CHEMOSPHERE
·
2022
·
IF 8.943
Wei Liu,Tao Lin,Xue Zhang,Fuchun Jiang,Xiaoshu Yan,Han Chen
The safety threat posed by Perfluoroalkyl acids (PFAAs) in drinking water is a growing concern. In this study, we loaded chitosan (CS) on granular activated carbon (GAC) to adsorb PFAAs, and we explored the role of nanobubbles in the adsorption process through experiments and density functional theory (DFT) calculations. Compared with GAC, we found that the use of the composite adsorbent (CS/GAC) enhanced the removal rate of perfluorooctanoic acid by 136% with the assistance of nanobubbles. PFAAs with different chain lengths have different adsorption mechanisms owing to surface activity differences. PFAAs with longer C–F chains can be directly enriched with amino groups on the CS or air–water interface on composite adsorbents. Additionally, PFAAs can be enriched with nanobubbles in solution to form nanobubble–PFAA colloids, which are adsorbed by protonated amino groups on CS through electrostatic interactions. We found that PFAAs with shorter C–F chains are less affected by nanobubbles, and DFT calculations indicated that the adsorption of short-chain PFAAs is mainly affected by electrostatic interactions. We also proved that the electrostatic interactions between CS and PFAAs are mainly derived from the abundant protonated amino groups.
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高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Qian Zhang,Yansha Qiao,Chaojing Li,Jing Lin,Hui Han,Xiaoli Li,Jifu Mao,Fujun Wang,Lu Wang
The inferior tendon healing after surgery is inextricably linked to the surgical suture. Poor load transfer along the suture often results in a high tendon re-tear rate. Besides, the severe inflammation and infection induced by sutures even cause a second surgery. Herein, to alleviate the above-mentioned issues, a multifunctional suture was fabricated by decorating chitosan/gelatin-tannic acid (CS/GE-TA) on the porous tape suture. The porous tape suture ensured the required mechanical properties and sufficient space for tissue integration. Compared to the pristine suture, the CS/GE-TA decorated suture (TA100) presented a 332% increase in pull-out force from the tendon, indicating potentially decreased re-tear rates. Meanwhile, TA100 showed superior anti-inflammatory and antibacterial performances. In vivo experiments further proved that TA100 could not only reduce inflammatory action but also facilitate collagen deposition and blood vessel formation . These results indicate that the multifunctional sutures are promising candidates for accelerating tendon healing.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Chongchong Liu,Panping Yang,Jingguo Li,Shaokui Cao,Jun Shi
Remotely multi-responsive chitosan (CS) hydrogels holds great promise in the design of anticancer drug carriers. In this paper, near-infrared (NIR)-/pH-dual responsive CS/β-GP/Ti 3 C 2 @AuNRs hybrid hydrogel was prepared based on CS/β-glycerol phosphate disodium salt (β-GP) crosslinking system embedded with NIR-responsive Ti 3 C 2 @gold nanorods (AuNRs) nanosheets . Excess β-GP promoted the formation of massive electronegative cavities, which endowed hybrid hydrogels with high drug loading efficiency for electropositive DOX (around 88.5 %). The collapse of chitosan network in acidic medium gave the hybrid hydrogel with distinct pH response. In addition, the distinct temperature increase owing to the strong NIR responsiveness of Ti 3 C 2 @AuNRs nanosheets would accelerate the DOX release dramatically. Therefore, NIR-, pH- and thermal-multi-responsiveness would synergistically endow CS/β-GP/Ti 3 C 2 @AuNRs hybrid hydrogel with notable NIR-triggered photothermal effect and remotely controllable drug delivery properties.
