CERAMICS INTERNATIONAL
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2024
·
IF 5.1
Yan Sun,Aowen Chen,Jingdao Yang,Kun Zhang,Sikai Wang,Xuerong Xu,Luyue Niu,Yue Jing,Ci Wang,Jing Ren,Jianzhong Zhang
Expanding gain bandwidth into the L-band for erbium-doped fiber amplifiers (EDFAs) is a crucial strategy to overcome limitations in prevalent C-band focused commercial silica-based EDFAs, significantly boosting optical network transmission capacity. Herein, we synthesized Er 3+ -doped broadband near-infrared emission tellurite glasses utilizing the melt quenching process, systematically exploring the impact of ZnCl 2 on the glass structure and optical properties. The 82TeO 2 –3Nb 2 O 5 –15ZnCl 2 –3Er 2 O 3 (TNZ15) glass emerged as a standout candidate for broadband amplifiers around wavelength at 1.55 μm. With escalating ZnCl 2 concentration, a discernible red shift in the emission peak wave lines was observed, accompanied by an expansion of the full width at half maximum (FWHM) from 98 nm to 106 nm. Noteworthy characteristics of all samples included exceptional thermal stability and elevated near-infrared (NIR) transmittance. Application of the Judd-Ofelt (J-O) theory facilitated the calculation of J-O parameter intensity, providing deeper insights into the optical behavior of the materials. Finally, the evaluation of TNZ15 planar optical waveguides, employing the vertical top pumping mode of two 980 nm LEDs, encompassed both the C-band (1530–1565 nm) and the L-band (1565–1625 nm). The results underscore the potential of TNZ15 glass as a promising gain material for broadband optical amplifiers and lasers, offering valuable insights into the development of next-generation optical amplification technologies.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Tian Liu,Yun Zhang,Ze Wu,Chen-jing Zhao,Xi Dong,He-xin Gong,Bing Jin,Miao-miao Han,Jin-jia Wu,Yi-kai Fan,Nan Li,Ying-xia Xiong,Zi-qian Zhang,Zheng-qi Dong
The macrophage to myofibroblasts transition (MMT) has been reported as a newly key target in renal fibrosis. Lycium barbarum L. is a traditional Chinese medicine for improving renal function, in which its polysaccharides (LBPs) are the mainly active components. However, whether the role of LBPs in treating renal fibrosis is related to MMT process remain unclear. The purpose of this study was to explore the relationship between the regulating effect on MMT process and the anti-fibrotic effect of LBPs. Initially, small molecular weight LBPs fractions (LBP-S) were firstly isolated via Sephadex G-100 column. Then, the potent inhibitory effect of LBP-S on MMT process was revealed on bone marrow-derived macrophages (BMDM) model induced by TGF-β. Subsequently, the chemical structure of LBP-S was elucidated through monosaccharide, methylation and NMR spectrum analysis. In vivo biodistribution characteristics studies demonstrated that LBP-S exhibited effectively accumulation in kidney via intraperitoneal administration. Finally, LBP-S showed a satisfactory anti-renal fibrotic effect on unilateral ureteral obstruction operation (UUO) mice, which was significantly reduced following macrophage depletion. Overall, our findings indicated that LPB-S could alleviate renal fibrosis through regulating MMT process and providing new candidate agents for chronic kidney disease (CKD) related fibrosis treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yixuan Wu,Qingqing Yu,Xuyue Zhou,Weixiao Ding,Xinmeng Li,Peng Zhou,Yalei Qiao,Zhen Huang,Shujun Wang,Jiaan Zhang,Luyu Yang,Lei Zhang,Dongping Sun
Electrical stimulation therapy is effective in promoting wound healing by rescuing the decreased endogenous electrical field, where self-powered and miniaturized devices such as nanogenerators become the emerging trends. While high-voltage and unidirectional electric field may pose thermal effect and damage to the skin, nanogenerators with lower voltages, pulsed or bidirectional currents, and less invasive electrodes are preferred. Herein, we construct a polydopamine (PDA)-modified poly-L-lactic acid (PLLA) /MXene (PDMP/MXene) nanofibrous composite membrane that generates piezoelectric voltages matching the transepithelial potential (TEP) to accelerate wound healing. PDA coating not only enhances the piezoelectricity of PLLA by dipole attraction and alignment, but also increases its hydrophilicity and facilitates subsequent MXene adhesion for electrical conductivity and stability in physiological environment. When applied as wound dressings in mice, the PDMP/MXene membranes act as a nanogenerators with reduced internal resistances and satisfactory piezoelectric performances that resemble bioelectric potentials (~10 mV) responding to physical activities. The membrane significantly accelerates wound closure by facilitating fibroblast migration, collagen deposition and angiogenesis, and suppressing the expression of inflammatory responses. This piezoelectric fibrous membrane therefore provides a convenient solution for speeding up wound healing by sustained low voltage mimicking bioelectricity, better cell affinity.
