MACROMOLECULAR RESEARCH
·
2017
·Vol. 25
·期 11
·1070-1075
·
IF 1.405
Wu Dan,Lv Yin,Guo Rui,Li Jiahui,Habadati Aerman,Lu Bowen,Wang Heyun,Wei Zhong
To evaluate the effects of different alcohols (primary, secondary, and two different tertiary alcohols) as initiators on the structure of polycaprolactone (PCL) in ring-opening polymerization (ROP), four experiments were conducted in toluene with tin(II) 2-ethylhexanoate (Sn(Oct) 2 ) as the catalyst. The kinetics of ε -caprolactone ( ε -CL) ROP at different temperatures and monomer concentrations were studied with n -butanol as the initiator and Sn(Oct) 2 as the catalyst. The kinetic plot of ln(M 0 /M t ) vs. time ( t ) seems a linear, which indicates that the propagation rate is in the first order with respect to monomer concentration. When the reaction temperature increased, the reaction rate and the final relative maximum monomer conversions also increased. The molecular weight of PCL initially increased and then decreased as monomer conversion increased. This behavior can be attributed to the high viscosity of the system, which affected monomer diffusion and polymer chain propagation. In addition, prolonging reaction time caused inter-/intramolecular transesterification. However, when monomer concentration decreased, the reaction rate decreased. The actual activation energy of Sn(Oct) 2 -catalyzed ROP of ε -CL in toluene was -75 kJ/mol.
研究领域:
高分子化学
·
材料科学
·
有机催化
·
化学反应工程
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DOI
高影响因子
Journal of Industrial Textiles
·
2025
·
IF 2
Hongyan Wu,Wenna Xing,Chuyan Zheng,Liuyao Wang,Jialu Li
The safety of blood transfusions faces significant challenges due to the presence of leukocytes, which can trigger severe immune responses and facilitate virus transmission. Existing leukocyte reduction filters, predominantly composed of melt-blown nonwovens, encounter difficulties in completely eliminating leukocytes for specific patient populations such as organ transplant recipients. This research introduces electrospun membranes composed of PBS and CS/PBS nanofiber membranes as a novel filtration material. Through the optimization of electrospinning parameters (including voltage, receiving distance, and solution volume), membranes with adjustable pore sizes ranging from 1.3 to 2.1 μm and substantial specific surface areas were developed. Blood filtration trials revealed that nanofiber membranes with an optimal pore size range of 1.9–2.1 μm achieved complete leukocyte removal while preserving a red blood cell (RBC) recovery rate of 87.72%–90.65%. In comparison to conventional filters, these electrospun nanofiber membranes present a promising strategy for highly efficient leukocyte depletion, catering to the demands of critical transfusion scenarios.
研究领域:
生物医学工程
·
纳米技术
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输血医学
·
材料科学
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免疫学
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DOI
高影响因子
Horticultural Plant Journal
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2017
·Vol. 3
·期 4
·165-171
·
IF 0
Yanhui ZHANG,Peiying LIU,Qianqian KONG,Shiyan XING,Xiaojing LIU,Limin SUN
Flavonoids and terpene trilactones, especially, ginkgo flavonglycosides, ginkgolides and bilobalides in leaves of ginkgo trees, need to be studied for effective application of these active components with high medical and health-care values. This study was aimed to provide scientific bases for genealogies selection and harvest season confirmation for Ginkgo biloba . A high-performance liquid chromatographic method (HPLC-ELSD) was developed to determine the contents of terpene trilactone and flavonoid of 36 ancient G. biloba genealogies from 19 provinces in China. The study indicated that the content gradually increased from April to August, and thereafter declined. Analysis of variance indicated that the contents of terpene trilactone, flavonoids, and their respective components had significant difference among 36 genealogies. The cluster analysis showed that No. 72 (Xing'an, Guangxi), No. 58 (Youyang, Chongqing), No. 82 (Rugao, Jiangsu), No. 123 (Huixian, Gansu), No. 99 (Dujun, Guizhou), No. 10 (Tai'an, Shandong) and No. 133 (Mentougou, Beijing) genealogies have higher content of terpene trilactone and flavonoid. These results can help us to select superior variety containing high content of terpene trilactone and flavonoid.
