Applied Materials Today
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2025
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IF 6.9
Jun Zeng,Tao Jia,Tong Chen,Huilin Liu,Zhaojie Sun,Xiaoyong Huang,Yunfei Shang,Shuwei Hao,Chunhui Yang
Cancer phototheranostics has emerged as a cornerstone of personalized precision medicine to achieve efficient and targeted tumor treatment. Upconversion nanoparticles (UCNPs)-mediated phototheranostics exhibited remarkable potential for imaging diagnostics and therapeutic applications. Nevertheless, integrating programmable photoactivation functions of imaging and therapy within a single UCNP with negligible phototoxicity remains a huge challenge, primarily due to the absence of precise photoswitching strategies. Herein, a pulse-responsive upconversion nanoagent (UCNA) is designed to enable imaging-guided precision phototherapy through tunable red/green emissions. The UCNA is constructed based on a UCNPs@mSiO 2 core–shell structure conjugated with photosensitizer (neutral red) and drug (curcumin), and gated by a β-cyclodextrin-adamantane (β-CD-AD) host–guest supramolecular complex. The red emission is utilized for determining the tumor area through fluorescence imaging under 980 nm laser irradiation with a long pulse width (LPW). By switching the laser duty cycle into a short pulse width (SPW) mode, the resultant green emission can active photosensitizer to produce cytotoxic singlet oxygen ( 1 O 2 ), and simultaneously trigger drug release for antitumor therapy. The results demonstrate the attractive performance of UCNP-mediated deep-tissue imaging and enhanced anti-tumor efficacy without obvious systemic toxicity. In general, this work provides a facile approach for tuning upconversion emission, thereby realizing the photoswitchable activation of imaging diagnostics and photodynamic therapeutics.
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DYES AND PIGMENTS
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2026
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IF 3.9
Qin Fang,Mengdie Qin,Ke-jun Tan
The development of simple and efficient synthesis strategies for multicolor fluorescent carbon dots (CDs) is crucial for advancing their applications in fields such as optoelectronic devices and fingerprint detection, and other fields. This study reports a “one-step synthesis combined with Thin Layer Chromatography (TLC) separation” strategy for the successful preparation of multicolor fluorescent CDs covering the entire visible spectrum (499-628 nm) under constant solvothermal conditions, using Neutral Red as the sole core precursor. The separated monochrome components—red (R-CDs), orange (O-CDs), yellow (Y-CDs), and green (G-CDs)—exhibit excellent optical properties, with R-CDs achieving a quantum yield (QY) as high as 20.3%. Systematic structural and spectral characterization reveals that the multicolor luminescence of these CDs does not originate from the conventional quantum confinement effect but is dominated by their surface states. The energy of these surface states is precisely tuned by the graphitization degree of the carbon core and the type of nitrogen-containing functional groups. Leveraging their superior optical properties and solid-state luminescence, the separated multicolor CDs were successfully applied in solid-state lighting to fabricate monochrome light-emitting diodes (LEDs) emitting bright orange, yellow, and green light, respectively. Furthermore, by compounding the highly luminescent R-CDs with starch, high-fidelity imaging of latent fingerprints (LFPs) was achieved, with second-level details being clearly visible. This research provides a new pathway for the low-cost production of multicolor fluorescent carbon dots, showcasing their broad application prospects in the field of advanced functional materials.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
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IF 4.8
Jie Hu,Hui Chen,Ruibin He,Pran Gopal Karmaker,Xiupei Yang,Fenglin Tang
Rapid and sensitive detection of picric acid (PA), a highly toxic and water-mobile nitroaromatic pollutant, is essential for environmental safety and public health protection. Herein, we fabricate a dual-emission ratiometric fluorescent probe by immobilizing high-load red-emitting carbon dots (R-CDs) onto NH₂-functionalized MIL-53(Al), forming an R-CDs/NH 2 -MIL-53(Al) composite for selective aqueous-phase PA sensing. R-CDs were hydrothermally synthesized with citric acid and neutral red as co-precursors. The loading efficiency was maximized by systematically optimizing precursor molar ratios and dilution conditions. The composite exhibits distinct selective fluorescence quenching in the presence of PA. Mechanistic characterizations, including fluorescence lifetime decay measurements and spectral overlap analysis, verify that the fluorescence quenching originates from two synergistic quenching pathways, namely competitive light absorption and fluorescence resonance energy transfer (FRET), rather than nonspecific physical interactions. This ratiometric sensing platform achieves a wide linear detection range of 0.1–70 μM and an ultralow limit of detection (LOD) of 32.9 nM. Spike-and-recovery assays using real environmental water samples (tap water, commercial bottled mineral water, and Jialing River surface water) produced recoveries of 99.7%–105.1%, with relative standard deviations (RSD) below 5.86% ( n = 3). Furthermore, a smartphone-enabled visual quantitative method based on RGB color channel analysis was constructed, enabling portable on-site detection without large-scale laboratory instrumentation.
