NUTRITIONAL NEUROSCIENCE
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2026
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IF 3.1
Dawei Xu,Luge Chen,Xiaohu Chen,Weiming Jiang,Lijuan Sun
Background and Objectives Insomnia is a major public health issue that impairs daily functions and quality of life. Sleep-onset difficulty, a common complaint among patients, is accompanied by reduced central serotonin (5-HT) function. β-myrcene from lavender has sedative–hypnotic effects via serotonergic pathways, but most previous studies used intraperitoneal injection, which causes stress and limits clinical translation. Here, we asked whether non-invasive inhalation of β-myrcene produced similar effects in a mouse model of insomnia with low 5-HT function, and explored the underlying mechanisms.Methods β-myrcene was given to PCPA-induced insomnia mice by inhalation (with intraperitoneal injection as a pharmacodynamic control). In the inhalation group, sleep and behavior were evaluated using the amobarbital sodium sleep test and spontaneous locomotor activity test. ELISA, RT-qPCR, Western blot, and 16S rRNA sequencing were applied to study mechanisms.Results Inhaled β-myrcene shortened sleep latency and prolonged sleep duration. It also reduced oxidative stress and modulated GABA, 5-HT, and glutamate levels. These changes were accompanied by upregulation of mRNAs such as GABAARγ2 and 5-HT1A, as well as proteins including GAD65/67 and PKA, suggesting involvement of 5-HT1A/PKA signaling. Additionally, inhalation of β-myrcene was correlated with alterations in gut microbiota composition in PCPA-induced insomnia mice.Conclusions Our findings indicate that inhaled β-myrcene is associated with sedative–hypnotic effects and alterations in gut microbiota composition in PCPA-induced insomnia mice, potentially involving modulation of 5-HT1A/PKA signaling.
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高影响因子
Journal of Physical Chemistry C
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2025
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IF 3.2
Youmin Cao,Geoffrey I. N. Waterhouse,Yan Li
In this study, a highly active NiAl-GCN non-noble-metal catalyst was developed for the selective catalytic oxidation of 5-hydroxymethylfurfural (HMF) to furandicarboxylic acid (FDCA). NiAl-layered double hydroxide (NiAl-LDH) was first synthesized via a hydrothermal method and then blended with dicyandiamide (2-fold by mass) and heated at 550 °C for 6 h to obtain the NiAl-GCN catalyst (consisting of a NiAl mixed metal oxide and g-C3N4). The prepared catalyst was then characterized using X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), N2 physisorption measurements, and X-ray photoelectron spectroscopy (XPS) to explore its structure, morphology, chemical composition, and physicochemical properties. Next, HMF oxidation tests were carried out, and the effects of reaction time, reaction temperature, amount of oxidant, and amount of catalyst on HMF conversion and product distribution were investigated to optimize the reaction conditions. In batch tests under the optimized testing conditions (acetonitrile as solvent, t-BuOOH as the oxidant, 120 °C, 12 h), the NiAl-GCN catalyst achieved a HMF conversion of 100%, FDCA selectivity of 80.6%, and good stability during recycling experiments. The synergistic electron transfer between GCN and NiAl-MMO enhances the adsorption of HMF and activation of oxidants, leading to superior catalytic efficiency and FDCA selectivity compared to single-component catalysts.
