ACS Applied Optical Materials
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2025
·
IF 3.8
Yan Zhang,Junzhe Wang,Liang Li,Honggang Zhang,Bei Li,Xiangxiang Zhang,Zeyan Wang,Yuanyuan Liu,Peng Wang,Hefeng Cheng,Ying Dai,Baibiao Huang,Zhaoke Zheng
The design of organic–inorganic heterojunctions can facilitate the separation of photoinduced charge carriers by modulating the electronic structure at the surface and interface states, showing promising applications in the field of photocatalytic CO2 cycloaddition. However, the details of the surface/interface effects between these two components are still poorly understood. Herein, Cu2O@Cu3(HHTP)2 (HHTP = 2, 3, 6, 7, 10, 11-hexahydroxytriphenylene) heterojunctions were synthesized, where Cu2O nanoparticles (NPs) featuring distinct crystal facets were utilized as substrates for the in situ growth of the copper-based metal–organic framework (Cu3(HHTP)2). Among them, t-Cu2O@Cu3(HHTP)2, centered on t-Cu2O with {111} and {100} facets, exhibits superior performance toward photocatalytic CO2 cycloaddition to chlorinated propylene carbonate, with a conversion efficiency of 372 mmol g–1 h–1 under light. Notably, single-particle spectroscopy reveals a more efficient photogenerated carrier transfer between t-Cu2O and Cu3(HHTP)2. The results confirm that crystalline facet dependence is a key factor in semiconductor photocatalysis and an important strategy for optimizing the reactivity of photocatalysts, which provides a way to improve the photocatalytic CO2 cycloaddition performance by modulating the interfacial states of organic–inorganic heterojunction structures.
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JOURNAL OF MATERIALS SCIENCE
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2025
·
IF 3.9
Pang Renze,Dong Xueyu,Wu Shaowei,Cheng Xinhua
High-performance 3D-Zn@Zn 3 (PO 4 ) 2 anode was constructed by a simple two-step strategy with 3D-Zn electrode prepared via electrodeposition followed by Zn 3 (PO 4 ) 2 protective layer decorated on its surface via chemical reaction exhibiting good universality. 3D-Zn@Zn 3 (PO 4 ) 2 anode demonstrated high hydrogen evolution overpotential and transference number of Zn 2+ besides low desolvation energy barrier and rapid transfer kinetics of Zn 2+ . Its symmetric cell could understand more than 1200 h at 1 mA cm −2 for 1 mA h cm −2 . When the anode was assembled into zinc-ion battery with MnO 2 cathode, it delivered specific capacity of 229.43 mA h g −1 at 0.1 A g −1 as well as exhibited remarkable rate capability and long-term cycling stability with capacity retention of 65.0% and Coulombic efficiency of 99.6% after 400 cycles under 1 A g −1 . The synergistic effect was studied between Zn 2+ -conductive hopeite layer and 3D-Zn electrode with (002) crystal plane orientation as well as three-dimensional (3D) microstructure as a template.
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Journal of Environmental Sciences
·
2010
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IF 1.412
Shuyan Zang,Bin Lian,Juan Wang,Yanjie Yang
To explore biodegradation of 2-naphthol and its metabolites accumulated in wastewater treatment, a series of bio-degradation experiments were conducted. Two main metabolites of 2-naphthol, 1,2-naphthalene-diol and 1,2-naphthoquinone, were identified by high-performance liquid chromatography with standards. Combining fungus Aspergillus niger with bacterium Bacillus subtilis in the treatment enhanced 2-naphthol degradation efficiency, lowered the accumulation of the two toxic metabolites. There were two main phases during the degradation process by the kinetic analysis: 2-naphthol was first partly degraded by the fungus, producing labile and easily accumulated metabolites, and then the metabolites were mainly degraded by the bacterium, attested by the degradation processes of 1,2-naphthalene-diol and 1,2-naphthoquinone as sole source of carbon and energy. Sodium succinate, as a co-metabolic substrate, was the most suitable compound for the continuous degradation. The optimum concentration of 2-naphthol was 50 mg/L. The overall 2-naphthol degradation rate was 92%, and the COD Cr removal rate was 80% on day 10. These results indicated that high degradation rate of 2-naphthol should not be considered as the sole desirable criterion for the bioremediation of 2-naphthol-contaminated soils/wastewater.