研究领域:
植物化学
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药用植物学
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天然产物化学
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林木遗传育种
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药物代谢
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DOI
JOURNAL OF APPLIED POLYMER SCIENCE
·
2016
·Vol. 133
·期 39
·
IF 1.866
Sha Liu,Jianxin Zong,Zhen Wei,Hang Zhang,Ligai Bai,Haiyan Liu,Hongyuan Yan
An ionic liquid (IL)-based monolithic poly(ionic liquid glycidylmethacrylate- co -ethylene glycol dimethacrylate) column was prepared via in situ free-radical polymerization with 1-vinyl-3-butylimidazolium chlorine as one of the comonomers. The obtained monolithic column was used as the sorbent of solid-phase extraction (SPE) and coupled with high-performance liquid chromatography for the simultaneous determination of the macrolide antibiotics roxithromycin (ROX) and acetylspiramycin (ACE) in processed pure milk. The monolithic column was characterized by Fourier transform infrared spectrometry, scanning electron microscopy, nitrogen absorption–desorption, mercury intrusion porosimetry, and thermogravimetric analysis. The results reveal that the monolithic column exhibited a high selectivity and good permeability to the macrolide antibiotics in milk. The optimized method offered excellent linearity with a linear regression coefficient greater than 0.998. The precisions for interday and intraday were both less than 7.7%. The accuracies expressed by the recoveries for ROX and ACE were in the ranges 92.5–103.8 and 93.0–107.6%, respectively. Compared to the previous methods, this method had a low limit of detection and a good accuracy. As a result, the polymer IL based monolithic column could feasibly be used as a high-selectivity online SPE sorbent for determining trace macrolide antibiotics in milk. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43943.
研究领域:
药物分析
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食品安全
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色谱技术
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分子印迹
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药物残留检测
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DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
·
2013
·Vol. 101
·期 8
·1359-1366
·
IF 2.308
Yu-fei Wang,Hong-feng Guo,Da-jun Ying
Dural closure after the neurosurgery can prevent postoperative complications. Although many types of dural substitute have been developed, most of them lack functional and structural characteristics compared with the natural dura mater. In this study, we used electrospinning method to fabricate a multilayer scaffold to promote dural repair. The inner layer of the scaffold that faces the brain tissue is composed of poly-lactic acid (PLA) to reduce tissue adhesion. The middle layer of the scaffold is composed of poly-ɛ-caprolactone and PLA, which provides a watertight seal. The outer layer of the scaffold contains a large amount of collagen to promote cell attachment and proliferation. The results from in vitro study and an animal model have shown that this multilayer fibrous scaffold has sufficient mechanic strength and biochemical properties to enhance dural repair. Therefore, fabrication of scaffold with multiple functional and structural layers may provide a novel approach for tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1359–1366, 2013.
研究领域:
生物材料
·
神经外科
·
组织工程
·
再生医学
·
生物医学工程
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DOI
高影响因子
International Journal of Bioprinting
·
2017
·Vol. 3
·期 1
·009
·
IF 0
Hang Liu,Sanjairaj Vijayavenkataraman,Dandan Wang,Linzhi Jing,Jie Sun,Kai He
One of the important constituents in tissue engineering is scaffold, which provides structural support and suitable microenvironment for the cell attachment, growth and proliferation. To fabricate micro/nano structures for soft tissue repair and three-dimensional (3D) cell culture, the key is to improve fibre-based scaffold fabrication. Electrohydrodynamic (EHD) jetting is capable of producing and orientating submicron fibres for 3D scaffold fabrication. In this work, an EHD-jetting system was developed to explore the relationship between vital processing parameters and fibre characteristics. In this study, polycaprolactone (PCL) solution prepared by dissolving PCL pellets in acetic acid was used to fabricate the scaffolds. The influence of voltage, motorized stage speed, solution feed rate, and solution concentration on fibre characteristics and scaffold pattern were studied. Morphology of the EHD-jetted PCL fibres and scaffolds were analysed using optical microscope images and scanning electron microscope (SEM) images. Multi-layer scaffolds with the varied coiled pattern were fabricated and analysed. Cell attachment and proliferation have to be investigated in the future by further cell culture studies on these multi-layer coiled scaffolds.
