JOURNAL OF LUMINESCENCE
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2019
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IF 2.961
Hui Gao,Siyuan Liu,Zhipeng Xue,Wenjing Liu,Yanguang Nie,Guoqing Chen,Xiaolong Li
Herein, CsPbBr 3 quantum dots (QDs) were successfully synthesized via the supersaturated recrystallization (SR) method by using para-xylene as the anti-solvent. The as-prepared CsPbBr 3 QDs exhibited high quantum efficiency (78%) and narrow luminescent peaks with a full width at half maximum of around 21.2 nm. Compared with the commonly-used anti-solvents, para-xylene shows low toxic effect and high freezing point (13.3 °C). Therefore, CsPbBr 3 QDs can be easily preserved in the refrigerator like an ice-cream for further use. The maximum photoluminescence (PL) emission intensity would reach 90% retention after 60 days’ storage in the refrigerator. By using this simple method, the stability of CsPbBr 3 QDs has been effectively improved for long-term storage and further application.
研究领域:
材料科学
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纳米科技
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光电子学
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无机化学
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半导体材料
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高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
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2019
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IF 2.29
Kai Kang,Xiaodong Liang,Georgios M. Kontogeorgis,Xiaopo Wang
In this work, the experimental measurements for liquid densities of n -decane and m -xylene binary mixtures were performed over the entire composition range with a high-pressure vibrating-tube densimeter. The range of temperatures for the present measurements was from 293.15 K to 363.15 K and the pressures were up to 60 MPa. The combined expanded uncertainty of the density measurements is estimated to be 0.001 ρ with 0.95 confidence. Experimental density values were correlated by the modified Tammann-Tait equation. The simplified Perturbed Associating Fluid Theory (sPC-SAFT) and Cubic Plus Associated (CPA) equations of state (EoS) were applied to predict the densities of n -decane and m -xylene and their mixtures. Reasonably results were observed between the experimental data and calculated results for the two equations, and the deviation is less than 0.48% and 0.89% with sPC-SAFT and CPA EoS, respectively. In addition, excess molar volumes were determined from the experimental density data as well as from sPC-SAFT and CPA models. The effects of pressure and temperature on the excess molar volume were also discussed.
研究领域:
化学工程
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热力学
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流体相行为
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高压物理化学
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状态方程建模
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Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
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2019
·Vol. 29
·期 1
·46-53
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IF 1.754
Peng Wei,Han Ping,Yu Luyao,Chen Ying,Ye Bingzhu,Qin Luping,Xin Hailiang,Han Ting
The fruits of Xanthium strumarium L., Asteraceae, have been used for various diseases in Chinese folk medicine, including allergic rhinitis, tympanitis, arthritis, ozena etc. The current study was aimed to investigate the therapeutic effects of caffeoylquinic acids from fruits of X. strumarium on allergic rhinitis in animals. The toxicity test indicated that the caffeoylquinic acids have no obvious toxicity. By using HPLC assays combined with reference standards, ten caffeoylquinic acids were identified as the predominant constituents. Anti-allergic activities of the caffeoylquinic acids were evaluated using passive cutaneous anaphylaxis test and Schultz-Dale test; dimethylbenzene induced ear edema test was performed to evaluate its anti-inflammatory effect. Then, the allergic rhinitis model in rats was established to evaluate the therapeutic effects of the caffeoylquinic acids against allergic rhinitis with the following indexes: allergic rhinitis symptom scores, serum levels of pro-inflammatory cytokines, histopathological examination, and histamine release. Our study revealed that the caffeoylquinic acids showed obvious anti-allergic and anti-inflammatory properties, and its treatments were beneficial for ameliorating the nasal symptoms, decreasing pro-inflammatory cytokines, and inhibiting the releases of histamine. Collectively, the caffeoylquinic acids might be utilized as effective and safe disease therapeutic agents for allergic rhinitis.
