,Zeqian Huang,Guihong Chai,Yanjuan Huang,Yanfang Zhao,Chunshun Zhao
The development of activatable photosensitizers (aPSs) responding to tumor-specific biomarkers for precision photodynamic therapy (PDT) is urgently required. Due to the unique proteolytic activity and highly restricted distribution of tumor-specific enzymes, enzyme activatable photosensitizers display superior selectivity. Methods: Herein, a series of novel Fibroblast Activation Protein α (FAPα) activatable theranostic pro-photosensitizers were designed by conjugating the different N -terminal blocked FAPα-sensitive dipeptide substrates with a clinical PS, methylene blue (MB), through a self-immolative linker, which resulting in the annihilation of the photoactivity (fluorescence and phototoxicity). The best FAPα-responsive pro-photosensitizer was screened out through hydrolytic efficiency and blood stability. Subsequently, a series of in vitro and in vivo experiments were carried out to investigate the FAPα responsiveness and enhanced PDT efficacy. Results: The pro-photosensitizers could be effectively activated by tumor-specific FAPα in the tumor sites. After response to FAPα, the “uncaged” MB can recover its fluorescence and phototoxicity for tumor imaging and cytotoxic singlet oxygen ( 1 O 2 ) generation, eventually achieving accurate imaging-guided PDT. Simultaneously, the generated azaquinone methide (AQM) could serve as a glutathione (GSH) scavenger to rapidly and irreversibly weaken intracellular antioxidant capacity, realizing synergistic oxidative stress amplification and enhanced PDT effect. Conclusion: This novel FAPα activatable theranostic pro-photosensitizers allow for accurate tumor imaging and admirable PDT efficacy with minimal systemic side effects, offering great potential in clinical precision antitumor application.
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高影响因子
Materials Chemistry Frontiers
·
2021
·Vol. 5
·期 18
·7032-7040
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IF 6.482
Xiaojia Jiang,Mingsong Zang,Fei Li,Chunxi Hou,Quan Luo,Jiayun Xu,Junqiu Liu
Recently, biological nanopore-based techniques have attracted more and more attention in the field of single-molecule detection because they allow real-time, sensitive, high-throughput analysis. Herein, we report an engineered biological nanopore sensor by introducing a macrocyclic host molecule carboxylatopillar[5]arene (CP[5]A) that acts as an aptamer into the lumen of a mutant (E111R/K147R)7 αHL nanopore for detecting highly toxic paraquat (PQ) via host–guest interactions at the single-molecule level. By taking advantage of introducing positively charged arginine (Arg) into the lumen of the αHL nanopore, our engineered nanopore sensor exhibits higher stability. More importantly, this nanopore sensor shows high sensitivity, and the limit of detection (LOD) for PQ can reach a nanomolar level of 0.37 ppb. The CP[5]A-based nanopore sensing strategy developed in this work may bring inspiration for single-molecule detection and hold great potential in public health applications.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Bowen Zhang,Lulu Guo,Jiayue Xin,Guangrui Xiang,Shengxuan Xu,Yu Gong,Xiaohan Sun,LeTian Zhao,Ke Wu,Fan Li,Zhimin Yang
The development of self-powered humidity sensors featuring rapid response, low hysteresis, and dual-mode signal output is highly anticipated in healthcare monitoring, wearable electronics and human-machine interaction. Here, we present a hydrogen bonding-mediated self-assembly strategy to synthesize α-Fe 2 O 3 -decorated reduced graphene oxide (Fe 2 O 3 -rGO) hybrids for high-performance dual-mode humidity sensing. In impedance mode, the sensor demonstrates a broad detection range (11–98 % RH), a response value of 71.1 at 98 % RH, fast response/recovery times (1 s/5 s), and minimal hysteresis (3.7 %). The sensing mechanism, elucidated through complex impedance spectroscopy and water adsorption isotherms, reveals synergistic proton transport and p-n heterojunction effects at the α-Fe 2 O 3 -rGO interface. Notably, the sensor also operates in a self-powered mode, generating an ultrahigh output voltage (1.1 V at 98 % RH) through humidity-triggered galvanic reactions, enabling capacitor charging and light-emitting diode (LED) driving. Practical applicability is demonstrated through real-time respiratory monitoring, Morse code communication, and non-contact finger motion tracking, underscoring its utility in wearable electronics. This work provides a scalable and cost-effective approach to designing multifunctional humidity sensors with broad applicability in smart systems and healthcare.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2022
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IF 5.876
You Liang,Sijin Wang,Huijuan Jia,Yijia Yao,Jiehui Song,Wenchao Yang,Yongsong Cao,Feng Zhu,Zhongyang Huo
The development of stimuli-responsive controlled release formulations is a promising strategy to enhance the utilization efficiency and reduce the environmental pollution of pesticides. In this work, a smart pH/redox/α-amylase triple stimuli-responsive pesticide delivery system was constructed by bonding carboxymethyl starch (CMS) with metal-organic frameworks (MIL-101(Fe)–NH 2 nanoparticles) which loaded with CAR ( [email protected] (Fe)-CMS nanoparticles). The results indicated that the loading capacity of [email protected] (Fe)-CMS nanoparticles for CAR was approximately 18.3% and the CMS attached on the surface of [email protected] (Fe)–NH 2 nanoparticles could protect CAR from photolysis effectively. Meanwhile, the coated CMS and metal-organic framework structure of the nanoparticles could be decomposed and consequently release pesticide active ingredients on demand when [email protected] (Fe)-CMS nanoparticles were metabolized by glutathione and α-amylase in the insect alkaline midgut. The bioactivity survey confirmed that [email protected] (Fe)-CMS nanoparticles had a longer duration in controlling Spodoptera frugiperda larvae compared to CAR suspension concentrate. In addition, the MIL-101(Fe)-CMS nanocarriers were safe for the growth of maize and could be used as fertilizer to promote the growth and development of crops. Thus, this smart stimuli-responsive pesticide-fertilizer all-in-one combination strategy has great potential in pest management.
