Drug Delivery and Translational Research
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2026
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IF 6.9
Chen Jiaxin,Qiu Guirong,Jiang Nan,Guo Bohong,Qiu Yuqin
Oral colchicine remains a first-line therapy for acute gout arthritis. However, its clinical utility is limited by an extremely narrow therapeutic window and the frequent onset of dose-limiting gastrointestinal toxicity. To overcome these challenges, we developed high-strength silk fibroin separable microneedles (HSF SMNs) for transdermal colchicine delivery. The microneedles were fabricated from regenerated silk fibroin pre-modified with methanol vapor to enhance mechanical properties. Fourier-transform infrared spectroscopy and mechanical tests showed that treating the silk fibroin solution for 30 min induced substantial β-sheet formation, yielding HSF SMNs with a fracture force of 3.01 N per needle. In vitro permeation studies demonstrated that colchicine-loaded HSF SMNs exhibited a significantly higher transdermal flux compared to an aqueous solution. Notably, the system maintained 84.3% of its initial transdermal flux at 12 h after backing layer separation, indicating robust sustained-release capability. In a rat model of acute gouty arthritis, transdermal administration of HSF SMNs at low, medium, and high doses effectively suppressed paw swelling and reduced serum levels of IL-1β and TNF-α in an administered dose-dependent manner. Importantly, the therapeutic efficacy was superior to that achieved via oral gavage. To our knowledge, this work provides the first systematic dose-response analysis for transdermal colchicine delivered via microneedles, offering a promising non-oral alternative and supporting further development of this strategy. Graphic abstract The alternative text for this image may have been generated using AI.
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JOURNAL OF MATERIALS SCIENCE
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2026
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IF 4.4
Yan Shujie,Zhou Shiqing,Xiang Lingfeng,Zhang Xiang,Wang Xiaofeng,Li Qian
The development of high-performance flexible strain sensors is hampered by the difficulty in simultaneously achieving high sensitivity, broad stretchability, and long-term stability. In this study, an electrospinning liquid metal (LM)-based membrane was developed for the high-sensitivity detection of biomechanical signals and physiological parameters. Thermoplastic polyurethane (TPU), selected for its excellent biocompatibility and flexibility, was chosen for the application. LM nanoparticles were ultrasonically dispersed into TPU via electrospinning to obtain the highly elastic, stretchable nanofiber membrane. Polyaniline (PANI) and gallium–indium alloy (EGaIn) droplets were then combined with the electrospun membrane via in situ polymerization and coating methods, forming a multi-scale three-dimensional (3D) conductive network structure. The developed composite demonstrated exceptional operational resilience, maintaining consistent performance over 10,000 mechanical cycles while achieving a maximum detectable strain of 300%. The developed flexible strain sensor achieved a high gauge factor of 206, demonstrating its significant potential for applications in health monitoring and human–machine interaction. Graphical abstract
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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2026
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IF 4
Mu Shengmou,Liu Baolai
Doxorubicin (DOX), a natural compound with anticancer properties, is limited in its therapeutic application by low bioavailability and inadequate solubility. This paper presents a novel nanoparticle system designed to tackle these challenges by self-assembled DOX, polydopamine (PD) altered, and macrophage membrane (MM) coated nanoparticles (DOX-PD@MM NPs). The DOX-PD@MM NPs exhibited significant antitumor efficacy, elevated drug-loading capacity, enhanced stability, and exceptional photothermal properties. Further, the macrophage membrane endows the DOX-PD@MM NPs with active targeting to cancer tissues. We employed the U87-MG glioblastoma cell line to assess the in vitro anticancer activity of DOX-PD@MM. The findings indicate that DOX-PD@MM may efficiently induce cell death by producing reactive oxygen species (ROS) and releasing DOX. The amalgamation of DOX-PD@MM and near-infrared irradiation significantly enhanced anticancer efficacy by promoting DOX release and photothermal treatment. The DOX-PD@MM system enables drug delivery for poorly soluble drugs, thereby harnessing their full anticancer potential.