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JOURNAL OF POROUS MATERIALS
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2025
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IF 3.2
Ding Yunlong,Wang Jiayin,Zhang Yanting,Pu Yongzhi,Hou Nan,Li Ning,Song Jinrui,Liang Yaning,Li Xiaofeng
This study aimed to synthesize a novel mesoporous template agent, KHBA, using 3-glycidoxypropyltrimethoxysilane (KH-560) and butylamine as raw materials, and to explore its application in the synthesis of ZSM-5 zeolites with nanocrystal aggregates. The physical and chemical properties of the synthesized ZSM-5 zeolites were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TG), and low-temperature N 2 adsorption–desorption The results showed that the introduction of KHBA effectively inhibited excessive crystal growth and promoted the formation of nanocrystal aggregates with a mesoporous structure. In the synthesis system with a KHBA-to-Al 2 O 3 molar ratio ranging from 1.6 to 4.8, the external surface area and mesoporous volume of the samples increased with increasing KHBA content. The sample synthesized with a KHBA-to-Al 2 O 3 molar ratio of 4.8 exhibited the highest external surface area (250.43 m 2 /g) and mesoporous volume (0.24 cm 3 /g). In the catalytic performance test for C8 aromatic hydrocarbon isomerization, the catalyst prepared with a KHBA-to-Al 2 O 3 molar ratio of 4.8 demonstrated the best performance, with isomerization activity of 23.79%, ethylbenzene conversion of 88.94%, and xylene loss of 3.42%. These findings highlight the potential of KHBA as an effective template agent for the synthesis of high-performance ZSM-5 zeolites in catalytic applications.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Chunyan Tu,Hao Wang,Weiming Zhai,Chunting Liu,Wei Huang,Wenlin Li
Direct synthesis of aromatics from ethane and CO 2 using bifunctional catalysts composed of Zn and zeolite has drawn considerable interest in both academia and industry. Although a lot of research has explored the influence of Zn states on aromatization, the impact of zeolite defect structure on activity is still a black box. In this study, the distribution of Si and Al within the zeolite framework was precisely generated and tailored using post-treatment methods. A comprehensive set of characterization techniques, including XRD, SEM, nitrogen adsorption–desorption, MAS NMR, CP/MAS NMR, OH-FTIR, Py-IR, NH 3 -TPD, UV–vis DRS, XPS, and TG-MS, was employed to determine the structural changes. Our studies revealed that the active Si–OH sites could be effectively eliminated by the two-step alkali treatment. The chemical shielding of active Si–OH sites played a pivotal role in preserving the [Zn(OH)] + sites, which was crucial for the activation of ethane and CO 2 . The synergistic effect of Zn and Brønsted acid sites in zeolites catalyzing dehydroaromatization could be suppressed by the formation of [ZnO x ] 2+ sites within the zeolite. Notably, a high aromatics space–time yield of 3.3 mmol aromatics /g cat /h was achieved at 570 ℃ with a time on stream of 720 min on the Zn/ATH-0.1 catalyst, due to the joint contributions of Zn and Brønsted acid sites. We demonstrated the formation of Al pairs through the unique treatment, which subsequently served as key sites for regulating aromatics selectivity. These findings offer new insights into zeolite engineering, highlighting the importance of controlling Si–OH sites distribution for enhancing CO 2 -assisted ethane aromatization.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Yu Hu,Hongchen Song,Zhenghua Qu,Jun Dong,Fengxing Jiang,Congcong Liu,Xiaofang Liu,Qinglin Jiang,Cheng Liu,Jingkun Xu,Peipei Liu
LaNiO 3 , as a promising pseudocapacitive material, exhibits multiple valence states (Ni²⁺/Ni³⁺) and adjustable conductivity. However, the poor cycle life and limited electrolyte accessibility of LaNiO 3 currently restrict its potential applications. To address these challenges, poly(5-nitroindole) is loaded on LaNiO 3 /carbon cloth by a simple electrodeposition method as a novel electrode for supercapacitors. The electron-withdrawing nitro (-NO 2 ) group in poly(5-nitroindole) not only enhances surface hydrophilicity but also introduces additional redox active sites, substantially boosting the pseudocapacitance performance. Furthermore, the synergistic combination of LaNiO 3 with high conductivity and poly(5-nitroindole) with porous nano-network structure establishes an efficient conductive framework, significantly reducing charge transfer resistance and enhancing the stability of composite electrodes. As a result, the composite electrode delivers a high areal/gravimetric capacitance of 594.4 mF cm −2 /807.6 F g −1 at 0.5 mA cm −2 and long cycling stability with 76.0 % retention of its initial capacitance after 10,000 cycles. Moreover, the electrochemical behavior analysis has confirmed the simultaneous effect of surface storage capacitance and diffusion processes of the prepared composite electrode, and the porous nano-network structure of poly(5-nitroindole) effectively optimizes the adsorption/diffusion pathways of electrolyte ions. This work provides a feasible strategy for designing high-performance supercapacitor electrodes by integrating conductive perovskites with functionalized conducting polymers.
