CNS Neuroscience & Therapeutics
·
2022
·
IF 7.035
Jing Li,Jianhao Liang,Meiqin Zeng,Kaijian Sun,Yunhao Luo,Huaping Zheng,Feng Li,Wen Yuan,Hongwei Zhou,Junshan Liu,Haitao Sun
Introduction White matter injury (WMI) significantly affects neurobehavioral recovery in intracerebral hemorrhage (ICH) patients. Gut dysbiosis plays an important role in the pathogenesis of neurological disorders. Oxymatrine (OMT) has therapeutic effects on inflammation-mediated diseases. Whether OMT exerts therapeutic effects on WMI after ICH and the role of gut microbiota involved in this process is largely unknown. Methods Neurological deficits, WMI, gut microbial composition, intestinal barrier function, and systemic inflammation were investigated after ICH. Fecal microbiota transplantation (FMT) was performed to elucidate the role of gut microbiota in the pathogenesis of ICH. Results OMT promoted long-term neurological function recovery and ameliorated WMI in the peri-hematoma region and distal corticospinal tract ( CST ) region after ICH. ICH induced significant and persistent gut dysbiosis, which was obviously regulated by OMT. In addition, OMT alleviated intestinal barrier dysfunction and systemic inflammation. Correlation analysis revealed that gut microbiota alteration was significantly correlated with inflammation, intestinal barrier permeability, and neurological deficits after ICH. Moreover, OMT-induced gut microbiota alteration could confer protection against neurological deficits and intestinal barrier disruption. Conclusions Our study demonstrates that OMT ameliorates ICH-induced WMI and neurological deficits by modulating gut microbiota.
研究领域:
神经病学
·
肠道微生物学
·
分子药理学
·
神经免疫学
·
转化医学
✓ 已验证
DOI
高影响因子
CHEMISTRY AND PHYSICS OF LIPIDS
·
2019
·
IF 2.536
Yuan Gao,Shimin Wu,Renhuai Cong,Junyong Xiao,Fangli Ma
Schisandra chinensis is a medicinal and edible plant that contains various bioactive compounds. Among these, lignans are the major functional compounds. Nevertheless, detailed information about lignans in Schisandra chinensis oil remains scarce. A powerful UPLC-Q/TOF-MS method was established for the rapid identification of the lignan constituents of Schisandra chinensis oils. The results showed that 21 lignans have been unambiguously identified, and four lignans have been tentatively identified in the Schisandra chinensis oils. In addition, semi-quantitative analysis indicated that the total lignan content in the Schisandra chinensis oils was distributed from 67.73 ± 0.06 to 87.61 ± 1.83 mg/g. Schisandrin and schisandrin B were the most abundant lignans in the Schisandra chinensis oils, their content ranging from 15.85 ± 0.09 to 20.57 ± 0.38 mg/g. Additionally, this study provided a systematic characterization of lignans in Schisandra chinensis oil and indicated that the oil might be used as lignan-related functional foods.
研究领域:
植物化学
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分析化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2018
·
IF 2.196
Li Zhang,Fangxiang Song,Yonggui Wu,Liang Cheng,Jin Qian,Shuai Wang,Qianlin Chen,Yan Li
In this study, the as-prepared spherical mesoporous silica was modified by amino and cyano groups via grafting, and the amino and carboxyl functionalized adsorption materials (MSS@NH2@COOH) were obtained after cyano group hydrolysis. The introduction of amino and carboxyl groups increases the surface active sites of the materials. The materials were characterized by SEM, TEM, XRD, N2 adsorption/desorption, XPS, etc. BET analysis revealed the amino and carboxyl functionalized mesoporous silica maintained their mesostructure nature and its specific surface area was 113 m2·g–1. TG-DTA and FT-IR confirmed effective grafting on the surface of mesoporous silica with functionalized groups. The simulated wastewater of Ni(II) was carried out to test the adsorption properties of the materials, and several influential factors (pH, initial nickel ion concentration, adsorbent dose) were discussed. The saturated adsorption capacity increased clearly from 46.55 mg·g–1 of MSS to 125.57 mg·g–1 of MSS@NH2@COOH. Even recycling three times, the removal rate of Ni(II) ions using MSS@NH2@COOH as an adsorbent could still be over 75%. Adsorption isotherms, kinetics, and thermodynamics of adsorption were taken to clarify the adsorption process. This newly developed adsorbent material does exhibit good reusable performance and effective removal of the heavy metal ions of Ni(II).
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Kai Liu,Ye Zhang,Ti Zhou,Xiaohe Liu,Bo Chen,Xin Wang,Xiaojun Zhao,Jianzhong Huo,Yajing Wang,Bolin Zhu
A novel multifunctional sensor based on the ‘privileged ligand’ salen scaffold conjugated with BODIPY was designed and synthesized. This conjugate displays a sequential recognition of Hg 2+ and I − with high selectivity and sensitivity via formation of three-component ensembles.These new approaches have been successfully applied for the detection of their corresponding targets in Haihe River with acceptable recovery.