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Contrast Media & Molecular Imaging
·
2018
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IF 2.934
Shengjuan Luo,Jinsong Ding,Peiqi Wang,Zheng Wang,Xiaoqian Ma,Cejun Yang,Qi Liang,Pengfei Rong,Wei Wang
Perfluorooctyl bromide (PFOB) enclosed nanoparticles (NPs) as ultrasonic contrasts have shown promising results in the recent years. However, NPs display poor contrast enhancement in vivo. In this work, we used the copolymers poly(lactide-co-glycolide) carboxylic acid (PLGA-COOH) and poly(lactide-co- glycolide) poly(ethylene glycol) carboxylic acid (PLGA-PEG-COOH) as a shell to encapsulate PFOB to prepare a nanoultrasonic contrast agent. The NPs were small and uniform ( nm with a polydispersity index of ) with a complete shell nuclear structure under the transmission electron microscopy (TEM). In vitro, when concentration of NPs was ≥10 mg/ml and clinical diagnostic frequency was ≥9 MHz, NPs produced intensive enhancement of ultrasonic gray-scale signals. NPs could produce stable and obvious gray enhancement with high mechanical index (MI) (MI > 0.6). In vivo, the NPs offered good ultrasound enhancement in tumor after more than 24 h and optical imaging also indicated that NPs were mainly located at tumor site. Subsequent analysis confirmed that large accumulation of fluorescence was observed in the frozen section of the tumor tissue. All these results caused the conclusion that NPs encapsulated PFOB has achieved tumor-selective imaging in vivo.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2018
·Vol. 316
·期 1
·71-80
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IF 1.181
Chen Huai,Chen Quan Shui,Huang Bin,Wang Shi Wei,Wang Ling Yu
In this work, a brand new organic superficial active sorbent l -Cysteine hydrochloride modified bentonite (LCMB) has been developed and proposed for treatment of contaminated water containing uranium. Correlation between different factors such as pH, contact time, temperature, initial concentration of U(VI) and efficiency of LCMB for uranium absorption are discussed. At uranium content in water from 25 to 250 mg L −1 , the sorption capacity for LCMB reached 208.3 mg g −1 that is essentially higher in comparison with other sorbents and notably improved from 77 mg g −1 after modification.
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Journal of Magnetic Resonance Open
·
2025
·
IF 2
Bowen Han,Jing He,Shaohua Huang
Chiral amino acids play an indispensable role in living organisms. Diffusion-ordered NMR spectroscopy is an effective NMR tool and a noninvasive analytical method for the analyses of mixture without the need for physical separation of the analytes. However, conventional diffusion-ordered NMR spectroscopy method usually fails to resolve the mixtures of chiral amino acids because of their same molecular masses, sizes, and shapes. Microcrystalline cellulose has been gradually gained more and more interest owing to its wide compatibility, surface area, excellent separation efficiency, non-toxicity, cost-effective, and mechanical stability in many fields. Herein we provide a fast, simple, specific and sensitive method to resolve some D and L-amino acids mixtures by using microcrystalline cellulose as a matrix. This work recognized some D and L- proteinogenic amino acid enantiomers with diffusion-ordered NMR for the first time.