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MICROPOROUS AND MESOPOROUS MATERIALS
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2024
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IF 4.8
Yuxin Li,Juanping Zhou,Hu Wen,Haitao Yin,Shunyu Han,Nanzhe Jiang
Clay is a rich aluminosilicate resource with unique advantages as a raw material for zeolites production. However, synthesizing nanosized single-crystalline zeolites through a simple approach using clay remains a significant challenge. In this paper, acid-washed montmorillonite (MSR) was used to prepare nano-H-ZSM-5 single crystals with high crystallinity, uniform grain size and permeable straight pores under the induction of a small amount of organic template tetrapropylammonium hydroxide (TPAOH). Through temperature-staged treatment, the nucleation and growth process of zeolite were decoupled, ultimately achieving precise control over the size of the nano-single crystals. Mechanistic study showed that the low-temperature aging process produces smaller structural units which probably derived from the geopolymer topology of the clay, providing more active sites for zeolite nucleation, leading to the rapid crystallization during the high-temperature process. The porous structure promotes material diffusion, inhibits aromatic cycling and reduces carbon formation in the pores. The large specific surface area and nanoscale multilayer pore structure delay carbon accumulation and increase carbon holding capacity. These properties make nano-ZSM-5 single crystals an excellent choice for high olefin selectivity and long catalytic life in the methanol-to-olefin reaction. This synthetic route provides a general strategy for preparing nanosized zeolite single crystals from clay.
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FOOD RESEARCH INTERNATIONAL
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2025
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IF 8
Yongxin Li,Wenni Tian,Fang Tian,Yanrong Zhao,Xuguang Zhang,Jie Xiao
This study introduces an innovative double emulsion (DE) system for the co-delivery of water-soluble 5-methyltetrahydrofolate calcium (5-MTHF-Ca) and lipid-soluble vitamin D 3 (VD 3 ), addressing the challenge of synchronized delivery for nutrients with divergent solubility. Through a two-step emulsification strategy, co-loaded DEs (C-5-MTHF-Ca & VD 3 ) exhibited superior colloidal stability compared to single-loaded counterparts (S-5-MTHF-Ca and S-VD 3 ), retaining 88.17 ± 2.64 % of 5-MTHF-Ca and 81.99 ± 2.45 % of VD 3 after 15-day storage. During in vitro digestion, co-loaded DEs demonstrated delayed lipid hydrolysis (38.01 ± 5.55 % FFA release at 30 min vs. 43.88 ± 13.79 % for S-VD 3 ) and preserved structural integrity through gastric phases, while synchronized intestinal micellar incorporation increased VD 3 bioaccessibility by 19.82 %. Ex vivo fluorescence tracking in mice revealed spatiotemporal co-localization of both actives, with jejunal accumulation peaking at 2–4 h post-administration, aligning with Ussing chamber results showing 2.13-fold enhanced VD 3 permeation and 1.80-fold enhanced 5-MTHF-Ca transport in co-loaded systems. Pharmacokinetic studies in rats confirmed bioavailability enhancement, with co-loaded DEs achieving 1.37-fold higher VD 3 AUC (6707.08 ± 1123.82 vs. 4898.36 ± 685.16 ng·h/mL) and 1.19-fold increased 5-MTHF-Ca C max compared to single-loaded formulations. The extended T max (by twofold) and prolonged t 1/2 K a (1.81-fold for 5-MTHF-Ca) indicated optimized intestinal retention, attributed to the phase-separated W/O/W architecture protecting actives from premature degradation. These findings establish a platform for nutrient co-delivery, where rational DE design enables spatiotemporally coordinated gastrointestinal transit, and synergistic absorption.