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高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Chenlu Zhu,Zebin Liu,Lishi Ren,Siming Jiao,Xuebing Zhang,Qiukuan Wang,Zhimin Li,Yuguang Du,Jian-Jun Li
Endo -fucoidanases are important in structural analysis of fucoidans and preparation of fuco-oligosaccharides. However their enzymological properties and analysis of degradation products are scarcely investigated. Truncated endo - α (1 → 3)-fucoidanase Fda1 (tFda1B from Alteromonas sp. was overexpressed and characterized, showing highest activity at pH 7.0, 35 °C, and 1.0 M NaCl. Its K m and k cat were 3.88 ± 0.81 mg/mL and 0.82 ± 0.17 min −1 . Fe 3+ and Mn 2+ enhanced activity by 100% and 19.5% respectively. Co 2+ and Cu 2+ completely inactivated tFda1B, whereas Ni 2+ , Mg 2+ , Zn 2+ , Pb 2+ , Ca 2+ , Ba 2+ and Li + decreased activity by 58.8%, 56.0%, 50.6%, 47.7%, 28.9%, 15.6% and 37.5%, respectively. Catalytic residues were identified through structure and sequence alignment, and confirmed by mutagenesis. Degradation products of Kjellmaniella crassifolia fucoidan by tFda1B were characterized by LC-ESI-MS/MS, confirming tFda1B belongs to endo -(1 → 3)-fucoidanases, and backbone of K. crassifolia fucoidan is 1 → 3 fucoside linkage. This endo - α (1 → 3)-fucoidanase would be useful for elucidating fucoidan structures, and be used as a food enzyme.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Qian Huang,Wei-Ming Chai,Zuo-Yuan Ma,Chong Ou-Yang,Qi-Ming Wei,Shuang Song,Zheng-Rong Zou,Yi-Yuan Peng
The inhibition of α-glucosidase and glycation is considered as an effective approach for the treatment of type 2 diabetes. In this study, multispectroscopic and molecular docking techniques were employed to investigate the inhibition of tannic acid on α-glucosidase and glycation. Kinetics analyses revealed that tannic acid had a significant inhibition on α-glucosidase (IC 50 = 0.35 ± 0.02 μM) in a reversible and mixed competitive manner. The results acquired from fluorescence quenching and ANS-binding fluorescence methods revealed that tannic acid could bind to α-glucosidase and reduce the hydrophobic area on the surface of the enzyme . In addition, synchronous fluorescence analysis showed that tannic acid decreased the hydrophobicity of α-glucosidase and changed the conformation of the enzyme. In vitro glycation assays showed that tannic acid had strong inhibitory effects on the formation of fructosamine , dicarbonyl compounds, and fluorescent AGEs . ANS-binding fluorescence analysis showed that tannic acid could bind to BSA and reduce the hydrophobicity of BSA in glycation. Moreover, the results of molecular docking showed the interaction between tannic acid and α-glucosidase was mainly driven by hydrogen bond , electrostatic, and hydrophobic interaction. And the interaction between tannic acid and BSA was mainly driven by hydrogen bond and hydrophobic interaction.
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高影响因子
Polymers
·
2018
·Vol. 10
·期 4
·385
·
IF 2.935
Lei Zhu,Bojie Li,Shan Wang,Wei Wang,Liansheng Wang,Liang Ding,Caiqin Qin
The first example of an environmentally-benign chitosan supported copper catalyzed conjugate silylation of α,β-unsaturated acceptors was accomplished in water under mild conditions. This protocol provides an efficient pathway to achieve an important class of β-silyl carbonyl compounds and the desired products were obtained in good to excellent yields. Gram-scale synthesis and easy transformation of obtained β-silyl products were also been demonstrated. Remarkably, this chitosan supported copper catalyst can be easily recycled and reused six times without any significant decrease of catalytic activity. The advantages of this newly developed method include operational simplicity, good functional group tolerance, scale-up ability, ready availability, and easy recyclability of catalyst.
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高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Xu Dai,Ji-Na Hao,Jinlou Gu,Yongsheng Li
α-Ketoglutaric acid (α-KA) is an important endogenous metabolite in the Krebs cycle and considered a critical marker for various diseases. Several approaches for identifying α-KA have been reported. However, most of them are limited to single-signal transduction modes in one assay and working in the suspension state, which easily cause quantification errors and lead to false-positive detection results. Herein, a multivalue-responsive and semi-solid EuMOF-gel (EuMOG) logic biosensor is first designed and fabricated, which can realize the specific, rapid, and easy-to-differentiate naked-eye detection of the disease-associated marker of α-KA in serum through implementing one-to-two logic operation with three multicolor gates. The implementation of one-to-two logic operation can be rationally achieved by assembling 2,6-naphthalenedicarboxylic acid as both the energy donor and blue-colored output 1, photoactive Eu3+ ions as the red-emissive output 2, and α-KA stimuli as an input and energy blocker between the dual spectrum-resolved outputs into one unit. With the specific input of α-KA among various analytes, the binary code of the logic decoder switches from (0,1) to (1,0) with an obvious color change from red to cyan. Moreover, by integrating the output chromaticity into the logical operations, the concentration levels of α-KA could be easily evaluated with the intelligent EuMOG detector, which has three multicolor gates in parallel encoding low (0,1), normal (1,1), and danger (1,0) statuses. Such multivalued logic biosensor provides a facile strategy to improve the analysis reliability of disease-associated biomarkers.
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