METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
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2023
·
IF 3
Han Ziqi,Liu Zhihong,Li Qihou,Wang Kai,Yu Zhiqian,Xia Longgong
Ternary compounds in the Al–Te–O system have been considered as potential materials for Low-Temperature Co-fired Ceramics preparation. Two ternary compounds, Al 2 TeO 6 and Al 2 Te 2 O 7 , have been found in the Al–Te–O system under 920 °C in air. The decomposition behavior of these two compounds has been studied with Thermogravimetric Analysis-Differential Scanning Calorimetry (TGA-DSC) and equilibration experiments. Phase equilibrium of the Al 2 O 3 –TeO 2 system has also been experimentally investigated at ambient atmosphere, and corresponding phase diagram has been derived. Obtained results showed that Al 2 Te 2 O 7 , could only be found when TeO 2 was 66.7-70.0 mol pct and temperature was at 590 °C to 610 °C. Al 2 TeO 6 decomposed into Al 2 O 3 , TeO 2 (g), and O 2 (g) when temperature was above 920 °C. Al 2 Te 2 O 7 converted into Al 2 TeO 6 at 620 ± 2 °C, and then followed the decomposition path of Al 2 TeO 6 . In phase equilibrium study, when the initial sample started from the Al 2 O 3 –Al 2 TeO 6 region, Al 2 TeO 6 and Al 2 O 3 were found in quenched samples at the temperature range of 500 °C to 915 °C. When the initial sample started from the Al 2 TeO 6 –TeO 2 phase region, two solid phases, Al 2 TeO 6 and TeO 2 , could be found in samples prepared under 725 ± 2 °C. When the temperature was above 730 ± 2 °C, there were Al 2 TeO 6 and one oxide liquid phase. In the Al 2 Te 2 O 7 –TeO 2 region, all equilibrated samples had Al 2 Te 2 O 7 and TeO 2 .
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2026
·
IF 1.7
Wang Xinyu,Qin Yilin,Gong Junyuan,Zhang Guohao,Peng Yinyin,Sun Gen,Ji Yanhao,Huang Yaling,Li Yahui,Nie Xiaoqin
This study aimed to enhance U(VI) removal from water by constructing a ternary system of Shewanella putrefaciens ( S. putrefaciens ), chlorite, and humic acid (HA). The ternary system achieved significantly higher U(VI) immobilization than single or binary systems, owing to synergistic effects of adsorption enrichment, electron shuttling, and bioreduction. Under optimal conditions, the U(VI) removal efficiency reached 91.6%. Importantly, pre-forming the ternary composite before U(VI) addition avoided false removal caused by HA-U(VI) complexation, ensuring accurate assessment of reductive immobilization. This work provides a reliable strategy for uranium-contaminated water remediation. Graphical abstract
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ACTA PHARMACOLOGICA SINICA
·
2020
·Vol. 42
·期 2
·290-300
·
IF 5.064
Yu Xiao-xuan,Zhu Meng-yuan,Wang Jia-rong,Li Hui,Hu Po,Qing Ying-jie,Wang Xiang-yuan,Wang Hong-zheng,Wang Zhan-yu,Xu Jing-yan,Guo Qing-long,Hui Hui
Cutaneous T-cell lymphoma (CTCL) is characterized by a heterogeneous group of extranodal non-Hodgkin lymphomas, in which monoclonal T lymphocytes infiltrate the skin. LW-213, a derivative of wogonin, was found to induce cell apoptosis in chronic myeloid leukemia (CML). In this study, we investigated the effects of LW-213 on CTCL cells and the underlying mechanisms. We showed that LW-213 (1–25 μM) dose-dependently inhibited human CTCL cell lines (Hut-102, Hut-78, MyLa, and HH) with IC 50 values of around 10 μM, meanwhile it potently inhibited primary leukemia cells derived from peripheral blood of T-cell lymphoma patients. We revealed that LW-213-induced apoptosis was accompanied by ROS formation and the release of calcium from endoplasmic reticulum (ER) through IP 3 R-1channel. LW-213 selectively activated CHOP and induced apoptosis in Hut-102 cells via activating PERK–eIF2α–ATF4 pathway. Interestingly, the degree of apoptosis and expression of ER stress-related proteins were alleviated in the presence of either N-acetyl cysteine (NAC), an ROS scavenger, or 2-aminoethyl diphenylborinate (2-APB), an IP 3 R-1 inhibitor, implicating ROS/calcium-dependent ER stress in LW-213-induced apoptosis. In NOD/SCID mice bearing Hut-102 cell line xenografts, administration of LW-213 (10 mg/kg, ip, every other day for 4 weeks) markedly inhibited the growth of Hut-102 derived xenografts and prolonged survival. In conclusion, our study provides a new insight into the mechanism of LW-213-induced apoptosis, suggesting the potential of LW-213 as a promising agent against CTCL.