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高影响因子
JOURNAL OF INFECTION
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2018
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IF 4.603
Shuyi Wang,Juan Xue,Ping Lu,Chunshan Ni,Hao Cheng,Rui Han,Stijn van der Veen
Summary Objectives The rise in multidrug resistant Neisseria gonorrhoeae poses a threat to healthcare, while the development of an effective vaccine has remained elusive due to antigenic and phase variability of surface-expressed proteins. In the current study, we identified a fully conserved surface expressed protein and characterized its suitability as a vaccine antigen. Methods An in silico approach was used to predict surface-expressed proteins and analyze sequence conservation and phase variability. The most conserved protein and its surface-exposed Loop 2, which was displayed as both a structural and linear epitope on the oligomerization domain of C4b binding protein, were used to immunize mice. Immunogenicity was subsequently analyzed by determination of antibody titers and serum bactericidal activity. Results MtrE was identified as one of the most conserved surface-expressed proteins. Furthermore, MtrE and both Loop 2-containing fusion proteins elicited high protein-specific antibody titers and particularly the two Loop 2 fusion proteins showed high anti-Loop 2 titers. In addition, antibodies raised against all three proteins were able to recognize MtrE expressed on the surface of N. gonorrhoeae and showed high MtrE-dependent bactericidal activity. Conclusions Our results show that MtrE and Loop 2 are promising novel conserved surface-expressed antigens for vaccine development against N. gonorrhoeae .
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高影响因子
TALANTA
·
2022
·
IF 6.556
Bin Yang,Xiaowei Zeng,Jin Zhang,Jilie Kong,Xueen Fang
Delta (B.1.617.2), a highly infectious variant of SARS-CoV-2, has been sweeping the world, and threatening the safety of human life seriously. It is urgent to develop a highly selective and sensitive assay to accurately identify the SARS-CoV-2 variant Delta. In this work, we constructed a graphene/CRISPR-dCas9 electrochemical biosensor to accurately identify SARS-CoV-2 variant Delta, where the signal was further amplified by embedded electrochemical probe [Ru(phen) 2 dppz]BF 4 . This detection assay could be finished within 47 min totally, with the detection limit of 1.2 pM and good reproducibility with a C·V.% of 2.48% (n = 5). And the biosensor could selectively identify Delta among SARS-CoV-2 and other variants, including Alpha, Beta, Gamma. This assay was further validated by 26 real clinical samples, showing 100% clinical sensitivity and 100% clinical specificity, which provides a new direction for identifying other SARS-CoV-2 variants in the future.
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高影响因子
Anti-Cancer Agents in Medicinal Chemistry
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2018
·Vol. 18
·期 3
·422-427
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IF 2.556
Kuang Shan,Sima Zhenhua,Liu Jiawei,Li Wuguo,Song Qiaoling,Zhang Qing,Yu Qiang
Background: 2-Methoxystypandrone (2-MS), isolated from the roots of Polygonum cuspidatum, is a potent dual inhibitor of the STAT3 and NF-ΚB pathways. Objective: To investigate the molecular targets and mechanisms of 2-MS. Method: A biotin-conjugated 2-MS analog, named
2-MS-Biotin, was designed and synthesized. The effects of 2-MS-Biotin on the STAT3 and NF-ΚB pathways were examined by Western blotting. The cytotoxicity of 2- MS-Biotin was evaluated using real-time cell analysis system. Proteins directly bound to 2-MS-Biotin were pulled down through
streptavidin agarose beads and were detected using Western blotting. Results: 2-MS-Biotin retained the inhibition activities of the parent compound 2-MS on the STAT3 and NF-ΚB pathways as well as on cancer cell growth. Also, JAK2 and IKK proteins can be effectively pulled down by
2- MS-Biotin. Conclusion: Using 2-MS-Biotin as a tool, both JAK2 and IKK were identified as the targets of 2-MS.
