ACS Food Science & Technology
·
2026
·
IF 3
Jiayi Chen,Dandan Zhang,Lu Liu,Xiaoli Wu,Meihan Guo,Hong Yan Zou,Xi Yang
Herein, a cost-effective, naked-eye-readable platform for on-site biogenic amines (BAs) detection and shrimp freshness monitoring was developed based on a ratiometric fluorescent CDs–RhB hybrid nanosystem that was constructed by integrating carbon dots (CDs) with rhodamine B (RhB). Biogenic amines induced a significant enhancement in the green fluorescence emission of CDs, while the red fluorescence emission of RhB remained unchanged, enabling an instant self-calibration during detection. Loaded on filter paper to form disposable test strips, the nanosystem enabled a visible color transition from orange to green with increasing BAs concentration. Readable via a smartphone RGB app, the paper-based assay showed a linear response of 5.0–250 μM with a limit of detection (LOD) of 3.56 μM using histamine as the model analyte. Validated through on-site shrimp quality evaluation, the paper-based sensor established a reliable “nanoprobe–paper–phone” strategy, facilitating on-site and quantitative freshness assessment in real-world demand scenarios.
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Small Methods
·
2026
·
IF 8.7
Tianshun Ding,Shi Feng,Hao Li,Zelong Zhang,Shengyang Tao
Chiral materials have broad applications in optics. Precise regulation of the chiral signal, however, remains highly challenging. Herein, a microfluidic strategy is proposed in which the cooperative action of dual driving forces regulates vortical flow inside droplets. The flow rate and interfacial tension are adjusted to induce ordered Marangoni convection and shear flow within microdroplets. Under these conditions, chiral signals are transmitted both within droplets and across the liquid-liquid interface. Tetrakis(4-sulfonatophenyl)porphyrin and phenethylamine are employed as a supramolecular co-assembly pair to probe the relation between vortex strength/distribution and chiral-signal transfer. Assemblies obtained under microdroplet vortex fields exhibit markedly enhanced and nearly mirror-image circular dichroism (CD) responses in comparison with those prepared under conventional magnetic stirring. These observations confirm that vortical flow efficiently promotes chiral amplification and enantioselective supramolecular assembly. Flow-field visualization by micro-particle image velocimetry (μ-PIV), combined with hydrodynamic analysis, reveals the formation mechanism and evolution of microvortices under the dual driving forces. Overall, this study demonstrates a practical approach to modulating supramolecular chiroptical signals via vortexes in confined environments.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Yunlong Han,Jining Sun,Hao Jing,Suping Li,Qing Wang,Zhiyuan Zhang,Xuanyao Wang,Yayong Wang,Yongjie Guo,Zepeng Bao,Yi Zhang,Qianhao Xiao,Mengfan Lv,Ruonan Hao,Zhenqiang Shi,Yuanqian Zeng,Lei Zhang
Facilitating entropic elastic deformation is central to strengthening the mechanical resilience of 3D-printable elastomers. Despite extensive efforts that have focused on enhancing entropy-driven responses through regulating inter-chain interactions, the role of dangling chain conformational constraints in modulating elastic energy dissipation and mechanical reinforcement has remained largely overlooked. Herein, we challenge this prevailing convention by constraining polymer chain termini, thereby eliminating unbound ends and creating a fully connected molecular network. This end-constraint reweights the deformation response by suppressing slippage and enhancing entropic elasticity, unlocking a unique combination of high modulus, creep resistance, and toughness unattainable with conventional designs. By coupling terminal constraint and interchain physical crosslinking, 3D-printable elastomers achieve enhancement of over 571.1% and 388.2% in strength and toughness, while preserving printability and resilience. This work establishes chain-end engineering as a powerful principle for molecular design, opening avenues toward recyclable, durable, and high-performance soft materials for 3D printing, wearable electronics, and soft robotics.