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WOOD SCIENCE AND TECHNOLOGY
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2026
·Vol. 60
·期 3
·53
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IF 3.2
Wu Ling,Liu Yang,Zhang Tingwei,Jin Yongcan,Xiao Huining
Silicon (Si) is regarded as one of the most promising lithium-ion storage materials owing to its large theoretical specific capacity (4200 mAh/g) and low operating potential. However, during lithiation/delithiation processes, the tremendous volume change (~ 300%) and poor conductivity of Si materials restrict their large-scale application in the field of electrodes. Herein, a novel encapsulating strategy was proposed to prepare silicon/carbon composites (650-4-glu). The self-assembly process, driven by electrostatic interaction between lignosulfonate and chitosan, initially enwrapped silicon nanoparticles. Furthermore, glucose was introduced through simple grinding with the lignin-Si-chitosan assembly. After carbonization, physicochemical characterization revealed that the carbon framework derived from lignin-chitosan largely coated silicon, and glucose-derived carbon served as a supplementary phase to enhance the encapsulation effect. The formation of Si-O-C linkages between carbon and silicon tightly bound the silicon particles, which was crucial for improving cycling stability and rate performance. Sample 650-4-glu exhibited an excellent specific capacity, retaining 734.3 mAh/g after 200 cycles at 0.5 A/g and 584.1 mAh/g after 500 cycles at 1.0 A/g. This work demonstrated a sustainable and effective approach for utilizing lignosulfonate, a byproduct in the papermaking industry, in high-performance lithium-ion battery electrodes.
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Science China-Technological Sciences
·
2026
·Vol. 69
·期 5
·1520202
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IF 5.1
Niu Jiaxin,Ling Hangyang,Sun Xu,Sun Gongxian,Wang Shengyan,Li Feiyan,Zhang Na,Chen Tianshuang,Zhuo Xiaolu,Zhu Jinjin,Zhang Han,Kong Xiangdong
Bacterial infections pose persistent threats to global public health, while the antimicrobial resistance caused by the overuse of antibiotics further exacerbates this problem. The development of novel disinfectants that are efficient, durable, broad-spectrum, and deploy non-antibiotic mechanisms is therefore highly desired. Multifunctional nanocomposites with multi-effect antibacterial properties can meet the above demands. Herein, we developed a core-shell nanocomposite of Au-Ag nano-urchins coated with room-temperature synthesized covalent organic frameworks for efficient morin loading and multi-scenario antibacterial applications. This material achieves exceptional bactericidal efficacy at ultralow doses by combining photothermal therapy, tip-mediated physical puncture, and the action of released antibacterial components. It achieves over 99.99% in-activation of both Escherichia coli and Staphylococcus aureus at a low concentration of 8 µg mL −1 under weak xenon lamp illumination of 0.3 W cm −2 . The nanocomposites can be readily spray-coated onto various surfaces, forming a durable and stable antibacterial layer. Furthermore, in the in vivo infected wound healing model, the nanocomposite demonstrated excellent antibacterial efficacy and promoted nearly complete wound closure within 7 days. By integrating physical puncture, photothermal effect, and controlled drug/ion release, this nanocomposite offers an effective strategy for daily antibacterial applications.
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Science China-Materials
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2026
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IF 7.7
Chen Jiayue,Zhou Zhou,Luo Weili,Yue Yiying
Recent advancements in sustainable bio-sourced functional materials have focused on enhancing the valorization of lignin-derived biopolymers through innovative transformation methodologies. This study highlights breakthroughs in lignin-based Z-scheme heterojunction photocatalytic systems, emphasizing extended spectral responsiveness, optimized interfacial photoexcited carrier separation and reduced energy loss mechanisms. Two photocatalysts, Bi 2 WO 6 (BWO) and ZnIn 2 S 4 (ZIS) were co-engineered via a Z-scheme charge-transfer pathway using coaxial electrospinning and hydrothermal synthesis with lignin-based carbon nanofibers (CNFs), preserving the fibrous skeleton intact. The all-component photocatalytic nanomembrane exhibited superior mechanical strength (Young’s modulus = 20.38 MPa, toughness = 2.48 kJ/m 3 ) under wet conditions along with accelerated stabilization kinetics (1°C/min, representing a 10-fold increase), resulting in significant energy savings. Using methylene blue (MB) as a model pollutant, the CNFs@BWO/ZIS nanomembrane achieved 94.4% degradation efficiency ( k = 0.01664 min −1 ) after 120 min of solar irradiation, while maintaining excellent recyclability through five successive cycles. Furthermore, we elucidated the systematic mechanism of surface charge-carrier migration in the Z-scheme heterojunction and MB decomposition. This photocatalytic system utilizing sustainable biomass functional materials paves the way for wastewater treatment, with the goal of achieving peak carbon emissions and carbon neutrality. The alternative text for this image may have been generated using AI.