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Bioactive Carbohydrates and Dietary Fibre
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2026
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IF 3.3
Zengfeng Xia,Lingyan Wang,Zhengwei Ying,Qiongyan Fang,Chunyu Niu,Yan Chen,Leifang Zhang,Yin Chen
Hypocrella bambusae is a special medical fungus known for its valuable bioactive pigments, yet its polysaccharide components have remained underexplored. This study aimed to investigate the structure of a heteropolysaccharide (HB0-1) isolated and purified from the stromata of H. bambusae and to evaluate its immunomodulatory activity. The analysis revealed that HB0-1 was composed of galactose, glucose, and mannose with a (1→6)-α-D-mannopyranose backbone. Its side chains include β-D-galactofuranose, α-D-glucopyranose, and β-D-galactopyranose residues. In cellular assays, HB0-1 significantly increased the viability, phagocytic activity, reactive oxygen species (ROS) production, and the secretion of pro-inflammatory cytokines—interleukin-6 (IL-6), interleukin-12 (IL-12), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α)—as well as the expression of inducible nitric oxide synthase (iNOS) in RAW264.7 macrophages. Further mechanistic studies demonstrated that HB0-1 activated the MAPK signaling pathway in a concentration-dependent manner, thereby enhancing immune responses. These results revealed that the highly branched architecture of HB0-1, featuring a (1→6)-α-D-mannan backbone densely substituted with glucose- and galactose-rich side chains (including furanose motifs), is responsible for its potent MAPK-mediated macrophage activation. This structural–functional relationship positions HB0-1 as a promising immunomodulatory candidate for functional food and therapeutic applications.
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Sustainable Materials and Technologies
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2025
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IF 9.2
Xiongchao Liu,Xinyu Li,Na Gao,Zhiwei Liu,Yuangang Li,Mingli Wang,Tifeng Jiao
In recent years, nanomaterials have garnered significant attention from both academic and industrial sectors owing to their exceptional properties and diverse application potential. In this context, the Langmuir-Blodgett (LB) technique, as an efficient self-assembly method, has been widely used for the preparation of functional thin films. Based on this, in this work, thin films based on perylene diimide (PDI) and naphthalene diimide (NDI) derivatives composites with dyes were successfully prepared using the LB technique and tested for their performance in gas sensing and Surface-Enhanced Raman Scattering (SERS). The experimental results show that the composite films have excellent response in acid-base gas sensing, especially in the CR dye subphase, and the PDI/CR and NDI/CR composite films are sensitive to HCl and NH 3 gases, with the NDI/CR composite films showing the most sensitive performance. In addition, the PDI/RhB 40-layer composite membranes exhibited significant SERS of R6G molecules with an enhancement factor as high as 3.94 × 10 5 , which is superior to many similar materials. The results presented herein demonstrate the substantial potential of LB technology in the development of multifunctional thin-film devices and its application in gas sensing and SERS.
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Frontiers in Nutrition
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2024
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IF 4
Wang Yi,Hu Yaozhong,Niu Zhenhua,Zhang Xuejiao,Fan Dancai,Ji Xuemeng,Lv Huan,Wang Shuo,Zhao Yanrong
Single nutrient likes polyphenol or dietary fiber have been exhaustively investigated to validate their positive intervention in health or disease. Meanwhile, the common interaction of inner systems with the nutrient complex has not been well elucidated, which raises the scientific issue of the modulatory effect of the nutrient complex on immunity. The representative prebiotics of epigallocatechin-3-gallate (EGCG), ginseng extract, and polydextrose (PDX) were selected on behalf of the classification of polyphenol, flavone or polysaccharides, and dietary fiber to generally cover the daily food intake in this study to explore their intervention in inflammation and macrophage polarization. The intervention of selected nutrients on inflammation and macrophage polarization has been evaluated against macrophages to unveil their comprehensive effects. The synergistic effect of selected nutrients was demonstrated by inhibiting M1 macrophage polarization and the promotion of M2 macrophage polarization. Then, the nutrient formula was set up to verify the intervention effect, and the results revealed the significant inhibition of cell inflammation and the effect on cell proliferation through promoting the cell cycle in the G2 phase. The nutrient complex could inhibit M1 macrophage polarization to inhibit M1-mediated inflammation and promote M2 macrophages for anti-inflammatory effect and enhance cell phagocytosis. Moreover, the varied intervention effects of the nutrient complex with different formulas could be summarized. In general, the formula containing EGCG, ginseng extract, and PDX was demonstrated to possess an enhanced immunomodulatory effect on cell inflammation and macrophage polarization, which could potentially inspire the investigation of complex nutrients in health and diseases.