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Journal of Physical Chemistry Letters
·
2025
·
IF 4.6
Yuan Yu,Xiangping Zhao,Chenghao Liu,Zhiyong Pang,Wei Qin
The chiral spatial structure of chiral perovskite materials enriches the physical and optical properties of perovskite materials, making them an excellent platform to deeply understand charge–spin–photon interactions. In this work, we fabricated chiral perovskite crystals and their nonchiral isomeric counterparts. The significant differences in the crystal structures of these two types of materials lead to notable variations in their fluorescence lifetimes and electron–phonon coupling strength, which present an externally presentable change in physical properties, such as the dielectric constant. Moreover, inside chiral structures, the chiral orbit should be taken into account. Under the effect of a magnetic field versus a chiral orbit, dipolar polarization and charge recombination will be rebalanced after disruption, where the dielectric constants and photoluminescence intensities of the S- and R-type chiral perovskites display opposite trends. It is also noted that chiral orbit-induced spin relaxation determined the spin dependence of recombination, which presents a potential materials platform to fabricate devices resisting external signal interference well.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Yidan Zhang,Yuhua Lai,Yifei Ma,Lin Ge,Jinhua Liu
Since excess histamine (His) in seafood poses a significant health threat, the development of intelligent, on-site, and visual multimodal methods for detecting fish freshness has attracted widespread attention. In this study, we developed a Lewis base-induced paper-based chip coupled with smartphone RGB (Red Green Blue) recognition for the real-time colorimetric/fluorescent dual-mode detection of His in fish meat. The sensing mechanism was based on the catalytic role of His in rapidly forming a green fluorescent compound (GFC) from dopamine and 3-ethylamino-4-methylphenol. Interestingly, the introduction of 1% Tween (TW) 80 was found to significantly enhance the fluorescence signal and real-time stability of the system, achieving an exceptional detection limit of 16.67 nM for His. By immobilizing the GFC probe on Whatman 1 filter paper, a paper-based test strip for His was further developed. His quantification is achieved through RGB analysis with a smartphone, allowing visual and real-time assessment of fish meat freshness directly in the field. The developed sensor exhibits outstanding selectivity, stability, and sensitivity, and has been successfully applied to monitor His levels in fish meat samples (crucian, saury and golden pomfret) over time, providing a reliable means to prevent His poisoning. Therefore, this work presents a robust, low-cost, and user-friendly point-of-care testing platform that holds significant potential for applications in intelligent food monitoring and environmental sensing.
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TALANTA
·
2026
·
IF 6.1
Hongyu Chen,Jiayi Guo,Xinrui Sun,Peipei Tian,Wenping Zhu,Manman Sun,Zengchen Liu,Qingfeng Li,Yahong Chen
A novel nano-sensing system was developed to enhance the selectivity and sensitivity of dopamine (DA) detection by integrating the strong cleavage effect of β-mercaptoethylamine (MEA) on trypsin-stabilized gold nanoflowers (Trypsin-AuNFs), the Schiff base/Michael addition reactions triggered by the bisphenol structure of DA, and the intramolecular hydrogen bonding within DA. Multiple characterizations including TEM, XPS and FT-IR confirmed that trypsin was anchored on the flower-shaped surface of AuNFs via Au-S bonds, endowing Trypsin-AuNFs with excellent structural stability. In addition, Trypsin-AuNFs can both effectively prevent the interference of biothiols ((cysteine (Cys), homocysteine (Hcy), glutathione (GSH)) in serum and have a strong interaction with MEA, resulting in the rapid cleavage of Trypsin-AuNFs. This is because MEA both induced the cleavage of Trypsin-AuNFs through the formation of Au-S bonds, and directly interacted with trypsin, disrupting its structure and accelerating the decomposition of Trypsin-AuNFs. These dual actions significantly enhanced the selectivity and sensitivity of the sensing system. It is worth noting that a detailed study of the interaction between MEA and trypsin and the optimal binding site through molecular docking was conducted for the first time. A detailed study of the impact of MEA on the spatial structure of trypsin was also conducted for the first time by using molecular dynamics. Moreover, the precise regulation of the Trypsin-AuNFs cleavage mechanism triggered by the DA-bisphenol structure through a Schiff base/Michael addition reaction was thoroughly investigated using UV-vis absorption spectroscopy (including functional group identification, steric hindrance comparison, and bisphenol regulation), 1 H NMR, zeta potential measurements, and TEM. This work provides a novel strategy for probing the interaction between MEA and proteins and offers a new perspective for improving the specificity of DA detection.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Wei Xiaolan,Wang Peng,Li Linjin,Luo Zhu,Ye Xinyuan,Long Jiujiang,Liu Xianghui
Biogenic amines (BAs), primarily formed through the microbial degradation of proteins, are important markers indicating food fermentation and spoilage. On the demand of on-site monitoring of food quality and safety, electrochemical and optical sensors have been developed, focusing on the detection of the total volatile amines or a specific amine. However, the multiplex detection of BAs with high accuracy and sensitivity still remains a major challenge. The sensor array strategy that mimics the biological olfactory sense provides an effective and powerful route to achieve multiplex detection of BAs. Herein, (metallo)porphyrin-based hydrogen-bonded organic frameworks embedded with silver nanoparticles were prepared and used as receptors to construct the surface-enhanced Raman scattering (SERS) sensor array, leveraging the multiple chemical interactions and the sharp Raman signals of (metallo)porphyrins, and the porous and flexible structure of the supramolecular frameworks. This SERS sensor array demonstrated a successful discrimination of ten BAs, an accurate quantitation of three BAs, and a successful simultaneous determination of three BAs in pork samples. Using the total volatile basic nitrogen as a spoilage label, the platform achieved over 90% accuracies in freshness discriminations for pork, beef, and chicken samples. In comparison with the existing detection methods, the proposed SERS sensor array strategy based on porphyrin- and metalloporphyrin-based hydrogen-bonded organic frameworks exhibits operational simplicity, rapid response, high sensitivity, as well as multiplex detection capability. Thus, it demonstrates a significant practical potential for applications in the production line and the supply chain of foods.