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Nature Communications
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2026
·
IF 18.1
Zhong Huamei,Hu Zhifeng,Xiang Chengjie,Yang Chun,Wang Ruzhu
Ice accretion severely compromises titanium alloy components in maritime environments. Conventional anti-icing coatings provide passive protection but often fail at the metal–coating interface under thermal and mechanical stresses, highlighting the need for in-situ engineered icephobic surfaces. Herein, we report an in-situ fabricated titanium surface integrating superhydrophobicity, photothermal conversion, and corrosion resistance through electrochemical treatment and vacuum annealing. The hierarchical micro–nano architecture with three-dimensional nanotubes establishes a robust superhydrophobic state. The reduced bandgap of titanium oxide enhances light absorption and thermal confinement, enabling rapid heating to 86 °C under 1 sun illumination. A stable oxide layer ensures excellent corrosion resistance after 120 h immersion in NaCl solution. Owing to these synergistic features, the surface demonstrates outstanding anti-icing and de-icing performance for pure and saline water, including outdoor conditions, achieving ice sliding within 235 s under 0.3 sun illumination. The surface retains superhydrophobicity after prolonged UV exposure, chemical corrosion, and mechanical abrasion, and exhibits anti-biofouling capability after 72 h immersion. This work provides a durable multifunctional strategy for mitigating ice formation on titanium components in complex environments.
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TOPICS IN CATALYSIS
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2026
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IF 3.7
Wu Jundao,Huang Zeai,Zhang Fan,Liu Jiayi,He Yi,Hu Wei,Tang Xiao,Zairov Rustem,Sinyashin Oleg G.
The substantial presence of nitrogen oxides (NO and NO 2 ) in outdoor environments detrimentally impacts natural ecosystems and exerts significant influence on urban climates. Conventional NO x treatment methods frequently suffer from challenges such as harsh reaction conditions and high energy consumption. Consequently, the development of advanced photocatalytic systems to efficiently degrade NO x while minimizing the formation of toxic byproducts represents a critical challenge in environmental catalysis. In this study, a novel ternary composite material (5% Mo-CN/InP-NBOC) was constructed via hydrothermal synthesis and surface modification strategies, achieving 42% NO oxidation efficiency under visible light irradiation with a mere 0.9% NO 2 generation rate. This performance demonstrates efficient photocatalytic NO oxidation while effectively suppressing NO 2 production. Systematic characterization techniques, including XRD, TEM, and XPS, confirmed the successful integration of InP quantum dots (5–10 nm) and amorphous Mo-CN onto NBOC nanosheets, forming an intimate heterojunction structure. PL and ESR analyses revealed that Mo-CN enhances charge carrier separation and governs the NO oxidation process through the activation of dual free radical pathways (⋅O 2 − and ⋅OH). This work establishes a “quantum dot-primary catalyst-cocatalyst” ternary collaborative design paradigm, providing experimental evidence and theoretical models to address the challenges of synergistic optimization among activity, selectivity, and stability in photocatalytic NO x treatment.
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Cell Death & Disease
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2026
·Vol. 17
·期 1
·326
·
IF 12.2
Xin Hu,Meiqi Feng,Chengjin Qi,Boran Li,Hongjuan He,Kai Li,Lu Chen,Boshu Ji,Haoran Yu,Yue Zhao,Tong Wu,Ruiheng Ma,Yuhao Dong,Yan Zhang,Qiong Wu
Investigating the epigenetic mechanisms underlying lung adenocarcinoma (LUAD) through the lens of N 4-acetylcytosine (ac4C) modification could innovate cancer treatment strategies and targets. We used biological information methods to analyze shared data, with a focus on studying N -acetyltransferase 10 (NAT10), which is the only known ac4C “writer” protein. Our analysis revealed a significant upregulation of NAT10 expression in LUAD, a finding that was corroborated by investigations in both LUAD cancer tissue samples and cell lines. Subsequently, we employed CRISPR/Cas9 technology to knock out the NAT10 gene and analyzed the resulting knockout cells using acRIP-seq and RNA-seq techniques. Our findings demonstrated different expressions of the genes C-X-C motif chemokine ligand 5 (CXCL5) and DEK proto-oncogene (DEK), and functional enrichment analysis indicated a strong association with the adhesion signaling pathway. Laboratory experiments revealed that NAT10 acts as an ac4C “writer,” promoting the acetylation of CXCL5 and DEK and thus preventing the degradation of their mRNAs. Moreover, NAT10 was found to significantly affect the number of metastases and tumor growth following the injection of cancer cells into the tail vein of mice. Our research data suggests that targeting NAT10 has the potential to serve as a diagnostic biomarker or prognostic target for developing anti-metastatic therapies aimed at disrupting the adhesion process.