研究领域:
分析化学
·
环境监测
·
分子探针
·
生物传感
·
无机离子检测
✓ 已验证
DOI
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2019
·
IF 3.834
Yunlei Zhang,Bing Li,Yanan Wei,Changhao Yan,Minjia Meng,Yongsheng Yan
Developing a green and economically viable approach for the direct synthesis of metal-organic frameworks (MOFs) catalysts with multifunctional active sites remains the key step for their applications in heterogeneous catalysis field. Herein, we report a green (aqueous solutions), mild (90 °C, atmospheric pressure), and modulated hydrothermal (MHT) approach to synthesize UiO-66-type MOFs catalysts with acid–base bi-functional sites, which were obtained via the coordination of monosodium 2-sulfoterephthalate and 2-aminoterephthalic with zirconium (Zr) ions. More importantly, a series of acid, base and acid–base catalysts with varied acid–base strengths can be readily prepared, by simply varying the ratio of organic ligands for preparing MOFs. The synthesized catalysts were characterized and their performances in glucose dehydration to produce 5-hydroxymethylfurfural (5-HMF) have been evaluated. The developed approach in this work has clearly depicted a roadmap for the facile synthesis of MOFs catalysts to facilitate their potential use in acid–base catalysis.
研究领域:
化学工程
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Xin Wen,Zhanfang Cao,Jing Wang,Shuai Wang,Hong Zhong
A novel tri-isopropanolamine functionalized graphene oxide (TI-GO) adsorbent was synthesized by one-step reaction at 358K. Then the prepared TI-GO was characterized by SEM-EDS, FTIR, Raman spectra, TG, BET and XPS. The characterization results indicated the TI-GO has been synthesized successfully and it interact with Pb(II) ions through its nitrogen and oxygen-containing functional groups. Batch adsorption experiments were applied to evaluate the optimized conditions of adsorption. The results indicated that the TI-GO can reach equilibrium adsorption in 30 min and get maximum adsorption capacity at 293 K, pH 5.0. Besides, the adsorption kinetic and adsorption isotherm research indicated that the adsorption of TI-GO fit pseudo-second-order (PSO) kinetic and Langmuir adsorption isotherm model. In addition, the maximum adsorption capacity evaluated by Langmuir adsorption isotherm equation is 1478 mg/g.
研究领域:
环境科学
·
材料科学
·
化学工程
·
环境污染治理
·
吸附材料
✓ 已验证
DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 90
·49153-49160
·
IF 3.708
Dan Liu,Nan Song,Ye-Chun Cheng,Dai-Xiong Chen,Qiong Jia,Ying-Wei Yang
Poly(glycidyl methacrylate-co-ethylene dimethacrylate) modified with a new supramolecular macrocycle, carboxylatopillar[5]arene, was successfully prepared inside a capillary. The functionalized polymer monolith material was characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, and Fourier-transformed infrared spectra. The experimental results showed that this type of polymer possess a good network skeleton structure and excellent extraction properties for the enrichment of parabens by polymer monolith solid-phase microextraction coupled with high performance liquid chromatography. Compared with other pre-treatment methods, the simple operation and inexpensive instrumentation characteristics of the developed polymer monolith SPME method make it more suitable for the extraction of parabens in red wine samples with great potential for further broadening its applications in the enrichment of other real samples.
研究领域:
分析化学
·
环境科学
·
食品安全
·
材料科学
·
色谱学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2020
·
IF 5.065
Jianwei Bai,Xiaofei Ma,Cen Gong,Yiming Chen,Huijun Yan,Kewei Wang,Jun Wang
Traditional adsorption resin prepared by a low efficiency method has a low porosity and surface area , which limits the adsorption performance of the resin. Therefore, a novel porous resin was developed by structural design of the resins through post- modification with HPA and a post-crosslinked method. The novel porous post-modification resin was successfully prepared by the multistep method. Meanwhile, the high surface area and abundant micropores in HCR-AO can improve the adsorption rate by accelerating the diffusion of uranium in the external diffusion stage. The removal capacity of HCR-AO increased 366% for HCR and 120% for PSD-AO at the same initial concentration. HCR-AO takes less time to reach equilibrium than PSD-AO and HCR. Excitingly, the adsorption amount of the material dropped only slightly even after 8 cycles. The short equilibrium time and outstanding removal efficiency makes it a novel candidate for further extraction of U (VI) from seawater .