研究领域:
药理学
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免疫学
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过敏
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植物化学
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AQUATIC TOXICOLOGY
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2025
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IF 4.3
Xue Yang,Qiwei Zhang,Lihua Yang
The subchronic cardiotoxicity of 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ), an unregulated disinfection byproduct with high environmental detection rates, remains poorly characterized. Using integrated multi-omics (transcriptomics, proteomics, phosphoproteomics) and histopathological analyses in zebrafish, this study systematically elucidated its dose-dependent (low-dose, 10 nM; medium-dose, 100 nM; high-dose, 1000 nM) cardiotoxicity, from adaptive remodeling to failure, over a 35-day exposure period. A reduction in atrioventricular inflow ranging from 81.4 % to 93.9 %, along with lipid droplet accumulation and Z-disc rupture, indicate a dose-dependent cardiac crisis induced by 2,6-DCBQ. Multi-omics analyses, revealed that the kinase cascade involving braf (Myhpc2_T1545), camk2a (Mybpc3_S291), and mark3b (Ttn.1_S28131) arranged dose-dependent cytoskeletal remodeling. High-dose exposure initiated an inflammation-cytoskeleton vicious cycle, wherein chemokine-driven collagen degradation exacerbated Z-disc rupture, while lipotoxic lipid droplets recruit inflammatory infiltrates, collectively escalating irreversible cardiac decompensation. These findings demonstrate that subchronic exposure to 2,6-DCBQ initiates cardiac remodeling, escalating cardiovascular susceptibility in exposed populations.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Jiamei Liu,Jian Zhao,Zhenyan Lu,Guichao Tian,Hong Zhang,Chao Jia,Meifang Zhu
The inherent hydrophilicity of cotton fabrics (CFs) limits their application in advanced functional textiles. Superhydrophobic surface modification has emerged as an effective strategy to impart functionalities such as self-cleaning and oil-water separation. Here, a two-step surface modification approach—combining graft condensation with free radical copolymerization—is developed to fabricate superhydrophobic CFs. The resulting fabrics exhibit a high water contact angle of 163° and a low sliding angle of 7°, indicating excellent surface hydrophobicity. The hydrophobic layer demonstrates exceptional mechanical robustness and chemical stability, maintaining a contact angle above 144° after 150 abrasion and 30 washing cycles. Furthermore, the hydrophobicity remains stable (contact angle >150°) under harsh conditions, including exposure to organic solvents, UV irradiation, elevated temperatures, and acidic/alkaline environments. The modified CFs also exhibit excellent self-cleaning performance and maintain oil-water separation efficiency exceeding 98 % after 20 cycles. These results highlight the potential of the developed modified CFs for applications in outdoor gear, anti-fouling textiles, and marine oil spill remediation.
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APPLIED SURFACE SCIENCE
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2025
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IF 6.9
Wenju Zhu,Shuolong Wang,Wei Peng,Shuang Xu,Jiarui Liu,Kai Ma,Yanyan Ji,Zhao Dai,Bowen Cheng
The research progress on the surface modification and flame retardancy of cotton fibers has been rapid. Driven by considerations of environmental safety and economic feasibility, bio-based flame retardants are favored for their eco-friendly and sustainable characteristics. This study successfully scaled up the preparation of a P/N-rich cottonseed meal-based flame retardant (PmC) − a functional material in which phosphate groups are chemically introduced into the natural components of cottonseed meal. The innovative mechanical grinding method refines solid biomass for application on the surface of cotton fibers. PmC integrates with cotton fibers through a flame-retardant finishing process, forming hydrogen bonds and covalent bonds between PmC and cotton fibers, thereby achieving durable wash resistance for flame-retardant cotton fibers. The limiting oxygen index (LOI) of 110 g/L PmC treated cotton fibers reaches 38.4 %, with a damage length of only 50 mm. Cone calorimetry tests revealed that the total heat release (THR) and peak heat release rate (pHRR) of PmC-treated cotton fibers were reduced by 38.7 % and 82.9 %, respectively. Comprehensive analysis using TG-IR, XPS of the residual char, SEM-EDS further indicated that PmC primarily exerts its flame-retardant effect by acting on the condensed phase of cotton fabrics.
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HISTOLOGY AND HISTOPATHOLOGY
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2026
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IF 2.2
Min Zhang,Yue Chen,Lü Ren,Jinzhi Xia,Lu Tao,Jianguo Hu,Jing Li,Xiaofeng Zhang,Zhijun Geng,Yueyue Wang,Xue Song
Objective: To enhance the quality and efficiency of paraffin-embedded pathological section preparation, this study aims to investigate the potential benefits of utilizing the ultrasound oscillation flotation method (UOFM) for section spreading. Methods: Specimens of various tissue types were processed using both the conventional and UOFM for section spreading. The presence of wrinkles or damage during this process was assessed through HE staining, with the number of wrinkles being quantified. The optimal frequency and power density for section spreading were determined by evaluating the qualified rate of sections at various frequencies and power densities, and the average time required for section spreading was compared between the two methods. Results: The results showed that pathological sections of various tissue types rarely showed paraffin dissolution and section breaking after the UOFM. HE staining also revealed that the group exhibited significantly reduced wrinkling and a more intact tissue structure compared with the conventional method group ( p <0.05). Statistical analysis further indicated that the highest rate of section qualification was achieved when employing a frequency of 33 kHz with a power density of 60% or a frequency of 40 kHz with a power density of 75% ( p <0.05). Additionally, the mean duration of section spreading in the group utilizing the UOFM was significantly reduced ( p <0.05). Conclusions: The UOFM effectively maintains the structural integrity of paraffin pathological sections, significantly enhancing the quality of sections and optimizing section preparation efficiency.