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高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-14
·
IF 16.6
Xu Hongcheng,Zheng Weihao,Zhang Yang,Zhao Daqing,Wang Lu,Zhao Yunlong,Wang Weidong,Yuan Yangbo,Zhang Ji,Huo Zimin,Wang Yuejiao,Zhao Ningjuan,Qin Yuxin,Liu Ke,Xi Ruida,Chen Gang,Zhang Haiyan,Tang Chu,Yan Junyu,Ge Qi,Cheng Huanyu,Lu Yang,Gao Libo
Post-surgical treatments of the human throat often require continuous monitoring of diverse vital and muscle activities. However, wireless, continuous monitoring and analysis of these activities directly from the throat skin have not been developed. Here, we report the design and validation of a fully integrated standalone stretchable device platform that provides wireless measurements and machine learning-based analysis of diverse vibrations and muscle electrical activities from the throat. We demonstrate that the modified composite hydrogel with low contact impedance and reduced adhesion provides high-quality long-term monitoring of local muscle electrical signals. We show that the integrated triaxial broad-band accelerometer also measures large body movements and subtle physiological activities/vibrations. We find that the combined data processed by a 2D-like sequential feature extractor with fully connected neurons facilitates the classification of various motion/speech features at a high accuracy of over 90%, which adapts to the data with noise from motion artifacts or the data from new human subjects. The resulting standalone stretchable device with wireless monitoring and machine learning-based processing capabilities paves the way to design and apply wearable skin-interfaced systems for the remote monitoring and treatment evaluation of various diseases.
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Advanced Composites and Hybrid Materials
·
2023
·Vol. 6
·期 6
·1-11
·
IF 20.1
Liu Yinfeng,Wang Jing,Chen Jianwen,Yuan Qiang,Zhu Yutian
Recently, flexible iontronic pressure sensor composed of an ionogel dielectric layer with various designed bugle structures and two flexible electrodes normally exhibits great advantages in detecting pressure, such as ultrahigh sensitivity and resolution. However, the core component, i.e., the patterned ionogel dielectric layer, was usually fabricated via template transferring from various artificially designed templates by time consuming and sophisticated high-resolution 3D printing or laser etching. Herein, an ionogel dielectric layer with rose bionic pattern was easily fabricated via a two-step transfer printing process from natural rose petals, which could further assemble with two compressible and porous electrodes to form a high-performance iontronic pressure sensor. Owing to the generation of electric double layer and high compressibility of the patterned dielectric layer as well as the soft electrode, the prepared sensor shows a high sensitivity of 480.7 kPa −1 (0–0.5 kPa), rapid response/recovery (10 and 29 ms, respectively), and excellent durability (over 2000 cycles). Because of these outstanding sensing properties, the sensor has versatile applications in detecting human motion, physiological signal, and encrypted transmission of information, which shows great potential in healthcare monitoring devices and wearable electronics.
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CHEMICAL PAPERS
·
2023
·
IF 2.2
Zhang Tongyao,Ma Litao,Ren Dazhong,Huang Ying,Zhang Hanpeng
The development of recyclable, durable and widely adaptable porous hydrophobic materials is of vital importance for the effective separation of leaking oil–water mixtures. Herein, we functionally modified melamine formaldehyde resin sponge (MFRS) with PMMA, PDMS-PMMA and PDMS-PGMA via a facile solution-immersion process. Compared with PMMA-coated MFRS, the improvement of the water contact angle (WCA) and oil–water mixture separation efficiency of PDMS-PMMA/MFRS was sufficient enough to verify that the introduction of PDMS block enhanced the hydrophobic performances. Moreover, the importance of the GMA block in PDMS-PGMA/MFRS was confirmed by the excellent performance of the material in oil–water separation recycling experiments, with 91.5% separation efficiency after 8 runs. The fabricated PDMS-PMMA/MFRS with improved WCA (155°) and oil–water mixture separation efficiency (99.1%) demonstrated superhydrophobic property, which was attributed to the introduction of hydrophobic block PDMS and coating-induced surface geometric folds. Besides, the acid resistance and widely adaptable (efficient separation of various oil–water mixtures) performances of PDMS-PGMA/MFRS were experimentally confirmed. The freely available manufacturing raw materials and facile functionalization process of PDMS-PMMA/MFRS offer possibilities for its adoption in the efficient cleanup of oil spills.