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Nature Communications
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2026
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IF 18.1
Xiao Hua,Yanyan Guo,Pincheng Li,Yu Wang,Xiaona Han,Junyou Chen,Junjiang Li,Guo-Chao Chu,Jing Shi,Lei Liu,Yi-Ming Li
A long-standing goal in biomedical research is to label and manipulate intracellular targets, which could be achieved through the cytosolic delivery of exogenous functional proteins. The development of Tat clusters has advanced the nontoxic intracellular delivery of functional antibodies at low concentrations, but the variety of proteins that can be successfully delivered remains limited. Here, we find that by simply reversibly modifying the surface of functional proteins with anionic peptide patches, various protein cargoes (which are normally difficult to deliver) can be delivered into living cells by synergetic electrostatic interactions with the cationic cell-penetrating peptide clusters TAT 3 . To demonstrate the applicability of this approach, we successfully deliver functional proteins with widely varying molecular weights (∼1.5 kDa to 430 kDa) and isoelectric points (less than 5 to greater than 9) into the cytosol of cells. By exploiting this method, we also achieve protein delivery in plant tissues, which is more challenging due to the presence of intact plant cell walls. This strategy is further applied for the cytosolic delivery of synthetic protein probes carrying posttranslational modifications (PTMs), which can aid in in situ mapping of the intracellular PTM-mediated interactome. Overall, this strategy is expected to enrich cytosolic protein delivery technology and help to repurpose a wide range of customized and therapeutic proteins for emerging intracellular applications. The development of Tat clusters has advanced the intracellular delivery of functional antibodies at low concentrations, but the variety of proteins that can be successfully delivered remains limited. Here, the authors report that by reversibly modifying the surface of functional proteins with anionic peptides, various protein cargoes (otherwise difficult to deliver) can be delivered into living cells by synergetic electrostatic interactions with the cationic cell-penetrating peptide clusters TAT 3 .
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Nature Communications
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2026
·
IF 18.1
Cheng Tao,Zhao Ming,Li Tianyu,Wang Shuo,Yin Yanbin,Li Xianfeng
The cation design of the multi-component dynamic concentration electrolytes that simultaneously achieve effective phase transition prevention and rapid kinetic process is challenging but vital for enhancing the performance of low-temperature zinc-bromine flow batteries. Herein, we employ NH 4 + as supporting electrolyte cation to break inherent trade-off between salting-out at low temperatures and ion transport kinetic from the alkali cations (K + , Na + and Li + ). Compared to commonly used K + in the traditional electrolyte, NH 4 + achieves an improved ability to prevent the phase transition of the electrolyte and obtains better ion transport property, which is a characteristic that Na + and Li + do not possess. Additionally, NH 4 + can significantly enhance the cycling stability by appropriately increasing the solubility of polybromides. Consequently, the zinc-bromine flow batteries supported by NH 4 + not only demonstrate sustained lifespan (>2,300 cycles at 40 mA cm −2 , 40 mAh cm −2 , over half a year) and consistent high-rate cyclic stability (charging at 200 mA cm −2 , discharging at 80 mA cm −2 , >3,300 h) at room temperature; they also exhibit stable cyclic stability (over 1,600 cycles at 40 mA cm −2 ) at −20 °C. This work provides an effective path for the design of complex electrolytes for low-temperature aqueous zinc-based flow batteries.
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PHARMACEUTICAL RESEARCH
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2026
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IF 4.1
Xu Zi-Ting,Li Bogang,Deng Jiayin,Lv Jia-Yi,Ouyang Defang,Fang Wei-Jie
Purposes Peptide drugs are a vital category of biologics. However, unlike the well-studied effects of buffers on small-molecule or macromolecule drugs, the understanding of selecting appropriate buffers for peptide formulations and their specific impacts remains insufficient. This study aimed to systematically evaluate how different buffers affect the stability of the model peptide, glucagon, and to investigate the underlying mechanisms at the molecular level. Methods This work employed glucagon as a model peptide and integrated experimental techniques with computational approaches. Experimental techniques included reverse-phase high-performance liquid chromatography (RP-HPLC), Thioflavin T fluorescence assays, and circular dichroism (CD). Molecular dynamics (MD) simulations were further conducted, utilizing models with different buffer systems and varying peptide counts, to examine the interaction mechanisms between buffers and glucagon from multiple perspectives. Results Compared with other buffers, citrate exerted a unique and significant impact on glucagon stability. RP-HPLC demonstrated its destabilizing effect on the structure, while CD and MD simulations confirmed its role in preserving glucagon’s α-helical structure, attributed to its highest binding energy. However, this strong binding reduced the ζ-potential, compromised colloidal stability, and ultimately promoted aggregation/precipitation. MD simulations further showed that citrate anions formed a denser solvation shell around glucagon, driving oligomerization and aggregation. Conclusions This work uncovers the dual role of citrate buffer on glucagon stability: maintaining local secondary structure while disrupting overall colloidal stability. It provides molecular insights into peptide-excipient interactions and offers valuable guidance for optimizing formulations for other peptide drugs. Graphical
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