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ACS Applied Materials & Interfaces
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2026
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IF 8.2
Hui Ying Bai,Rui Hao Chen,Iek Man Lei,Zhi Jian Wang,Zi Liang Wu
The Marangoni effect, driven by interfacial tension gradients, provides a powerful mechanism for achieving autonomous motion in robotics. In gels containing low-surface-tension solvents, motion behavior is primarily governed by solvent-release dynamics and gel’s body geometry, which together define the interfacial net force or torque and thus the resulting motion mode. However, conventional systems based on such Marangoni effect exhibit a single, fixed motion mode because the shape and composition of the material are predetermined. Here, we demonstrate a patterned gel with ethanol as the solvent that integrates two types of gels with distinct solvent-release and swelling behaviors in water, enabling spontaneous changes in shape and motion mode during Marangoni-effect-driven propulsion. When the gel is placed on water, ethanol release from the gel generates a tension gradient that drives motion. The initial geometry of the patterned gel determines the early propulsion mode, while time-dependent solvent diffusion and swelling continuously reshape the gel and thus alter the surface-tension gradient. These evolved variations enable autonomous transition between distinct motion modes, such as spontaneous switching from clockwise to anticlockwise rotation, or from rotation to translation. Such locomotion with time-variant motion modes establishes a new paradigm for programmable and adaptive motion, expanding opportunities in soft robotics and cargo transportation.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Guohua Li,Pengfei Bian,Ran Wang,Yan Li,Huiju Cao,Senlin Zhang,Zongshuo Hao,Mingli Wang,Tifeng Jiao
Through this study, a variety of carbon spheres/dye (CS/dye) composite films were prepared based on the Langmuir-Blodgett (LB) technology. The prepared CS/dye composite films were tested for acid and alkali gases discoloration characteristics. The CS/CR composite film shows good acid/alkaline gas sensing performances, and its characteristic absorption peaks have a significant movement in the UV–vis spectrum. In addition, the surface enhancement of the Raman scattering (SERS) experiment proves the good Raman enhancement performance of the prepared composite LB film with the enhanced factor (EF) of 8.5 × 10 4 . The relative standard deviation of Raman intensity is 24.74 %, indicating the good reproducibility and uniformity of composite film, which makes it applicable to the detection of trace molecules. Furthermore, the CS/NR composite film has a current density of 1217 μA/cm 2 when the potential voltage is 1 V, indicating that the composite film has a high carrier transfer rate, which provides a reference for further exploration of optoelectronic devices of CSs system.
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2023
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IF 3.4
HuaYang Si,Yimeng Chen,Jie Yang,Xiaodong Wen
Although the roots of Achyranthes bidentata (AB), Cyathula officinalis (CO) and Achyranthes aspera (AA) are different drugs, they are always confused in clinical practice due to their similar chemical components and functions. As polysaccharides are abundant in these drugs, a systematic comparison of polysaccharides from AB, CO and AA is not only necessary to understand their similar but not identical functions, but also helpful for the quality control of them. In this study, polysaccharides from 22 batches of AB, CO and AA were compared with monosaccharide composition , molecular weight distribution and saccharide mapping. Polysaccharides of AB, CO and AA had similar monosaccharide compositions but their relative contents of fructose, glucuronic acid , galacturonic acid and glucose were significant different, and could be used as key markers to distinguish them. Results from molecular weight distribution and saccharide mapping showed polysaccharides from AB, CO and AA were mainly composed of fructans with β-2,1 and β-2, 6- D -fructosidic linkages, but their degree of polymerization were different. Meanwhile, pectins were also contained in these three drugs. AB is partial to immunomodulation while CO is partial to removing blood stasis . Fructans and pectins are the similar bioactive substance basis of AB, CO and AA whereas their structural difference might be contributed to the efficacy differentia of these three drugs. This study provides a better understanding on the profiles of polysaccharides from AB, CO and AA, further guiding their clinical usage and facilitating their quality control.