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Cell Death Discovery
·
2023
·Vol. 9
·期 1
·1-15
·
IF 7
Li Hong-Ying,Wei Ting-Ting,Zhuang Miao,Tan Cheng-Ye,Xie Tian-Hua,Cai Jiping,Yao Yong,Zhu Lingpeng
Cellular senescence is a hallmark of aging and has been linked to age-related diseases. Age-related macular degeneration (AMD), the most common aging-related retinal disease, is prospectively associated with retinal pigment epithelial (RPE) senescence. However, the mechanism of RPE cell senescence remains unknown. In this study, tert-butyl hydroperoxide (TBH)-induced ARPE-19 cells and D-galactose-treated C57 mice were used to examine the cause of elevated iron in RPE cell senescence. Ferric ammonium citrate (FAC)-treated ARPE-19 cells and C57 mice were used to elucidated the mechanism of iron overload-induced RPE cell senescence. Molecular biology techniques for the assessment of iron metabolism, cellular senescence, autophagy, and mitochondrial function in vivo and in vitro. We found that iron level was increased during the senescence process. Ferritin, a major iron storage protein, is negatively correlated with intracellular iron levels and cell senescence. NCOA4, a cargo receptor for ferritinophagy, mediates degradation of ferritin and contributes to iron accumulation. Besides, we found that iron overload leads to mitochondrial dysfunction. As a result, mitochondrial DNA (mtDNA) is released from damaged mitochondria to cytoplasm. Cytoplasm mtDNA activates the cGAS-STING pathway and promotes inflammatory senescence-associated secretory phenotype (SASP) and cell senescence. Meanwhile, iron chelator Deferoxamine (DFO) significantly rescues RPE senescence and retinopathy induced by FAC or D-gal in mice. Taken together, these findings imply that iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway. Inhibiting iron accumulation may represent a promising therapeutic approach for age-related diseases such as AMD.
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IONICS
·
2023
·
IF 2.8
Wang Peng,Zhu Xinxin,Ding Yihong,Shao Lixiong,Jin Huile,Zhang Lichen,Wang Xintong,Zeng Tianbiao
As a new type of negative electrode material for SIBs, (iron germanium sulfide) Fe 2 GeS 4 is considered a highly promising negative electrode material for SIBs owing to its high theoretical capacity, fast Na + diffusion kinetics, and good thermal stability. In practical applications, it is crucial to synthesize the high-capacity/reversible nanostructured Fe 2 GeS 4 -based negative electrodes through an easily executable method. In this study, a two-step synthesis method to prepare nanostructured Fe 2 GeS 4 anchored on graphite (Fe 2 GeS 4 /G-15%) was employed: the commercial FeS, S, and Ge powders were mixed and heated, and then graphite was added for ball milling. X-ray photoelectron spectroscopy (XPS) and density functional theory (DFT) calculations revealed that there is a strong interaction between the nanostructured Fe 2 GeS 4 powder and the exfoliated graphite, forming a highly stable nanocomposite material, which is beneficial for improving the reversible charge-discharge performance of the material. When used as a negative electrode material for SIBs, the prepared Fe 2 GeS 4 /G-15% exhibited a capacity of 665.5 mAh g −1 during the second cycle at 0.1 A g −1 and could maintain a capacity of 519 mAh g −1 even after the 60th cycle. Considering the simple synthesis process employed in this study, it provides a reference for the production of high-performance Fe 2 GeS 4 -based negative electrode materials for SIBs. Graphical abstract
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Science China-Materials
·
2023
·Vol. 66
·期 4
·1435-1446
·
IF 8.1
Wang Guoan,Deng Quanhua,Li Haiping,Hou Wanguo
Oxygen vacancies (Ovs) in semiconductors, which can adsorb and activate N 2 molecules, are active sites for photocatalytic nitrogen reduction to ammonia. However, simple and effective methods for creating Ovs still need to be explored. Herein, mannitol was used to selectively create Ovs at Mo in Bi 2 MoO 6 (BMO) and form BMO short nanorods (SNRs) through a hydrothermal process, with the Ov content, SNR size, and surface area of the sample effectively tuned by pH. BMO SNRs containing the most Ovs exhibit the highest visible light absorption, fastest photoexcited charge separation, and best photocatalytic nitrogen fixation performance, with an N 2 reduction reaction rate in pure water reaching approximately 107-fold that of BMO nanosheets synthesized in the absence of mannitol, and an apparent quantum yield of 2.78% at 420 nm, superior to all of the reported BMO-based photocatalysts. This work provides a new and simple method for selective Ov creation and the morphological tuning of BMO to expedite the photocatalytic N 2 reduction.