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ACS Nano
·
2025
·
IF 16
Hengyu Cao,Lutao Li,Qiankun Li,Weiyu Cheng,Chen Wang,Ruonan Wang,Xiangle Sun,Fengcheng Zhang,Xiawei Zhang,Ming Huang,Lu You,Guifu Zou
Single crystal high-resolution array patterning of halide perovskite films is a crucial step toward unlocking their full potential for various optoelectronic applications. The top-down manufacturing strategies are hindered by the intrinsic fragility and thermal instability of halide perovskites. Herein, we establish an integrated growth-patterning strategy using a polymer with polar functional groups, leveraging the polymer’s steric hindrance effect during crystal growth, thus reducing nucleation density and suppressing crystal growth rate, and simultaneously, improving its mechanical strength and thermal stability by a coordinative polymer protective layer with the film surface. Moreover, the polar functional groups effectively suppress surface defects and enhance the crystalline quality through coordinative interaction. This integrated method can also be used to realize centimeter-sized (∼200 mm2) and high aspect ratio (104) single crystal films growth and patterning in a variety of halide perovskites. The integrated growth-patterning strategy facilitates the commercialization of halide perovskites.
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Materials Today Chemistry
·
2023
·
IF 7.3
D. Ma,Y. Lan,D. Zhang,X. Qin,Z. Yang,H. He,X. Dai,Z. Ye,X. Cao
Organic-inorganic perovskite materials have shown excellent performance and strong competitiveness in high-performance photovoltaic and optoelectronic devices. Besides the color-tunable and narrow-band emissions realized in hybrid perovskites, broadband emission from lead-halide perovskites has also attracted strong interest for applications in the next generation of solid-state lighting. Although great progress has been made in lead halide perovskites, a very important aspect that hinders their commercial exploitation is the severe lead toxicity. In this research, a lead-free copper(I)-iodine hybrid was synthesized by a solution evaporation method at room temperature. Single crystal X-ray diffraction shows that this hybrid possesses the chemical formula of C 6 H 5 CH 2 CH 2 NH 3 CuI 2 . The C 6 H 5 CH 2 CH 2 NH 3 CuI 2 belongs to the monoclinic phase with the C2/c space group, where the edge-sharing [CuI 4 ] tetrahedral chains are separated by organic C 6 H 5 CH 2 CH 2 NH 3 + ions, exhibiting one-dimensional (1D) crystal structure. The optical band-gap of C 6 H 5 CH 2 CH 2 NH 3 CuI 2 was determined to be 4.02 eV. The photoluminescence (PL) spectrum shows a broadband emission ranging from 380 nm to 780 nm and peaks at 542 nm together with a small peak at 336 nm, which can be attributed to the emission of self-trapped exciton (STE) and free exciton (FE), respectively. The large Stokes shift of 230 nm between the PL and photoluminescence excitation (PLE) as well as the broad emission was ascribed to the Jahn–Teller lattice distortion of [CuI 4 ] tetrahedra. The reduced 1D characteristic facilitates the tetrahedral distortion. PL decay analysis shows that the average lifetime of STE is about 66.9 ns? Temperature and time-dependent PL measurements show that the normal working temperature of this luminescent material should be no higher than 100 °C. Theoretical calculations were performed to better understand this compound. The successful synthesis and preliminary optical investigations on C 6 H 5 CH 2 CH 2 NH 3 CuI 2 can be of great significance for offering more environmental-benign options in both solid-state lighting and other perovskite optoelectronic devices.