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JOURNAL OF ORGANIC CHEMISTRY
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2025
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IF 3.6
Huanhuan Cui,Chunyu Hu,Xiulin Qiao,Tiesheng Shi,Chao Chen,Wei Wei,Zu-Li Wang,Zhuoming Ma
An efficient visible-light-induced EDA strategy has been developed for constructing 3-difluoroalkylated quinoxalin-2(1H)-ones through the C–H difluoroalkylation of quinoxalin-2(1H)-ones with fluoroalkyl bromides. This transformation could provide a series of 3-difluoroalkylated quinoxalin-2(1H)-ones in moderate to good yields under mild and metal-free conditions. Mechanistic studies revealed that the formation of the EDA complex between fluoroalkyl bromide and TMEDA was essential to initiate this transformation.
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高影响因子
MOLECULES
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2025
·Vol. 30
·期 23
·4526
·
IF 4.6
Mingjun Yu,Xin Zhang,Hui Zhu,Xiaoqian Zhang
A series of 4-phenylurea chalcones (2a–2s) as VEGFR-2 inhibitors has been designed, synthesized, and evaluated for in vitro cytotoxic activity against K562, SiHa, and B16 cancer cells. Compared to sorafenib, the compounds exhibited strong cytotoxicity against K562, SiHa and B16 cells. Compounds2r,2o, and2lexhibited remarkable cytotoxicity against K562, SiHa, and B16 cells, with IC50values of 0.97 μM, 1.22 μM, and 1.39 μM, respectively. Moreover, compound2lexhibited potent cytotoxicity against K562, SiHa, and B16, with IC50values ranging from 1.25 μM to 1.39 μM. Compounds2land2oalso exhibited excellent inhibitory activity on VEGFR-2 kinase, with IC50values of 0.42 ± 0.03 and 0.31 ± 0.02 μM, respectively. Molecular docking proved that the target compounds had strong binding interactions with VEGFR-2 proteins. Flow cytometry analysis showed that compound2linduced apoptosis and arrested the cell cycle at the G1 and S phases.
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JOURNAL OF MOLECULAR ENDOCRINOLOGY
·
2015
·Vol. 55
·期 2
·119-31
·
IF 3.081
Leping Zhao,Yong Pan,Kesong Peng,Zhe Wang,Jieli Li,Dan Li,Chao Tong,Yi Wang,Guang Liang
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) controls the production of active glucocorticoid (GC) and has been proposed as a new target for the treatment of type 2 diabetes. We have previously reported that a natural product, curcumin, exhibited moderate inhibition and selectivity on 11β-HSD1. By analyzing the models of protein, microsome, cells and GCs-induced mice in vitro and in vivo, this study presented a novel curcumin analog, LG13, as a potent selective 11β-HSD1 inhibitor. In vivo, Type 2 diabetic mice were treated with LG13 for 42 days to assess the pharmacological benefits of 11β-HSD1 inhibitor on hepatic glucose metabolism. In vitro studies revealed that LG13 selectively inhibited 11β-HSD1 with IC50 values at nanomolar level and high selectivity over 11β-HSD2. Targeting 11β-HSD1, LG13 could inhibit prednisone-induced adverse changes in mice, but had no effects on dexamethasone-induced ones. Further, the 11β-HSD1 inhibitors also suppressed 11β-HSD1 and GR expression, indicating a possible positive feedback system in the 11β-HSD1/GR cycle. In type 2 diabetic mice induced by high fat diet plus low-dosage STZ injection, oral administration with LG13 for 6 weeks significantly decreased fasting blood glucose, hepatic glucose metabolism, structural disorders, and lipid deposits. LG13 exhibited better pharmacological effects in vivo than insulin sensitizer pioglitazone and potential 11β-HSD1 inhibitor PF-915275. These pharmacological and mechanistic insights on LG13 also provide us novel agents, leading structures, and strategy for the development of 11β-HSD1 inhibitors treating metabolic syndromes.