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MEDICINAL CHEMISTRY RESEARCH
·
2013
·Vol. 23
·期 5
·2360-2367
·
IF 1.612
Liu Xin,Hu Yan,Wei Dongfeng
The orthogonal design was used to optimize enzyme-based ultrasonic/microwave-assisted extraction (EUMAE) of orcinol glucoside (OG)-enriched extract from the rhizomes of Curculigo orchioides Gaertn. (RCO). The results indicated that the highest extraction yield of OG by EUMAE could reach 92.13 % using 70 % ethanol as solvent under the optimal conditions (the ratio of raw material to solvent was 1:8, extraction time was 15 min, extraction temperature was 50 °C, amount of enzyme was 3 mL, and microwave irradiation power was 400 W), which was more efficient than that by the conventional and classical extraction methods. Finally, the crude extract was then purified by macroporous adsorption resin, the OG content in the purified extract increased to 91.70 %. Compared to the conventional and classical methods, EUMAE was superior in terms of higher yields, less energy consumption, and better selectivity of the extracts controlled by the extraction parameters. Furthermore, it was obvious that OG from RCO had significant effect on the antioxidant activity.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 12
·1-9
·
IF 5.7
Wang Ting,Zhang Jieyuan,Wu Yue,Wang Shiyi,Jiang Xinhui,Zhang Zhengwei,Li Siqiao
Developing an intelligent, sensitive, and visual strategy for quickly identifying anthrax biomarkers is crucial for ensuring food safety and preventing disease outbreaks. Herein, a smartphone-integrated ratiometric fluorescent sensing platform based on bimetallic metal–organic framework (Eu x /Tb 1-x -MOF) nanowires was designed for specific recognition of pyridine-2,6-dicarboxylic acid (DPA, anthrax biomarker). The Eu x /Tb 1-x -MOF was prepared by coordinating Eu 3+ and Tb 3+ with BBDC ligands, which exhibited a uniform fibrous morphology and dual-emission fluorescence at 543 and 614 nm. After the introduction of DPA, the red emission at 614 nm displayed obvious fluorescence quenching, while the green emission at 543 nm was gradually enhanced. The ratiometric sensing offered a wide linear equation in the range of 0.06–15 µg/mL and a low detection limit (LOD) of 20.69 ng/mL. Furthermore, a portable smartphone installing the color recognition application can achieve sensitive, real-time, and visual detection of DPA. As a simple and effective smartphone-assisted sensing platform, this work holds admirable promise to broaden the applications in biomarker real-time determinations and other fields. Graphical Abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Meng Hui-Hui,Liu Wen-Ya,Zhao Wen-Long,Zheng Qi,Wang Jun-Song
Trichlorfon, one of the most widely used organophosphate insecticides, is commonly employed in aquaculture and agriculture to combat parasitic infestations. However, its inherent instability leads to rapid decomposition into dichlorvos (DDVP), increasing its toxicity by eightfold. Therefore, the environmental effects of trichlorfon in real-world scenarios involve the combined effects of trichlorfon and its degradation product, DDVP. In this study, we systematically investigated the degradation of trichlorfon in tap water over time using HPLC and LC–MS/MS analysis. Subsequently, an experiment was conducted to assess the acute toxicity of trichlorfon and DDVP on goldfish ( Carassius auratus ), employing a 1 H NMR-based metabolic approach in conjunction with serum biochemistry, histopathological inspection, and correlation network analysis. Exposure to trichlorfon and its degradation product DDVP leads to increased lipid peroxidation, reduced antioxidant activity, and severe hepatotoxicity and nephrotoxicity in goldfish. Based on the observed pathological changes and metabolite alterations, short-term exposure to trichlorfon significantly affected the liver and kidney functions of goldfish, while exerting minimal influence on the brain, potentially due to the presence of the blood–brain barrier. The changes in the metabolic profile indicated that trichlorfon and DDVP influenced several pathways, including oxidative stress, protein synthesis, energy metabolism, and nucleic acid metabolism. This study demonstrated the applicability and potential of 1 H NMR-based metabonomics in pesticide environmental risk assessment, providing a feasible method for the comprehensive study of pesticide toxicity in water environments. Graphical abstract
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