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Meijiao Duan,Qiyue Sun,Jiaqi Duan,Zhuo Chen,Chunyan Yang,Cui Zhai,Meng Cao,Huan Liu,Mengqian Wei,Yunong Chen,Lei Lei,Xingchun Gou,Liujiao Bian,Jing Luan
This study presents a groundbreaking investigation into the molecular interaction between microRNAs (miRNAs) from the traditional Chinese medicine Astragali Radix and the anti-angiogenic protein Kringle 5 (K5). We successfully screened and identified 10 highly enriched miRNAs that exhibit a significant binding affinity to K5. Through a combination of bioinformatics and experimental techniques, including molecular docking and affinity chromatography, we found that specific miRNAs, particularly miR1, act as natural aptamers, binding to K5 with high selectivity and an association constant ( K a ) of approximately 5.80 × 10 4 L/mol. Our findings reveal that the conserved stem-ring structure of these miRNAs is crucial for their recognition and binding to K5, mediated by electrostatic, hydrophobic, and hydrogen bond interactions. Functional assays in vitro demonstrate that miR1 effectively neutralizes K5-mediated inhibition of endothelial cell proliferation and restores the HIF-1α/VEGF signaling pathway. This research provides a novel biochemical perspective suggesting that Astragalus -derived miRNAs may function as natural molecular decoys to modulate K5 activity, thereby supporting angiogenesis. These findings offer new insights into the bioactive landscape of traditional Chinese medicine and providing a strong foundation for the development of novel nucleic acid-based drugs. Download: Download high-res image (114KB) Download: Download full-size image
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PubMed
高影响因子
ChemCatChem
·
2026
·Vol. 18
·期 5
·e70662
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IF 4.1
Mengjiao Yu,Xiong-Fei Zhang,DongEn Zhang,Jianhao Qiu,Jianfeng Yao
The development of stable, efficient catalysts for fructose conversion to 5-hydroxymethylfurfural (5-HMF) remains a challenge. While sulfonation enhances Brønsted acidity in metal–organic frameworks (MOFs), it often compromises their structural integrity. This work addresses the critical challenge by demonstrating that amino (–NH 2 ) functionalization in MIL-53(Al) acts as a stabilizer, enabling the framework to withstand direct modification with chlorosulfonic acid and facilitating the introduction of sulfonic acid groups. The resulting sulfonated catalyst, MIL-53-N/S(1), achieves an outstanding 5-HMF yield of 84.3% in a biphasic system (170°C, 6 h). This work underscores the dual role of amino functionalization in stabilizing MOFs and enabling efficient acid catalysis for biomass conversion. Graphical A strategy using amino-functionalized MIL-53(Al) was proposed, where pre-grafted –NH 2 groups facilitate effective sulfonation to create abundant –SO 3 H sites without compromising framework stability. This approach addresses the challenge between acidity and structural degradation of MOFs. Under optimized conditions, MIL-53-N/S(1) achieves an HMF yield of 84.3%, demonstrating its potential for practical biomass valorization.