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MOLECULES
·
2024
·Vol. 29
·期 11
·2426
·
IF 4.2
Liming He,Hongda Xu,Yang Cui,Jian Qi,Xiaolong Wang,Quan Jin
Carbon-based magnetic metal composites derived from metal–organic frameworks (MOFs) are promising materials for the preparation of broadband microwave absorbers. In this work, the leaf-like co-doped porous carbon/carbon nanotube heterostructure was obtained using ZIF-L@ZIF-67 as precursor. The number of carbon nanotubes can be controlled by varying the amount of ZIF-67, thus regulating the dielectric constant of the sample. An optimum reflection loss of −42.2 dB is attained when ZIF-67 is added at 2 mmol. An effective absorption bandwidth (EAB) of 4.8 GHz is achieved with a thickness of 2.2 mm and a filler weight of 12%. The excellent microwave absorption (MA) ability is generated from the mesopore structure, uniform heterogeneous interfaces, and high conduction loss. The work offers useful guidelines to devise and prepare such nanostructured materials for MA materials.
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ANALYTICA CHIMICA ACTA
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2012
·
IF 4.555
Yu Chen,Lei Chen,Ruilin Bi,Lan Xu,Yan Liu
A novel chiral molecularly imprinted polymer (MIP) sensor for l -Phenylalanine has been developed, which is constructed by electrochemically driven cross-linking a pendant polymer precursor, poly[2-( N -carbazolyl)ethyl methacrylate-co-meth-acrylic acid]s (PCEMMAs). In this MIP sensing material, the recognition sites, the insulating polymethylacrylic acid (PMAA), were covalently bonded to the conducting polycarbazole which could be used as signal transfer interface between recognition layer and electrode. The mole ratio of copolymerizing monomers, 2-( N -carbazolyl) ethyl methacrylate:methylacrylic acid (CE:MAA), and the scanning cycles of electropolymerization were adjusted during the preparation of MIP sensing material. The optimized conditions, CE:MAA = 3:2 and 20 scanning cycles, were obtained. And then the properties of MIP films were characterized by atomic force microscope (AFM), X-ray photoelectron spectroscopy (XPS) and water contact angle. Open circuit potential–time technique was used to estimate the enantioselectivity of the MIP sensor. The results indicate that the promising sensor preferentially responses l -Phenylalanine ( l -Phe) over d -Phenylalanine ( d -Phe) with a selectivity coefficient K D L = 5.75 × 10 − 4 and the limit of detection (LOD) is 1.37 μM, which reveals its good enantioselectivity and sensitivity.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2012
·
IF 3.456
Qin Tu,Jian-Chun Wang,Rui Liu,Yanrong Zhang,Juan Xu,Jianjun Liu,Mao-Sen Yuan,Wenming Liu,Jinyi Wang
A new antifouling polyester monomethoxy-poly(ethylene glycol)-b-poly( l -lactide)-b-poly(sulfobetaine methacrylate) (MPEG-PLA-PSBMA) was obtained by ring-opening polymerization of l -lactide, and subsequent click chemistry to graft the azide end-functionalized poly(sulfobetaine methacrylate) (polySBMA) moieties onto the alkyne end-functionalized MPEG-PLA (MPEG-PLA-alkyne). The chemical structure of the polymer was characterized using 1 H nuclear magnetic resonance and Fourier-transform infrared spectroscopy, and its physical properties (including molecular weight, glass transition temperature, and melting point) were determined using gel permeation chromatography and differential scanning calorimetry. To investigate its hydrophilicity and stability, as well as its antifouling properties, the polymer was also prepared as a surface coating on glass substrates. The wettability and stability of this polyester was examined by contact angle measurements. Furthermore, its antifouling properties were investigated via protein adsorption, cell adhesion studies, and bacterial attachment assays. The results suggest that the prepared zwitterionic polyester exhibits durable wettability and stability, as well as significant antifouling properties. The new zwitterionic polyester MPEG-PLA-PSBMA could be developed as a promising antifouling material with extensive biomedical applications.