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APPLIED SURFACE SCIENCE
·
2023
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IF 6.7
Boxuan Yao,Ke Zhang,Xiaoyang Liu,Hua Wei,Zihan Li,Jiarui Zhou,Guangfei Yuan,Xin Wang,Shenghong Yang,Jian Liu
Pursuing special negatively charged adsorbents is critical to selectively removing cationic pollutants from effluent. Herein, we proposed a versatile preparation strategy of negatively charged saccharide-based polymers using easily available saccharides as building blocks and hexachlorocyclotriphosphazene as a linker in a facile “one-step” method. Because of the existence of numerous hydroxyl groups and phosphine nitrile units in the skeleton, these polymers show selective adsorption capacity towards cationic dyes and pharmaceuticals, but not for ionic dyes and uncharged bisphenol A. Notably, β-cyclodextrin-based polymers (β-CDPs) displayed remarkable adsorption towards methylene blue (Q m , 1563 mg g −1 ) and promethazine (Q m , 944 mg g −1 ). Systematic experiments revealed that the synergy of “host-guest” inclusion, electrostatic attraction, and π-π interaction promoted the selective and efficient adsorption of cationic pollutants. Given the efficiently selective adsorption of cationic dyes and pharmaceuticals, these negatively charged saccharide-based polymers should be candidates for the adsorption of other cationic pollutants, including heavy metal ions. This work expanded the scope of the special utilization of biomass-based adsorbents for water remediation.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2022
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IF 10.753
Chenxi Zhao,Ruihui Xie,Qiuhui Qian,Jin Yan,Huili Wang,Xuedong Wang
As a broad-spectrum antibacterial agent, triclosan (TCS) has been confirmed to possess potential immunotoxicity to organisms, but the underlying mechanisms remains unclear. Herein, with the aid of transgenic zebrafish strains Tg ( coro 1A: EGFP) and Tg ( rag 2: DsRed), we intuitively observed acute TCS exposure caused the drastic differentiation, abnormal development and distribution of innate immune cells, as well as barriers to formation of adaptive immune T cells. These abnormalities implied occurrence of the cytokine storm, which was further evidenced by expression changes of immune-related genes, and functional biomarkers. Based on transcriptome deep sequencing, target gene prediction and dual luciferase validation, the highly conservative and up-regulated miR-19a was chosen as the research target. Under TCS exposure, miR-19a up-regulation triggered down-regulation of its target gene socs3b , and simultaneously activated the downstream IL-6/STAT3 signaling pathway. Artificial over-expression and knock-down of miR-19a was realized by microinjecting agomir and antagomir, respectively, in 1–2-cell embryos. The miR-19a up-regulation inhibited socs3b expression to activate IL-6/STAT3 pathway, and yielded abnormal changes in the functional cytokine biomarkers, along with the sharp activation of immune responses. These findings disclose the molecular mechanisms regarding TCS-induced immunotoxicity, and offer important theoretical guidance for healthy safety evaluation and disease early warning from TCS pollution.
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Frontiers in Immunology
·
2022
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IF 8.786
Bochen Song,Peng Li,Shaojia Yan,Yan Liu,Mingkun Gao,Huiyuan Lv,Zengpeng Lv,Yuming Guo
This study aimed to investigate the effects of dietary astragalus polysaccharide (APS) supplementation on the immune function, gut microbiota and metabolism of broiler chickens challenged with necrotic enteritis (NE). Two hundred forty Arbor Acres broiler chicks (one day old) were randomly assigned using a 2 × 2 factorial arrangement into two groups fed different levels of dietary APS (0 or 200 ppm of diet) and two disease challenge groups (control or NE challenged). The results showed that NE infection significantly increased FCR, mortality rate, Th17/Treg (Th17 cells% in blood and ileum, Th17/Treg, IL-17 and IL-17/IL-10 in blood), NO, lysozyme activity and IL-1β in blood, intestinal immune cell proportion and activity (Tc%, Treg% and monocyte phagocytic activity in ileum), intestinal inflammatory cytokines (TLR2, NF-κB, TNF-α and IL- 6) gene expression levels, and the number of Clostridium perfringens in cecum. NE infection significantly reduced body weight gain, thymus index, lymphocyte proliferation activity in blood and ileum, villus height and V/C in jejunum, Th cells% and Mucin2 gene expression in ileum. Dietary APS supplementation significantly increased body weight, feed intake, proportion of immune cells (T cells in blood and Tc, Treg in ileum), lymphocyte proliferation activity, V/C in jejunum, and ZO-1 gene expression in ileum. Dietary APS supplementation significantly reduced FCR and mortality rate, Th17/Treg, Th17%, intestinal pathology scores, intestinal inflammatory cytokine gene expression levels, and the number of Clostridium perfringens in cecum. In addition, broilers challenged with NE significantly increased Staphylococcus and Turicibacte r and reduced α diversity of microbiota in ileum. Dietary APS supplementation significantly increased α diversity, Romboutsia , Halomonas , propionic acid, butyric acid, formononetin, taurine, cholic acid and equol and downregulated uric acid, L-arginine and serotonin in ileum. Spearman’s correlation analysis revealed that Romboutsia, Turicibacter, Staphylocpccus, Halomonas, Streptococcus, Escherichia-Shigella, Prevotella , uric acid, L-arginine, jerivne, sodium cholate and cholic acid were related to inflammation and Th17/Treg balance. In conclusion, APS alleviated intestinal inflammation in broilers challenged with NE probably by regulating intestinal immune, Th17/Treg balance, as well as intestinal microbiota and metabolites.
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