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Frontiers in Bioengineering and Biotechnology
·
2020
·
IF 3.644
Qiu Tianyang,Jiang Wei,Yan Pei,Jiao Li,Wang Xibin
Bioresorbable polymeric stents have attracted great interest for coronary artery disease because they can provide mechanical support first and then disappear within a desired time period. The conventional manufacturing process is laser cutting, and generally they are fabricated from tubular prototypes produced by injection molding or melt extrusion. The aim of this study is to fabricate and characterize a novel bioresorbable polymeric stent for treatment of coronary artery disease. Polycaprolactone (PCL) is investigated as suitable material for biomedical stents. A rotary 3D printing method is developed to fabricate the polymeric stents. Surface modification of polymeric stent is performed by immobilization of 2-N, 6-O-sulfated chitosan (26SCS). Physical and chemical characterization results showed that the surface microstructure of 3D-pinted PCL stents can be influenced by 26SCS modification, but no significant difference was observed for their mechanical behavior. Biocompatibility assessment results indicated that PCL and S-PCL stents possess good compatibility with blood and cells, and 26SCS modification can enhance cell proliferation. These results suggest that 3D printed PCL stent can be a potential candidate for coronary artery disease by modification of sulfated chitosan (CS).
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高影响因子
CURRENT MOLECULAR MEDICINE
·
2018
·Vol. 18
·期 6
·383-391
·
IF 2.254
Li Yue,Lin Yan,Liufu Chun,Tu Jiawei,Yang Chaopin,Chen ZhiYi
Objective: To study transfection efficiency of folate-modified chitosan (FACS) nanoparticles as a non-viral vector delivering pEGFP-C3plasmid (FA-CS/P) to 293T cells with or without the combination of ultrasound and microbubble. Method: pEGFP-C3 was used as a reporter gene and
FA-CS nanoparticles, which were prepared by complex coagulation method, were used as biological carriers. Transfection efficiency to 293T cells mediated by FA-CS/P nanoparticles, ultrasound (US) and microbubble (MB) was assessed by fluorescence microscopy and flow cytometry. Result: FA-CS/P
nanoparticles have a particle size of 355.1 nm and zeta potential of 10.4 mV. Significant green fluorescence could be observed in CS/P group, FA-CS/P group, US+MB/P group, US+FA-CS/P group, Liposome 2000 (L) group under an inverted fluorescence microscope, while for US+MB+FA-CS/P group, only
scattered fluorescence was observed. Result of flow cytometry showed that the transfection rate of US+MB+FA-CS/P group was (2.0±0.2)%, which was significantly lower than other groups (P<0.05). CCK-8 experiments showed that cell vitality of US+MB+FA-CS/P was groups (P<0.05). CCK-8
experiments showed that cell vitality of US+MB+FA-CS/P was (64.1±4.6)%, which was also lower than other groups (P<0.05). Conclusion: In this study, FA-CS was successfully synthesized. FA-CS could combine with pEGFP-C3 effectively forming nanoparticles with nanoparticle size,
well dispersion, high encapsulation efficiency and no significant toxicity to cells. The application of ultrasound increased the transfection rate of FA-CS/P. However, while being exposed to ultrasound and microbubble, the transfection rate of FA-CS/P decreased obviously, may indicate that
there was no synergistic effect for gene transfection by the combination of ultrasound, folate modified chitosan and microbubbles.
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CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Ting Wu,Weiping Liao,Wei Wang,Jie Zhou,Weiguo Tan,Weibing Xiang,Jinglin Zhang,Lina Guo,Tao Chen,Dong Ma,Weiye Yu,Xiang Cai
Lung-targeted genipin-crosslinked deacetylated chitosan (GEN-CS)/isoniazid (INH)/rifampin (RMP) nanogel particles (NGPs) were prepared as a treatment for tuberculosis caused by multidrug-resistant Mycobacterium tuberculosis (MTB) to surmount the undesirable side effects and decrease the cytotoxicity of INH and RMP when being against MTB. The size, morphology, in vitro release property, long-term antibacterial performance, stability, in vitro cytotoxicity, in vivo toxicity, and in vivo release property of GEN-CS/INH/RMP NGPs inhalation powder were investigated. The results showed that the GEN-CS/INH/RMP NGPs inhalation powder exhibited extended antibacterial activity because of its long-term release of INH and RMP. A simplex GEN-CS/INH/RMP NGPs pulmonary dose led to the therapeutic drug concentration of 40%–60% in lung and other organs (＜5%) for 24 h. Furthermore, this GEN-CS/INH/RMP NGPs lyophilized inhalation powder displayed lung-targeted property and lower in vivo toxicity. These results suggested that this GEN-CS/INH/RMP NGPs inhalation powder would be a more useful dosage form than separate dose of INH or RMP for MTB.