研究领域:
环境化学
·
核化学
·
材料科学
·
吸附分离
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海洋资源提取
✓ 已验证
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2017
·
IF 6.395
H.R. Jiang,W. Shyy,M.C. Wu,L. Wei,T.S. Zhao
The potential of B 4 C as a metal-free catalyst for vanadium redox reactions is investigated by first-principles calculations. Results show that the central carbon atom of B 4 C can act as a highly active reaction site for redox reactions , due primarily to the abundant unpaired electrons around it. The catalytic effect is then verified experimentally by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) tests, both of which demonstrate that B 4 C nanoparticles can enhance the kinetics for both V 2+ /V 3+ and VO 2+ /VO 2 + redox reactions, indicating a bi-functional effect. The B 4 C-nanoparticle-modified graphite felt electrodes are finally prepared and tested in vanadium redox flow batteries (VRFBs). It is shown that the batteries with the prepared electrodes exhibit energy efficiencies of 88.9% and 80.0% at the current densities of 80 and 160 mA cm −2 , which are 16.6% and 18.8% higher than those with the original graphite felt electrodes. With a further increase in current densities to 240 and 320 mA cm −2 , the batteries can still maintain energy efficiencies of 72.0% and 63.8%, respectively. All these results show that the B 4 C-nanoparticle-modified graphite felt electrode outperforms existing metal-free catalyst modified electrodes , and thus can be promising electrodes for VRFBs.
研究领域:
电化学
·
能源材料
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催化化学
·
储能技术
·
材料科学
✓ 已验证
DOI
高影响因子
CARBON
·
2012
·Vol. 50
·期 8
·2810-2815
·
IF 5.378
Yongqiang Dong,Ruixue Wang,Hao Li,Jingwei Shao,Yuwu Chi,Xiaomei Lin,Guonan Chen
Polyamine-functionalized carbon quantum dots (CQDs) with high fluorescence quantum yield (42.5%) have been synthesized by the low temperature (<200 °C) carbonization of citric acid with branched polyethylenimine (BPEI) in one simple step. The obtained BPEI–CQDs are spherical graphite nanocrystals (average 6.2 nm in size) capped with abundant BPEI at their surfaces. It is the first report that CQDs are both amino-functionalized and highly fluorescent, which suggests their promising applications in chemical sensing.
研究领域:
分析化学
·
纳米材料
·
生物传感
·
荧光成像
·
分子探针
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2020
·
IF 6.551
Hao Lei,Daohui Zhou,Jiao Tang,Xiaoping Hu,Ning Pan,Hao Zou,Fangting Chi,Xiaoqiang Wang
A novel approach to synthesize phytic acid (PA) functionalized graphene oxide (P-pFGO-7) treated by the photo-Fenton reaction has been designed, which has been used as an adsorbent for efficient capture of U(VI) from aqueous solution. The structure and morphology of P-pFGO-7 were characterized well. The adsorption property for P-pFGO-7 was comprehensively assessed by batch experiments, showing the high adsorption capacity (266.7 mg/g, at pH = 4.0, T = 298 K), fast adsorption kinetics (~10 min), good selectivity for U(VI) and Ln-An ions in various coexisting ions and excellent regeneration capacity. With the assistance of various characterization techniques and batch adsorption results, it is found that PA makes the most contribution to coordinate U(VI) heavily depending on the P O moiety. P-pFGO-7 could be regenerated by 0.1 mol/L Na 2 CO 3 with ~95% desorption efficiency and reused well after five recycles. This present work provides a feasible route to modify graphene oxide and extend PA for potentially practical application in the removal of U(VI) from radioactive wastewater .
研究领域:
环境化学
·
核科学与技术
·
材料科学
·
水处理技术
·
放射化学
·
纳米材料
·
吸附科学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2013
·Vol. 34
·期 16
·1319-1324
·
IF 4.929
Chaohong Zhang,Ci Song,Wantai Yang,Jianping Deng
This communication reports the first gold nanoparticles (NPs) chirally functionalized with optically active helical substituted polyacetylene (the resulting hybrid particles are defined as Au@PPA NPs). The novel nanoparticles consist of gold as core and optically active helical poly( N -propargylamide) as shell and show considerable optical activity derived from helical poly( N -propargylamide) chains with predominantly one-handed screw sense. The Au@PPA NPs are prepared by a three-step approach: i) a thiol-containing N -propargylamide monomer [M th , HC≡CCH 2 NHCO(CH 2 ) 10 SH] is synthesized and characterized with FTIR and 1 HNMR spectroscopy and elemental analysis; ii) a copolymer (poly(M th - co -M ch )) was prepared by starting from monomer M th and another chiral N -propargylamide monomer (M ch ); poly(M th - co -M ch ) formed helical conformations and showed optical activities; and, iii) Au@PPA NPs are prepared from hydrogen tetrachloroaurate (III) and poly(M th - co -M ch ) through a one-spot procedure by using LiBH 4 as reducing agent. The as-obtained hybrid nanoparticles are characterized by FTIR spectroscopy, TEM, UV-vis absorption and circular dichroism (CD) techniques. UV-vis and CD measurements demonstrated the remarkable optical activity of the Au@PPA NPs. More interestingly, the Au@PPA NPs show much stronger UV-vis and CD sigals when compared to the corresponding orginal helical copolymer, poly(M th - co -M ch ). The chiral hybrid nanoparticles demonstrate different absorption toward (R)-(+)- and (S)-(−)-1-phenylethylamines, preferentially adsorbing the (S)-isomer.
研究领域:
纳米医学
·
生物材料
·
分子识别
·
药物递送
·
化学生物学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）