研究领域:
生物材料
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组织工程
·
高分子科学
·
再生医学
·
生物制造
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DOI
PubMed
COLLOID AND POLYMER SCIENCE
·
2013
·Vol. 291
·期 9
·2155-2162
·
IF 2.161
Zhou Xi,Hong Liangzhi
( R )-(−)-1,1′-Binaphthyl-2,2′-diyl hydrogen phosphate (BPA) has been demonstrated as an efficient organocatalyst for controlled ring-opening homopolymerization of ε-caprolactone (ε-CL) and copolymerization of ε-CL with glycolide and lactide. High molar mass PCL with narrow molar mass distribution has also been synthesized from the bulk ring-opening polymerization (ROP) of ε-CL with BPA as catalysts; the highest molar mass of PCL is 4.35 × 10 4 g/mol with polydispersity index of 1.20. The successful synthesis of high molar mass PCL is attributed to the bifunctional activation mechanism for the ROP of ε-CL catalyzed by BPA. More interestingly, ppm level of BPA is sufficient to catalyze controlled ROP of ε-CL.
研究领域:
高分子化学
·
生物材料
·
有机催化
·
可控聚合
·
可降解材料
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DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2018
·
IF 5.08
Huikang Yang,Nianhua Wang,Lei Mo,Mei Wu,Ruimeng Yang,Xiangdong Xu,Yugang Huang,Jiantao Lin,Li-Ming Zhang,Xinqing Jiang
Tumor-targeted multifunctional nanocarriers play an important role in tumor diagnosis and treatment. Herein, disulfide bonds linked amphiphilic hyaluronan-SS-poly(ε-caprolactone) diblock copolymers (HA-SS-PCL) were synthesized and studied as theranostic nanocarriers for tumor diagnosis and treatment. The chemical structure of HA-SS-PCL was confirmed by Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance ( 1 H NMR). The self-assembling behavior of the HA-SS-PCL into GSH-responsive micelles and their degradation were characterized by fluorescence spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). Theranostic nanocarriers encapsulating doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) were formed via a dialysis. In vitro drug release results suggested that the HA-SS-PCL micelles possessed reductant-triggered doxorubicin release ability, which was confirmed by 100% of DOX release from HA-SS-PCL micelles within 12 h under 10 mM of glutathione (GSH), whereas about 40% of DOX was released under non-reductive condition within 24 h. Both flow cytometry and confocal laser scanning microscopy (CLSM) analysis revealed that the HA-SS-PCL micelles loaded with DOX were internalized in HepG2 cell via a receptor mediated mechanism between hyaluronan and the CD44 receptor. Furthermore, the MTT assay and cell apoptosis analysis revealed that the DOX-loaded HA-SS-PCL micelles exhibited pronounced antitumor ability towards HepG2 cells compared with that of the reduction-insensitive HA-PCL micelles at the same DOX dosage. The r 2 relaxivity value of the DOX/SPIO loaded HA-SS-PCL micelles was up to 221.2 mM −1 s −1 (Fe). Thus, the obtained HA-SS-PCL block copolymers demonstrate promising potential as tumor targeting theranostic nanocarriers in the field of tumor diagnosis and treatment.
研究领域:
生物材料
·
肿瘤学
·
药剂学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Qi Huang,Yanmei Zhou,Qingyou Zhang,Enze Wang,Yinghao Min,Han Qiao,Junli Zhang,Tongsen Ma
Based on spirolactam ring-opening reaction, a chromogenic and “off–on” fluorescent sensor for determination of palladium (II) was developed in this paper. The novel sensor was easily synthesized from rhodamine B hydrazide and diacetyl monoxime named RBM. The structure of the sensor has been characterized by ESI-MS and NMR. EDTA-adding experiment indicated that the binding of chemosensor RBM and Pd 2+ was chemically reversible. The fluorescence intensity and absorbance of the sensor showed a good linearity with the concentration of Pd 2+ in the range of 0–15 μM and 0–17 μM, respectively, with detection limits of 0.015 μM and 0.200 μM. Moreover, it has been successfully applied to detect Pd 2+ in palladium-containing catalyst, natural water samples and imaging of Pd 2+ in living cells with satisfying results. The study indicated that this novel sensor could be an attractive approach to detect Pd 2+ in environmental systems and biological systems.