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Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Ye Ma,Lian Xin,Huaping Tan,Ming Fan,Jianliang Li,Yang Jia,Zhonghua Ling,Yong Chen,Xiaohong Hu
Transparent and flexible chitosan-based membranes containing antibacterial drugs were prepared through a casting/solvent evaporation method from suspension of chitosan floccule. To enhance mechanical properties, glycerin was incorporated into the floccule suspension to conjugate chitosan as a plasticizer. The mechanism of membrane formation is attributed to inter- and intro-hydrogen bonding between chitosan and glycerol molecules. The results showed that incorporation of glycerol has a significant influence on the properties of the chitosan membranes. With the increase of glycerol content, the tensile strength, swelling rate, water vapor permeability and wettability of membranes were significantly improved. In vitro enzymatic degradation revealed that the chitosan membrane had long-term stability regardless of the glycerol content. To enhance antibacterial properties, tetracycline hydrochloride (TH) and silver sulfadiazine (AgSD), representing the water-soluble and water-insoluble drug models, were integrated into the membranes, respectively. The results of controlled-release efficacy and inhibition zone indicate that the glycerol toughened chitosan membranes containing drugs have a promising future in treatment of bacterial infection as wound dressing.
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高影响因子
ELECTROANALYSIS
·
2020
·Vol. 33
·期 3
·723-732
·
IF 2.544
Lincai Peng,Yingjie Luo,Hongping Xiong,Shun Yao,Minghui Zhu,Hang Song
A novel enzymatic biosensing platform toward glucose is achieved with nanocomposite of magnetic nanoparticles (Fe 3 O 4 −CS−CD) and multi-walled carbon nanotubes (MWCNTs). The synergistic effect of chitosan, β-cyclodextrin and MWCNTs can facilitate electron transfer between enzyme and electrode based on the promoting results of the cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The new biosensors exhibited direct electron transfer (DET) from enzyme to electrode after glucose oxidase (GOx) was immobilized on the modified electrode with the nanocomposite. Consequently, the enzymatic glucose biosensor displayed a considerably wide linear range (40 μM to 1.04 mM) with a high sensitivity of 23.59 μA mM −1 cm −2 , low detection limit of 19.30 μM, good selectivity, reproducibility and repeatability for detecting glucose. In addition, the current response still retained at 93.4 % after 25 days. Furthermore, the practical application of glucose biosensor was test in human serum samples with satisfactory accuracy, demonstrating promising and practical potential in biomedical diagnostics.
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MINERALS ENGINEERING
·
2020
·
IF 3.795
Tao Wang,Bo Feng,Yutao Guo,Wenpu Zhang,Yibei Rao,Chunhui Zhong,Liangzhu Zhang,Chen Cheng,Huihui Wang,Xianping Luo
The separation of apatite from calcite has been recognized as one of the most difficult subjects in mineral processing owing to their similar surface properties, thus finding high-efficiency depressants become the key for the separation. In this paper, carboxymethyl chitosan was tested as a potential selective depressant in the separation of apatite and calcite using sodium oleate (NaOL) as a collector. Contact angle measurements, adsorption tests, zeta potential tests, FTIR analysis and XPS analysis were performed to explain the selective depression mechanism of carboxymethyl chitosan. The micro-flotation experiment indicated that carboxymethyl chitosan had significantly depression effect on calcite but had a little influence on apatite at pulp pH 9. A series of mechanism tests show that the carboxymethyl chitosan adsorption quantity on calcite surface more than that on apatite surface, which is due to that carboxymethyl chitosan adsorbed on apatite surface by hydrogen bonding, while absorbed on calcite surface mainly through chemical chelating between Ca on mineral surface and –COO − on the depressant. Moreover, both apatite and carboxymethyl chitosan are negatively charged, strong electrostatic repulsive force and steric hindrance between carboxymethyl chitosan and apatite also make the carboxymethyl chitosan adsorb on apatite surface more difficult. These adsorption differences lead to the flotation separation of the two minerals.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2012