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JOURNAL OF THE CHINESE CHEMICAL SOCIETY
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2012
·Vol. 59
·期 12
·1571-1577
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IF 0.678
Wei Sun,Li Xu,Tongtong Li,Xiuzhen Wang,Guangjiu Li,Zhenfan Sun
A new electrochemical method was proposed for the determination of adenosine-5′-triphosphate (ATP) based on the electrooxidation at a molecular wire (MW) modified carbon paste electrode (CPE), which was fabricated with diphenylacetylene (DPA) as the binder. A single well-defined irreversible oxidation peak of ATP appeared on MW-CPE with adsorption-controlled process and enhanced electrochemical response in a pH 3.0 Britton-Robinson buffer solution, which was due to the presence of high conductive DPA in the electrode. The electrochemical parameters of ATP were calculated with the electron transfer coefficient (α) as 0.54, the electron transfer number ( n ) as 1.9, the apparent heterogeneous electron transfer rate constant ( k s ) as 2.67 × 10 −5 s −1 and the surface coverage (Γ T ) as 4.15 × 10 −10 mol cm −2 . Under the selected conditions the oxidation peak current was proportional to ATP concentration in the range from 1.0 × 10 −7 mol L −1 to 2.0 × 10 −3 mol L −1 with the detection limit as 1.28 × 10 −8 mol L −1 (3σ) by sensitive differential pulse voltammetry. The proposed method showed good selectivity without the interferences of coexisting substances and was successful applied to the ATP injection samples detection.
研究领域:
电化学
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分析化学
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生物传感器
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生物电化学
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高影响因子
FUEL
·
2022
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IF 8.035
Chenxi Lu,Yuanzhuo Zhou,Liangzhi Li,Hongwei Chen,Lishi Yan
Catalytic production of 5-hydroxymethylfurfural (5-HMF) from glucose is a promising routine for generation of varied value-added chemicals. Herein, Mixed-Metal metal–organic frameworks (MOFs)–Fe/MIL-101(Cr) and MIL-101(Cr, Fe) obtained from post-synthesis modification and one-pot synthesis approach respectively were applied for catalytic converting glucose to 5-HMF. The synthesized Mixed-Metal MOFs were characterized by PXRD, SEM, N 2 adsorption–desorption analysis, TGA, XPS and NH 3 -TPD. Cr-and Fe-containing Mixed-Metal MOFs Fe/MIL-101(Cr) and MIL-101(Cr, Fe) presented synergistic effect with enhanced catalytic ability for glucose transformation to 5-HMF compared with typical single-metal MOFs and sulfonic acid-functionalized MOFs. Moreover, these two Mixed-Metal MOFs also presented better thermal stability than single-metal MOFs like MIL-101(Cr). Fe/MIL-101(Cr) was found to possess higher catalytic performance than MIL-101(Cr, Fe). 55.8 % 5-HMF yield was obtained with Fe/MIL-101(Cr) at 170 °C for 2 h in DMSO/water system. In addition, Fe/MIL-101(Cr) demonstrated desired recyclability for five times without incredible loss in its activity. This study provides a Mixed-Metal strategy on MOFs for improving catalytic efficiency of glucose conversion to 5-HMF.
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Advanced Materials Interfaces
·
2022
·Vol. 9
·期 35
·2201688
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IF 6.389
Liu-Qin Zhang,Hua-Li Li,Xiao-Hu Zhang,Qiu-Ping Li,Shu-Wen Luo,Fa-Qian Liu
Metal–organic gels or metallogels (MOGs), which usually made up with metal ions and organic ligands, are promising in the area of medicine, environment, and biology. Herein, a new metal–organic gel containing Cu + (Cu-MOG-5) is prepared at room temperature using 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) and CuI. Considering the excellent low surface energy characteristics of polydimethylsiloxane (PDMS), the as-prepared Cu-MOG-5 is infused into porous PDMS to obtain Cu-MOG-5/PDMS coating, which combines the bactericidal properties of Cu + containing hydrogels and the low surface energy of PDMS. The morphology of the Cu-MOG-5 and Cu-MOG-5/PDMS coating is investigated by FE-SEM, and the structure of the new Cu-MOG-5 is verified by FT-IR, 1 H NMR, XPS, EDS, and elemental analysis. The antibiofouling properties are assessed using Escherichia coli ( E. coli ) and mussel. The results show that the newly prepared Cu-MOG-5/PDMS coating exhibits superior antibiofouling performance because of the synchronous action of hydrogel including Cu + and PDMS.
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