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Cancer Communications
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2026
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IF 28.4
Nianke Zang,Jinfeng Gan,Ye Chen,Zheng Huang,Chichu Xie,Junlong Dang,Changyuan Huang,Linjie Yang,Xuelian Chen,Guangli Rong,Jianbo Sun,Yiming Shao,Julie Wang,Guangying Qi,Yu Liu,Song Guo Zheng
Background: T-LAK cell-originated protein kinase (TOPK), a serine/threonine kinase, is aberrantly overexpressed in human tumors and promotes malignant proliferation. Melanoma is a highly immunogenic tumor in which CD8+ T cell-mediated cytotoxicity is usually less effective in tumor control and responsive to immune checkpoint blockade. It is unclear whether the expression and functional characterization of TOPK within the immune cells affect the tumor microenvironment (TME) in patients with melanoma. This study aims to elucidate the expression pattern and immunoregulatory function of TOPK in CD8+ T lymphocytes during antitumor responses. Methods: Public single-cell RNA-sequencing (scRNA-seq) dataset analysis and flow cytometry assessed TOPK in tumor-infiltrating CD8+ T cells from patients with melanoma. Genetic deletion and pharmacological inhibition of TOPK using HI-TOPK-032 tested T cell-mediated melanoma control. Flow cytometry and tumor cell coculture killing assays measured effector release and target-cell apoptosis. Mechanistic analyses included assessment of interferon regulatory factor 5 (IRF5) expression, together with combination therapy using a programmed cell death protein 1 (PD-1)-blocking antibody in vivo. scRNA-seq of tumor-infiltrating lymphocytes (TILs) from Topkfl/fl and Cd8CreTopkfl/fl mice was also performed to define TOPK-dependent immune programs within the melanoma TME. Results: Single-cell transcriptomes identified a TOPK+ subset of tumor-infiltrating CD8+ T cells in melanoma, which was higher than that in normal lymph nodes (LNs), and exhibited suppressed cytotoxic and cytokine programs. CD8+ T cell-specific Topk deletion increased granzyme B (GzmB), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) secretion and improved tumor control. TOPK-deficient CD8+ T cells showed elevated activation-associated signaling pathways and immune effector gene expression. In murine TIL scRNA-seq, Cd8CreTopkfl/fl tumors exhibited increased effector and activation programs, reduced exhaustion and dysfunction programs, and enhanced immune crosstalk in the TME. Mechanistically, TOPK suppressed IRF5 expression and HI-TOPK-032 restored CD8+ T cell cytotoxicity in vitro and, with anti-PD-1, further inhibited tumor growth and increased intratumoral cytokine production. In human CD8+ T cells, enforced TOPK expression impaired cytotoxicity and cytokine secretion, reversed by IRF5 coexpression. Conclusions: These findings establish TOPK as the immune checkpoint limiting CD8+ T cell functionality in tumors and indicate the potential of TOPK inhibition as a strategy to augment T cell-based immunotherapies.
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PubMed
高影响因子
BIOMASS & BIOENERGY
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2026
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IF 7
Ge-liang Xie,Yu Luo,Kai-cheng Xia,Sheng-ren Li,Lujiang Xu,Zhen Fang
Aromatic amines, particularly aniline derivatives, serve as pivotal intermediates in the manufacture of dyes, pharmaceuticals, and polymers. However, their conventional synthesis remains heavily reliant on fossil feedstocks and frequently employs toxic reagents. The valorization of lignin presents a promising, renewable pathway to these valuable compounds, yet the reactivity of lignin-derived phenols varies markedly depending on their functional group substituents. Herein, a pronounced "promotion-inhibition dichotomy" is reported. Alkyl substituents substantially enhance reactivity-achieving a 44.3 mol% yield of aromatic amines from 4-propylphenol, representing a 34.7% increase over phenol. Conversely, methoxy groups exert a strong inhibitory effect in limiting the yield of aromatic amines from 4-propylguaiacol to only 11.0 mol%. Furthermore, Mo-Ga/HZSM-5 catalyst employed under NH 3 -H 2 atmosphere effectively doubled the yield of aromatic amines to 25.9 mol%. A sequential hydrodeoxygenation-amination strategy is further devised, boosting the yield to 34.1 mol%. Notably, by integrating this two-step strategy with a lignin-first biorefining approach, a 16.6 mol% of aromatic amines (based on lignin) could be achieved from birch. This study elucidates key reactivity principles in lignin valorization and demonstrates an integrated strategy that advances the sustainable production of aromatic amines from renewable biomass.