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Pharmaceutics
·
2024
·Vol. 16
·期 9
·1178
·
IF 4.9
Xiao Duan,Qiang Wang,Yue Wang,Xinping Liu,Manman Lu,Zhifang Li,Xuelian Jiang,Jingquan Ji
Using an endogenous carrier is the best method to address the biocompatibility of carriers in the drug delivery field. Herein, we prepared a glutathione-responsive paclitaxel prodrug micelle based on an endogenous molecule of L-glutathione oxidized (GSSG) for cancer therapy using one-pot synthesis. The carboxyl groups in L-glutathione oxidized were reacted with the hydroxyl group in paclitaxel (PTX) using the catalysts dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP). Then, the amino-polyethylene glycol monomethyl ether (mPEG-NH2) was conjugated with GSSG to prepare PTX-GSSG-PEG. The structure of PTX-GSSG-PEG was characterized using infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (NMR), and mass spectrometry (MS). The drug release kinetics of PTX within PTX-GSSG-PEG were quantified using ultraviolet spectroscopy (UV-Vis). The size of the PTX-GSSG-PEG micelles was 83 nm, as evaluated using dynamic light scattering (DLS), and their particle size remained stable in a pH 7.4 PBS for 7 days. Moreover, the micelles could responsively degrade and release PTX in a reduced glutathione environment. The drug loading of PTX in PTX-GSSG-PEG was 13%, as determined using NMR. Furthermore, the cumulative drug release rate of PTX from the micelles reached 72.1% in a reduced glutathione environment of 5 mg/mL at 120 h. Cell viability experiments demonstrated that the PTX-GSSG-PEG micelles could induce the apoptosis of MCF-7 cells. Additionally, cell uptake showed that the micelles could distribute to the cell nuclei within 7 h. To sum up, with this glutathione-responsive paclitaxel prodrug micelle based on the endogenous molecule GSSG, it may be possible to develop novel nanomedicines in the future.
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ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Jia’nan Zhang,Zizhen Liu,Yihan Wang,Bo Yu
l-Homoserine is proven to be a promising precursor for the synthesis of l-phosphinothricin, which is a broad-spectrum herbicide with low toxicity. To enhance the sustainability of the process, the utilization of nonfood carbon sources for l-homoserine production is highly sought-after. Acetate, which can be captured from C1 gases, has the potential to become the most abundant feedstock for biomanufacturing. In this study, we systematically engineered the Escherichia coli strain to generate l-homoserine from acetate. The production of l-homoserine from acetate was initially achieved by deleting branch pathways, activating the glyoxylate shunt, and enhancing the synthetic pathway. The strain’s tolerance and acetate assimilation capabilities were strengthened through adaptive laboratory evolution. Reducing the flux toward gluconeogenesis further facilitated the production of l-homoserine. Finally, the engineered strain produced 15.96 g/L l-homoserine solely from CO2-derived acetate and formate in a 5 L fermentor via a fed-batch process. This study provides insights into the development of a low-carbon bioeconomy for the herbicide industry.
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Materials Research Express
·
2024
·Vol. 11
·期 11
·115401
·
IF 1.8
Jian Lu,Wenlong Xia,Xiangyang Ye,Xiaofeng Song
The biomaterials that can respond to environmental stimuli have attracted increasing attention because their applications will greatly expand the boundaries of modern medicine. In the work, poly(N-isopropylacrylamide)-poly(ε-caprolactone) (PNIPAm-PCL) with the low critical solution temperature (LCST) was synthesized by a combination of chain transfer and ring-opening method to endow poly (lactic acid) (PLLA) with the temperature-controlled wettability. The effects of PNIPAm-PCL on the thermal properties, mechanical properties, and temperature-controlled wettability were studied. At 20 wt% of PNIPAm-PCL/PLLA, the tensile strength of the material reduces slightly, but its elongation at break is enhanced significantly, which reaches 135.1%. PNIPAm-PCL/PLLA exhibits good temperature-controlled wettability. With the temperature rising from 0 to 45 °C, the water contact angle increases from 29.8° to 80.1°; conversely, it goes down, and there is a hysteresis. The material still has good stability and degradability. This work provides an example for the development of intelligent tissue engineering materials.
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