研究领域:
分析化学
·
环境科学
·
生物无机化学
·
分子影像
·
化学生物学
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DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2019
·Vol. 33
·期 5
·e4890
·
IF 3.259
Farah Naz,Bibimaryam Mousavi,Zhixiong Luo,Christia Jabbour,Philippe M. Heynderickx,Somboon Chaemchuen,Francis Verpoort
A series of spray dried zeolitic imidazolate frameworks (ZIFs = ZIF-8, ZIF-67, and Zn/Co-ZIF) are used as a catalyst for the bulk ring-opening polymerization of δ-valerolactone without any co-catalyst to generate polyvalerolactone. Interestingly, using the same catalyst under the same reaction conditions could manipulate the structure of the product polymer, and thus its physical properties. Thus, using a dried substrate leads to the formation of the cyclic polymer while a linear polymer was formed on using the commercially available substrate. An activated monomer mechanism has been suggested where the propagating zinc alkoxide undergoes an intramolecular transesterification to release cyclic or linear polyvalerolactone. The ROP of δ-VL without drying shows that the polymeric zwitterions have little tendency to cyclize in the presence of moisture. At 140 °C, ZIF-8 shows a superior catalytic activity resulting in the production of cyclic polyvalerolactone having a high molecular weight as compared to ZIF-67 or Zn/Co-ZIF due to the presence of highly active sites. The catalyst could be recycled and reused without any significant loss of catalytic activity.
研究领域:
高分子化学
·
材料科学
·
催化化学
·
生物可降解材料
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DOI
高影响因子
CATALYSIS TODAY
·
2018
·
IF 4.667
Xiaoyan Liu,Guojun Lan,Panpan Su,Lihua Qian,Tomas Ramirez Reina,Liang Wang,Ying Li,Jian Liu
The hydrogenation of levulinic acid to γ-valerolactone with water as solvent is a crucial reaction for producing fine chemicals. However, the development of highly stable catalysts is still a major challenge. Here, we prepared a Ru nanoparticles incorporated in mesoporous-carbon (Ru-MC) catalyst to achieve high stability in acidic aqueous medium. The Ru-MC showed excellent catalytic performance (12024 h −1 turnover frequency) in the hydrogenation of LA-to-GVL. Compared with Ru supported on mesoporous carbon catalyst (Ru/MC) prepared by conventional wet impregnation method, the Ru-MC showed excellent reusability (more than 6 times) and thermal stability (up to 600 °C). Based on H 2 -TPR-MS characterization, it was proposed that the incorporated structure significantly increased the interaction between Ru nanoparticles and carbon support, which effectively prevent the leaching and sintering of Ru nanoparticles and contributed to increased high reusability and thermal stability of the Ru-MC.
研究领域:
催化化学
·
绿色化学
·
生物质转化
·
纳米材料
·
能源化学
·
有机合成
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
·
IF 3.141
Yanping Huang,Nianhua Dan,Weihua Dan,Weifeng Zhao,Zhongxiang Bai,Yining Chen,Changkai Yang
The aim of this study was to fabricate a novel bilayered wound dressing with excellent antibacterial performance through electrospinning and in situ cross-linking polymerization. Quaternary ammonium salts ([2-(methacryloyloxy)ethyl] trimethylammonium, MTA) were first polymerized and cross-linked in the presence of polycaprolactone (PCL) to form PCL/PMTA composites. Then, PCL was electrospun as the cytocompatible inner layer that directly contacts the wound, and the PCL/PMTA layer was placed as the outer layer as a defense against bacteria. The PCL/PMTA layer exhibited a hydrophilic surface and showed a strong antibacterial effect on E. coli and S. aureus. All bilayered antimicrobial nanofiber membranes did not release any toxic agents to cells, and the PCL layer exhibited better effects on cell growth. The electrospun bilayered nanofiber membranes are promising candidates for antimicrobial wound dressings.
研究领域:
生物材料学
·
组织工程
·
纳米医学
·
创伤修复
·
高分子科学
·
抗菌材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）