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Food Analytical Methods
·
2023
·Vol. 16
·期 5
·909-917
·
IF 2.9
Xu Yanfen,Lu Ying,Yu Jianna,Liu Wen,Jing Guoxing,Li Wenshan,Liu Wenjie
Tuna is one of the most popular fish and therefore among the most commercially valuable seafood. However, inadequate refrigeration during the whole supply chain causes serious economic loss and food poisoning. One important result of tuna spoilage is the accumulation of biogenic amines such as histamine, which can be used as a sensitive indicator for Tuna freshness. Thus, the development of rapid, sensitive, and economic analytical methods for biogenic amines in Tuna is highly desired. This research developed a method that combines high-performance liquid chromatography (HPLC) and electrospray ionization ion mobility spectrometry (ESI-IMS) to detect 7 kinds of biogenic amines including tryptamine, tyramine, spermidine, cadaverine, β-phenylethylamine, putrescine, and histamine in tuna. The limit of detections (LODs) for 7 biogenic amines are 0.01, 0.02, 0.02, 0.17, 0.03, 0.04, and 0.15 mg L −1 respectively. The linear range of histamine and spermidine is 2–100 mg kg −1 , and the linear range of other biogenic amines is 0.5–10 mg L −1 . The recoveries of biogenic amines are between 69.39 and 112.65%. Compared to the traditional HPLC-based analytical method, the proposed method does not involve any derivatization steps, which greatly decreased the sample preparation time and cost. Another advantage of the developed method is the supplementary separation to the HPLC, in which coeluted biogenic amines can clearly be separated in the ion mobility dimension. The proposed method is applied to determining the concentration of biogenic amines in tuna storage, which showed that this method can quickly and accurately monitor the changes of biogenic amines in tuna during storage.
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NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 16
·7588-7594
·
IF 3.3
Jianfeng Yan,Quanbin Fu,Shikai Zhang,Xianbao Shi,Yuanhong Zhang,Juying Hou,Junling Duan,Shiyun Ai
As a kind of organic basic compound containing nitrogen, biogenic amine is released from food spoilage and considered as an indicator for monitoring food freshness. Herein, an excellent dual-emission ratiometric fluorescent sensor for eight kinds of biogenic amines was established via the facile mixing of pH-responsive carbon dots and Rhodamine B. The developed sensor shows a rapid response (10 s), low limit of detection (0.733–3.943 μM) and a wide linear range (0–150 μM). More importantly, a portable fluorescent filter paper was prepared by simple dispersing the filter paper in a solution mixture of carbon dots and Rhodamine B. The obtained fluorescent filter paper based sensor showed an obvious color change in the presence of biogenic amine vapor derived from shrimp and mushroom. The results revealed that this sensor could realize the on-site and visual detection of biogenic amines in real food samples, making it suitable for potential application in food safety monitoring.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Qiuyang Huang,Xiaoling Zang,Zhiwei Zhang,Hang Yu,Baoyan Ding,Zhuangzhuang Li,Simin Cheng,Xin Zhang,Mustafa R.K. Ali,Xue Qiu,Zhihua Lv
The discovery of new anti-cancer drugs targeting the PD-1/PD-L1 pathway has been a research hotspot in recent years. In this study, biological affinity ultrafiltration (BAU), UPLC-HRMS, molecular dynamic (MD) simulations and molecular docking methods were applied to search for endogenous active compounds that can inhibit the binding of PD-L1 to PD-1. We screened dozens of potential cancer related endogenous compounds. Surprisingly, cyclic adenosine monophosphate (cAMP) was found to have a direct inhibitory effect on the PD-1/PD-L1 binding with an in vitro IC 50 value of about 36.4 ± 9.3 μM determined by homogeneous time-resolved fluorescence (HTRF) assay. cAMP could recover the proliferation of Jurkat T cells co-cultured with DU-145 cells and may suppress PD-L1 expression of DU-145 cells. cAMP was demonstrated to bind and induce PD-L1 dimerization by FRET assay, and also predicted by MD simulations and molecular docking. The finding of cAMP as a potential inhibitor directly targeting the PD-1/PD-L1 interaction could advance our understanding of the activity of endogenous compounds regulating PD-L1.
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危险品化学品经营许可证（带存储）