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Frontiers in Pharmacology
·
2026
·
IF 5.4
Shan Luo,Yake Lan,Ruoqi Zhang,Zhongqiu Luan
Introduction Diabetic nephropathy (DN), as a complication of diabetes, is one of the major causes of end-stage renal disease. Licochalcone B (LCB), a flavonoid active component derived from licorice, is well known for its anti-inflammatory and antioxidant properties. However, the influence of LCB on DN remains unclear. This research investigated the effect of LCB on DN and elucidated the regulatory mechanism. Methods We employed male C57BL/6 mice to construct a DN mouse model induced by a high-fat diet (HFD)/streptozotocin (STZ). In vitro , a high glucose (HG)-induced injury model in HK-2 (human renal tubular epithelial) cells was used to further confirm the protective effects of LCB. Results LCB treatment (20 mg/kg and 40 mg/kg) decreased blood glucose levels, kidney injury, glycogen deposition, and collagen accumulation in the DN mice. Moreover, LCB at a dosage of 40 mg/kg reduced albumin, creatinine, and blood urea nitrogen levels by about 70.7%, 33.4%, and 45.6%, respectively, indicating an improvement in kidney function. In renal tissues, LCB suppressed oxidative stress and apoptosis in HFD/STZ-induced mice. Consistent with in vivo findings, LCB alleviated HG-induced oxidative stress and apoptosis in HK-2 cells. Transcriptome analysis revealed that LCB affects oxidative stress and renal function-related pathways to alleviate DN. Further mechanistic studies demonstrated that LCB treatment upregulates the expressions of heme oxygenase-1 (HO-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2), suggesting activation of the Nrf2/HO-1 signaling pathway. Conclusion Taken together, this research demonstrates that LCB suppresses oxidative stress and apoptosis accompanied by modulating the Nrf2/HO-1 pathway to ameliorate DN, which provides a promising strategy for DN treatment.
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PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Tao Zhang,Chunguang Chen,Jia Liu,Muyuan Liu,Xingcai Wu,Xuewen Hua,Da-xia Zhang,Feng Liu
The insufficient understanding of the diffusion-reaction-polymerization coupling in membrane formation dynamics hinders the application of interfacial polymerization membranes in drug delivery and membrane separation. Here, the relationship between the hydrophilicity of the oil phase and water mass transfer behavior is taken as the breakthrough point. From the perspective of diffusion, the water mass transfer flux is positively correlated with the membrane thickness. From the perspective of polymerization, under the diffusion-limited aggregation model, the polymerization of oligomers leads to uneven membrane thickening. This accounts for the paradoxical observation that thicker membranes exhibit lower encapsulation and rejection rates. Building on a comprehensive understanding of membrane formation dynamics, an AI model that can predict performance with high precision was developed. Furthermore, universal regulation strategies can increase the encapsulation efficiency and rejection rate by 32.3–54.8% and 6.8–23.9%, respectively. This study provides both theoretical basis and technical approaches for designing high-performance microcapsule and separation membrane.
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JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2026
·Vol. 109
·期 2
·e70571
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IF 4.2
Shaoheng Zhang,Fucheng Xie,Gaoming Mo,Haijun Chen,Qing Huang
This study presents the synthesis of low-carbon polyborocarbosilane (PBCS) through a high-temperature and high-pressure method using polysilacarbosilane (PSCS) and o-carborane, addressing the issue of excess carbon and difficulty in introducing boron (B) in conventional polycarbosilane (PCS) precursors. The incorporation of o-carborane significantly accelerates the reaction kinetics compared to conventional PCS synthesis, and structural characterization (FTIR, NMR) confirms the successful integration of boron into the polymer backbone. The PBCS precursor exhibits a reduced carbon content (C/Si molar ratio: 1.48) and enhanced branching degree. During pyrolysis, TG-MS and FTIR analyses reveal accelerated polymer-to-ceramic conversion below 800°C, due to the crosslinking reactions among B─H, Si─H, and Si─CH 3 groups, which promote hydrocarbon release and yield near-stoichiometric SiC ceramics (C/Si = 1.08 at 1800°C). Furthermore, ultrafine PBCS fibers are fabricated via electrospinning of PBCS, after direct thermal curing (without oxidative crosslinking) and pyrolysis, ultrafine near-stoichiometric crystalline SiC ultrafine fibers with low oxygen content and dense structure are obtained. During the sintering process, the formation of B─C/B─Si bonds promotes densification of the SiC ultrafine fibers and suppresses abnormal grain growth, potentially through the formation of boron solid solutions.
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