·Vol. 14
·期 4
·1-9
·
IF 3.287
Duan Jinghua,Liu Mujun,Zhang Yangde,Zhao Jinfeng,Pan Yifeng,Yang Xiyun
A novel chitosan coated poly(butyl cyanoacrylate) (PBCA) nanoparticles loaded doxorubicin (DOX) were synthesized and then conjugated with folic acid to produce a folate-targeted drug carrier for tumor-specific drug delivery. Prepared nanoparticles were surface modified by folate for targeting cancer cells, which is confirmed by FTIR spectroscopy and characterized for shape, size, and zeta potential measurements. The size and zeta potential of prepared DOX-PBCA nanoparticles (DOX-PBCA NPs) were almost 174 ± 8.23 nm and +23.14 ± 4.25 mV, respectively with 46.8 ± 3.32% encapsulation capacity. The transmission electron microscopy study revealed that preparation allowed the formation of spherical nanometric and homogeneous. Fluorescent microscopy imaging and flow cytometry analysis revealed that DOX-PBCA NPs were endocytosed into MCF-7 cells through the interaction with overexpressed folate receptors on the surface of the cancer cells. The results demonstrate that folate-conjugated DOX-PBCA NPs drug delivery system could provide increased therapeutic benefit by delivering the encapsulated drug to the folate receptor positive cancer cells.
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CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Lei Xu,Fenbo Ma,Frankie K.L. Leung,Chenghe Qin,William W. Lu,Bin Tang
Bone defects caused by trauma have become increasingly common in aged populations. Clinically, because of the relatively decreased bone healing capacity compared with the youth adults, bone defect repair in the elderly remains challenging. The development of effective biomaterials targeted at bone defects in the elderly is a key component of bone-tissue engineering strategies. However, little attention has been paid to bone regeneration in the elderly. Here, we developed a new scaffold chitosan-Strontium chondroitin sulfate (CH-SrCS) and evaluated its effect on improving bone regeneration. We find that the CH-SrCS scaffold displayed positive effects on downregulation of inflammation and osteoclastogenesis related mRNA expressions while demonstrating a significant increase in the expression level of BMP2. Finally, we show that the bone defects healing effects as assessed using an aged rats' bone defects model. Ultimately, this work also provides insights into the design of effective biomaterials targeted at bone defects in the elderly.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Tangjun Ren,Junyu Meng,Mengke Sun,Qi Zhang,Chenyang Yao,Haonan Wu,Xinting Wang,John Osilama Thomas,Liuliu yang,Enpeng Gu,Xi Wang,Jian Yang
As a physiological process maintaining skin integrity, wound healing is often disrupted by complex microenvironments, infection, and abnormal pH levels, leading to delayed healing. Additionally, irregularly shaped wounds are complex enough to cover adequately with traditional dressings. To address these issues, we developed a functional hydrogel via the Schiff base reaction between chitosan (CS) and difunctional telechelic-polyethylene glycol (DT-PEGn) of varying molecular weights, which was subsequently loaded with ciprofloxacin (CIP) to form a CS@DT-PEGn@CIP composite system. The results demonstrate that DT-PEGn of different molecular weights effectively modulate the hydrogel's swelling ratio, mechanical properties, injectability, self-healing capacity, and drug release characteristics, thereby conferring tunable functional advantages in wound repair. In vitro antibacterial assays and a rat full-thickness wound model further confirmed the outstanding efficacy of CS@DT-PEGn@CIP in significantly inhibiting bacterial growth and accelerating wound healing. Notably, the CS@DT-PEG6000 hydrogel containing only one-third of the free CIP dose exhibited superior therapeutic outcomes compared to free CIP alone, highlighting the high efficiency and safety of the composite system. In summary, this study systematically demonstrates the unique advantages of CS@DT-PEGn hydrogel in promoting wound healing, including its responsiveness to microenvironmental pH, antibacterial properties, and excellent conformability to wound surfaces. These findings provide novel strategies and potential applications for clinical wound management.
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