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高影响因子
Scientific Reports
·
2014
·Vol. 4
·期 1
·1-9
·
IF 5.078
Gu Yong,Lee Waisin,Shen Jiangang
Site-2 protease (S2P) is a membrane-embedded protease that site-specifically cleaves intramembrane transcription factors, a necessary step for their maturation. S2P is well known to regulate cholesterol biosynthesis and endoplasmic reticulum stress in mammalian cells. In this study, we hypothesized that S2P could be responsible for the regulation of cellular oxidative injury under oxidative stress. Wild type Chinese hamster ovary (WT CHO) cells and their mutant M19 cells with defective S2P gene were exposed to different oxidative stress conditions. Results showed that oxidative stress significantly up-regulated S2P expression in WT CHO cells. Notably, M19 cells had remarkably higher level of superoxide and elevated rates of cell death than WT CHO cells. The vulnerability to oxidative stress was reversed by the transfection of S2P gene but not rescued by exogenous supplement of cholesterol, oleate and mevalonate, indicating that lack of S2P gene leads cells to be more vulnerable to oxidative stress. Furthermore, compared with WT CHO cells, M19 cells had higher nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and lower paraoxonase-2 expression. Taken together, these results suggest that S2P can be a protease responding to oxidative stress and has the function of regulating cellular oxidative injury.
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Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 24
·4633-4647
·
IF 4.543
Yanjun Chai,Dan Lin,Yifan Ma,Yuan Yuan,Changsheng Liu
With the worldwide rising need of severe bone defect treatment, the development of available bone substitutes with optimal mechanical strength, sustained drug release, cell affinity and osteoinductivity remains a great challenge. In this study, an rhBMP-2 loaded polymer-coated mesoporous bioactive glass (MBG) composite scaffold was developed. The uncrosslinked poly(glycerol sebacate) (PGS) or PEGylated PGS (PEGS) coating modification had enhanced the mechanical strength of the composite scaffold, solved the brittleness problem of the MBG matrix, increased the cell affinity of the material surface, and diminished the initial burst release of rhBMP-2 from mesopores of MBG. The results indicated that the PGS coating promoted the proliferation of rat bone marrow stem cells (rBMSCs), while the PEGS coating exhibited an enhancement in the osteogenic differentiation of rBMSCs. The in vivo ectopic bone formation results provide strong evidence that the rhBMP-2-loaded MBG/PEGS composite scaffolds exhibited a rapid bone forming capacity and might yield extraordinary achievements in the field of bone tissue engineering. The design considerations can be extended to other artificial scaffolds and are expected to provide new thoughts on the development of future tissue engineering materials.
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Biomedical Optics Express
·
2022
·Vol. 13
·期 9
·4592-4605
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IF 3.562
Qin Tan,Shengnan Wu,Shengnan Wu,Shengnan Wu,Shengnan Wu,Zhenchao Liu,Xun Wu,Erik Forsberg,Sailing He,Sailing He,Sailing He,Sailing He
Since the outbreak of coronavirus disease 2019 (COVID-19), efficient real-time monitoring has become one of the challenges faced in SARS-CoV-2 virus detection. A compact all-fiber Mach-Zehnder interferometer optofluidic sensor based on a hollow eccentric core fiber (HECF) for the detection and real-time monitoring of SARS-CoV-2 spike glycoprotein (SARS-CoV-2 S2) is proposed, analyzed and demonstrated. The sensor is comprised of fusion splicing single mode fiber (SMF), hollow core fiber (HCF) and HECF. After the incident light passes through the HCF from the SMF, it uniformly enters the air hole and the suspended micrometer-scale fiber core of the HECF to form a compact all-fiber Mach-Zehnder interferometer (MZI). HECF is side polished to remove part of the cladding that the suspended fiber core can contact the external environment. Subsequently, the mouse anti SARS-CoV-2 S2 antibody is fixed on the surface of the suspended-core for the sake of achieving high sensitivity and specific sensing of SARS-CoV-2 S2. The limit of detection (LOD) of the sensor is 26.8 pM. The proposed sensor has high sensitivity, satisfactory selectivity, and can be fabricated at low cost making it highly suitable for point-of-care testing and high-throughput detection of early stage of COVID-19 infection.
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